INCREASE OF LIPIDS DURING HCV TREATMENT: VIRUS ACTION OR MEDICATION?

ABSTRACT BACKGROUND: The interaction between serum lipids and C virus infection is well known, as are serum lipid levels in the Peg-IFN / RBV-based treatment. However, with direct action antivirals (DAAs) this behavior is still unclear. OBJECTIVE: To compare serum lipids levels between patients treated with Peg-IFN/RBV and DAAs and to evaluate lipids in sustained virological response (SVR) with DAAs. METHODS: Retro prospective study comparing the behavior of total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG) serum levels during treatment with DAAs (G-DAAs) and a control historic group Peg-IFN/RBV (G-PR). Coorte, prospective study, to study the behavior of lipids in the SVR with DAAs. Data were collected at the beginning of treatment (baseline: t-base) and at week 12 of treatment (t-12) for G-DAAs and at week 24 (t-24) for G-PR, groups. In the cohort evaluation, the samples at t-base and at week 12 after the end of treatment (t-SVR). Delta lipids: difference between lipids in t-12 / t-24 minus t-base for comparison between G-PR and G-AADs groups and t-SVR minus t-base for lipid analysis in SVR. Analysis with Kruskal Wallis and Wilcoxon tests to compare the delta lipids of the groups. The P value was 0.05. RESULTS: In the assessment between G-PR and G-DAAs groups, we included 63 and 121 patients, respectively. The groups did not differ one from the other (BMI, sex, genotype, fibrosis, total cholesterol, LDL, and TG) except by age (50.38±10.44 vs 56±9.69, P=0.0006). We observed a decrease in levels of TC and LDL and an increase in TG, in G-PR, and in G-DAAs the opposite (Δ TC -13.9±34.5 vs 4.12±34.3 P=0.0005, Δ LDL -7.16±32 vs 10.13±29.92, P=0.003, Δ TG 4.51±53.7 vs -8.24±49.93, P=0.0025). In the coorte analysis, we included 102 patients, 70% men and 56% F4, 95 of them reached SVR. We observed an increase of TC and LDL and a decrease of TG in both groups (SVR and non SVR), with no statistical difference (Δ TC P=0.68; Δ LDL P=0.69; Δ TG P=0.43). We did not find significant difference in delta evaluation by genotype 1 and 3 (Δ TC +29.7±40.2 vs +13.4±30.3, P=0.06; Δ LDL +21.4±28.6 vs +16.6±31.3, P=0.41; Δ TG -3.6±60.6 vs -0.7±40, P=0.91). CONCLUSION: Serum lipids level differed during treatment with Peg-IFN and DAAs. Treatment with DAAs was associated with an increase of TC and LDL and a decrease of TG, independently of SVR.

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Apolipoprotein E Phenotypes and Serum Lipids in Newborns and 3-Year-Old Children: The Cardiovascular Risk in Young Finns Study

PEDIATRICS ◽

10.1542/peds.94.4.489 ◽

1994 ◽

Vol 94 (4) ◽

pp. 489-493 ◽

Cited By ~ 1

Author(s):

Terho Lehtimäki ◽

Tapio Nikkari ◽

Kimmo Porkka ◽

Jorma Viikari ◽

Christian Ehnholm ◽

...

Keyword(s):

Apolipoprotein E ◽

Total Cholesterol ◽

Serum Lipids ◽

Ldl Cholesterol ◽

Disease Risk ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Serum Levels ◽

Heart Disease Risk Factors ◽

Apoe Phenotype

Background. Apolipoprotein E (apoE) phenotype is a genetic determinant of plasma total cholesterol and low density lipoprotein (LDL) cholesterol concentrations, that are classical coronary heart disease risk factors. ApoE appears in three major isoforms E2, E3, and E4, coded by corresponding alleles ∈2, ∈3, and ∈4. These give rise to six different phenotypes. Objective. To study the associations of apoE phenotype with cord serum lipids (during minimal enteral nutrition), and with serum lipids of 3-year-old children. Subjects and methods. We determined serum lipid levels and apoE phenotypes in 206 newborns and 259 3-year-old children in connection with a larger follow-up study of atherosclerosis precursors in children and young adults. ApoE phenotyping was done directly from plasma by isoelectric focusing followed by immunoblotting. Results. The effect of apoE phenotype on serum total and LDL cholesterol was significantly different in newborns and 3-year-old children (two-way ANOVA, interaction between apoE phenotype and age group: P < .001 for both). In 3-year-old children, the concentrations of serum total cholesterol and LDL cholesterol increased with apoE phenotype in the order of E3/2, E3/3, E4/3, and E4/4, in both males and females (P < .0001). On the contrary, in neonates total cholesterol and LDL cholesterol concentrations were low and did not differ significantly between apoE phenotypes (P > .05) either in males or in females. The mean serum levels of triglycerides and high density lipoprotein cholesterol did not differ between apoE phenotypes either in 3-year-old children or newborns. Conclusions. The results show that the differences in serum total and LDL cholesterol levels between apoE phenotypes are formed after birth by the influence of environmental factors and suggest that both genetic and external factors influence the levels of serum cholesterol concentrations during the first years of life.

