scholarly journals Sleeve Gastrectomy vs. Fundus Resection in Bariatric Surgery (Animal Study)

2020 ◽  
Vol 21 (6) ◽  
Author(s):  
Alimohammad Bananzadeh ◽  
Seyed Vahid Hosseini ◽  
Hajar Khazraei ◽  
Mohammad Mehdi Lashkarizadeh ◽  
Leila Ghahramani ◽  
...  

Background: Bariatric surgery has resulted in body weight loss, which claimed by surgery removal specific parts of the stomach with enzyme or sleeve gastrectomy. Objectives: The aim of this study is to determine weight loss and endocrine changes by 12-week fundus resection and sleeve gastrectomy in rabbits. Methods: Twenty-one rabbits, weighing 2.5 - 3.5 kg, were divided into three groups (n = 7): sleeve gastrectomy, experimental fundus resection, and sham group. The weight of rabbits and total ghrelin and leptin levels in the plasma before and after surgery were measured in 12 weeks. Statistical analyses were performed using the Kruskal-Walis test for comparison of the means between the groups, and the difference after months in one group was assayed by Friedman test. Results: The results showed sleeve gastrectomy had a significant weight loss after one month when compared to fundus resection and sham-operated controls (P = 0.008). There was no significant difference in the ghrelin levels after these surgeries, but leptin levels decreased significantly after the fundectomy (P = 0.025). Conclusions: Sleeve gastrectomy is more efficient than the fundus resection in weight loss. It could be suggested as a new option in metabolic disorders due to the high level of leptin.

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Marwan Alkassis ◽  
Fady Gh Haddad ◽  
Joseph Gharios ◽  
Roger Noun ◽  
Ghassan Chakhtoura

Introduction. Obesity is increasing worldwide and in Lebanon with a negative impact on the quality of life. The primary objective of this study is to measure the quality of life in obese subjects before and after bariatric surgery, depending on age, sex, and degree of weight loss. A secondary objective is to determine the impact of bariatric surgery on comorbidities associated with obesity. Materials and methods. Patients undergoing laparoscopic sleeve gastrectomy for BMI ≥ 30 kg/m2 between August 2016 and April 2017 were included. Participants completed the Moorehead-Ardelt Quality of Life Questionnaire II (MA II) prior to operation and one year after. Statistical analysis was carried out using SPSS statistics version 20.0. Results. 75 patients participated in the study. The majority were women (75%), and the mean age was 36.3 years. The mean weight loss was 36.57 kg (16–76). Initially, the total MA II score was −0.33 ± 0.93. Postoperatively, it increased to 1.68 ± 0.62 (p≤0.001). All MA II parameters improved after surgery (p≤0.001), but this improvement was independent of age and sex. Improvement in self-esteem, physical activity, work performance, and sexual pleasure was influenced by the degree of weight loss (p≤0.001). All comorbidities associated with obesity regressed significantly after sleeve gastrectomy (p<0.05) with the exception of gastroesophageal reflux and varicose veins of the lower limbs. Conclusion. Sleeve gastrectomy improves quality of life and allows reduction of comorbidities.


2016 ◽  
Vol 82 (5) ◽  
pp. 448-455
Author(s):  
Christopher W. Mangieri ◽  
Matthew A. Strode ◽  
William E. Sherman ◽  
Matthew L. Pierotti ◽  
Byron J. Faler ◽  
...  

Laparoscopic sleeve gastrectomy (LSG) is a recent addition to the bariatric surgery armamentarium. It has been demonstrated to be an efficacious stand-alone bariatric procedure in regard to weight loss. This study evaluates the progress of our initial experience with LSG. Retrospective review of prospective data from 2008 to 2010. Compared data between our first operative year of experience with LSG (2008) and our third year of experience (2010). Data compared for up to three years postoperatively. End points were percentage of excess body weight loss (%EWL) and percentage of excess body mass index loss (%EBL). Institutional improvement in %EWL and %EBL rates as our collective experience increased with LSG. Mean increase in %EWL of 14 per cent and mean increase of %EBL of 22 per cent. In our first year performing LSG the institutional weight loss was <50 per cent EWL, which is often cited as a benchmark level for “success” after bariatric surgery. By our third year of experience with LSG we achieved an institutional weight loss >50 per cent EWL. Institutional improvement in weight loss results with LSG as the collective experience increased. Several factors could have contributed to this observation to include a surgical men-torship program and the institution of formal nutritional education. This study demonstrates that institutional experience is a significant factor in weight loss results with LSG.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A23-A23
Author(s):  
Narriane Chaves Pereira Holanda ◽  
Mariana Braga Lacerda ◽  
Caio Chaves de Holanda Limeira ◽  
Heloisa Calegari Borges ◽  
Marilia Moreira Sales ◽  
...  

