scholarly journals Nodular fasciitis on the zygomatic region: a rare presentation

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 89-92 ◽  
Author(s):  
Ilner de Souza e Souza ◽  
Mayra Carriijo Rochael ◽  
Rogério Estevam Farias ◽  
Roberto Bezerra Vieira ◽  
Janaina Silva Tirapelle Vieira ◽  
...  
Keyword(s):  
Benign Tumor ◽  
Histopathological Examination ◽  
Excisional Biopsy ◽  
Nodular Fasciitis ◽  
Rare Presentation ◽  
Ki 67 ◽  
Immunohistochemical Markers ◽  
The Face ◽  
Rare Location ◽  
High Cellularity

Nodular fasciitis is a benign tumor, resulting from reactive proliferation composed of fibroblastic/myofibroblastic cells. Due to its rapid growth and high cellularity it may be mistaken for sarcoma. Despite the possibility of spontaneous regression, excision is the treatment of choice. A 24-year-old female patient presented with a nodule on the zygomatic region with 3 months of evolution. Excisional biopsy was performed. Histopathological examination associated with immunohistochemical markers HHF35, AML and Ki-67 allowed diagnostic confirmation. The main relevance of the case presented is its rare location, suggesting its inclusion among the differential diagnoses of tumor lesions on the face.

scholarly journals A Rare Case of Synovial Osteochondromatosis of the Elbow

2019 ◽  
pp. 49
Author(s):  
Loh Li Loong ◽  
Wong Kai An ◽  
Zamzuri Zakaria @Mohamad
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Tissue Sample ◽  
Excisional Biopsy ◽  
Synovial Chondromatosis ◽  
Loose Body ◽  
Radiological Findings ◽  
Arthroscopic Synovectomy ◽  
Rare Presentation ◽  
Synovial Osteochondromatosis

We report here a rare presentation of a primary synovial osteochondromatosis of the elbow. Clinical presentation and radiological findings were suggestive of synovial osteochondromatosis. Arthroscopic synovectomy, debridement, excisional biopsy and loose body removal was performed and histopathological examination of the tissue sample is consistent with the diagnosis of synovial osteochondromatosis. This article highlights the surgical technique in managing synovial chondromatosis to achieve better functional outcome

scholarly journals Adult pancreatic cavernous hemangioma: case presentation of a benign tumor with a complex composition

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tao Lianyuan ◽  
Wang Yafeng ◽  
Yu Haibo ◽  
Dong Yadong ◽  
Ma Jiahao ◽  
...  
Keyword(s):  
Cavernous Hemangioma ◽  
Benign Tumor ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Complex Composition ◽  
Ki 67 ◽  
Case Presentation ◽  
Multilocular Cyst ◽  
Imaging Examination ◽  
Upper Abdominal

Abstract Background Pancreatic cavernous hemangioma is an extremely rare benign tumor that is difficult to diagnose on an imaging examination, and its histopathological examination has rarely been reported. Case presentation Herein, we present the case of a 63-year-old man who was admitted to the hospital due to left upper abdominal pain and defecation unformed for more than 2 years. None of the positive results obtained from the physical examination could explain his symptoms. The imaging examination indicated a multilocular cyst with septa in the head of the pancreas. The patient underwent a pancreaticoduodenectomy, and the pathologic diagnosis was pancreatic cavernous hemangioma. The histopathological examination showed that the lesion was positive for benign vascular markers, such as CD31, CD34 and F8, and negative for lymphocyte markers, such as D2–40. Moreover, it was also positive for ERG and cytokeratin markers, CAM5.2 and AE1/AE3, indicating the complexity of its components, and Ki-67 negativity revealed its benign nature. Conclusions Pancreatic cavernous hemangioma has a complex composition that may be reflected not only in the imaging examination but also in the immunohistochemical detection, and it may achieve a good outcome by surgical excision.

scholarly journals Lipoma, the universal tumor: in a rare location

2017 ◽  
Vol 4 (10) ◽  
pp. 3542
Author(s):  
Devendra K. Prajapati ◽  
Salil Mahajan ◽  
Jyoti M. Prajapati
Keyword(s):  
Adipose Tissue ◽  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Benign Tumor ◽  
Histopathological Examination ◽  
Fat Cells ◽  
Tissue Tumor ◽  
Plantar Aspect ◽  
Rare Location ◽  
Benign Soft Tissue Tumor

