scholarly journals Arthroscopical treatment of elbow joint disease

2012 ◽  
Vol 64 (1) ◽  
pp. 9-14 ◽  
Author(s):  
C.M.F. Rezende ◽  
E.G. Melo ◽  
C. Malm ◽  
V.A. Gheller
Keyword(s):  
Early Diagnosis ◽  
Osteochondritis Dissecans ◽  
Elbow Joint ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Arthroscopic Treatment ◽  
Joint Disease ◽  
Elbow Arthroscopy ◽  
Medial Condyle ◽  
Clinical Recovery

Elbow arthroscopy was performed in 30 dogs of different breeds. The procedure was performed bilaterally in 20 of these dogs, yielding a total of 50 joints. Different lesions were found, varying from cartilage fissures (8) to fragmentation (42) of medial coronoid process (FCP) of the ulna. Osteochondritis dissecans (OCD) of the humerus medial condyle was associated in four of them. All of these cases displayed varying degrees of synovitis. Osteoarthrosis (OA) in varying intensity was observed in 44 joints. The majority of cases were treated two to four months after the manifestation of clinical signs. Good clinical recovery occurred in dogs with minimal joint lesions, where these were diagnosed and treated within four weeks of the onset of clinical symptoms. Early diagnosis and arthroscopic treatment prevent osteoarthrosis and preserve locomotor function.

Arthroscopy of the Elbow in Dogs

1997 ◽  
Vol 10 (02) ◽  
pp. 60-66 ◽  
Author(s):  
J. F. Bardet
Keyword(s):  
Osteochondritis Dissecans ◽  
Elbow Joint ◽  
Coronoid Process ◽  
Loose Bodies ◽  
Medial Condyle ◽  
Condylar Fractures

SummaryThe craniolateral portal of the elbow is described. The technique was applied and evaluated in 34 dogs (38 elbows). A detailed description and classification of the fragmented coronoid process (FCP) is given. All patients with FCP were treated successfully using a second craniomedial portal. Complications were not observed. The technique appears to be safe and reliable and could also be used for other procedures such as removal of loose bodies, treatment of osteochondritis dissecans of the medial condyle, reduction of selective humeral condylar fractures, excision of osteophytes and other diagnostic purposes. It also eliminates the need for exploratory arthrotomies of the elbow joint in dogs.The cranial portals of the 38 elbows in 34 dogs allowed proper evaluation and treatment of the lesions of the medial coronoid process. A classification in 7 types of lesions of the medial coronoid process was established. All dogs were treated successfully by either removal of the FCP or by a proximal ulnar sliding osteotomy.

scholarly journals Optimization of Early Diagnostics of Prostate Cancer

2020 ◽  
Vol 6 (5) ◽  
pp. 97-104
Author(s):  
N. Stepanov ◽  
Z. Duvayarov ◽  
I, Bystrova ◽  
T. Chepaikina ◽  
V. Kostrova
Keyword(s):  
Prostate Cancer ◽  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Diagnostic Errors ◽  
Decay Products ◽  
Examination Methods ◽  
Special Examination ◽  
Diagnostic Capabilities

The prevalence and incidence of prostate cancer is gradually increasing both in our country and in countries near and far abroad. The difficulties in the differential diagnosis of prostate cancer are convincingly evidenced by the fact that the level of diagnostic errors reaches 40%. It should be noted that in assessing the differential diagnostic capabilities of the indicators of the clinical and special examination methods for patients with lower urinary tract symptoms, disagreements were found in 46–77% of the analyzed clinical signs, the changes of which mainly reflect the negative nature of the effect of tumor decay products on the patient’s body. The aim of the study was to improve the early diagnosis of prostate cancer by using the mathematical method of differential diagnosis of prostate pathology, as well as the rationale for the proposed method for early diagnosis of prostate cancer in patients with clinical symptoms. Using our proposed method for early diagnosis of prostate cancer makes the diagnosis not only reliable and accurate, but also independent of the level of qualification of the urologist and his personal experience, allows you to unify, optimize and personify the differential diagnosis of prostatic hypertrophy and prostate cancer.

