Evidence of beneficial effects of strict glycemic control on diabetic vascular complications - A prospective study with artificial devices.

Atherosclerosis, a chronic and progressive disease characterized by vascular inflammation, is a leading cause of death in diabetes patients. Doinseunggitang (DYSGT), traditional prescription, has been used for promoting blood circulation to remove blood stasis. The aim of this study was to investigate the beneficial effects of DYSGT on endothelial dysfunction in diabetic atherosclerosis animal model. Apolipoprotein E knockout (ApoE KO) mice fed on a Western diet were treated with DYSGT (200 mg/kg/day). DYSGT significantly lowered blood glucose level and glucose tolerance as well as systolic blood pressure. Metabolic parameter showed that DYSGT markedly decreased triglyceride and LDL-cholesterol levels. In the thoracic aorta, the impairment of vasorelaxation response to acetylcholine and atherosclerotic lesion was attenuated by DYSGT. Furthermore, DYSGT restored the reduction of endothelial nitric oxide synthase (eNOS) expression, leading to the inhibition of intracellular adhesion molecule-1 (ICAM-1) and endothelin-1 (ET-1) expression. In conclusion, DYSGT improved the development of diabetic atherosclerosis via attenuation of the endothelial dysfunction, possibly by inhibiting ET-1, cell adhesion molecules, and lesion formation. Therefore, these results suggest that Korean traditional prescription Doinseunggitang may be useful in the treatment and prevention of diabetic vascular complications.

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Wagner’s Classification for Management and Evaluation of Diabetic Foot: A Prospective Study

International Journal of Research and Review ◽

10.52403/ijrr.20210745 ◽

2021 ◽

Vol 8 (7) ◽

pp. 327-331

Author(s):

Prashant G.K. ◽

Suryanarayan Reddy V

Keyword(s):

Surgical Treatment ◽

Glycemic Control ◽

Diabetic Foot ◽

Small Subset ◽

Strict Glycemic Control ◽

Foot Disease ◽

Long Course ◽

A Prospective Study ◽

Keywords Antibiotics ◽

Time Of Presentation

Background: In our community diabetes is one of the most common co-morbid illnesses. Out of its several complications in long course diabetic foot is one of them. Morbidity and mortality due to this complication is a major health issue. Objective: This study is undertaken for management and evaluation of foot ulceration to avoid amputation of lower extremities due to diabetic foot disease. Methods: This prospective observational study conducted between July 2019 and September 2020, 40 patients with diabetic foot admitted to Department of General Surgery, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar (TS) were subjected to surgical treatment depending upon the Wagner’s classification. Data was collected and analyzed by statistical software SPSS V 25. Results: Majority of the patients presented with higher grade and with poor glycemic control at the time of presentation. Conservative management with antibiotics was useful in a small subset of the patients. Majority of the patients needed surgical treatment in the form of debridement to amputations. Conclusion: Patient education and strict glycemic control can reduce the burden of diabetic foot. Early diagnosis and hospitalization, appropriate treatment including medical and surgical treatment according to the grade can reduce the morbidity mortality and improve the outcome of the disease. Keywords: Antibiotics; Amputation; Wagner classification; Complications; Glycemic control.

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An analytical study of the prevalence and prescribed pattern vascular complication for type II diabetic patient in Indian tertiary care hospitals

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl4.3791 ◽

2020 ◽

Vol 11 (SPL4) ◽

pp. 310-314

Author(s):

Satya Preethi ◽

Beeraka Chandra Sekhar ◽

Pandiyan K R ◽

Rajkumar R

Keyword(s):

