scholarly journals Genetic Polymorphism in MMP9 May Be Associated With Anterior Open Bite in Children

2017 ◽  
Vol 28 (3) ◽  
pp. 277-280 ◽  
Author(s):  
Erika Calvano Küchler ◽  
Driely Barreiros ◽  
Raphaela Oliveira da Silva ◽  
Júlia Guimarães Barcellos de Abreu ◽  
Ellen Cardoso Teixeira ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Protective Factor ◽  
Recessive Model ◽  
Open Bite ◽  
Anterior Open Bite ◽  
Chi Square ◽  
Genotype Frequencies ◽  
Chi Square Test

Abstract Anterior open bite (AOB) has a multifactorial etiology caused by the interaction of sucking habits and genetic factors. The aim of this study was to evaluate the association between AOB and polymorphisms in genes that encode Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Four hundred and seventy-two children that presented at least one sucking habit were evaluated. Children were examined clinically for the presence of AOB. Genomic DNA was extracted from saliva. Genotyping of the selected polymorphisms in MMP2, MMP3, MMP9, TIMP1 and TIMP2 was carried out by real-time PCR using the TaqMan method. Allele and genotype frequencies were compared between the groups with and without AOB using the PLINK® software in a free and in a recessive model using a chi-square test. Logistic regression analysis was implemented (p≤0.05). Two hundred nineteen children had AOB while 253 did not. The polymorphism rs17576 in MMP9 was significantly associated with AOB (p=0.009). In a recessive model GG genotype was a protective factor for AOB (p=0.014; OR 4.6, 95%CI 1.3-16.2). In the logistic regression analysis, none of the genes was associated with AOB. In conclusion, the polymorphism rs17576 (glutamine for arginine substitution) in MMP9 was a protective factor for AOB.

scholarly journals Lumbar spondylolisthesis is a risk factor for osteoporotic vertebral fractures: a case–control study

2018 ◽  
Vol 46 (9) ◽  
pp. 3605-3612
Author(s):  
Peng Wang ◽  
Feng Wang ◽  
Yan-Long Gao ◽  
Jia-qi Li ◽  
Jing-tao Zhang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Previous History ◽  
Vertebral Compression Fractures ◽  
Chi Square ◽  
Compression Fractures ◽  
Chi Square Test ◽  
History Of ◽  
Lumbar Spondylolisthesis

Objective This study aimed to identify the risk factors for vertebral compression fractures in patients with osteoporosis. Methods A total of 864 patients with osteoporosis were enrolled in a retrospective study from February 2010 to June 2016. Patients with diseases, such as pathological fractures, high-energy direct injury to the thoracic or lumbar vertebrae, and severe spinal deformity, were excluded. The patients were divided into two groups: those with vertebral compression fractures (288) and those with no vertebral compression fractures (576). Information on the patients’ age, sex, lumbar bone mineral density (BMD), trauma, body mass index, previous history of vertebral compression fractures, and spondylolisthesis was recorded. Logistic regression analysis and the chi-square test were applied for comparisons. Results Univariate logistic regression analysis and chi-square test results showed no significant differences in age, sex, body mass index, type 2 diabetes, previous history of vertebral fracture, and trivial trauma between the groups. Multivariate analysis showed significant associations between spondylolisthesis and BMD. Logistic regression analysis showed that spondylolisthesis and BMD were risk factors for vertebral compression fractures. Conclusions Lumbar spondylolisthesis is an independent risk factor for vertebral compression fractures in patients with osteoporosis. Therefore, patients with osteoporosis and lumbar spondylolisthesis require more attention.

scholarly journals A Study of Taiwanese Banks’ Home Loan Life Insurance Attached to Home Loans

2020 ◽  
pp. 225-239
Author(s):  
Pih-Shuw Chen ◽  
Jia-Jan Lee ◽  
Pei-Fen Ou
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Life Insurance ◽  
Insurance Industry ◽  
Chi Square ◽  
Factors Influencing ◽  
Chi Square Test ◽  
Main Factors ◽  
Housing Guarantee

The purpose of this study is to understand the main factors influencing the additional purchase of home loan life insurance at the time of home loan processing with Taiwan's banks. We used Taiwanese banks 417 customers who applied for housing guarantee loans from between 2014-2018. The chi-square test shows that gender and occupation significantly influence the purchase of home loan life insurance. The logistic regression analysis indicates that occupation significantly influences the purchase of home loan life insurance. This study may provide a basis for banking practitioners to develop future customers in the insurance industry.

scholarly journals Validating HMMR Expression and Its Prognostic Significance in Lung Adenocarcinoma Based on Data Mining and Bioinformatics Methods

