RADIOACTIVE CEMENT OF PMMA AND HAP-Sm-153, Ho-166, OR RE-188 FOR BONE METASTASIS TREATMENT

ABSTRACT Polymethylmetacrylte (PMMA) is used in the fields of dentistry and biomedicine as a constituent of bone cements. Hydroxyapatite (HAp) is a bioceramic produced naturally in the bones. PMMA and HAp are fundamental constituents in the preparation of bone cements. Bisphosphonates have also been used as radiopharmaceutical in dental implants and nuclear medicine, or as palliative systemic treatment for pain reduction in bone metastasis. Vertebroplasty and kyphoplasty are bone cement-based techniques used in orthopedics, being minimally invasive procedures with low risks of infections, applied in osteoporosis and high-impact fractures. Recently, Núcleo de Radiações Ionizantes da Universidade Federal de Minas Gerais proposed a synthetic composite of M-HAp with a metallic nuclide M. After irradiation, M-HAp was added to PMMA, compounding a radioactive bone cement that can recover bone body stabilization, pasting microfractures and recomposing the anatomy and functionality of the affected parts by the compression of bone metastases, with possible pain reduction through quick radiation-induced decompression. Computational dosimetric models, and the synthesis and characterization of bioceramics that incorporate Re-188, Ho-166, or Sm-153 have demonstrated the benefits of these biometrics as promising alternative therapies, mainly from their ability to maintain the ionization in the bone structure, thereby sparing the spinal cord. This article presents a review on this topic. Level of Evidence V, Expert Opinion.

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WITHDRAWN: Preparation and characterization of PMMA-based bone cements containing magnetic nanoparticles for application in therapeutic hyperthermia of bone metastasis

Materials Letters ◽

10.1016/j.matlet.2013.04.046 ◽

2013 ◽

Author(s):

Zhenghai Tang ◽

Xiaowen Wang ◽

Jieying Zhang ◽

Jintian Tang

Keyword(s):

Magnetic Nanoparticles ◽

Bone Metastasis ◽

Bone Cements ◽

Therapeutic Hyperthermia

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Development and Characterization of Acrylic Based Bone Cements

Journal of Biomaterials and Tissue Engineering ◽

10.1166/jbt.2022.2933 ◽

2022 ◽

Vol 12 (3) ◽

pp. 471-479

Author(s):

Aqsa Khan ◽

Ghazna Hassan Khan ◽

Eraj Humayun Mirza ◽

Alidad Chandio ◽

Maliha Mohsin ◽

...

Keyword(s):

Bone Cement ◽

Morphological Changes ◽

Chemical Properties ◽

Bone Cements ◽

Mechanical And Thermal Properties ◽

X Ray Diffraction ◽

X Ray ◽

Physical And Chemical ◽

And Chemical Properties

Bone tissue engineering has emerged as a multidisciplinary field in recent times with an aim to expedite the process of regeneration of damaged or diseased tissues. This study is an attempt to fabricate and characterize Tricalcium Phosphate (TCP) and Chitosan incorporated Polymethylmethacrylate (PMMA) based bone cement. In total two experimental PMMA based bone cements were fabricated that were differentiated by presence and absence of Chitosan. In both groups (10 and 30 wt.%) TCP were incorporated into Methyl methacrylate (MMA) monomer. PMMA was used as a control. The physical, mechanical and thermal properties of the composites were assessed. Morphological changes of PMMA after the introduction of TCP and Chitosan were observed by means of X-ray diffraction (XRD). Major peak shifts in Fourier transform Infrared spectroscopy (FTIR) spectra demonstrated the strong bonding of PMMA with incorporated materials. PMMA incorporated with 10% TCP showed the maximum wettability in absence of Chitosan. Hardness of the tested specimens decreased with increasing content of TCP which in turns enhanced ductility. It was also observed that neither of the samples showed significant degradation. The incorporation of additives enhance the physical and chemical properties of PMMA as bone cement.

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Applications of ultramicrotomy for materials characterization

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100147004 ◽

1993 ◽

Vol 51 ◽

pp. 232-233

Author(s):

R.T. Blackham ◽

J.J. Haugh ◽

C.W. Hughes ◽

M.G. Burke

Keyword(s):

Materials Science ◽

Microstructural Analysis ◽

Analytical Electron Microscopy ◽

Austenitic Stainless Steels ◽

Specimen Preparation ◽

Preparation Technique ◽

Thermally Induced ◽

Radiation Induced ◽

Characterization Of Materials

Essential to the characterization of materials using analytical electron microscopy (AEM) techniques is the specimen itself. Without suitable samples, detailed microstructural analysis is not possible. Ultramicrotomy, or diamond knife sectioning, is a well-known mechanical specimen preparation technique which has been gaining attention in the materials science area. Malis and co-workers and Glanvill have demonstrated the usefulness and applicability of this technique to the study of a wide variety of materials including Al alloys, composites, and semiconductors. Ultramicrotomed specimens have uniform thickness with relatively large electron-transparent areas which are suitable for AEM anaysis.Interface Analysis in Type 316 Austenitic Stainless Steel: STEM-EDS microanalysis of grain boundaries in austenitic stainless steels provides important information concerning the development of Cr-depleted zones which accompany M23C6 precipitation, and documentation of radiation induced segregation (RIS). Conventional methods of TEM sample preparation are suitable for the evaluation of thermally induced segregation, but neutron irradiated samples present a variety of problems in both the preparation and in the AEM analysis, in addition to the handling hazard.