Glycemic Control ◽

Lifestyle Modification ◽

Patient Adherence ◽

Microvascular Complications ◽

Tertiary Care ◽

Blood Glucose Control ◽

Vascular Complications ◽

Vascular Complication ◽

Diabetic Patients ◽

Diabetic Vascular Complications

Diabetes mellitus (DM) is a common metabolic disorder. It is associated with complications which will affect the quality of life. Failure to control elevated blood sugar or inadequate treatment of diabetes could cause many complications. A prospective observational study is used to assess the prevalence of diabetic vascular complications in 105 types of II diabetic patients. A date was collected regarding patient's demographic and clinical characteristics. Based on our study criteria, males were more when compared to females in getting vascular complications & also. Complications were more prominent in the age group of 50-65years. Of all microvascular complications, Nephropathy was major, whereas, in macro-vascular complications, CAD was prominent. Poor glycemic control and a long length of ailment appear to be the most significant danger factors for these complexities. Doctors assume a significant function to endorse hostile to diabetic meds and Pharmacist plays a sharp task to assess the medicine design so as to accomplish fruitful treatment. The currently anti-diabetic drugs are effective, but a lot of factors such as patient adherence, education related to diabetes, lifestyle modification, cost and type of medication have an association with glycemic control. The commonly prescribed anti-diabetic drug was Insulin. Metformin was the most preferred drug both as monotherapy and combination therapy. Although polypharmacy was observed, drug utilization pattern can be rational owing to a higher prevalence of complications. Minimization of the occurrence of complications should be courage by early diagnosis, intensive blood glucose control and rational drug selections.

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BENEFICIAL EFFECTS OF PEEP ON RESPIRATORY COMPLIANCE MONITORED BY NEWER GENERATION OF ANESTHESIA VENTILATORS IN ANESTHESIZED PATIENTS: RESULTS OF A PROSPECTIVE STUDY

British Journal of Anaesthesia ◽

10.1093/bja/el_9474 ◽

2012 ◽

Vol 109 (eLetters) ◽

Author(s):

Guillaume Lacroix

Keyword(s):

Prospective Study ◽

Beneficial Effects ◽

Respiratory Compliance ◽

A Prospective Study

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Modeling patient empowerment and health literacy to glycemic control in insulin-treated patients: A prospective study

Patient Education and Counseling ◽

10.1016/j.pec.2019.02.005 ◽

2019 ◽

Vol 102 (7) ◽

pp. 1336-1341 ◽

Cited By ~ 1

Author(s):

Ruey-Hsia Wang ◽

Hui-Chun Hsu ◽

Shi-Yu Chen ◽

Chang-Hsun Hsieh ◽

Yau-Jiunn Lee

Keyword(s):

Health Literacy ◽

Glycemic Control ◽

Prospective Study ◽

Patient Empowerment ◽

A Prospective Study

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Phycocyanin and phycocyanobilin fromSpirulina platensisprotect against diabetic nephropathy by inhibiting oxidative stress

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00648.2011 ◽

2013 ◽

Vol 304 (2) ◽

pp. R110-R120 ◽

Cited By ~ 70

Author(s):

Jing Zheng ◽

Toyoshi Inoguchi ◽

Shuji Sasaki ◽

Yasutaka Maeda ◽

Mark F. McCarty ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetic Nephropathy ◽

Oral Administration ◽

Mesangial Cells ◽

Vascular Complications ◽

Blue Green Algae ◽

Beneficial Effects ◽

Diabetic Vascular Complications ◽

Tumor Growth Factor ◽

Antioxidant Effects

We and other investigators have reported that bilirubin and its precursor biliverdin may have beneficial effects on diabetic vascular complications, including nephropathy, via its antioxidant effects. Here, we investigated whether phycocyanin derived from Spirulina platensis, a blue-green algae, and its chromophore phycocyanobilin, which has a chemical structure similar to that of biliverdin, protect against oxidative stress and renal dysfunction in db/db mice, a rodent model for Type 2 diabetes. Oral administration of phycocyanin (300 mg/kg) for 10 wk protected against albuminuria and renal mesangial expansion in db/db mice, and normalized tumor growth factor-β and fibronectin expression. Phycocyanin also normalized urinary and renal oxidative stress markers and the expression of NAD(P)H oxidase components. Similar antioxidant effects were observed following oral administration of phycocyanobilin (15 mg/kg) for 2 wk. Phycocyanobilin, bilirubin, and biliverdin also inhibited NADPH dependent superoxide production in cultured renal mesangial cells. In conclusion, oral administration of phycocyanin and phycocyanobilin may offer a novel and feasible therapeutic approach for preventing diabetic nephropathy.

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