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SIMVASTATIN GENERIK

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v20i2.1076 ◽

2018 ◽

Vol 20 (2) ◽

pp. 107

Author(s):

DAP. Rasmika Dewi ◽

DG. Diah Dharma Santhi ◽

DM Sukrama ◽

AA. Raka Karsana

Keyword(s):

Statistical Analysis ◽

Lipid Profile ◽

Total Cholesterol ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

P Value ◽

Low Density ◽

Serum Samples ◽

Significant Difference ◽

Before And After

This study aims to know and determine the lipid profile in patients with hyperlipidemia who consumed Generic Simvastatin comparedwith its patent product contained in the Formularium at Sanglah Hospital. The observations made, were the measurement of the totalcholesterol and low-density lipoprotein (LDL) before and after the drug administration. A total of 30 subjects who met the inclusioncriteria, were divided into two (2) groups, each group consist of 15 persons, the first group was given 20 mg generic Simvastatin(1 tablet daily) for 15 days and Group II given 20 mg patent Simvastatin (1 tablet daily) for 15 day. After 15 days, their blood sampleswere taken and examined for total cholesterol and LDL. Once the data were collected, statistical analysis was done by using the normalitytest, homogeneity and t. Statistical analysis using p-value less than or equal to 0.05 was the limit of significance. The statistical analysisshowed that the data was normally distributed and homogeneous (p≥0.05). The T-test showed that there were significant differencesin the levels of total cholesterol and LDL serum samples before and after the administration of generic simvastatin and patents the(sig.=0.000). However, there was no significant difference in decreased levels of totall cholesterol samples between the generic Simvastatinand patent (sig=0.365 with α=0.05 level). Besides this, there was also no significant difference in the decreased levels of LDL betweengeneric Simvastatin and the patent one (sig=0.372 with α=0.05 level).

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Is low total cholesterol associated with primary intracerebral hemorrhage in Bangladeshi population?

Bangladesh Critical Care Journal ◽

10.3329/bccj.v6i1.36609 ◽

2018 ◽

Vol 6 (1) ◽

pp. 26-30

Author(s):

Md Anwarul Kibria ◽

Md Hassanuzzaman ◽

Pradip Kumar Kayasthagir ◽

Md Rabiul Karim ◽

Asifur Rahman ◽

...

Keyword(s):

Intracerebral Hemorrhage ◽

Total Cholesterol ◽

Total Cholesterol Level ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Control Group ◽

P Value ◽

Older Individuals ◽

Increased Risk ◽

Significant Difference

Background: This study was carried out to see the association of the low total cholesterol level with primary Intracerebral Hemorrhage (ICH) in Bangladeshi population.Materials and Methods: This was a case–control study carried out in the department of Neurology, Chittagong Medical College and Hospital from January 2013 to December 2013. Total of 132 patients were enrolled where 67 patients of hemorrhagic stroke were in the experimental group and 65 age and sex matched persons were in the control group. Low total cholesterol was designated as level less than 200mg/dl. Data were analyzed and compared by SPSS version 19.Results:The proportion of ICH patients with low total cholesterol was significantly higher than the controls (74.6% vs. 32.3%). Mean total cholesterol was also significantly low in ICH patients compared with controls (180 mg/dL vs. 217 mg/dl; P-value = 0.001). Low-density lipoprotein cholesterol (LDL-c) and triglycerides were also significantly low in ICH patients compared with controls. Mean LDL-c in the ICH patient group was 106 mg/dL, whereas it was 128.5 mg/dL in the control group (P-value = 0.001). There was no significant difference in the high-density lipoprotein (HDL) levels in both groups. Although lower mean cholesterol was seen in both young and older individuals in the ICH group than in controls, the difference was significant only in the older group (age >60 years). In multivariate analysis, odds ratio of low cholesterol in the hemorrhage cases was 6.03 (95% CI = 2.1–16.059) which was adjusted other risk factors of hemorrhagic stroke.Conclusions: The inference of this study is that, there is an increased risk of primary ICH associated with low total cholesterol, especially in older individuals.Bangladesh Crit Care J March 2018; 6(1): 26-30

