Functional lung rejuvenation in obese patients after bariatric surgery

Summary Objective: To determine the lung age (LA) in obese people before and after bariatric surgery, compare the LA with the chronological age (CA) before and after the peration, and verify whether there was a functional pulmonary rejuvenation after it. Methods: A prospective longitudinal study including 43 morbidly obese patients who underwent bariatric surgery. The patients underwent clinical and spirometric evaluation in two stages, before and after the surgery. In both stages, LA, CA and spirometric variables were measured. Results: A significant improvement in the spirometric variables (FVC; FEV1; and FEV1/FVC ratio) was found after the operation (p≤ 0.0001). Comparing the LA before (50.93±13.36 years) and after the surgery (39.02±12.95 years), there was an important reduction of 11.90±9.12 years (95CI:9.10-14.71; p≤0.0001) in LA after surgery. The difference between LA and CA before surgery was 12.20± 11.71 years (95CI:8.60-15.81) with significant difference (p≤0.0001), and the difference between LA and CA after surgery was -1.95±11.83 years (95CI: -5.59-1.69) with no significant difference (p≤0.28). Regarding LA, we observed a pulmonary aging of 12.20±11.71 years before the surgery and a pulmonary rejuvenation of 11.90±9.12 years after it. Conclusion: Morbid obesity is responsible for early damage and functional accelerated pulmonary aging. After the correction of the body weight by surgery, there is a functional pulmonary rejuvenation demonstrated by the normalization of LA in relation to CA.

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Sleeve Gastrectomy vs. Fundus Resection in Bariatric Surgery (Animal Study)

Shiraz E-Medical Journal ◽

10.5812/semj.95198 ◽

2020 ◽

Vol 21 (6) ◽

Author(s):

Alimohammad Bananzadeh ◽

Seyed Vahid Hosseini ◽

Hajar Khazraei ◽

Mohammad Mehdi Lashkarizadeh ◽

Leila Ghahramani ◽

...

Keyword(s):

Bariatric Surgery ◽

Weight Loss ◽

Sleeve Gastrectomy ◽

Body Weight Loss ◽

Test Results ◽

Significant Difference ◽

Before And After ◽

Total Ghrelin ◽

The Difference ◽

High Level

Background: Bariatric surgery has resulted in body weight loss, which claimed by surgery removal specific parts of the stomach with enzyme or sleeve gastrectomy. Objectives: The aim of this study is to determine weight loss and endocrine changes by 12-week fundus resection and sleeve gastrectomy in rabbits. Methods: Twenty-one rabbits, weighing 2.5 - 3.5 kg, were divided into three groups (n = 7): sleeve gastrectomy, experimental fundus resection, and sham group. The weight of rabbits and total ghrelin and leptin levels in the plasma before and after surgery were measured in 12 weeks. Statistical analyses were performed using the Kruskal-Walis test for comparison of the means between the groups, and the difference after months in one group was assayed by Friedman test. Results: The results showed sleeve gastrectomy had a significant weight loss after one month when compared to fundus resection and sham-operated controls (P = 0.008). There was no significant difference in the ghrelin levels after these surgeries, but leptin levels decreased significantly after the fundectomy (P = 0.025). Conclusions: Sleeve gastrectomy is more efficient than the fundus resection in weight loss. It could be suggested as a new option in metabolic disorders due to the high level of leptin.

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Outcome of Anticoagulant Therapy Following Bariatric Surgery

QJM ◽

10.1093/qjmed/hcaa050.068 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

A M Yousef ◽

A F Mohamed ◽

B H Elshayeb ◽

G M Abdelmalak

Keyword(s):

