THE ONSET AND ESTABLISHMENT OF SPERMATOGENESIS IN RATS IN RELATION TO GONADOTROPHIN AND TESTOSTERONE LEVELS

1977 ◽  
Vol 75 (2) ◽  
pp. 197-207 ◽  
Author(s):  
F. H. DE JONG ◽  
R. M. SHARPE
Keyword(s):  
Growth Rate ◽  
Plasma Levels ◽  
Prostate Gland ◽  
Age Groups ◽  
Seminal Vesicles ◽  
Ventral Prostate ◽  
Spermatogenic Cells ◽  
Cell Type ◽  
Measurable Level ◽  
Pachytene Spermatocytes

The concentrations of LH and FSH in the plasma and pituitary gland, and testosterone in the plasma and testes were measured in individual rats between 21 and 180 days of age. Spermatogenesis was quantitated in the same animals and correlations between the various parameters were calculated. The numbers of Sertoli and spermatogenic cells up to pachytene spermatocytes increased in parallel with the peripheral levels of FSH up to days 33 or 35. The concentration of FSH in the plasma started to decrease after day 55, but this decrease could not be correlated with the appearance of any cell type in the testes of the same animals; it was probably due to the high levels of peripheral testosterone at this age. Testicular and plasma levels of testosterone were closely correlated in all age groups studied. The first significant increase occurred between days 39 and 41 and coincided with an increased growth rate of the seminal vesicles and ventral prostate gland. The increase in the concentration of testosterone occurred 10 days after the concentration of LH in the plasma rose to a measurable level. Spermatogenesis had proceeded up to step 16 spermatids at this age.

[3H]thymidine uptake by the epididymis, seminal vesicles and prostate gland during postnatal development of the rat

1991 ◽  
Vol 3 (3) ◽  
pp. 313 ◽  
Author(s):  
S Sujarit ◽  
RC Jones
Keyword(s):  
Postnatal Development ◽  
Similar Pattern ◽  
Initial Segment ◽  
Prostate Gland ◽  
Seminal Vesicles ◽  
Ventral Prostate ◽  
Thymidine Uptake ◽  
Low Levels ◽  
Cauda Epididymidis

The uptake of [3H]thymidine by the epididymis, ventral prostate gland and seminal vesicles was determined in vivo for rats aged 15, 20, 25, 30, 35, 45 and 55 days. The pattern of uptake varied considerably between organs and generally was different from patterns of growth measured as mass or ratio of mass of DNA:tissue. The 'initial segment' of the epididymis and caput and corpus epididymidis showed a similar pattern of [3H]thymidine uptake, being greatest in 15-day-old animals and declining thereafter. On Day 15 the cauda epididymidis had a lower uptake than more proximal regions of the epididymis, but it subsequently showed two significant peaks of increased uptake on Days 25-30 and Day 45. The uptake by the seminal vesicles was high on Day 15, fell to low levels on Day 20, increased considerably from Days 20 to 35, then gradually decreased from Day 35 to 55. The uptake by the prostate gland was a little lower than by the seminal vesicles on Days 15 and 20, then reduced to about the same level as non-reproductive tissues.

SOME EFFECTS OF SIMULTANEOUS ADMINISTRATION OF NORETHANDROLONE AND CORTISONE IN THE RAT

1959 ◽  
Vol XXXII (IV) ◽  
pp. 536-544 ◽  
Author(s):  
J. G. Llaurado ◽  
J. B. Trunnell ◽  
J. L. Claus
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Opposite Effect ◽  
Levator Ani ◽  
Seminal Vesicles ◽  
Ventral Prostate ◽  
Simultaneous Administration ◽  
Concurrent Administration ◽  
Consistent Effect ◽  
Delayed Growth

ABSTRACT An investigation was undertaken in an attempt to determine whether norethandrolone (NEA) antagonizes all or some of the catabolic effects of 17-hydroxycorticoids. Fourteen groups of eight male young rats (intact, gonadectomized, adrenalectomized and adrenalectomized-gonadectomized) were given subcutaneously either the solvent, NEA (1 mg/day), cortisone (1 mg/day) or a combination of both for 21 days. Results show that administration of NEA has a moderate but consistent effect in increasing body weight of rats receiving no other steroid as well as in preventing the delayed growth rate of those receiving cortisone. In both intact and gonadectomized animals, NEA largely prevented the intense atrophy of the adrenals induced by cortisone. An increase in levator ani weight was promoted by NEA regardless of concurrent administration of cortisone. The latter induced a diminution in the size of seminal vesicles, coagulating glands and ventral prostate, whereas NEA had the opposite effect; when given together the effect of NEA was potentiated. Treatment with NEA alone was shown to have a marked thymolytic effect and also to potentiate the thymolytic effect of cortisone when given together. These results suggest that in some tissues NEA antagonizes, and in others augments, some of the catabolic actions of 17-hydroxycorticoids