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Molecular Characterization of Radiation-induced Glioblastoma

10.1055/s-0038-1675281 ◽

2018 ◽

Author(s):

MY Deng ◽

D Sturm ◽

E Pfaff ◽

GP Balasubrama ◽

J Schittenhelm ◽

...

Keyword(s):

Molecular Characterization ◽

Radiation Induced

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Isolation and Characterization of Salmonella Jumbo-Phage pSal-SNUABM-04

Viruses ◽

10.3390/v13010027 ◽

2020 ◽

Vol 13 (1) ◽

pp. 27

Author(s):

Jun Kwon ◽

Sang Guen Kim ◽

Hyoun Joong Kim ◽

Sib Sankar Giri ◽

Sang Wha Kim ◽

...

Keyword(s):

Morphological Traits ◽

Open Reading Frames ◽

Genome Comparison ◽

The Novel ◽

Promising Alternative ◽

Isolation And Characterization ◽

Global Issue ◽

Reading Frames ◽

Predicted Function

The increasing emergence of antimicrobial resistance has become a global issue. Therefore, many researchers have attempted to develop alternative antibiotics. One promising alternative is bacteriophage. In this study, we focused on a jumbo-phage infecting Salmonella isolated from exotic pet markets. Using a Salmonella strain isolated from reptiles as a host, we isolated and characterized the novel jumbo-bacteriophage pSal-SNUABM-04. This phage was investigated in terms of its morphology, host infectivity, growth and lysis kinetics, and genome. The phage was classified as Myoviridae based on its morphological traits and showed a comparatively wide host range. The lysis efficacy test showed that the phage can inhibit bacterial growth in the planktonic state. Genetic analysis revealed that the phage possesses a 239,626-base pair genome with 280 putative open reading frames, 76 of which have a predicted function and 195 of which have none. By genome comparison with other jumbo phages, the phage was designated as a novel member of Machinavirus composed of Erwnina phages.

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Design and characterization of injectable abalone shell/calcium sulfate bone cement scaffold for bone defect repair

Chemical Engineering Journal ◽

10.1016/j.cej.2021.129866 ◽

2021 ◽

Vol 420 ◽

pp. 129866

Author(s):

Mingzu Du ◽

Qian Li ◽

Jingdi Chen ◽

Kaihua Liu ◽

Cui Song

Keyword(s):

Bone Cement ◽

Bone Defect ◽

Calcium Sulfate ◽

Bone Defect Repair ◽

Defect Repair ◽

Abalone Shell

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Characterization of Feline Whole-blood Cultures and Determination of the Frequency of Radiation-induced Dicentrics in Human and Feline Lymphocytes

International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine ◽

10.1080/09553007914550421 ◽

1979 ◽

Vol 35 (4) ◽

pp. 351-359 ◽

Cited By ~ 14

Author(s):

G. Stephan ◽

I.-D. Adler ◽

D. Schwartz-Porsche ◽

K.-U. Hollihn ◽

G. Obe

Keyword(s):

Whole Blood ◽

Blood Cultures ◽

Radiation Induced

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A Novel Processing Route for the Fabrication of Monolithic and Composite Silicon Nitride

MRS Proceedings ◽

10.1557/proc-287-309 ◽

1992 ◽

Vol 287 ◽

Author(s):

R. V. Raman ◽

S. V. Rele

Keyword(s):

Volume Fraction ◽

Hot Isostatic Pressing ◽

Thermal Exposure ◽

Processing Route ◽

Promising Alternative ◽

Α Phase ◽

Key Issues ◽

Novel Processing ◽

Composite Silicon

ABSTRACTCurrent hot isostatic consolidation methodology used for the fabrication of complex-shaped Si3N4-based components requires the use of an expensive glass encapsulation technique and extended thermal exposure (in hours) of the specimen. An alternative consolidation approach involving the use of solid pressure transmitting media under high pressure, has enabled the consolidation of Si3N4 alloys without the need for glass encapsulation.Characterization of microstructures and mechanical properties of this (MOR, fracture toughness) material has been carried out and will be presented. It has been noted that in Si 3N4/8%Y2O3-4%Al2O3 composition, consolidated using this approach, a significantly larger volume fraction of α phase has been retained compared with typically observed conversion in α⇒ β in hot isostatically pressed material or sintered material.Key issues for addressing densification and microstructure control using this process are presented. This rapid consolidation approach appears to be a promising alternative to hot isostatic pressing for the fabrication of complex-shaped Si3N4 components.

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