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A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup

Indian Journal of Medical Biochemistry ◽

10.5005/jp-journals-10054-0024 ◽

2017 ◽

Vol 21 (2) ◽

pp. 73-75

Author(s):

S Vinod Babu ◽

Anusha R Jagadeesan ◽

Jothimalar Ramalingam

Keyword(s):

Comparative Study ◽

Lipid Profile ◽

Total Cholesterol ◽

Ldl Cholesterol ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

P Value ◽

Health Checkup ◽

Group I ◽

Significant Difference

ABSTRACT Introduction Obesity is emerging as an epidemic worldwide. Obesity is associated with a number of comorbid conditions, such as diabetes mellitus, hypertension, cancer, dyslipidemia, cardiovascular abnormalities, anemia, obstructive sleep apnea, and psychosocial abnormalities. Aim This study aims at comparing the lipid profile levels of obese and nonobese men. Materials and methods This was a case—control study conducted at a tertiary care center. Totally, 80 men in the age group of 20 to 47 years attending the master health checkup were included in the study, out of which 40 men with normal body mass index (BMI) of 18 to 25 belonged to group I and 40 men with increased BMI of 30 and above belonged to group II. Lipid profile parameters, such as triglycerides (TGLs), total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were estimated in them. The data were statistically analyzed using Statistical Package for the Social Sciences (SPSS) software version 15.0. Results Statistically significant difference was found in the total cholesterol levels with a p-value of 0.040 while the difference in LDL cholesterol was statistically highly significant with a p-value of 0.040. Conclusion Among lipid profile parameters, only total cholesterol and LDL cholesterol showed significant difference between the obese and nonobese individuals. However, the other parameters like HDL cholesterol and TGLs did not show any significant difference. How to cite this article Babu SV, Jagadeesan AR, Ramalingam J. A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup. Indian J Med Biochem 2017;21(2):73-75.

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Comparación de lípidos sanguíneos entre pollos de engorde y gallinas ponedoras

Revista de la Facultad de Medicina Veterinaria y de Zootecnia ◽

10.15446/rfmvz.v65n1.72021 ◽

2018 ◽

Vol 65 (1) ◽

Author(s):

J. H. Osorio ◽

J. D. Flores

Keyword(s):

High Density Lipoprotein ◽

Total Cholesterol ◽

High Density Lipoprotein Cholesterol ◽

Laying Hens ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Serum Levels ◽

Lipoprotein Cholesterol ◽

Low Density ◽

Low Density Lipoprotein Cholesterol

Objective: To compare serum levels of total cholesterol, triglycerides, low density lipoprotein cholesterol and high density lipoprotein cholesterol between broilers and laying hens. Materials and Methods: the present is a cross study, descriptive and analytic. Data was analyzed using simple ANOVA, the program Statgraphics Plus 5.1 was used. The study was performed at Universidad de Caldas in Manizales (Colombia). After fasting, blood from 30 broilers (Cobb 500 line) of 35-day-old and 40 laying hens (Hy-Line W-36 line) of 26-weeks-old. Serum levels of triglycerides, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol was measured by enzymatic colorimetric methods, direct method (detergent + N,Nbis (4-sulfobutyl)-m-toluidine) was used for the lipoprotein cholesterol. Results: Between broilers (Cobb 500 line) and (laying hens (Hy-line W-36 line) was significant difference in serum levels of triglycerides and in serum levels of high density lipoprotein cholesterol (P <0.05); serum levels of total cholesterol and serum levels of low density lipoprotein cholesterol, no differences were found (P> 0.05) Conclusions: Despite differences in gender, age, and production system among broilers Cobb 500 line and laying hens Hy-Line W-36, no differences were found between serum total cholesterol and low density lipoprotein cholesterol.

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Metabolic evaluation in overweight and obese cats and association with blood pressure

Ciência Rural ◽

10.1590/0103-8478cr20170217 ◽

2017 ◽

Vol 48 (1) ◽

Author(s):

Vanessa Danielle de Freitas ◽

Alessandra Ramos Castilho ◽

Luciana Auxiliadora Viebrantz da Conceição ◽

Valéria Régia Franco Sousa ◽

Adriane Jorge Mendonça ◽

...