scholarly journals Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Daryoosh Fahimi ◽  
Leila Khedmat ◽  
Azadeh Afshin ◽  
Zahra Noparast ◽  
Maryam Jafaripor ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Early Diagnosis ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Ureteral Stones ◽  
Cross Sectional ◽  
Laboratory Markers ◽  
Febrile Uti ◽  
Iranian Children

Abstract Background Upper urinary tract infection (UTI) or pyelonephritis may increase the pathogenesis rate and risk of severe complications in children due to kidney atrophy. Objective A set of clinical symptoms, laboratory markers, and ultrasound findings were assessed to achieve the early diagnosis and prognosis of pyelonephritis in hospitalized pediatrics. Methods A cross-sectional study with 104 Iranian children (95 girls and 9 boys) aged 1 month to 12 years with acute pyelonephritis during 2012–2018 was conducted. The ultrasound examination of kidneys and urinary tract during hospitalization, the incidence of clinical symptoms, and laboratory markers in blood and urine were monitored to identify the best predictive factors of early diagnosis of this bacterial infection. Results Three-fourth of the patients had one of the four clinical symptoms of abdominal pain, constipation, dysuria, and vomiting, while others were asymptomatic. A much frequency of pyuria (88.46%), Escherichia coli in urine (92.31%), leukocytosis (81.73%), and high ESR (> 10 mm/h, 92.30%) and CRP (> 10 mg/L, 82.82%) was observed. The kidney and urinary tract ultrasonography only in 32.7% of children revealed findings in favor of pyelonephritis (cystitis, ureteral stones, and hydronephrosis). Conclusion There was a high frequency of clinical signs and laboratory markers associated with pyelonephritis. Ultrasound alone was not an efficient tool to track febrile UTI as most patients presented normal sonography.

Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease

Blood ◽  
2003 ◽  
Vol 102 (3) ◽  
pp. 1114-1120 ◽  
Author(s):  
Thomas Lion ◽  
Rosi Baumgartinger ◽  
Franz Watzinger ◽  
Susanne Matthes-Martin ◽  
Magdalena Suda ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Real Time ◽  
Peripheral Blood ◽  
Clinical Symptoms ◽  
Virus Disease ◽  
Antiviral Treatment ◽  
Allogeneic Bone Marrow Transplantation ◽  
Clinical Signs ◽  
Allogeneic Bone ◽  
Disseminated Disease

AbstractAdenovirus (AdV) infection in the course of allogeneic stem cell transplantation (SCT) is associated with high transplant-related morbidity and mortality. Disseminated AdV disease is lethal in most instances. Early detection of AdV infection and identification of patients carrying a high risk of disseminated disease therefore remain a major challenge. In view of the large number of existing AdV types, we have established real-time polymerase chain reaction (PCR) assays permitting sensitive detection and quantification of all 51 currently known human AdV serotypes. In a series of 132 consecutive pediatric patients undergoing SCT, more than 5000 samples derived from peripheral blood (PB), stool, urine, and throat were screened for adenovirus infection by PCR during the posttransplantation period. Thirty-six patients (27%) tested positive by PCR, revealing AdV types of the subgenera A, B, C, D, and F. Except for enteritis in some patients with AdV positivity in stool, detection of the virus at sites other than PB was not associated with clinical signs of virus disease, and transplant-related mortality was not significantly different from AdV-negative patients. By contrast, 82% of patients who had detectable AdV in PB died from infectious complications (P < .001). Monitoring of PB specimens by real-time PCR permitted early diagnosis of invasive AdV infection in all instances. In patients who developed disseminated AdV disease, detection of the virus in PB preceded onset of clinical symptoms by a median of more than 3 weeks. The observation of AdV in peripheral blood may therefore serve as a basis for early initiation of preemptive antiviral treatment.

scholarly journals Problems of early diagnosis of systemic lupus erythematosus during the COVID-19 pandemic