Lipoma is universal and abundantly located benign soft tissue tumor, which is composed of fat cells. These tumors often develop where adipose tissue is predominant. Lipomas are soft to firm/cystic, usually movable, and painless. They grow very slowly, and have rarely found to be cancerous. However, these are rarely localized in the plantar aspect of the foot. Here we find out a large benign tumor located in the planter surface of foot, finally diagnosed by histopathological examination.  

scholarly journals Rare presentation of capillary haemangioma

2019 ◽  
Vol 12 (8) ◽  
pp. e230222
Author(s):  
Saswati Sen ◽  
Sandip Kumar Sahu ◽  
Chennamgere Shivadevappa Lalitha ◽  
Sucheta Parija
Keyword(s):  
Histopathological Examination ◽  
Cutaneous Lesion ◽  
Excisional Biopsy ◽  
Systemic Diseases ◽  
Age Group ◽  
Vascular Tumour ◽  
Rare Presentation ◽  
Capillary Haemangioma ◽  
Nodular Growth

Conjunctival capillary haemangiomas are very rare above 40 years of age group, with few cases reported in the literature. Adding to the scanty literature of this uncommon vascular tumour, we present the case of a 45-year-old man who presented with a nodular growth in the conjunctiva without any associated systemic diseases or cutaneous lesion. Excisional biopsy of the mass was done. Histopathological examination showed lobulated capillary haemangioma which is very rare in this age group.

scholarly journals Intramuscular hemangioma in masseter muscle: a rare presentation

2020 ◽  
Vol 6 (4) ◽  
pp. 790
Author(s):  
E. Siva Kumar ◽  
C. A. Swapna ◽  
Lavanya Karanam
Keyword(s):  
Masseter Muscle ◽  
Histopathological Examination ◽  
Young Male ◽  
Neck Region ◽  
Excisional Biopsy ◽  
Rare Presentation ◽  
Parotid Region ◽  
Intramuscular Hemangioma ◽  
The Right ◽  
Work Up

<p class="abstract">Intramuscular hemangioma contribute to less than 1% of all hemangioma forming around 0.8%. It is commonly located in trunk and extremities. Only 10 to 20% can be found in the head and neck region arising from masseter and trapezius. We present a rare case of a young male with intramuscular hemangioma of masseter muscle. A 20 year old male patient presented to the OPD with complaints of swelling over right side of face over parotid region for the past 6 years. On clinical examination, there was a oblong swelling of about 3×2 cm around the right parotid region. In MRI neck the features were suggestive of intramuscular hemangioma in the right masseter muscle. The patient was planned for an excisional biopsy. Histopathological examination confirmed the diagnosis of intramuscular hemangioma. Although intramuscular hemangioma of masseter is a very rare possibility, still it should be kept in consideration in the list of differential diagnoses of the tumours around parotid region. As this diagnosis will make a difference in the work up plan and management of the patient.</p>

scholarly journals Multi-dermatomal unilateral nevus comedonicus along the lines of Blaschko: a rare presentation

2017 ◽  
Vol 3 (4) ◽  
pp. 541
Author(s):  
Krishnendra Varma ◽  
Shashank Bhargava
Keyword(s):  
Histopathological Examination ◽  
Normal Skin ◽  
The Body ◽  
Ocular Involvement ◽  
Rare Presentation ◽  
Left Half ◽  
Lines Of Blaschko ◽  
The Face ◽  
History Of ◽  
Hair Shafts

