AN EXPERIMENTAL STUDY OF POST-PARTUM ENDOMETRIAL REPAIR IN THE GUINEA-PIG AND RAT

1952 ◽  
Vol 8 (2) ◽  
pp. 162-NP
Author(s):  
A. SHARMAN
Keyword(s):  
Experimental Study ◽  
Guinea Pig ◽  
Corpus Luteum ◽  
Guinea Pigs ◽  
Post Partum ◽  
The Third ◽  
Endometrial Regeneration

An experimental study was made of post-partum endometrial regeneration in twenty-one healthy guinea-pigs and in twenty healthy rats. To serve as controls, one guinea-pig was killed on the day of parturition and another 6½ days following parturition: three rats were killed on the day of parturition and one 6½ days following parturition. All the remaining animals were ovariectomized. Groups of three were killed at the following intervals after parturition, viz.: 22, 40, 58, 84 hr. and 6½ days. In each group, one animal was left uninjected, another injected with oestrogenic hormone and the third injected with corpus luteum hormone. Endometrial regeneration appeared to proceed normally in all the animals.

VI.—Studies on the Reproductive System in the Guinea-Pig : Observations on the Ovaries, with special reference to the Corpus Luteum

1935 ◽  
Vol 54 ◽  
pp. 56-66 ◽  
Author(s):  
Thomas Nicol
Keyword(s):  
Guinea Pig ◽  
Special Reference ◽  
Corpus Luteum ◽  
Reproductive System ◽  
Guinea Pigs ◽  
Post Partum ◽  
Corpora Lutea ◽  
Tabular Form

The object of the present paper is to put upon record for the guinea-pig data which I have collected regarding (1) the relation between the number of young in a litter and the number of corpora lutea of pregnancy in the ovaries, (2) the distribution of corpora lutea between the two ovaries in two successive ovulations, and (3) the utilisation of the uterine horns in successive pregnancies. The data were obtained in the course of other researches and are arranged in tabular form (Tables I and II). The records from which they have been collected refer to 40 female guinea-pigs killed post partum, of which 16 were pregnant and 24 had not been reimpregnated. The size of the previous litter is known for 38 of these females; both ovaries were serially sectioned at 10 microns in the 40 animals, but in 4 the records of only one ovary were preserved.

scholarly journals EXTIRPATION OF THE THYMUS IN THE GUINEA PIG

1917 ◽  
Vol 25 (1) ◽  
pp. 129-152 ◽  
Author(s):  
Edwards A. Park
Keyword(s):  
Guinea Pig ◽  
Serial Section ◽  
Guinea Pigs ◽  
Close Association ◽  
Main Lobe ◽  
Technical Error ◽  
Serial Sections ◽  
Pharyngeal Pouch ◽  
The Third ◽  
Third Pharyngeal Pouch

1. Accessory lobes of thymus, derived from the third pharyngeal pouch, occurring in close association with the parathyroids from the third pouch, were found in serial section of the cervical tissues of eleven out of fourteen guinea pigs, and probably would have been found in all fourteen but for a technical error. 2. It is probable, therefore, that accessory lobes of thymus having this situation and origin are usually, if not always, present in the guinea pig. 3. Additional accessory lobes of thymus belonging to, but at some distance from the main lobe were also present in several of the animals. 4. The discovery of these accessory lobes makes it certain that the guinea pig is unsuitable material for complete thymectomy, and probably complete extirpation of the thymus in this animal is rarely, if ever accomplished. 5. The extirpation experiments of previous investigators in the guinea pig must now be regarded as partial extirpations, and their results interpreted in that light. 6. Extirpation of the thymus in the guinea pig produced no changes in the writer's experiments. 7. The study of the serial sections of the cervical tissues of the guinea pig indicates that Ruben's statements regarding the parathyroid derived from the fourth pharyngeal pouch in the guinea pig are correct,—that it is much smaller than parathyroid III, may be rudimentary, and is sometimes absent at least on one side. 8. No accessory lobe of thymus was found accompanying the parathyroid from the fourth pouch, a finding also bearing out Ruben's statement that no thymus anlarge springs from the fourth pouch in the guinea pig.

CHANGES IN THE CONCENTRATIONS OF CORTISOL AND CORTICOSTERONE IN THE PLASMA AND ADRENAL GLANDS OF THE GUINEA-PIG FROM BIRTH TO WEANING

1974 ◽  
Vol 63 (3) ◽  
pp. 483-488 ◽  
Author(s):  
M. DALLE ◽  
P. DELOST
Keyword(s):  
Adrenal Gland ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Plasma Cortisol ◽  
Adrenal Glands ◽  
Post Partum ◽  
Cortisol Secretion ◽  
Male And Female ◽  
Steady Level ◽  
Very High

SUMMARY Concentrations of cortisol and corticosterone in the plasma and adrenal glands of male and female guinea-pigs were estimated throughout the first postnatal day and thereafter at intervals up to 3 weeks of age. In the guinea-pig, the basal level of cortisol secretion is established more slowly than in other species. The concentration of plasma cortisol is very high at birth, with a marked fall between days 1 and 10 post partum and then a steady level from day 10 to 20, the time of weaning. At day 10 the values for plasma cortisol and corticosterone approach the lower ones found in the adult. There were peaks in the amounts of corticosteroids found in the adrenal gland at 50 h, 4 and 7 days and these may have been due to increased hormonal synthesis between days 2 and 8.