2021 ◽  
Vol 11 ◽  
Author(s):  
Xia Li ◽  
Haiwei Zuo ◽  
Li Zhang ◽  
Qiuwen Sun ◽  
Yong Xin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Lung Adenocarcinoma ◽  
Signaling Pathways ◽  
Logistic Regression Analysis ◽  
Ppi Network ◽  
Chi Square ◽  
Kaplan Meier ◽  
Chi Square Test

Hyaluronic acid-mediated motility receptor (HMMR), a tumor-related gene, plays a vital role in the occurrence and progression of various cancers. This research is aimed to reveal the effect of HMMR in lung adenocarcinoma (LUAD). We first obtained the gene expression profiles and clinical data of patients with LUAD from The Cancer Genome Atlas (TCGA) database. Then, based on the TCGA cohort, the HMMR expression difference between LUAD tissues and nontumor tissues was detected and verified with public tissue microarrays (TMAs), clinical LUAD specimen cohort, and Gene Expression Omnibus (GEO) cohort. Logistic regression analysis and chi-square test were adopted to study the correlation between HMMR expression and clinicopathological parameters. The effect of HMMR expression on survival was evaluated by Kaplan–Meier survival analysis and using the Cox regression model. Furthermore, Gene Set Enrichment Analysis (GSEA) was utilized to screen out signaling pathways related to LUAD and the co-expression analysis was employed to build the protein–protein interaction (PPI) network. The HMMR expression level in LUAD tissues was dramatically higher than that in nontumor tissues. Logistic regression analysis and chi-square test demonstrated that the high HMMR expression in LUAD has relation with gender, pathological stage, T classification, lymph node metastasis, and distant metastasis. The Kaplan–Meier curve suggested a poor prognosis for LUAD patients with high HMMR expression. Multivariate analysis implied that the high HMMR expression was a vital independent predictor of poor overall survival (OS). GSEA indicated that a total of 15 signaling pathways were enriched in samples with the high HMMR expression phenotype. The PPI network gave 10 genes co-expressed with HMMR. HMMR may be an oncogene in LUAD and is expected to become a potential prognostic indicator and therapeutic target for LUAD.

scholarly journals Occlusal and orofacial myofunctional evaluation in children with primary dentition, anterior open bite and pacifier sucking habit

2006 ◽  
Vol 32 (1) ◽  
pp. 7-21
Author(s):  
Anna Verrastro ◽  
◽  
Fabiane Stefani ◽  
Célia Rodrigues ◽  
Marcia Wanderley
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Class Ii ◽  
Open Bite ◽  
Anterior Open Bite ◽  
Number Of Children ◽  
Normal Occlusion ◽  
The Mean ◽  
Intercanine Distance

The aim of this study was to evaluate occlusal and orofacial myofunctional characteristics in children three to five years of age with anterior open bite related to a pacifier sucking habit. Sixty-nine children participated in this study: 35 with anterior open bite (Anterior Open Bite Group - AOBG) and 34 with normal occlusion (Control Group - CG). In AOBG, the mean anterior open bite was 2.96 mm, the mean overjet was 4.1 mm and the mean upper intercanine distance was 28.7 mm. In the CG, the mean overjet was 2.6 mm and the upper intercanine distance was 30.3 mm. The mean overjet was greater (p=0.001) in AOBG than in CG, and the mean upper intercanine distance was smaller (p<0.001) in AOBG. The number of children with a canine Class II relationship was greater in AOBG than in CG (p<0.001). Simple logistic regression analysis showed that greater overjet, smaller upper intercanine distance and Class II canine relationship coexisted with anterior open bite. In AOBG, the number of children with incompetent lips, inadequate lip tonus, lack of proper tongue rest position, inadequate cheek tonus, anterior tongue interposition during swallowing and speech was greater (p<0.05) than in CG. Multiple logistic regression analysis identified anterior tongue interposition during swallow and speech, as well as incompetent lips, as the main orofacial myofunctional characteristics in children with anterior open bite.

scholarly journals Analysis and Factors Associated with Measles in Larut, Matang and Selama Districts, Perak, Malaysia

2020 ◽  
Vol 27 (5) ◽  
pp. 130-140
Author(s):  
Asraf Ahmad Qamruddin ◽  
Reza Qamruddin ◽  
Ayu Malik
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Incidence Rate ◽  
Logistic Regression Analysis ◽  
Protective Factor ◽  
Multiple Logistic Regression Analysis ◽  
Prior History ◽  
Multiple Logistic Regression ◽  
Case Definitions ◽  
Factors Associated

