scholarly journals Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in Argentina

2015 ◽  
Vol 73 (9) ◽  
pp. 751-754 ◽  
Author(s):  
Maximiliano A Hawkes ◽  
Miguel Wilken ◽  
Verónica Bruno ◽  
Virginia Pujol-Lereis ◽  
Guillermo Povedano ◽  
...  

CADASIL is the most common cause of hereditary stroke and vascular dementia. Published information about this disease in South America is scant. We describe clinical and demographic characteristics of 13 patients (10 families) with CADASIL from Argentina.Methods Medical records, diagnostic tests and family history of patients with CADASIL were reviewed.Results Thirteen patients with CADASIL (10 families) were included. All patients had European ancestry. Initial presentation was stroke in most patients (n = 11). Stroke patients later developed cognitive complaints (n = 9), migraine with aura (n = 1), apathy (n = 4) and depression (n = 6). External capsule and temporal lobe involvement on MRI were characteristic imaging findings. Two patients died after intracerebral hemorrhage.Conclusion This is the first report of non-related patients with CADASIL in South America addressing ancestry. Since European ancestry is not highly prevalent in all South American countries, there may be variable incidence of CADASIL within this region.

2008 ◽  
Vol 12 (3) ◽  
pp. 133-138 ◽  
Author(s):  
Patricia T. Ting ◽  
Benjamin Barankin

Background: Myiasis is a cutaneous infestation with larvae of Diptera, the two-winged arthropod order. Eggs and/or larvae are transmitted directly from the environment or via arthropod vectors. Larvae are able to burrow into the dermis of intact skin or external body orifices. Three clinical variants of myiasis are furuncular, migratory (creeping), and infestation of wounds. Methods: A 35-year-old male presented with a 1-month history of worsening furuncles on the left knee and posterior thigh following his return from Panama, South America. Clinical examination revealed tender 6 cm and 2 cm erythematous to violaceous furuncles with surrounding desquamation and central puncta draining serosanguinous fluid. Five-millimeter punch biopsies and tissue swabs were performed. Results: All larvae were of the Dermatobia hominis species. The patient was empirically treated with cephalexin and ciprofloxacin for secondary bacterial cellulitis. Tissue swabs later cultured group B streptococcus. A tetanus booster was recommended. Conclusion: This case report describes a relatively rare cutaneous infestation with D. hominis, a Central and South American endemic larva of the human botfly. Increasing trends toward immigration and global travel to tropical and subtropic areas will likely increase the frequency of encounters with such parasitic cutaneous infestations in North American outpatient dermatology clinics.


Lankesteriana ◽  
2019 ◽  
Author(s):  
Carlos Ossenbach ◽  
Rudolf Jenny

This study represents the first part of a series dedicated to the work of Rudolf Schlechter on the orchid flora of South America. The historical background of Schlechter’s botanical activity is outlined, and salient aspects of his biography, as well as his main scientific relationships, in particular with Oakes Ames, and the origins of his interest in tropical America are discussed. We also present a complete bibliography relative to Schlechter’s production on the orchid floras of South American countries, with his network of orchid collectors, growers and other purveyors, and checklists of all the new taxa that he described from each individual country.   Key words: bibliography, biography, history of botany, Orchidaceae, South America


eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Paloma Diaz-Maroto ◽  
Alba Rey-Iglesia ◽  
Isabel Cartajena ◽  
Lautaro Núñez ◽  
Michael V Westbury ◽  
...  

The study of South American camelids and their domestication is a highly debated topic in zooarchaeology. Identifying the domestic species (alpaca and llama) in archaeological sites based solely on morphological data is challenging due to their similarity with respect to their wild ancestors. Using genetic methods also presents challenges due to the hybridization history of the domestic species, which are thought to have extensively hybridized following the Spanish conquest of South America that resulted in camelids slaughtered en masse. In this study, we generated mitochondrial genomes for 61 ancient South American camelids dated between 3,500 and 2,400 years before the present (Early Formative period) from two archaeological sites in Northern Chile (Tulán-54 and Tulán-85), as well as 66 modern camelid mitogenomes and 815 modern mitochondrial control region sequences from across South America. In addition, we performed osteometric analyses to differentiate big and small body size camelids. A comparative analysis of these data suggests that a substantial proportion of the ancient vicuña genetic variation has been lost since the Early Formative period, as it is not present in modern specimens. Moreover, we propose a domestication hypothesis that includes an ancient guanaco population that no longer exists. Finally, we find evidence that interbreeding practices were widespread during the domestication process by the early camelid herders in the Atacama during the Early Formative period and predating the Spanish conquest.


2020 ◽  
Vol 48 (1) ◽  
pp. 287-325
Author(s):  
Matthew Brown

Historians have tended to ignore the South American experience of cycling. The continent’s diverse history of sports has been effaced by a popular and academic focus on soccer. The global history of cycling has therefore omitted South America from its analysis, perpetuating mistaken assumptions about the continent’s absence from technological and social innovation. This article analyses the sources located across the continent to demonstrate that cyclists raced, toured, and did acrobatics, often watched by thousands of spectators, attracting the attention of chroniclers and the media. The physical sensations of travelling through the environment on a pedal-powered machine were new and unexpected. With its focus on cycling as sport, recreation and mode of transport, this article inserts South America into the early global history of cycling.


