Ichthyosis associated with widespread tinea corporis: report of three cases

Ichthyoses are a common group of keratinization disorders. A non-inflammatory generalized persistent skin desquamation is observed. It is characterized by increased cell turnover, thickening of the stratum corneum and functional changes of sebaceous and sweat glands. All of these favor fungal proliferation. Dermatophytes may infect skin, hair and nails causing ringworm or tinea. They have the ability to obtain nutrients from keratinized material. One of its most prevalent genera is Trichophyton rubrum. Although tineas and ichthyoses are quite common, the association of the two entities is rarely reported in the literature. Three cases of ichthyosis associated with widespread infection by T. rubrum are presented. Resistance to several antifungal treatments was responsible for worsening of ichthyosis signs and symptoms.

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Tinea corporis caused by terbinafine‐resistant Trichophyton rubrum successfully treated with fosravuconazole

The Journal of Dermatology ◽

10.1111/1346-8138.15900 ◽

2021 ◽

Author(s):

Yurie Kitauchi ◽

Yoshiko Kumagai ◽

Yoko Inoue‐Masuda ◽

Makoto Sugiura ◽

Tomotaka Sato ◽

...

Keyword(s):

Trichophyton Rubrum ◽

Tinea Corporis

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ANTICHOLINERGIC POISONING: TREATMENT WITH PHYSOSTIGMINE

PEDIATRICS ◽

10.1542/peds.52.3.449 ◽

1973 ◽

Vol 52 (3) ◽

pp. 449-451

Author(s):

Barry H. Rumack

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Acetic Acid ◽

Specific Treatment ◽

Signs And Symptoms ◽

The Body ◽

Sweat Glands ◽

Exocrine Glands ◽

Anticholinergic Syndrome ◽

The Central Nervous System

The increased incidence of poisoning by overdoses of commonly used drugs with anticholinergic properties (Table I) and the general lack of knowledge concerning a specific treatment for these poisons warrants a summary of the problem at this time. Some plants containing anticholinergic alkaloids are also included in this group as they may also be taken intentionally or accidentally. Drugs with anticholinergic properties primanly antagonize acetylcholine competitively at the neuroreceptor site. Cardiac muscle, exocrine glands, and smooth muscle are most markedly affected.1 Action of the inhibitors is overcome by increasing the level of acetylcholine naturally generated in the body through inhibiting the enzyme (choline esterase) which normally prevents accumulation of excess acetylcholine. It does this by hydrolyzing that compound to inactive acetic acid and choline. Agents which inhibit this enzyme, so that acetylcholine accumulates at the neuroreceptor sites, are called anticholine esterases. Physostigmine, one of the anticholine esterases which is a tertiary amine, crosses into the central nervous system and can reverse both central and peripheral anticholinergic actions2. Neostigmine and pyridostigmine are also anticholine esterases but they are quaternary amines and are capable of acting only outside the central nervous system because of solubility and ionization characteristics. The anticholinergic syndrome has both central and peripheral signs and symptoms. Central toxic effects include anxiety, delirium, disorientation, hallucinations, hyperactivity, and seizures.2 Severe poisoning may produce coma, medullary paralysis, and death. Peripheral taxicity is characterized by tachycardia, hyperpyrexia, mydriasis, vasodilatation, urinary retention, diminution of gastrointestinal motility, decrease of secretion in salivary and sweat glands, and loss of secretions in the pharynx, bronchi, and nasal passages.

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Exercise, physical activity, and cystic fibrosis

10.1093/med/9780199232482.003.0033 ◽

2013 ◽

Cited By ~ 1

Author(s):

Susi Kriemler

Keyword(s):

Cystic Fibrosis ◽

Reproductive Tract ◽

Early Adulthood ◽

Genetic Defect ◽

Signs And Symptoms ◽

Sweat Glands ◽

Secretory Cells ◽

Transmembrane Conductance Regulator ◽

Asian Populations ◽

Caucasian Race

Cystic fibrosis (CF) is the most common genetic autosomal recessive disease of the Caucasian race, generally leading to death in early adulthood.1 The frequency of the gene carrier (heterozygote) is 1:20–25 in Caucasian populations, 1:2000 in African-Americans, and practically non-existent in Asian populations. The disease occurs in about 1 in every 2500 life births of the white population. Mean survival has risen from 8.4 years in 1969 to 32 years in 2000 due to improvements in treatment. The genetic defect causes a pathological electrolyte transport through the cell membranes by a defective chloride channel membrane transport protein [cystic fibrosis transmembrane conductance regulator (CFTR)]. With respect to the function, this affects mainly the exocrine glands of secretory cells, sinuses, lungs, pancreas, liver, and the reproductive tract of the human body leading to a highly viscous, water-depleted secretion. The secretion cannot leave the glands and in consequence causes local inflammation and destruction of various organs. The main symptoms include chronic inflammatory pulmonary disease with a progressive loss of lung function, exocrine and sometimes endocrine pancreas insufficiency, and an excessive salt loss through the sweat glands.1 A summary of the signs and symptoms of CF will be given with a special emphasis on the effect of exercise performance and capacity.