Bariatric Surgery ◽

Effective Means ◽

Cost Benefit ◽

Morbidly Obese ◽

Laparoscopic Bariatric Surgery ◽

Obese Patients ◽

University Hospitals ◽

Coagulation Therapy ◽

Anticoagulant Drugs ◽

Significant Difference

Abstract Background Bariatric surgery remains the most effective means of treating severe obesity. The number of severely obese patients is increasing and, consequently, more people are seeking bariatric surgery. Aim of the Work The Aim of This Study is to Outcome of Anticoagulant during Bariatric Surgery and Relation of Bariatric Surgery to Coagulopathy Disease. Patients and Methods This prospective study was conducted on 50 morbidly obese patients admitted to Hospital (Ahmed Maher Teaching Hospital and Ain Shams University Hospitals), for a primary one-stage laparoscopic bariatric surgery procedure over a 6-month period. The study is performed on 50 Patients, Who met all Inclusion criteria and none of Exclusion criteria. Results The study revealed no statistically significant difference between Enoxaparin and Rivaroxaban according to outcome of anti-coagulation therapy following bariatric surgery. Conclusion a high protective value of Chemical Thromboprophylaxis combined to Mechanical Thromboprophylaxis in preventing DVT safely. New Oral Anticoagulant drugs showed equal and may be superimposed the other traditional anticoagulant, but it needs more studies regarding its prophylactic dose, number of patient and its cost benefit in comparison with other Anticoagulant drugs were used in our study or other studies we mentioned above.

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A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?

Journal of Clinical Medicine ◽

10.3390/jcm9040976 ◽

2020 ◽

Vol 9 (4) ◽

pp. 976 ◽

Cited By ~ 5

Author(s):

Barbara Choromańska ◽

Piotr Myśliwiec ◽

Magdalena Łuba ◽

Piotr Wojskowicz ◽

Jacek Dadan ◽

...

Keyword(s):

Bariatric Surgery ◽

Metabolic Syndrome ◽

Superoxide Dismutase ◽

Uric Acid ◽

Oxidative Damage ◽

Redox Homeostasis ◽

Morbidly Obese ◽

Obese Patients ◽

Obese People ◽

Oxidative Damage To Proteins

This is the first study to evaluate both the antioxidant barrier, glutathione metabolism, and oxidative damage to proteins and lipids in morbidly obese patients undergoing bariatric treatment. The study included 65 patients with class 3 obesity divided into two subgroups: morbidly obese patients without metabolic syndrome (OB) and obese patients with metabolic syndrome (OB + MS). Blood samples were collected before surgery as well as one, three, six, and twelve months after the bariatric treatment. Superoxide dismutase and reduced glutathione (GSH) were significantly decreased, whereas glutathione reductase and uric acid were enhanced in morbidly obese patients before bariatric surgery as compared to lean control. Moreover, in the OB group, we observed the increase of superoxide dismutase (SOD) and the decrease of uric acid (UA) after the bariatric treatment; however, these changes were not observed in the OB + MS group. The oxidative damage to proteins (advanced glycation end products, AGE; advanced oxidation protein products, AOPP) and lipids (8-isoprostanes, 8-isop; 4-hydroxynoneal) was higher in OB as well as OB + MS patients. We noticed that AGE and AOPP levels diminished after the bariatric treatment, whereas redox status (ratio of GSH to oxidized glutathione) was still reduced in the OB + MS group. Summarizing, morbid obesity is associated with disturbances in the antioxidant barrier and enhanced oxidative damage to proteins and lipids. Although bariatric surgery improves redox homeostasis in obese patients, those with metabolic syndrome show a continuous decrease in the antioxidant status. In patients undergoing bariatric treatment, antioxidant supplementation may be considered.

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Response to Starvation before and after a Jejuno-Ileal Bypass Operation for Morbid Obesity

Scottish Medical Journal ◽

10.1177/003693307902400306 ◽

1979 ◽

Vol 24 (3) ◽

pp. 206-210 ◽

Cited By ~ 1

Author(s):

G. A. A. Al Shamma ◽

G. S. Fell ◽

S. N. Joffe

Keyword(s):

Morbid Obesity ◽

Metabolic Response ◽

Ketone Bodies ◽

The Body ◽

Metabolic Adaptation ◽

Morbidly Obese ◽

Obese Patients ◽

Bypass Operation ◽

Before And After ◽

Ileal Bypass

A greater metabolic response developed during a seven day starvation in two morbidly obese patients three months after a 90 per cent jejuno-ileal bypass operation when compared with a similar fast before operation. There was a greater degree of ketosis, a decreased urinary urea excretion and an earlier utilization of ketone bodies. These changes suggest a metabolic adaptation of the body to the semistarvation state caused by the operation with a more rapid utilization of adipose tissue as a fuel and a sparing of lean body mass.