2021 ◽  
Vol 59 (2) ◽  
pp. 119-128
Author(s):  
E. L. Nasonov ◽  
T. V. Popkova ◽  
T. A. Panafidina
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Early Diagnosis ◽  
Lupus Erythematosus ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Immunological Tolerance ◽  
Unknown Etiology ◽  
Systemic Lupus ◽  
Stress Effects ◽  
Autoimmune Rheumatic Disease

Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease of unknown etiology, characterized by overproduction of organ-nonspecific autoantibodies to various components of the cell nucleus and cytoplasm and the development of immune-inflammatory damage to internal organs. The debut of SLE is preceded by an asymptomatic period, characterized by impaired immunological tolerance to its own autoantigens, determined by the multifaceted interaction of external, genetic and epigenetic factors, hormonal disorders, microbiome pathology, stress effects, etc. Development of a certain spectrum of clinical symptoms characteristic of SLE along with the detection of a reflects the progression of the immunopathological process in SLE, however, there is no generally accepted term that defines the patient’s condition, which has individual serological and clinical signs characteristic of this disease. In rheumatology, the concept of «incomplete» SLE is currently most often used. The problems of early diagnosis of SLE, clinical and laboratory predictors of the transformation of “incomplete” SLE into “reliable” SLE, difficulties in diagnosing SLE during the COVID-19 pandemic are considered. Particular attention is paid to the comparative characteristics of the immunopathological mechanisms of SLE and COVID-19.

scholarly journals Return to Play Rates Following Arthroscopic Treatment of Elbow Osteochondritis Dissecans Lesions in Adolescent Baseball Players

2021 ◽  
Vol 9 (7_suppl4) ◽  
pp. 2325967121S0020
Author(s):  
Somnath Rao ◽  
Christopher Hadley ◽  
Michael Ciccotti ◽  
Steven Cohen ◽  
Christopher Dodson ◽  
...  
Keyword(s):  
Osteochondritis Dissecans ◽  
The Other ◽  
Arthroscopic Treatment ◽  
Return To Play ◽  
Osteochondral Lesions ◽  
Elbow Arthroscopy ◽  
Baseball Players ◽  
Overhead Throwing ◽  
Mayo Elbow Score

Objectives: Osteochondritis dissecans (OCD) of the humeral capitellum is a common elbow injury in adolescent overhead throwing athletes likely secondary to the excessive valgus stress placed on the joint during the throwing motion. The purpose of this study is to retrospectively investigate the clinical findings and outcomes, including return to play rates, of overhead throwing athletes who underwent elbow arthroscopy for the treatment of osteochondral lesions of elbow. Methods: Throwing athletes who underwent elbow arthroscopy over an eight-year period, 2010 to 2018, were identified and included in our analysis. From this cohort of patients, those who were treated for OCD of the elbow joint and were baseball players were selected for analysis. Non-baseball athletes and those who underwent a concurrent procedure that required an open approach were excluded. Patients were contacted via phone to complete the Kerlan-Jobe Orthopaedic Clinic Shoulder and Elbow Score (KJOC), the Mayo Elbow Score as well as a custom return to play and re-injury questionnaire. The minimum follow-up was 2 years from arthroscopic treatment. Results: Twenty patients met the inclusion criteria and were assessed in this analysis. All of the patients were male with an average BMI of 24.7 (range, 17.8-36.6). The average age at the time of surgery was 15.8 years old (range, 11.7-19.9). All 20 athletes played baseball pre-operatively and had no injury history or previous elbow surgery. Two patients had complications post-operatively. One patient received surgery for contracture release and debridement 7 months post-operatively. The other patient had a repeat arthroscopic microfracture procedure 4 months post-operatively followed by placement of an osteochondral allograft 11 months post-operatively for continued symptoms. Furthermore, three patients sustained an injury to the throwing shoulder or elbow after the operation. Two patients reported that the post-operative injury was throwing-related. One sustained an elbow stress fracture which was treated non-operatively while the other had a UCL reconstruction at 48 months post-operatively. The last patient reported sustaining an acromioclavicular joint separation that was treated operatively but not related to baseball or throwing. A total of 16 patients were available to complete the assessment. The average final follow-up was 5.5 (2.1-10.2) years with average KJOC of 64.6 (range, 13.9-97.0) and a Mayo Elbow Score of 90.0 (range, 60-100). Following surgery, 13/16 (81.2%) patients were able to return to their pre-injury sport and all returned to the same or higher level of competition. Seven patients reported improved symptoms, eight reported resolution of symptoms and one reported worsening of their symptoms after surgery. Overall patients were quite satisfied with their surgery, reporting an average 85.6% satisfaction rating. Conclusions: The results of this study indicate that elbow arthroscopy for osteochondral lesions in overhead throwing athletes is a reliable operation with 81.2% of athletes returning at the same or higher level of competition with low re-operation rates. In addition, these results boast a low complication rate and high patient satisfaction rate following elbow arthroscopy for OCD.