Objectives: To determine the incidence rate of measles and the factors associated with confirmed measles cases in Larut, Matang and Selama districts. Methods: Cross-sectional analysis was carried out looking at all suspected and laboratoryconfirmed measles cases in Larut, Matang and Selama districts between 2015 and 2019. Multiple logistic regression analysis was used to determine the associated factors for laboratory-confirmed measles cases. Results: The incidence rate for suspected measles showed an increasing trend from 2015–2019. For laboratory-confirmed measles cases, the incidence rate showed more variation with an increase to 36.11 per million population in 2017 from 5.67 per million population in 2015. The incidence rate later decreased to 10.99 per million population in 2018 and increased again to 24.47 per million population in 2019. From multiple logistic regression analysis, cases that fulfilled the case definition of measles were more likely to be laboratory-confirmed measles. On the other hand, a prior history of measles immunisation was a protective factor. Conclusion: Measles incidence is increasing in trend. Any suspected measles cases that fulfilled the clinical case definitions need to be further investigated. Immunisation should be promoted as they are effective in preventing and eliminating measles.

scholarly journals Prevalência de lesões em atletas de Brazilian jiu-jitsu: comparação entre diferentes níveis competitivos

2018 ◽  
Vol 20 (3) ◽  
pp. 280-289 ◽  
Author(s):  
Jorge Nelson da Silva Júnior ◽  
Rafael Lima Kons ◽  
Rodolfo André Dellagrana ◽  
Daniele Detanico
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Odds Ratio ◽  
Injury Severity ◽  
Chi Square ◽  
Risk Of Injury ◽  
Injury Occurrence ◽  
High Prevalence ◽  
Chi Square Test ◽  
Level Of Significance

This study aimed to identify types and sites of body injury, location of injury occurrence, and the mechanism and severity of injuries in novice and advanced Brazilian jiu-jitsu (BJJ) athletes. One hundred and eight BJJ athletes took part in this study separated in two groups: advanced (n = 53) and novice (n = 55). Athletes answered a questionnaire concerning regions of injury, locality of occurrence, injury severity and mechanism. Chi square test and a logistic regression analysis were used with the level of significance set at p < 0.05. The main results showed that shoulders and knees were the most injury location reported by novice and advanced athletes. Novice athletes demonstrated higher prevalence of injuries during training sessions (54.5%), whereas advanced athletes reported more injuries during competitions (66.1%). Significant associations between novice and advanced athletes were observed for major joints (p < 0.05). The odds ratio of having injury was 70-87% less for novice versus advanced athletes for the major joints cited. We concluded that BJJ athletes demonstrate high prevalence of injury mainly at knee and shoulder. While risk of injury appeared less in novice, the advanced demonstrated higher number of injuries during competitions as a consequence of injured joint keys. By contrast, novice athletes reported higher number of injuries associated with training sessions as a consequence of overuse.

scholarly journals Factors affecting the occurrence of proximal endoleak after endovascular abdominal aortic repair for abdominal aneurysms

2020 ◽  
Vol 48 (11) ◽  
pp. 030006052097151
Author(s):  
Daniela Mazzaccaro ◽  
Girolomina Mazzeo ◽  
Gianmarco Zuccon ◽  
Alfredo Modafferi ◽  
Giovanni Malacrida ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Aortic Aneurysms ◽  
P Value ◽  
Chi Square ◽  
Factors Affecting ◽  
Axial Diameter ◽  
Abdominal Aortic ◽  
Type Ia

Objective This retrospective study was performed to assess the clinical and radiological variables associated with proximal type IA endoleak (EL) in patients treated with elective endovascular repair for abdominal aortic aneurysms. Methods The chi-square test, t-test, and logistic regression analysis were performed as appropriate. A P value of <0.05 was considered statistically significant. Results The data of 79 patients were analyzed. No mortality occurred. During follow-up (median, 28.5 months; interquartile range, 12.8–43.0 months), 10 patients developed type IA EL. In the logistic regression analysis, undersizing of the endograft diameter by <10% significantly affected the occurrence of type IA EL. When the diameter was used for measurements, less oversizing was significantly associated with a higher risk of type IA EL. When the area was used for measurements, oversizing of >20% significantly affected the occurrence of type IA EL. Conclusion When sizing endografts, a discrepancy was noted between the measurements of the diameter and area of the proximal neck. The area might represent a more accurate measurement than the axial diameter to optimize the proximal sealing and lower the risk of developing type IA EL.