Abstract Background: Roux-en-y (RYGB) is considered a procedure with more malabsorptive impact than sleeve Gastrectomy (SG), so the risk of chronic complications seems greater. Aim: To describe the metabolic profile and weight regain of patients who underwent bariatric surgery, according to each procedure. Method: A retrospective cohort with patients who underwent bariatric surgery (2003–2018). The sample was divided into SG group and RYGB group. Comparisons were made to analyze the relationship between the procedure itself and metabolic improvements, weight loss and weight regain. Results: We included 117 eligible participants (91.5 % female, 51.2% RYGB surgery), mean follow-up was 4.4± 3.3 years. Mean age was 41.8±6.8 years, without significant difference between the groups. Before the surgery, the groups were similar according metabolic profile (fasting glucose, Hba1c, total cholesterol, LDLc, triglycerides and HOMA IR), except by non-HDLc (RYGB 108.8±26.3 vs SG 127.2±33.2 mg/dl, p=0,002) and 25OHD (RYGB 28.9±4,7 vs SG 34.3±9,5 ng/ml, p=0.044). The RYGB group had greater weight than the SG group (mean 114.1±13.5 kg vs 122.7±20.5 Kg, p&lt;0.0001) and almost 23.3% of the participants had T2DM and 36.2% of them had systemic arterial hypertension, without significant difference between the groups. The RYGB group had a greater postoperative time than the SG group (mean 5.0±4.0 vs 3.6± 2.9 years, respectively). After the surgery, although weight loss was greater in the RYGB group than the SG group (mean 39%±10.2 vs 34.1%±9.8, p&lt;0.0001, respectively), both groups were similar regarding BMI, body fat percentage (BFP) and abdominal circumference. Also, there were no differences in the metabolic profile (fasting glucose, Hba1c, HOMA IR, leptin, triglycerides and HDLc), according to the type of surgery, except in the total cholesterol and LDLc levels (RYGB 167.9±28.2 vs SG 187.9±35.1 and RYGB 92.6±25.6 vs SG 109.5±30.8). Nearly the whole sample (95%) has reached &gt; 20% weight loss. Despite that, 37.6% of the patients have regained &gt; 20% of weight loss, with no relation regarding the type of surgery. Only 7% of the patients remained with some degree of glucose intolerance, with no difference between the groups. Conclusion: We found similar benefits among metabolic markers and weight regain after SG, compared to RYGB.


2018 ◽  
Vol 9 (3) ◽  
pp. 367-373 ◽  
Author(s):  
G. Campisciano ◽  
S. Palmisano ◽  
C. Cason ◽  
M. Giuricin ◽  
M. Silvestri ◽  
...  

Intestinal microbiota analysis of obese patients after bariatric surgery showed that Proteobacteria decreased after laparoscopic sleeve gastrectomy (SG), while it increased after laparoscopic gastric bypass (LGB). Comparing to normal weight (NW) patients, obese patients that were selected for SG showed an almost equal amount of Firmicutes and Bacteroidetes and the ratio was not affected by the surgery. Obese patients before LGB showed a predominance of Bacteroidetes, whose amount regained a relative abundance similar to NW patients after surgery. Obese patients before LGB showed the predominance of Bacteroides, which decreased after surgery in favour of Prevotella, a bacterium associated with a healthy diet. The bacteria detected at the highest percentages belonged to biofilm forming species. In conclusion, in this study, we found that the characterization of the gut microbial communities and the modality of mucosal colonisation have a central role as markers for the clinical management of obesity and promote the maintenance of good health and the weight loss.