2019 ◽  
Author(s):  
Kevin Jiménez-Lara ◽  
Jhon González

AbstractThe evolutionary history of the South American anteaters, Vermilingua, is incompletely known as consequence of the fragmentary and geographically biased nature of the fossil record of this group. Neotamandua borealis is the only recorded extinct species from northern South America, specifically from the Middle Miocene of La Venta area, southwestern Colombia. A new genus and species of myrmecophagid for La Venta, Gen. et sp. nov., is here described based on a new partial skull. Additionally, given that the co-occurrent species of Gen. et sp. nov., N. borealis, was originally referred to as Neotamandua, the taxonomic status of this genus is revised. The morphological and taxonomic analyses of these taxa indicate that Gen. et sp. nov. may be related to Tamandua and that the justification of the generic assignments of the species referred to as Neotamandua is weak or insufficient. Two species previously referred to as Neotamandua (N. magna and N.? australis) were designated as species inquirendae and new diagnostic information for the redefined genus and its type species, N. conspicua, is provided. Together, these results suggest that the diversification of Myrmecophagidae was taxonomically and biogeographically more complex than what has been proposed so far. Considering the new evidence, it is proposed a synthetic model on the diversification of these xenartrans during the late Cenozoic based on the probable relationships between their intrinsic ecological constraints and some major abiotic changes in the Americas.


2018 ◽  
Vol 46 (1) ◽  
pp. 82 ◽  
Author(s):  
José Duque-Trujillo ◽  
Camilo Bustamante ◽  
Luigi Solari ◽  
Álvaro Gómez-Mafla ◽  
Gloria Toro-Villegas ◽  
...  

The Antioquia batholith represents the magmatic record of the interaction between the Farallón and Caribbean plates with the NW part of the South American Plate during the Meso-Cenozoic. Several authors have reported zircon U-Pb ages and whole rock geochemistry in order to constrain the crystallization history of this batholith and its formation conditions. The present work aims to gather the existing data with new data obtained from the Ovejas batholith and La Unión stock, both genetically related to the main intrusion. Gathering our new data with information obtained in previous works, we conclude that the Antioquia batholith was constructed by successive pulses from ca. 97 to 58 Ma in an arc-related setting. The initial pulses are related to syn-collisional tectonics, during the early interaction between the Farallón plate and NW South America. The final pulses, that record Eocene ages, are related to a post-collisional setting, similar to that recorded in other plutons of the Paleogene magmatic arc of the Central Cordillera.


2020 ◽  
Vol 8 ◽  
pp. 205031212096532
Author(s):  
Madeline R MacDonald ◽  
Sydney Zarriello ◽  
Justin Swanson ◽  
Noura Ayoubi ◽  
Rahul Mhaskar ◽  
...  

Objectives: Free clinics manage a diversity of diseases among the uninsured. We sought to assess the medical management of stroke in a population of uninsured patients. Methods: A retrospective chart review was conducted to collect chronic disease statistics from 6558 electronic medical records and paper charts at nine free clinics in Tampa, Florida, from January 2016 to December 2017. Demographics and risk factors were compared between stroke patients and non-stroke patients. Medication rates for several comorbidities were also assessed. Results: Two percent (107) of patients had been diagnosed with a stroke. Stroke patients were older (mean (M) = 56.0, standard deviation (SD) = 11.2) than the rest of the sample (M = 43.3, SD = 15.4), p < 0.001 and a majority were men (n = 62, 58%). Of the stroke patients with hypertension (n = 79), 81% (n = 64) were receiving anti-hypertensive medications. Of the stroke patients with diabetes (n = 43), 72% (n = 31) were receiving diabetes medications. Among all stroke patients, 44% were receiving aspirin therapy (n = 47). Similarly, 39% of all stroke patients (n = 42) were taking statins. Conclusions: Uninsured patients with a history of stroke may not be receiving adequate secondary prevention highlighting the risk and vulnerability of uninsured patients. This finding identifies an area for improvement in secondary stroke prevention in free clinics.


1995 ◽  
Vol 14 (1) ◽  
pp. 23-36 ◽  
Author(s):  
Sandra Herbert

This work is an analysis and edition of a previously unpublished essay by Charles Darwin entitled "Reflection on reading my Geological notes." The original draft of the essay appears to have been written in 1834, that is, during Darwin's voyage on H.M.S. Beagle (1831-1836). In the essay Darwin developed a theory of the geological formation of South America that included a narrative framework for the history of life on the continent. His treatment of the history of life is not yet transmutationist, but it is highly sequential.


2018 ◽  
Vol 285 (1885) ◽  
pp. 20180843 ◽  
Author(s):  
Paula Bona ◽  
Martín D. Ezcurra ◽  
Francisco Barrios ◽  
María V. Fernandez Blanco

Caimanines are crocodylians currently restricted to South and Central America and the oldest members are from lower Palaeocene localities of the Salamanca Formation (Chubut Province, Argentina). We report here a new caimanine from this same unit represented by a skull roof and partial braincase. Its phylogenetic relationships were explored in a cladistic analysis using standard characters and a morphogeometric two-dimensional configuration of the skull roof. The phylogenetic results were used for an event-based supermodel quantitative palaeobiogeographic analysis. The new species is recovered as the most basal member of the South American caimanines, and the Cretaceous North American lineage ‘ Brachychampsa and related forms' as the most basal Caimaninae. The biogeographic results estimated north-central North America as the ancestral area of Caimaninae, showing that the Cretaceous and Palaeocene species of the group were more widespread than thought and became regionally extinct in North America around the Cretaceous–Palaeocene boundary. A dispersal event from north-central North America during the middle Late Cretaceous explains the arrival of the group to South America. The Palaeogene assemblage of Patagonian crocodylians is composed of three lineages of caimanines as a consequence of independent dispersal events that occurred between North and South America and within South America around the Cretaceous–Palaeogene boundary.


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