Factors Predicting the Outcome of Intraarterial Thrombolysis in Peripheral Arterial and Graft Occlusions

1996 ◽  
Vol 37 (1P1) ◽  
pp. 299-304 ◽  
Author(s):  
G. Sandbæk ◽  
L. E. Staxrud ◽  
L. Rosen ◽  
D. Bay ◽  
M. Stiris ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Chi Square ◽  
Catheter Position ◽  
Intraarterial Infusion ◽  
Duration Of Symptoms ◽  
Intraarterial Thrombolysis ◽  
Peripheral Arterial ◽  
Catheter Localization

Purpose: To determine the association between successful intraarterial thrombolysis and the following factors: sex, age, symptoms, duration of symptoms, length of occlusion, conduit type, runoff, and catheter localization. Material and Methods: Forty-six patients with acute or subacute occlusions of peripheral native arteries and grafts were treated with continuous intraarterial infusion of streptokinase or urokinase. A univariate chi-square test and logistic regression analysis were used. Results: Successful lysis was achieved in 27 of 46 patients (59%). The logistic regression analysis revealed a significant association between successful thrombolysis and good runoff (p<0.01). A catheter position above the occlusion resulted in lysis in only one of 11 patients. The variables rest pain and claudication were slightly significant (p=0.07). None of the other variables were significant, but a trend toward a separate effect of duration of occlusion was found. Conclusion: Good runoff and intrathrombotic infusion are virtual necessities in obtaining a positive immediate outcome in peripheral arterial and graft occlusions. In our study, other factors were less important.

Malocclusion: Social, Functional and Emotional Influence on Children

2012 ◽  
Vol 37 (1) ◽  
pp. 103-108 ◽  
Author(s):  
PA Martins-Júnior ◽  
LS Marques ◽  
ML Ramos-Jorge ML
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Negative Influence ◽  
Open Bite ◽  
Anterior Open Bite ◽  
Chi Square ◽  
Exact Test ◽  
Chi Square Test ◽  
The Impact

Objectives: To determine the association between types of malocclusion and quality of life in children between 8-10 years of age and establish correlations between the severity of the malocclusion and particular bio-psychosocial variables. Study design: The sample was made up of 102 schoolchildren aged 8-10 years. Clinical exams were performed using the criteria of the Dental Aesthetic Index (DAI) to determine the presence and severity of malocclusions. The impact on quality of life was assessed using the Child Perceptions Questionnaire (CPQ8-10). Statistical analysis involved the chi-square test, Fisher's exact test and Spearman's correlation analysis. Results: Malocclusions affected 61% of the children examined. There was a positive correlation between total CPQ8-10 and DAI scores (P = 0.034). The following types of malocclusion had a significant effect on the quality of life of the children: upper anterior irregularity ≥ 2 mm, anterior open bite ≥ 2mm and diastema ≥ 2mm. Children with malocclusion experienced a greater negative impact on quality of life in comparison to those without malocclusion. Conclusions: Malocclusions had a negative influence over the quality of life of children between 8-10 years of age. More severe malocclusions had a greater impact with regard to social, emotional and functional aspects.

scholarly journals Contribution of rs1799998 polymorphism in CYP11B2 gene in susceptibility to preeclampsia

2020 ◽  
Vol 20 (2) ◽  
pp. 467-471
Author(s):  
Kaio Raffael Valotta Bezerra ◽  
Sarah Cristina Sato Vaz Tanaka ◽  
Vanessa Resende Souza Silva ◽  
Marina Carvalho Paschoinni ◽  
Roseane Lopes da Silva Grecco ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Multiple Logistic Regression Analysis ◽  
Recessive Model ◽  
Control Group ◽  
Study Group ◽  
Genotypic Frequency ◽  
Multiple Logistic Regression ◽  
Significant Difference

Abstract Objectives: the present study aimed to evaluate the association between the rs1799998 polymorphism of the CYP11B2 gene and the susceptibility to preeclampsia (PE) in a Brazilian population. Methods: the study group comprised 61 women who were diagnosed with PE. The control group included 116 women who did not show changes in their blood pressure levels during their pregnancies. The rs1799998 polymorphism of the CYP11B2 gene was amplified by allele-specific polymerase chain reaction (PCR). A multiple logistic regression analysis was performed using the SNPStat program to evaluate the risk of the CYP11B2 gene rs1799998 polymorphism contributing to PE. Results: the PE group had the following genotypes: 1.64% CC, 91.80% CT, and 6.56% TT. In the control group, the observed genotypic frequencies were: 11% CC, 73% CT, and 16% TT. The genotypic frequency distribution did not fit the Hardy Weinberg Equilibrium (HWE) in either study group. The multiple logistic regression analysis showed a statistically significant difference for the rs1799998 polymorphism in the recessive model. Conclusion: the results suggest an association between the recessive model of C/C genotype of the rs1799998 polymorphism of the CYP11B2 gene and susceptibility to PE.

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