THE EFFECT OF HYPOPHYSIAL STALK-SECTION ON THE CORPUS LUTEUM OF THE GUINEA-PIG

1971 ◽  
Vol 50 (4) ◽  
pp. 625-635 ◽  
Author(s):  
DOREEN V. ILLINGWORTH ◽  
J. S. PERRY
Keyword(s):  
Growth Rate ◽  
Guinea Pig ◽  
Corpus Luteum ◽  
Guinea Pigs ◽  
Oestrous Cycle ◽  
Corpora Lutea ◽  
Normal Cycle ◽  
Luteal Regression ◽  
Normal Regression ◽  
And Function

SUMMARY The effects of hypophysial stalk-section on the growth and function of the corpus luteum of the non-pregnant guinea-pig have been compared with the effects of hypophysectomy (as previously described) and with the effects of prolactin administered to hypophysectomized animals. Stalk-section soon after ovulation did not impair the growth of the corpora lutea nor their ability to secrete progesterone. Stalk-section before day 9 of the oestrous cycle prevented the normal regression of the corpora lutea; they continued to grow and 3 weeks after ovulation were as large as those of pregnant animals, or of non-pregnant hysterectomized guinea-pigs. The corpora lutea regressed irregularly during the following 2 weeks. When performed on, or later than day 9, stalk-section did not prevent luteal regression at the normal time. Administration of prolactin (10 i.u./day) to hypophysectomized guinea-pigs restored the growth-rate of the corpora lutea, which reached sizes comparable to those of the normal cycle, and those of stalk-sectioned animals, by 10 days after ovulation. Our results indicate that prolactin can have substantial luteotrophic activity in the guinea-pig.

CORPUS LUTEUM CONTROL IN HYSTERECTOMIZED GUINEA-PIGS

1965 ◽  
Vol 32 (2) ◽  
pp. 153-NP ◽  
Author(s):  
R. DEANESLY ◽  
J. S. PERRY
Keyword(s):  
Guinea Pig ◽  
Corpus Luteum ◽  
Guinea Pigs ◽  
Luteal Phase ◽  
Corpora Lutea ◽  
Vaginal Opening

SUMMARY Interruption of the prolonged luteal phase in hysterectomized guinea-pigs, followed by vaginal opening, can be caused by substances affecting the hypothalamus and hypophysis, which check gonadotrophin output. In the present experiments, both progesterone and reserpine were effective and caused regression of the corpora lutea. It may be concluded that in the guinea-pig, as in the sow and the sheep, the corpora lutea of hysterectomy do not function independently of the hypophysis. The uterine factor associated with normal cyclic corpora lutea regression, which is lacking after hysterectomy, presumably acts on the hypophysis rather than directly on the corpora lutea.

CHANGES IN CORTISOL BINDING AND METABOLISM DURING NEONATAL DEVELOPMENT IN THE GUINEA-PIG

1980 ◽  
Vol 85 (2) ◽  
pp. 219-227 ◽  
Author(s):  
M. DALLE ◽  
A. EL HANI ◽  
P. DELOST
Keyword(s):  
Guinea Pig ◽  
Clearance Rate ◽  
Guinea Pigs ◽  
Surgical Stress ◽  
Binding Capacity ◽  
Post Partum ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Male And Female ◽  
Free Cortisol

The metabolic clearance rate and the binding of cortisol in plasma of male and female guinea-pigs were estimated at five stages between birth and weaning. The metabolic clearance rate for cortisol remained low in both sexes until day 10 post partum but increased to adult values by day 20. The level of free cortisol in plasma and the cortisol binding capacity of the plasma were higher at birth than on day 10 post partum; the values found on day 20 were similar to those of the adult guinea-pig. Surgical stress increased levels of cortisol in plasma on day 20 but not at birth.

scholarly journals BOUND COMPLEMENT AND IMMUNOLOGIC INJURY OF BLOOD VESSELS

1965 ◽  
Vol 121 (2) ◽  
pp. 215-234 ◽  
Author(s):  
Peter A. Ward ◽  
Charles G. Cochrane
Keyword(s):  
Biological Activity ◽  
Guinea Pig ◽  
Specific Antibody ◽  
Guinea Pigs ◽  
Vascular Damage ◽  
The Third ◽  
Component C ◽  
Vascular Structures