LOKABASA ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 1-9
Author(s):  
Cica Zahra Nadia ◽  
Rahman Rahman

This research is motivated by the lack of students' abilities in Sundanese. The purpose of this study is to describe the ability of ngawih before and after using the Explicit Intruction model, whether or not increasing after using the Explicit Intruction model, as well as describing the difference between the ngawih ability before and after using the Explicit Intruction model. The method used in this study is a quasi-experimental method, to students of class XI KPU-2 SMK Negeri 12 Bandung by using a pre-test and post-test design. Based on the results of research conducted, the average before using the Explicit Intruction model is (30.14) which proves that students are not capable of being incompetent, while the average after using the Explicit Intruction model is (75.88) which proves students are capable of being incompetent. Based on the statistical test results the significance value (Sig.2-tailed) is (0,000 0.5) or less than 0.5. Thus, H1 is accepted and H0 is rejected. This means that there is a significant difference between the ability to appear before and after using the Explicit Instruction model. This shows that the Explicit Intruction learning model can improve the Sundanese ngawih ability of class XI KPU-2 students of SMK Negeri 12 Bandung in Academic Year 2018/2019. AbstrakPenelitian ini dilatarbelakangi oleh kurangnya kemampuan siswa dalam ngawih Sunda. Tujuan dari penelitian ini adalah untuk mendeskripsikan kemampuan ngawih sebelum dan setelah menggunakan model Explicit Intruction, meningkat atau tidaknya setelah menggunakan model Explicit Intruction, serta mendeskripsikan perbedaan antara kemampuan ngawih sebelum dan setelah menggunakan model Explicit Intruction. Metode yang digunakan dalam penelitian ini yaitu metode kuasi eksperimen, kepada siswa kelas XI KPU-2 SMK Negeri 12 Bandung dengan menggunakan desain pre-test dan post-test. Berdasarkan hasil penelitian yang dilaksanakan, rata –rata sebelum menggunakan model Explicit Intruction adalah (30,14) yang membuktikan bahwa siswa belum mampu ngawih, sedangkan rata-rata setelah menggunakan model Explicit Intruction adalah (75,88) yang membuktikan siswa mampu ngawih. Berdasarkan hasil uji statistika nilai signifikansi (Sig.2-tailed) yaitu (0,0000,5) atau kurang dari 0,5. Dengan demikian, H1 diterima serta H0 ditolak. Artinya ada perbedaan yang signifikan anatar kemampuan ngawih sebelum dan setelah menggunakan model Explicit Intruction. Hal ini menunjukan bahwa model pembelajaran Explicit Intruction dapat meningkatkan kemampuan ngawih Sunda siswa kelas XI KPU-2 SMK Negeri 12 Bandung Tahun Ajaran 2018/2019.


Author(s):  
C.M. Mazzi ◽  
M.I.T. Ferro ◽  
A.A.D. Coelho ◽  
V.J.M. Savino ◽  
M. Macari ◽  
...  

The variation in cloacal temperature, body weight loss and expression of the 70 kDa heat shock protein (Hsp70) in three naked neck broiler genotypes during heat stress were studied. Twelve birds of each genotype (Na/Na, Na/na and na/na) were reared to market weight (approximately 2.1kg) at thermoneutral temperature. Six birds from each group served as controls and the remaining six underwent gradual heat stress (from 28ºC to 36ºC). Cloacal temperature and body weight were measured before and after exposure to heat. Liver samples were collected and Hsp70 levels were quantified using western blotting with monoclonal anti-chicken Hsp70 antibody. Heterozygous (Na/na) birds had a significantly lower cloacal temperature variation and less body weight loss during heat stress than the other genotypes. There was no significant difference in the Hsp70 levels among the genotypes. Heterozygous birds (Na/na) appeared to have a slight advantage over the other genotypes during gradual heat stress, perhaps because of a heterotic effect.