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The Knowledge and The Hydration Status of Junior Martial Art Athletes

COMPETITOR: Jurnal Pendidikan Kepelatihan Olahraga ◽

10.26858/cjpko.v13i2.20246 ◽

2021 ◽

Vol 13 (2) ◽

pp. 164

Author(s):

Ajeng Sindi Tirtasari ◽

Kunjung Ashadi

Keyword(s):

Female Athletes ◽

The Body ◽

Hydration Status ◽

Multiple Choice Questions ◽

Male Athletes ◽

Youth Athletes ◽

Martial Art ◽

Significant Difference ◽

Before And After ◽

The Difference

The purpose of this study was to determine the adequacy of fluids in the body during training for youth athletes of martial arts. The research method uses descriptive quantitative. Data collection techniques were obtained from urine tests, interviews, and multiple choice questions on 10 athletes consisting of five male athletes and five female athletes of martial art with a maximum age criteria of 18 years. Data analysis techniques used mean, standard deviation, percentage, graph, normality, and different test Paired Sample T Test to find out the difference in the mean. Athletes' knowledge of hydration was in the moderate category and there was a significant difference (Sig. <0.05) in the average hydration before and after training by the Madiun Regency martial art athletes.

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Anti-Xa Levels in Morbidly Obese Patients Using Apixaban or Rivaroxaban, Before and After Bariatric Surgery

Obesity Surgery ◽

10.1007/s11695-021-05814-y ◽

2021 ◽

Author(s):

Thom Kok ◽

Hans de Boer ◽

Bart Witteman ◽

Marcel Hovens ◽

Matthijs van Luin ◽

...

Keyword(s):

Bariatric Surgery ◽

Morbidly Obese ◽

Obese Patients ◽

Before And After

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Analysis of the clinical efficacy of leuprolide acetate in the treatment of obese patients with endometriosis and its role on the expression of MIF gene

Cellular and Molecular Biology ◽

10.14715/cmb/2021.67.4.31 ◽

2022 ◽

Vol 67 (4) ◽

pp. 282-288

Author(s):

Jing Zhang ◽

Liang Dong ◽

Shuzhen Zhang ◽

Lei Wang

Keyword(s):

Side Effects ◽

Leuprolide Acetate ◽

Obese Patients ◽

Childbearing Age ◽

Obese People ◽

Uterine Muscle ◽

Estrogen Production ◽

Before And After ◽

The Difference

Endometriosis is an invasive but benign disease of women that develops in endometrial glands outside the endometrium and uterine muscle. It affects about 15-20% of women of childbearing age. One effective way to treat endometriosis is to use GnRH agonists, which inhibit estrogen production. However, one of the possible side effects of this treatment is obesity and BMI increasing, which is a concern for some patients. This study investigated the role of leuprolide acetate in treating overweight patients (BMI≥30) and their comparison with non-overweight patients (BMI<30) for six months. Also, the effect of this medicine was evaluated on the expression of the MIF gene, which is an effective gene in obesity. For this purpose, a clinical trial was performed on 75 women with endometriosis aged 18 to 35 years. These patients were divided into two groups. The first group consisted of 38 patients with BMI<30. The second group consisted of 37 patients with BMI≥30. Both groups were treated with leuprolide acetate at a dose of 3.75 mg/month (intramuscularly) for six months. In addition to clinical evaluations, the expression of the MIF gene was assessed by the real-time PCR technique. The results showed that treatment with leuprolide acetate during six months in both groups reduced dysmenorrhea, dyspareunia, and chronic pelvic pain (P<0.05). Although this decrease was greater in the BMI <30 group, the difference was not significant. Also, after collecting the side effects of the medication, it was found that hypoestrogenism, such as cramps and spotting, was more in the first group; Endogenous complications such as oily skin, acne, and hirsutism were also more common in the second group. The results of MIF gene expression showed that the expression level before and after the start of the experiment in the second group (BMI≥ 30) is higher than the first group (BMI <30). The results also showed that the two groups increased the expression of the MIF gene after treatment with leuprolide acetate. This increase was statistically significant in the second group (P = 0.042). Generally, it was found that this medication causes more weight gain in obese people and increases the risk of obesity-related diseases among these patients. Therefore, it is recommended that this treatment be used with caution in obese patients with endometriosis.