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Annular vesiculation. Bullous tinea corporis caused by Trichophyton rubrum

Archives of Dermatology ◽

10.1001/archderm.125.11.1569 ◽

1989 ◽

Vol 125 (11) ◽

pp. 1569-1569 ◽

Cited By ~ 3

Author(s):

S. D. Bennion

Keyword(s):

Trichophyton Rubrum ◽

Tinea Corporis

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Technical strategies for the transcallosal transforaminal approach to third ventricle tumors: expanding the operative corridor

Journal of Neurosurgery Pediatrics ◽

10.3171/2014.6.peds1452 ◽

2014 ◽

Vol 14 (4) ◽

pp. 365-371 ◽

Cited By ~ 10

Author(s):

Prayash Patel ◽

Aaron A. Cohen-Gadol ◽

Frederick Boop ◽

Paul Klimo

Keyword(s):

Short Term Memory ◽

Third Ventricle ◽

Signs And Symptoms ◽

Surgical Approaches ◽

Easy Method ◽

Foramen Of Monro ◽

Advantages And Disadvantages ◽

The Third ◽

Transforaminal Approach ◽

Common Group

Object There are a number of surgical approaches to the third ventricle, each with advantages and disadvantages. Which approach to use depends on the location of the lesion within the ventricle, the goals of the operation, and the surgeon's experience. The authors present their results in children with a modified approach through the expanded foramen of Monro. Methods A retrospective study was conducted to identify and analyze all children who underwent what the authors term the “expanded transforaminal” approach to the third ventricle between 2010 and 2013. Perioperative data included patient demographics, signs and symptoms on presentation, tumor characteristics (type, origin, and size), complications, and clinical and radiographic outcome at final follow-up. Results Twelve patients were identified (5 female, 7 male) with a mean age of 9 years (range 2–19 years). Two patients underwent gross-total resections, whereas 10 resections were less than total. There were no instances of venous infarction, significant intraoperative bleeding, or short-term memory deficits. Of the 12 patients, 7 suffered a total of 17 complications. Disruption of neuroendocrine function occurred in 4 patients: 2 with transient diabetes insipidus, 2 with permanent panhypopituitarism, and 1 with central hypothroidism (1 patient had 2 complications). The most common group of complications were CSF-related, including 2 patients requiring a new shunt. There was 1 approach-related injury to the fornix, which did not result in any clinical deficits. One child with an aggressive malignancy died of tumor progression 6 months after surgery. Of the remaining 11 patients, none have experienced tumor recurrence or progression to date. Conclusions The expanded transcallosal transforaminal approach is a safe and relatively easy method of exploiting a natural pathway to the third ventricle, but there remain blind zones in the anterosuperior and posterosuperior regions of the third ventricle.

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Tinea corporis due to Trichophyton rubrum in a Woman and Tinea capitis in her 15-Day-Old Baby: Molecular Evidence of Vertical Transmission

Mycopathologia ◽

10.1007/s11046-011-9492-9 ◽

2011 ◽

Vol 173 (2-3) ◽

pp. 135-138 ◽

Cited By ~ 3

Author(s):

E. T. M. Mapelli ◽

E. Borghi ◽

A. Cerri ◽

R. Sciota ◽

G. Morace ◽

...

Keyword(s):

Vertical Transmission ◽

Tinea Capitis ◽

Trichophyton Rubrum ◽

Tinea Corporis ◽

Molecular Evidence

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Profil dermatofitosis di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari – Desember 2013

e-CliniC ◽

10.35790/ecl.4.1.2016.12134 ◽

2016 ◽

Vol 4 (1) ◽

Author(s):

Cindy E.E.J. Sondakh ◽

Thigita A. Pandaleke ◽

Ferra O. Mawu

Keyword(s):