Rats and guinea pigs were depleted of complement (C') by treatment with heat aggregated human γ-globulin (agg HGG), zymosan, anti-ß1C globulin, and carrageenan. Although antigen and antibody were bound to vascular structures, Arthus reactions were inhibited. This inhibition was characterized by the lack of C' binding to walls of vessels, the lack of polymorphonuclear (PMN's) cellular infiltrates, and the lack of significant vascular damage. When the same animals were followed for several hours thereafter, levels of serum C' began to rise, C' was bound in tissues, PMN infiltrates appeared, and immunologic vasculitis developed. Blood counts, chemotaxis of PMN's induced by lysates of PMN granules, together with studies on motility and phagocytosis by PMN's obtained from C' depleted rats, failed to establish any abnormality in these cells which would account for inhibition of Arthus reactions. The specificity of C' depletion in terms of effects in the first four reacting components of guinea pig C' was studied. Treatment with agg HGG led to loss of activity in all components, whereas zymosan and anti-ß1C globulin predominately affected the third component (C'3c). Carrageenan mainly affected the first two reacting components of C'. Thus, the availability of the 3c component, or a subsequently reacting component, correlated with the attraction of PMN's to immune reactants in vivo. Various antibodies with different C' fixing capacities in vitro were tested for their ability to induce immunologic vasculitis in normal animals. In rats, only those antibodies which fixed C' in vitro possessed biological activity, whereas in guinea pigs, all antibodies tested, regardless of C' fixation in vitro, induced Arthus reactions. For a given antibody in rats the vasculitis-inducing property was reflected in its ability to bind C' in vascular structures. Rats depleted of circulating PMN's by specific antibody were tested for Arthus activity. Although concentrations of immune reactants and C' were readily detected in vascular structures, no PMN infiltration occurred and significant vascular damage was averted.

Wieland. Serodiagnosis of guinea pig serum tuberculosis and its significance for the experimental study of tuberculosis (Ztschr. F. Immunitätsf .. Bd 88, H. 1/2 193)

1937 ◽  
Vol 33 (5) ◽  
pp. 635-635
Keyword(s):  
Experimental Study ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
General Significance ◽  
Pig Serum

The author tried to resolve two questions: firstly, which of the serological reactions is most suitable for detecting changes in the blood of tuberculous guinea pigs, and, secondly, what is the general significance of serodiagnostics in this animal with tuberculosis.

Synaptic Bodies in the Different Rows of Outer Hair Cells in the Guinea Pig Cochlea

1988 ◽  
Vol 97 (3) ◽  
pp. 308-312 ◽  
Author(s):  
R. Swetlitschkin ◽  
L. Vollrath
Keyword(s):  
Guinea Pig ◽  
Hair Cells ◽  
Guinea Pigs ◽  
Functional Significance ◽  
Quantitative Data ◽  
Outer Hair Cells ◽  
Inner Hair Cells ◽  
Circadian Changes ◽  
The Third ◽  
Ribbon Synapses

The afferent synapses of the outer hair cells (OHCs) of the cochlea are peculiar, insofar as some of them contain special synaptic bodies (SBs) forming the so-called ribbon synapses. These SB-containing synapses are highly variable in number, exhibiting interspecies and intraspecies differences. As quantitative data on the incidence of SBs in the different rows of OHCs are lacking and as some of the above differences may have a circadian basis, in the present study SBs were counted in guinea pigs killed at different times of the day and night. In the second turn of the cochlea, synapses with perpendicular and parallel SBs were distinguished. Perpendicular SBs, but not parallel SBs, were significantly higher in number in the first than in the third row. Circadian changes were observed for perpendicular SBs, which were higher in number in the evening than in the morning. Circadian changes were absent in the parallel SBs of the OHCs and in the SBs of the inner hair cells. These results show that the afferent synapses of OHCs are rather complex, structurally as well as temporally; the functional significance of this finding remains to be elucidated.

ANTI-BRUCELLA SERUM: GUINEA PIG PROTECTION EXPERIMENTS

1938 ◽  
Vol 16d (12) ◽  
pp. 353-360 ◽  
Author(s):  
Ronald Gwatkin
Keyword(s):  
Guinea Pig ◽  
Brucella Abortus ◽  
Guinea Pigs ◽  
Rabbit Serum ◽  
Natural Manner ◽  
The Third ◽  
And Control

Guinea pigs were protected against infection with Brucella abortus by intraperitoneal injections of fresh, unpreserved, anti-abortus rabbit serum. In the first two experiments the serum-treated and control animals were exposed to infection by contact with infected guinea pigs, while in the third experiment they were exposed by instillation of the infecting organism into the eye. In the first experiment 60% of the controls and none of the treated animals were infected. In the second, 80% of the controls and 20% of the treated animals were infected. In the third, all of the treated animals were protected, while all of the controls became infected. The former method, although less certain than the latter, is worthy of consideration in experiments of this type, as it permits infection to occur in a natural manner.

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