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Impact of bariatric surgery on depression and anxiety symptons, bulimic behaviors and quality of life

Revista do Colégio Brasileiro de Cirurgiões ◽

10.1590/s0100-69912014000300004 ◽

2014 ◽

Vol 41 (3) ◽

pp. 155-160 ◽

Cited By ~ 9

Author(s):

Bárbara Tae ◽

Elisabeth Rosa Pelaggi ◽

Julia Guglielmi Moreira ◽

Jaques Waisberg ◽

Leandro Luongo de Matos ◽

...

Keyword(s):

Quality Of Life ◽

Bariatric Surgery ◽

Psychiatric Symptoms ◽

Depression And Anxiety ◽

Prospective Longitudinal Study ◽

Appetite Suppressants ◽

Before And After ◽

Treatment Of Obesity ◽

Prospective Longitudinal

OBJECTIVE: To assess psychiatric symptoms, substance use, quality of life and eating behavior of patients undergoing bariatric surgery before and after the procedure. METHODS: We conducted a prospective longitudinal study of 32 women undergoing bariatric surgery. To obtain data, the patients answered specific, self-administered questionnaires. RESULTS: We observed a reduction in depressive and anxious symptoms and also in bulimic behavior, as well as an improved quality of life in the physical, psychological and environmental domains. There was also a decrease in use of antidepressants and appetite suppressants, but the surgery was not a cessation factor in smoking and / or alcoholism. CONCLUSION: a decrease in psychiatric symptoms was observed after bariatric surgery, as well as the reduction in the use of psychoactive substances. In addition, there was an improvement in quality of life after surgical treatment of obesity.

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VOCAL COMPLAINT, AUDITORY-PERCEPTUAL ASSESSMENT OF VOICE AND VOCAL SELF-ASSESSMENT IN WOMEN WITH MORBID OBESITY

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/s0102-6720201500s100008 ◽

2015 ◽

Vol 28 (suppl 1) ◽

pp. 23-25 ◽

Cited By ~ 4

Author(s):

Lourdes Bernadete Rocha de SOUZA ◽

Leandro de Araujo PERNAMBUCO ◽

Marquiony Marques dos SANTOS ◽

Joana Cristina Vasconcelos da SILVA

Keyword(s):

Bariatric Surgery ◽

Morbid Obesity ◽

Morbidly Obese ◽

Self Assessment ◽

Obese People ◽

Voice Production ◽

Perceptual Evaluation ◽

Before And After ◽

Perceptual Assessment ◽

The Voice

Background : Obese people often have altered breathing patterns and therefore may experience difficulties in voice production. Aim : To verify the presence of vocal complaints and the correlation between the auditory-perceptual analysis of voice and vocal self-assessment of a group of women with morbid obesity before and after bariatric surgery. Methods : A longitudinal, exploratory, descriptive study of 21 morbidly obese women aged between 28 and 68 years, assessed before and after bariatric surgery, was performed. The women filled out a form containing identification data and type of vocal complaint. Perceptual evaluation of voice and vocal self-assessment were performed using a visual analog scale. For perceptual assessment of voice the women were asked to say three sentences from the Consensus Auditory-Perceptual Evaluation of Voice. Results : Of the 21 patients, 14 (66.6%) reported vocal complaints, of which 10 (71%) vocal fatigue, eight (57.14%) voice failures and seven (50%) vocal effort. All participants reported improvements in the voice after surgery, irrespective of having reported vocal complaints before surgery. There was no correlation between vocal self-assessment and auditory-perceptual assessment of the voice before or after the procedure. There was no correlation between vocal self-assessment and perceptual evaluation of the voice before surgery. Conclusion : Obesity interfered with voice production and influenced negative perception and therefore vocal complaints. Complaints about vocal production cannot be perceived by a speech therapist with the same impact as by patients, as both employ different criteria for vocal evaluation. Vocal self-assessment is an important tool in voice evaluation.

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