Keyword(s):

Blood Pressure ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Serum Levels ◽

Very Low Density Lipoprotein ◽

Low Density ◽

Metabolic Evaluation ◽

Morphometric Measurements ◽

Metabolic Alterations ◽

Significant Difference

ABSTRACT: Obesity has been increasing in cats andis associated with metabolic and cardiovascular diseases. The association of these alterations can trigger the onset of metabolic syndrome (MS). Therefore, this study aimed to analyze the serum levels of glucose, fructosamine, cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, very low-density lipoprotein (VLDL), andalanine aminotransferase of cats and to identify the possibility of MS,as well as to evaluate changes in arterial pressure. Thirty-seven cats were classified by ECC and morphometric measurements, namely, 15 obese, 12 overweight, and 10 controls. Nocat manifested MS. Only VLDL had a statistically significant difference (P<0.05) between groups. Therefore, obesity may not be associated with arterial hypertension, and more studies are needed to evaluate the metabolic alterations in overweight and obese cats.

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Effects of Low Molecular Weight and Unfractionated Heparin on Lipoprotein Lipase and Lipid Profile in haemodialysis patients

Rehman Journal of Health Sciences ◽

10.52442/rjhs.v3i1.110 ◽

2021 ◽

Vol 3 (1) ◽

pp. 56-59

Author(s):

Ahmad Jan ◽

Shah Jahan ◽

Nighat Aziz ◽

Sikandar Ali Khan ◽

Asia Asia ◽

...

Keyword(s):

Molecular Weight ◽

Lipid Profile ◽

Lipoprotein Lipase ◽

Low Density Lipoprotein ◽

Age Distribution ◽

Density Lipoprotein ◽

P Value ◽

Low Molecular Weight ◽

Significant Difference ◽

Study Population

Introduction: In haemodialysis patients, mortality from cardiovascular disease is much greater than in the general population. The current study aimed to evaluate the effects of two different types of heparin, low molecular weight heparins (LMWH) and high molecular weight heparin (HMWH), on lipid profile in patients undergoing haemodialysis.Material & Methods: A total of 60 patients on haemodialysis were selected from two main hospitals of Lahore, Pakistan and were divided into two major groups based on the type of heparin used. A 5 ml blood sample was taken from the dialysis machine to get the serum and was kept frozen at -20ºC for analysis of total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein. Comparison of lipoprotein lipase activity between groups were evaluated by using the student t-test. A P-value of ? 0.05 was considered statistically significant.Results: Gender wise distribution of study population (n=60) was 67% (n=40) males and 33% (n=20) females. The age distribution of individuals varied from 39-43 years. Moreover, use of HMWH was high in males (73%) as compared to female (27%) with an average age of 39 ± 12 years where duration of haemodialysis was 4.44 ± 2.83. A significant difference in LPL activity related to different times in all patients was observed. A clearer difference observed in case of LDL where LPL activity was markedly different in both groups. Our data showed that individuals using LMWH had less chances of dyslipidaemia as compared to those using HMWH.Conclusion: LMWH is a useful and safe anticoagulant during haemodialysis as compared to HMWH.

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Effect of Hyper and Hypothyroidism on Lipid Profile and Liver Function of Male Rats

Baghdad Science Journal ◽

10.21123/bsj.8.4.926-933 ◽

2011 ◽

Vol 8 (4) ◽

pp. 926-933

Author(s):

Baghdad Science Journal

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Physiological Saline ◽

Serum Levels ◽

Lipoprotein Cholesterol ◽

Male Rats ◽

Control Group ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Significant Difference

This study was designed to investigate the effect of thyroid hormone disturbance on lipids profiles and liver functions. Eighteen mature male rats Rattus norvegicus were divided into three groups. The first and the second groups were injected subcutaneously with thyroxine (T4) and carbimazol (both at 600 µg/kg BW) respectively on alternate days, to produce recurrent periods of hyper and hypothyroidism .The control group which is the third group was injected with physiological saline. The process continued 4 weeks, after that, injection, blood specimens were collected to estimate serum levels of T3 and T4, Total cholesterol (TC), Triglycerides (TG), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Very low density lipoprotein cholesterol (VLDL-C) were determined in the serum. In addition to that, we measure GOT, GPT and CPK enzymes activity. The results showed no significant difference in body weight and a significant increase (P

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Alteration of lipid profile and prognostic value of lipids on the length of hospital stay in COVID-19 pneumonia patients

10.21203/rs.3.rs-30552/v1 ◽

2020 ◽

Author(s):