PLASMA TESTOSTERONE AND ACCESSORY SEX GLANDS IN NORMAL AND CRYPTORCHID RATS

1972 ◽  
Vol 54 (2) ◽  
pp. 285-296 ◽  
Author(s):  
B. J. LLOYD
Keyword(s):  
Prostate Gland ◽  
Seminal Vesicles ◽  
Ventral Prostate ◽  
Plasma Testosterone ◽  
Progressive Decline ◽  
Testosterone Levels ◽  
Accessory Sex Glands ◽  
Gland Weight ◽  
Age Related ◽  
Fischer Rats

SUMMARY Plasma testosterone concentration and the weights of the seminal vesicles and ventral prostate gland were measured in normal and cryptorchid Fischer rats at 3, 4·5, 7·5 and 13·5 months of age, and in normal parabionts and cryptorchid parabionts of 13·5 months of age. Testosterone was measured individually by a protein-binding method. In normal rats, all parameters rose to a maximum at 7·5 months of age, then levelled off or declined at 13·5 months of age. In cryptorchid rats, a similar pattern at a lower level was found for accessory sex gland weight, but plasma testosterone levels showed a progressive decline from an above normal level at 3 months to a subnormal level at 13·5 months of age. Cryptorchid parabionts were less responsive to gonadotrophin stimulation from union with a castrated partner than normal parabionts. The present study showed that plasma testosterone levels in normal and cryptorchid rats are age-related. It also showed that the pattern of plasma testosterone levels observed in cryptorchid rats is different from that seen in normal rats. Accessory sex gland weight is also age-related but is not a reliable index of plasma testosterone levels.

scholarly journals Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats

2006 ◽  
Vol 2006 ◽  
pp. 1-7 ◽  
Author(s):  
D. Shanker ◽  
A. K. Rai ◽  
Y. P. Singh ◽  
H. Rehwani ◽  
V. Khushalani ◽  
...  
Keyword(s):  
Condensation Reaction ◽  
Reproductive Organs ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Control Group ◽  
Albino Rats ◽  
Elemental Analyses ◽  
Pachytene Spermatocytes ◽  
Antimony Complex

BenzothiazolineHNC6H4SC︹(C6H5)CH:C(OH)COOCH3 1prepared by the condensation reaction of aroyl pyruvate and 2-aminothiophenol has been treated withPh3Sb(OPri)2to yieldPh3Sb[SC6H4NC(C6H5)CH:CO︹COOCH3] 2. These compounds have been characterized by elemental analyses and molecular weight determinations. The probable structures of the ligand as well as antimony complex have been tentatively proposed on the basis of IR and NMR (H1andC13) spectral evidences. Both compounds have been tested for their antifertility activity in male albino rats. The oral administration of compounds1and2at the dose level of 10 mg/rat/day significantly reduced the weights of testes, epididymides, ventral prostate, and seminal vesicles. The production of preleptotene spermatocytes was decreased by36.57%;57.23%, pachytene spermatocytes by40.06%;62.01%, and secondary spermatocytes by52.45%;63.22%, following the treatment of compounds1and2, respectively. The marked reduction in sperm motility and density resulted in infertility by100%. Significant (P<.01) alterations were found in biochemical parameters of reproductive organs in treated animals as compared to control group. It is concluded that all these effects may finally impair the fertility of male rats.

ANTIANDROGENIC EFFECTS OF THE PINEAL GLAND AND MELATONIN IN CASTRATED AND INTACT PREPUBERTAL MALE RATS

1978 ◽  
Vol 79 (1) ◽  
pp. 77-83 ◽  
Author(s):  
R. ALONSO ◽  
L. PRIETO ◽  
C. HERNANDEZ ◽  
M. MAS
Keyword(s):  
Pineal Gland ◽  
Prostate Gland ◽  
Antagonistic Effect ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Inhibitory Influence ◽  
High Concentration ◽  
Accessory Sex Organs ◽  
Prepubertal Rats

In castrated prepubertal rats, pinealectomy enhanced the testosterone-induced growth response of the seminal vesicles and melatonin inhibited this effect in a dose-related manner. In entire animals, the serum concentration of LH was increased after pinealectomy with no significant changes in other parameters. Administration of melatonin to intact, pinealectomized rats did not affect the serum concentrations of LH or testosterone but caused a doserelated decrease in the weight of the seminal vesicles. The highest dose of melatonin tested reduced the weight of the ventral prostate gland and the uptake of radioactivity by both the ventral prostate gland and the testes after injection of [5-3H]uridine. It is suggested that the pineal gland and melatonin may exert an antagonistic effect on the biological activity of androgens administered to castrated rats and that melatonin can reduce the growth of the accessory sex organs of intact, pinealectomized rats, in spite of a high concentration of LH in the serum. The well-known inhibitory influence of systemically administered melatonin on the accessory sex organs in male rats may be due to its antagonistic effect at a peripheral level.