<p>Nevus comedonicus is a rare skin disorder due to defect in development of hair follicle presenting as groups of closely set, dilated follicular openings with dark keratin plugs resembling comedones. The lesions may be distributed in a linear, interrupted, unilateral or bilateral pattern and sometimes follow the lines of Blaschko. It may develop inflammatory acne-like lesions leading to cysts, abscesses and scarring. A 36 year-old woman presented with multiple pits on left half of the body involving the face, upper limb, shoulder, back and buttock since the age of 4 years. She also had a painful swelling over the back. There was no history of cranial, skeletal or ocular involvement. Physical examination revealed multiple circular honeycomb-type pitted scars sized from 0.1×0.1 to 0.5×0.5 mm present unilaterally along lines of Blaschko in an interrupted pattern over the left half of the body as mentioned above. Among these pitted scars few scattered comedones were present with interfollicular normal skin. There was an abscess along the margin of one of the lesions over the back which was tender, indurated and with local rise of temperature. Histopathological examination revealed deep, wide invagination of acanthotic epidermis, filled with concentric lamellae of keratin. Hair shafts were occasionally seen in the dermis, below the lower part of invagination. Based on clinical and histopathological picture a diagnosis of nevus comedonicus was made. She was treated with topical tretinoin and oral retinoids without much improvement. Nevus comedonicus in itself is a rare epidermal nevus, its multi-dermatomal unilateral distribution along the lines of Blaschko is even rarer.</p>

Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature

2021 ◽  
pp. 112067212110071
Author(s):  
Vijitha S Vempuluru ◽  
Monalisha Pattnaik ◽  
Neha Ghose ◽  
Swathi Kaliki
Keyword(s):  
Risk Factors ◽  
Ocular Surface ◽  
Histopathological Examination ◽  
Topical Steroid ◽  
Case Series ◽  
Intraepithelial Neoplasia ◽  
Excisional Biopsy ◽  
Ocular Surface Squamous Neoplasia ◽  
Retrospective Case

Purpose: To describe the risk factors, clinical presentation, management, and outcomes of patients with bilateral ocular surface squamous neoplasia (OSSN). Methods: Retrospective case series. Results: Of the 25 patients with bilateral OSSN, the mean age at diagnosis of OSSN was 31 years (median, 24 years; range, 2–60 years). Risk factors for bilateral OSSN included xeroderma pigmentosum ( n = 15, 60%), human immunodeficiency virus infection ( n = 3, 12%), conjunctival xerosis ( n = 1, 4%), and topical steroid use ( n = 1, 4%). There were no identifiable ocular or systemic risk factors in 7 (28%) patients. Presentation was synchronous in 14 (56%) and metachronous in 11 (44%) patients. Tumor morphology was bilaterally similar in 12 (48%) patients. Histopathological examination ( n = 36) revealed conjunctival intraepithelial neoplasia (CIN) grade 1 in 4 (8%); grade 2 in 7 (14%); carcinoma in situ in 5 (10%), and invasive carcinoma in 20 (40%). Primary management of OSSN ( n = 49) included excisional biopsy ( n = 31, 62%), topical immunotherapy (IFN α2B) ( n = 11; 22%), topical Mitomycin C (MMC) ( n = 3, 6%), enucleation ( n = 1, 2%), orbital exenteration ( n = 2, 4%), and plaque brachytherapy (PBT) ( n = 1, 2%). One patient was lost to follow-up after detection of tumor in the second eye. Recurrent tumors were noted in 16 (32%) eyes and binocular globe salvage was achieved in 16 (64%) patients at a mean follow up of 41 months (median 30 months; range, 1–164 months). Conclusion: OSSN occurrence can be synchronous or metachronous. Meticulous examination of the fellow eye is important for an early diagnosis of OSSN.

scholarly journals Histopathological specialized staining of oral lichen planus-induced fibrotic changes and surgical treatment of associated restricted mouth opening: a case report

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Atsushi Shudo
Keyword(s):  
Surgical Treatment ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Histopathological Examination ◽  
Mouth Opening ◽  
Ki 67 ◽  
Collagen Formation ◽  
Immune Mediated ◽  
Cytokeratin 13 ◽  
Oral Lichen