2016 ◽  
Vol 62 (2) ◽  
pp. 157-161 ◽  
Author(s):  
Saulo Maia Davila Melo ◽  
Pedro Alves Argentino ◽  
Murilo Matos de Santana Oliveira ◽  
Gabriela Nabuco Chaves Melo ◽  
Gildo Lima Souza Neto

Summary Objective: To determine the lung age (LA) in obese people before and after bariatric surgery, compare the LA with the chronological age (CA) before and after the peration, and verify whether there was a functional pulmonary rejuvenation after it. Methods: A prospective longitudinal study including 43 morbidly obese patients who underwent bariatric surgery. The patients underwent clinical and spirometric evaluation in two stages, before and after the surgery. In both stages, LA, CA and spirometric variables were measured. Results: A significant improvement in the spirometric variables (FVC; FEV1; and FEV1/FVC ratio) was found after the operation (p≤ 0.0001). Comparing the LA before (50.93±13.36 years) and after the surgery (39.02±12.95 years), there was an important reduction of 11.90±9.12 years (95CI:9.10-14.71; p≤0.0001) in LA after surgery. The difference between LA and CA before surgery was 12.20± 11.71 years (95CI:8.60-15.81) with significant difference (p≤0.0001), and the difference between LA and CA after surgery was -1.95±11.83 years (95CI: -5.59-1.69) with no significant difference (p≤0.28). Regarding LA, we observed a pulmonary aging of 12.20±11.71 years before the surgery and a pulmonary rejuvenation of 11.90±9.12 years after it. Conclusion: Morbid obesity is responsible for early damage and functional accelerated pulmonary aging. After the correction of the body weight by surgery, there is a functional pulmonary rejuvenation demonstrated by the normalization of LA in relation to CA.


2019 ◽  
Vol 316 (4) ◽  
pp. E615-E621 ◽  
Author(s):  
Maximilian Kleinert ◽  
Kirstine N. Bojsen-Møller ◽  
Nils B. Jørgensen ◽  
Maria S. Svane ◽  
Christoffer Martinussen ◽  
...  

Bariatric surgery results in marked body weight loss and improves type 2 diabetes in most patients with obesity. The growth differentiation factor 15 (GDF15) has recently emerged as a novel satiety factor. To begin to understand whether GDF15 is involved in mediating the effects of bariatric surgery on body weight and glycemia in humans, we measured plasma GDF15 in patients with obesity ( n = 25) and in patients with obesity and diabetes ( n = 22) before and after Roux-en-Y gastric bypass (RYGB) surgery. GDF15 was increased 1 wk after RYGB compared with before surgery (689 ± 45 vs. 487 ± 28 pg/ml, P < 0.001) and GDF15 remained elevated at 3 mo (554 ± 37 pg/ml, P < 0.05), at 1 yr (566 ± 37 pg/ml, P < 0.05), and at 2.5–4 yr (630 ± 50 pg/ml, P < 0.001) after RYGB surgery. Both age and insulin sensitivity correlated with GDF15 before the surgery ( r = 0.46, P < 0.0001 and r = 0.34, P < 0.001, respectively). These correlations disappeared at 2.5–4 yr following the surgery. Conversely, weight loss magnitude correlated with GDF15, measured 2.5–4 yr postsurgery ( r = 0.21, P < 0.0055). In summary, circulating GDF15 increases and correlates with body weight loss following RYGB surgery.


2018 ◽  
Vol 1 (2) ◽  
pp. 81
Author(s):  
Windy Sudiastuti

This article discusses the significance of differences in the ability to write text of complex procedures before and after using the demonstration method and then to observe the interest of student learning in grade XI SMA Pasundan 1 Cianjur. The method used is a quasi-experimental study involving one study group by giving pretest as a preliminary test and postes as a final test to see the difference of learning result then use questionnaire to see interest in learning. Processing results of pretest and postes value, calculated using the help of SPSS application, from wilcoxon test results obtained 0.000 significance meaning less than 0.05 indicates the difference of learning outcomes before and after applied method of demonstration then student learning interest showed good response with 100% answer want to relearn with this method. It was concluded that the application of demosntration method in writing text of complex procedure in class XI of Pasundan 1 Cianjur High School can give significant difference of learning result and student's learning interest showed good attitude.Keywords: demonstration methods, complex text procedures.


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