Stratum Corneum ◽

Skin Disease ◽

Tinea Pedis ◽

Tinea Capitis ◽

Topical Therapy ◽

Tinea Corporis ◽

Age Group ◽

Tinea Unguium ◽

Tinea Cruris ◽

Tinea Barbae

Abstract: Dermatophytosis is a disorder of tissues with keratinized ephithelia e. g. stratum corneum of epidermis, hair, and nails, caused by dermatophyte fungi from arthrodermataceae family. This family has more than 40 species divided into three genera: Epidermophyton, Microsporum, and Trichophyton. The distribution of dermatophytosis is based on its location: tinea capitis, tinea barbae, tinea cruris, tinea pedis et manum, tinea unguium, and tinea corporis. This study aimed to obtain the profile of dermatophytosis classified by location, age, gender, job and therapy at the Dermatovenerology Clinic of Prof. Dr. R. D. Kandou Hospital Manado during the period of January-December 2013. The results showed that of 4,099 skin disease cases in 2013, there were 153 (3.7%) cases of dermatophytosis with the most frequent found was tinea cruris (35.3%), the age group was 45-64 years old (32.7%), most patients were female (60.8%), commonly housewife (22.9%), and the most treatmen tused was topical therapy (68.6%).Keywords: dermatophyte, dermatophytosis, tinea Abstrak: Dermatofitosis merupakan penyakit pada jaringan yang mengandung zat tanduk, seperti stratum korneum pada epidermis, rambut dan kuku, yang disebabkan oleh jamur dermatofita dari famili arthrodermataceae. Famili ini terdiri lebih dari 40 spesies yang dibagi dalam tiga genus: Epidermophyton, Microsporum, dan Trichophyton. Pembagian dermatofitosis berdasarkan lokasinya yaitu tinea kapitis, tinea barbae, tinea kruris, tinea pedis et manum, tinea unguinum, dan tinea korporis. Penelitian ini bertujuan untuk mengetahui profil dermatofitosis di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2013 berdasarkan klasifikasi lokasi, usia, jenis kelamin, pekerjaan dan terapi yang diberikan. Hasil penelitian menunjukkan bahwa dari total 4.099 kasus penyakit kulit di tahun 2013, terdapat 153 (3,7%) kasus dermatofitosis dengan persentase tertingggi yang diperoleh ialah: tinea kruris (35,3%), golongan umur 45-64 tahun (32,7%), jenis kelamin perempuan (60,8%), ibu rumah tangga (22.9%), dan terapi kombinasi (68.6%) Kata kunci: dermatofitosis, tinea

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Disbalance of the intestinal epithelial cell turnover and apoptosis in a rat model of sporadic Alzheimer’s disease

10.1101/2021.04.22.440947 ◽

2021 ◽

Author(s):

Jan Homolak ◽

Ana Babic Perhoc ◽

Ana Knezovic ◽

Jelena Osmanovic Barilar ◽

Fatma Koc ◽

...

Keyword(s):

Oxidative Stress ◽

Epithelial Cell ◽

Rat Model ◽

Redox Regulation ◽

Caspase 3 ◽

Morphological Changes ◽

Brain State ◽

Cell Turnover ◽

Functional Changes ◽

The Brain

AbstractBackgroundDyshomeostasis of the gastrointestinal (GI) system is investigated as a potential contributor to metabolic dysfunction, systemic and neuro-inflammation recognized as important pathophysiological drivers of neurodegeneration. Gastrointestinal redox dyshomeostasis and dysfunctional brain-gut incretin axis have been reported in the rat model of insulin-resistant brain state (IRBS)-driven neurodegeneration induced by intracerebroventricular administration of streptozotocin (STZ-icv). The aim was to assess i) whether GI oxidative stress is accompanied by structural and functional changes of the epithelial barrier; ii) whether the brain glucose-dependent insulinotropic polypeptide receptor (GIP-R) is also involved in redox regulation of the gut; and iii) whether the STZ-icv brain-gut axis is resistant to pharmacological inhibition of the brain GIP-R.MethodsForty three-month-old male Wistar rats were treated with 3mg/kg STZ-icv or vehicle. One month later the animals were randomized to receive either saline or 85 μg/kg GIP-R inhibitor [Pro3]-GIP intracerebroventricularly and sacrificed 30 minutes later. Thiobarbituric acid reactive substances (TBARS) were measured in plasma and duodenum. Duodenal sections were subjected to morphometric analysis. Caspase-3 expression and activation were analyzed by western blot and spatial signal analysis was done by multiplex fluorescent signal amplification (MFSA). Data were analyzed by linear and linear mixed modeling, and exploration was done by principal component analysis.ResultsInhibition of the brain GIP-R decreased plasma TBARS in the controls and the STZ-icv animals and increased duodenal TBARS only in the controls. Acute inhibition of brain GIP-R affects duodenal epithelial cell, but not villus structure, while all morphometric parameters were altered in the STZ-icv-treated animals. Morphometric changes in the STZ-icv animals were accompanied by reduced levels of activated and total regulator of apoptosis – caspase-3. Acute inhibition of brain GIP-R inactivated duodenal apoptosis at the level of caspase-3 activation.ConclusionsBrain GIP-R is involved in the regulation of the systemic and duodenal redox homeostasis and epithelial function. Duodenal oxidative stress in the STZ-icv rats is accompanied by the resistance of the brain-gut GIP axis and morphological changes indicative of abnormal epithelial cell turnover and dysfunctional GI barrier. Dysfunction of the brain-gut incretin axis might be an important etiopathogenetic factor in neurodegeneration and a potential pharmacological target.

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