scholarly journals Clinical Manifestations, Laboratory Markers, and Renal Ultrasonographic Examinationsin 1-month to12-year-old Iranian Children with Pyelonephritis: A Six-year Cross-sectional Retrospectivestudy

2020 ◽  
Author(s):  
Daryoosh Fahimi ◽  
Leila Khedmat ◽  
Azadeh Afshin ◽  
Zahra Noparast ◽  
Maryam Jafaripor ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Early Diagnosis ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Ureteral Stones ◽  
Cross Sectional ◽  
Laboratory Markers ◽  
Hospitalization Period ◽  
Iranian Children

Abstract Background: Upper urinary tract infection (UTI) or pyelonephritismay increase the pathogenesis rate and risk of severe complications in children due to the atrophy of the kidneys.Objective: A set of clinical symptoms, laboratory markers, and ultrasound findings were assessed to reach early diagnosis and prognosis of pyelonephritis in hospitalized pediatrics.Methods: A cross-sectional study was conducted on 104 Iranian children (95 girls and 9 boys) aged 1 month to 12 years with acute pyelonephritis during 2012-2018. The ultrasound examination of kidneys and urinary tract during the hospitalization period, the incidence of clinical symptoms, and the monitoring of laboratory markersin blood and urine were studied to identify the best predictive factors of early diagnosis of this bacterial infection.Results: Three-fourth of the patients had one of the four clinical symptoms of abdominal pain, constipation, dysuria, andvomiting, whileotherswere asymptomatic. A considerable frequency of pyuria(88.4%), Escherichia coli in urine (92%), leukocytosis (81.7%), and high ESR (> mm/h, 80%) and CRP (> 10mg/L, 82.8%) was observed. The kidney and urinary tract ultrasonography onlyin 32.7% of children showed in favor of pyelonephritis (cystitis, ureteral stones, and hydronephrosis).Conclusion: In the majority of patients, there was a high prevalence of clinical signs and laboratory markers associated with pyelonephritis. Since most patients have normal sonography, ultrasound alonecould notbe an efficient tool fortracingfebrile UTI.

scholarly journals Concentrations of canine prostate specific esterase, CPSE, at baseline are associated with the relative size of the prostate at three-year follow-up

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Bodil S. Holst ◽  
Sofia Carlin ◽  
Virginie Fouriez-Lablée ◽  
Sofia Hanås ◽  
Sofie Ödling ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Specific Antigen ◽  
Relative Size ◽  
Clinical Signs ◽  
Serum Concentrations ◽  
Prostatic Disease ◽  
Follow Up Study ◽  
Prostate Size ◽  
Prostate Growth