Qin Chen ◽

Minghan Huang ◽

Ziwen Zhao ◽

Yukun Luo

Keyword(s):

Hospital Stay ◽

Prognostic Value ◽

Serum Lipids ◽

Plasma Lipids ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Length Of Hospital Stay ◽

Serum Levels ◽

Lipoprotein Cholesterol ◽

Novel Coronavirus

Abstract Background The outbreak of the novel coronavirus SARSCoV-2 (coronavirus disease 2019; COVID-19) has spread to most of countries in the world. The tight relationship of plasma lipids and COVID-19 pneumonia (NCIP-19) has not been well invested. To observe lipid profiles and their alterations in hospitalized patients with COVID-19 and evaluated the prognostic value of lipids for the length of hospital stay (LOS). Methods 248 NCIP-19 cases aged 18 years or older were enrolled in this study. Serum lipids, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were detected at admission. In 68 severe cases, levels of serum lipids were subsequently detected every 5 ~ 10 days. Results At admission, median levels of TG, TC, HDL-C, and LDL-C in all patients, were 1.11 mmol/L, 4.00 mmol/L, 0.89 mmol/L and 2.11 mmol/L, respectively. Compared with common cases (n = 174), higher TG and HDL-C, lower LDL-C were observed in severe cases (n = 74). Levels of TC and LDL-C at admission were negatively correlated with LOS. In severe cases, the average levels of serum lipids were lowest at admission and gradually increased during hospitalization. Compared with the LOS ≤ 29d group, serum levels of TC, HDL-C, and LDL-C were significantly lower in the LOS > 29d group at admission; this lower trend always existed during the following tests for TC and LDL-C, but not for HDL-C and TG. Patients with LDL-C ≥ 1.70 mmol/L at admission showed a lower risk of LOS prolongation (adjusted HR = 0.557, 95% CI: 0.409–0.759, p < 0.001). Conclusions In NCIP-19, serum lipid levels were low at admission. Levels of TC and LDL-C at admission were negatively correlated with LOS. LDL-C < 1.7 mmol/L at admission may act as the independent predictor of LOS prolongation. In severe cases, the gradual increase of TC, LDL-C, and HDL-C during the hospitalization might indicate the gradual recovery of the disease.

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Lipid Profile in Alcoholic and Non Alcoholic Fatty Liver Patients

10.21203/rs.3.rs-27765/v1 ◽

2020 ◽

Author(s):

Aakash Shahi ◽

Narayan Gautam ◽

Sanju Rawal ◽

Uday Sharma ◽

Archana Jayan

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Lipid Profile ◽

Fatty Liver Disease ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

P Value ◽

Alcoholic Fatty Liver ◽

Significant Difference ◽

Alcoholic Fatty Liver Disease

Abstract Background: Fatty liver disease is a common and major chronic liver disease. It has been implicated that patients have disorders of lipid metabolism and involved in the pathogenesis of fatty liver. Lipid profile plays a very important role in diagnosis of liver diseases hence it was designed to observe relationship between lipid profile and fatty liver disease (FLD) based on ultrasonography (USG).Method and methodology: This Cross-sectional and analytical study was undertaken in the Department of Internal Medicine with collaboration of Department of Radiology and Department of Biochemistry, Universal College of Medical Sciences-Teaching Hospital (UCMS-TH), Bhairahawa, Nepal from March 2019 to February 2020 in total 100 patients diagnosed with FLD by USG.Result: In 100 cases, the male to female ratio was 1.8:1. 56% of the total cases presented with alcoholic fatty liver disease (AFLD) while remaining 44% with non alcoholic fatty liver disease (NAFLD). The spectrum of lipid abnormality was observed with increased total cholesterol (TC), Low Density Lipoprotein (LDL), increased triglycerides (TG) and Very Low Density Lipoprotein (VLDL) in AFLD cases as compared to NAFLD cases. However, it has been observed that TG/HDL and Non-HDL/HDL were higher in NAFLD as compared to AFLD. There was statistical significant difference in HDL (p-value: 0.019) between alcoholic fatty liver disease grade 1 (AFLG1) and non-alcoholic fatty liver disease grade 1 (NAFLG1). Moreover, it was observed statistical significant difference in HDL between AFLG2 and NAFLG2 (p-value: 0.012).Conclusion:Elevated level of TG and decreased HDL has been implicated in the precipitation of the occlusive vascular disease. These parameters in conjunction with Non-HDL/HDL and TG/HDL can be useful in early screening and monitoring of dyslipidemia in the fatty liver patients to prevent cardiovascular diseases.

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