Abstract Background Oral lichen planus is a chronic inflammatory and immune-mediated disease that affects the oral mucosa. Recent findings have suggested that oral lichen planus is often associated with submucosal fibrotic changes. Fibrotic changes in the buccal submucosa may cause restricted mouth opening. This report discusses the histopathological examination (including specialized staining) and surgical treatment for oral lichen planus-induced fibrotic changes. Case presentation Here, we describe a 63-year-old woman who had oral lichen planus with fibrotic changes. Her maximum mouth opening distance was approximately 30 mm due to submucosal fibrotic changes, and she exhibited gradual fibrosis progression. Histological examinations were performed to assess the oral lichen planus-induced fibrotic changes. Then, double Z-plasty were performed as treatment for restricted mouth opening. The immunohistochemical staining results were negative for cytokeratin 13 and positive in some layers for cytokeratin 17 and Ki-67/MIB-1. Masson's trichrome staining showed enhanced collagen formation. Postoperative mouth opening training enabled the patient to achieve a mouth opening distance of > 50 mm. Conclusion Our findings suggest that histopathological examination with specialized staining can aid in the evaluation of oral lichen planus-induced fibrotic changes, and that Z-plasty is effective for the treatment of restricted mouth opening due to oral lichen planus.

scholarly journals The Role of Immunohistochemical Markers for the Diagnosis and Prognosis of Adrenocortical Neoplasms

2021 ◽  
Vol 11 (3) ◽  
pp. 208
Author(s):  
Anna Angelousi ◽  
Georgios Kyriakopoulos ◽  
Fani Athanasouli ◽  
Anastasia Dimitriadi ◽  
Eva Kassi ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Cox Regression ◽  
P53 Protein ◽  
Immunohistochemical Analysis ◽  
Ki 67 ◽  
Diagnosis And Prognosis ◽  
Immunohistochemical Markers ◽  
Small Series ◽  
Morphological Criteria ◽  
Survival And Development

Adrenal cortical carcinoma (ACC) is a rare cancer with poor prognosis that needs to be distinguished from adrenocortical adenomas (ACAs). Although, the recently developed transcriptome analysis seems to be a reliable tool for the differential diagnosis of adrenocortical neoplasms, it is not widely available in clinical practice. We aim to evaluate histological and immunohistochemical markers for the distinction of ACCs from ACAs along with assessing their prognostic role. Clinical data were retrospectively analyzed from 37 patients; 24 archived, formalin-fixed, and paraffin-embedded ACC samples underwent histochemical analysis of reticulin and immunohistochemical analysis of p27, p53, Ki-67 markers and were compared with 13 ACA samples. Weiss and Helsinki scores were also considered. Kaplan−Meier and univariate Cox regression methods were implemented to identify prognostic effects. Altered reticulin pattern, Ki-67% labelling index and overexpression of p53 protein were found to be useful histopathological markers for distinguishing ACAs from ACCs. Among the studied markers, only pathological p53 nuclear protein expression was found to reach statistically significant association with poor survival and development of metastases, although in a small series of patients. In conclusion, altered reticulin pattern and p53/Ki-67 expression are useful markers for distinguishing ACCs from ACAs. Immunohistopathology alone cannot discriminate ACCs with different prognosis and it should be combined with morphological criteria and transcriptome analysis.

Struma ovarii-A rare entity

2021 ◽  
Vol 11 (1) ◽  
pp. 1898-1901
Author(s):  
Moushami Singh ◽  
Raghu Ram Bhandary ◽  
Jitendra Pariyar ◽  
Swechha Maskey ◽  
Hari Prasad Dhakal
Keyword(s):  
Benign Tumor ◽  
Histopathological Examination ◽  
Frozen Section ◽  
Abdominal Mass ◽  
Thyroid Tissue ◽  
Blood Parameters ◽  
Immature Teratoma ◽  
Rare Entity ◽  
Struma Ovarii ◽  
Ovarian Mass

Struma ovarii, also known as goiter of the ovary is a rare disease.1 Considering the rarity of this tumor and constrained literature in Nepal’s context, we hereby present a case of a 46-year-old female, asymptomatic, with normal blood parameters who presented with an abdominal mass. She was suspected of malignant ovarian mass on an ultrasonogram. Intraoperative frozen section examination revealed a benign tumor suggestive of dermal tumor versus struma ovarii. Postoperatively, histopathological examination was performed to assess the percentage of thyroid tissue and a diagnosis of benign struma ovarii was made which was confirmed by thyroglobulin positivity on immunohistochemistry. No features of immature teratoma and malignancy were identified.

Sign in / Sign up

Export Citation Format

Share Document