Abstract Background Enlargement of the prostate is associated with prostatic diseases in dogs, and an estimation of prostatic size is a central part in the diagnostic workup. Ultrasonography is often the method of choice, but biomarkers constitute an alternative. Canine prostate specific esterase (CPSE) shares many characteristics with human prostate specific antigen (PSA) and is related to prostate size. In men with clinical symptoms of prostatic disease, PSA concentrations are related to prostate growth. The aims of the present follow-up study were to evaluate if the concentration of CPSE is associated with future growth of the prostate, and if analysis of a panel of 16 steroids gives further information on prostatic growth. Owners of dogs included in a previous study were 3 years later contacted for a follow-up study that included an interview and a clinical examination. The prostate was examined by ultrasonography. Serum concentrations of CPSE were measured, as was a panel of steroids. Results Of the 79 dogs included at baseline, owners of 77 dogs (97%) were reached for an interview, and 22 were available for a follow-up examination. Six of the 79 dogs had clinical signs of prostatic disease at baseline, and eight of the remaining 73 dogs (11%) developed clinical signs between baseline and follow-up, information was lacking for two dogs. Development of clinical signs was significantly more common in dogs with a relative prostate size of ≥2.5 at baseline (n = 20) than in dogs with smaller prostates (n = 51). Serum concentrations of CPSE at baseline were not associated with the change in prostatic size between baseline and follow-up. Serum concentrations of CPSE at baseline and at follow-up were positively associated with the relative prostatic size (Srel) at follow-up. Concentrations of corticosterone (P = 0.024), and the class corticosteroids (P = 0.0035) were positively associated with the difference in Srel between baseline and follow-up. Conclusions The results support the use of CPSE for estimating present and future prostatic size in dogs ≥4 years, and the clinical usefulness of prostatic size for predicting development of clinical signs of prostatic disease in the dog. The association between corticosteroids and prostate growth warrants further investigation.

scholarly journals The Role of Salivary Biomarkers in the Early Diagnosis of Alzheimer’s Disease and Parkinson’s Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 371
Author(s):  
Patrycja Pawlik ◽  
Katarzyna Błochowiak
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Early Diagnosis ◽  
Neurodegenerative Diseases ◽  
Diagnostic Tool ◽  
Clinical Symptoms ◽  
Early Screening ◽  
Salivary Biomarkers

Many neurodegenerative diseases present with progressive neuronal degeneration, which can lead to cognitive and motor impairment. Early screening and diagnosis of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are necessary to begin treatment before the onset of clinical symptoms and slow down the progression of the disease. Biomarkers have shown great potential as a diagnostic tool in the early diagnosis of many diseases, including AD and PD. However, screening for these biomarkers usually includes invasive, complex and expensive methods such as cerebrospinal fluid (CSF) sampling through a lumbar puncture. Researchers are continuously seeking to find a simpler and more reliable diagnostic tool that would be less invasive than CSF sampling. Saliva has been studied as a potential biological fluid that could be used in the diagnosis and early screening of neurodegenerative diseases. This review aims to provide an insight into the current literature concerning salivary biomarkers used in the diagnosis of AD and PD. The most commonly studied salivary biomarkers in AD are β-amyloid1-42/1-40 and TAU protein, as well as α-synuclein and protein deglycase (DJ-1) in PD. Studies continue to be conducted on this subject and researchers are attempting to find correlations between specific biomarkers and early clinical symptoms, which could be key in creating new treatments for patients before the onset of symptoms.

scholarly journals Osteoarthritis in pet guinea pigs: an update on diagnosis, treatment and management

2021 ◽  
Vol 26 (6) ◽  
pp. 100-106
Author(s):  
Emma Keeble
Keyword(s):  
Quality Of Life ◽  
Early Diagnosis ◽  
Guinea Pigs ◽  
Advanced Disease ◽  
Early Stage ◽  
Clinical Signs ◽  
Nutritional Supplements ◽  
Lifestyle Changes ◽  
Early Age

This article reviews the current literature on osteoarthritis in pet and laboratory guinea pigs. The associated clinical signs, diagnosis and treatment of osteoarthritis in pet guinea pigs will be discussed, with options for analgesia detailed. This condition is thought to be common in pet guinea pigs, even from an early age in some genetic lines, although osteoarthritis often goes undiagnosed in this species until advanced disease is present, posing a major welfare concern. Increasing awareness of this condition in veterinary practitioners should aid early diagnosis in pets and help improve their quality of life. Prevention may be possible using oral protective nutritional supplements to slow down the progression of this disease at an early stage. Lifestyle changes are also discussed for the management of this condition in pet guinea pigs.

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