Age related volume of cadaver-prostates in Bangladesh

1970 ◽  
Vol 4 (2) ◽  
pp. 74-77
Author(s):  
Rukshana Ahmed ◽  
Shamim Ara
Keyword(s):  
Prostate Gland ◽  
Age Groups ◽  
Clinical Settings ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Group A ◽  
Key Words Prostate ◽  
The Mean ◽  
Group B

Pathological changes in the prostate gland occur commonly with advancing age including inflammation, atrophy, hyperplasia and carcinoma and a change in volume is also evident. Estimation of volume of prostate may be useful in a variety of clinical settings. A cross-sectional descriptive study was designed to see the changes in volume of the prostate with advancing age and done in the Department of Anatomy, Dhaka Medical College, Dhaka from August 2006 to June 2007. The study was performed on 70 post-mortem human prostates collected from the unclaimed dead bodies that were under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into three age groups; group A (10-20 years), group B (21-40 years) and group C (41-70 years). Volume of the sample was measured by using the ellipsoid formula. The mean ± SD volume of prostate was 7.68 ± 3.64 cm3 in group A, 10.61 ± 3.99 cm3 in group B and 15.40 ± 6.31 cm3 in group C. Mean difference in volume between group A and group C, group B and group C were statistically significant (p<0.001). Statistically significant positive correlation was found between age and volume of prostate (r = + 0.579, p < 0.001). Key Words: Prostate; volume; Bangladeshi. DOI: 10.3329/imcj.v4i2.6501Ibrahim Med. Coll. J. 2010; 4(2): 74-77

METABOLISM AND MODE OF ACTION OF ANDROGENS IN TARGET TISSUES OF MALE RATS

1972 ◽  
Vol 69 (1) ◽  
pp. 165-173 ◽  
Author(s):  
H. Schmidt ◽  
I. Noack ◽  
K. D. Voigt
Keyword(s):  
Cell Proliferation ◽  
Cell Metabolism ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Nucleic Acid Content ◽  
The Difference ◽  
Independent Effects ◽  
Sites Of Action ◽  
Peripheral Metabolism

ABSTRACT The effect of testosterone and 5α-dihydrotestosterone on protein and nucleic acid content as well as on the activities of some enzymes has been studied in the ventral prostate and the seminal vesicles of immature castrated rats. Both androgens were given intraperitoneally in doses of 1 mg daily for one or three days the rats were sacrificed one day after the last injection. In the prostate it was found that 5α-dihydrotestosterone had a greater effect on DNA increase, i. e. cell proliferation than testosterone, whereas cell metabolism was stimulated by the two androgens to nearly the same extent. In the seminal vesicles a single dose led to the same results as had been obtained in the prostate, i. e. a greater cell proliferative action of 5α-dihydrotestosterone and an equal stimulation of cell metabolism by testosterone and 5α-dihydrotestosterone was also observed. When three doses of the two androgens were given, cell proliferation as well as cell metabolism in the seminal vesicles were significantly more increased after 5α-dihydrotestosterone than after testosterone. The difference of action after systemic administration of the two androgens is explained by their different accumulation and by their different peripheral metabolism in the target tissues. From the partly independent effects of various androgens on cell proliferation and cell metabolism the conclusion may be drawn that there exist at least two intracellular sites of action.

Changes in the Male Reproductive Organs of the Dugong, Dugong dugon (Sirenia: Dugondidae) with Age and Reproductive Activity

1984 ◽  
Vol 32 (6) ◽  
pp. 721 ◽  
Author(s):  
H Marsh ◽  
GE Heinsohn ◽  
TD Glover
Keyword(s):  
Reproductive Tract ◽  
Prostate Gland ◽  
Reproductive Activity ◽  
Reproductive Organs ◽  
Seminal Vesicles ◽  
Growth Layer ◽  
Male Reproductive Tract ◽  
Qualitative And Quantitative ◽  
Quantitative Examination ◽  
Testicular Histology

The anatomy and histology of the male reproductive tract of the dugong (Dugong dugon) is described. Each testis and its adjacent epididymis lie immediately caudal to the corresponding kidney. The seminal vesicles are large but there is no discrete prostate gland and the bulbo-urethral glands are also diffuse. Both qualitative and quantitative examination of the testes and epididymides of 59 males whose ages have been estimated from tusk dentinal growth layer counts indicate that the male dugong does not produce spermatozoa continuously, despite the absence of a distinct breeding season. Individual dugongs were observed with testes at all stages between complete quiescence and full spermatogenesis, and only 10 of the 40 mature males had fully spermatogenic testes and epididymides packed with spermatozoa. Androgenic and spermatogenic activity of the testes appeared to be in phase, but the testicular histology of some old males suggested that they may have been sterile for long periods.

scholarly journals Initiation and elongation of polyribonucleotide chains on rat ventral-prostate chromatin transcribed by homologous ribonucleic acid polymerase B.

1977 ◽  
Vol 166 (2) ◽  
pp. 189-198 ◽  
Author(s):  
P Thomas ◽  
P Davies ◽  
K Griffiths
Keyword(s):  
Rna Polymerase ◽  
Rna Synthesis ◽  
Prostate Gland ◽  
Ventral Prostate ◽  
Control Of Gene Expression ◽  
Rat Ventral Prostate ◽  
Associated Proteins ◽  
Ribonucleoside Triphosphate ◽  
Androgenic Steroids ◽  
Transcriptional Process

The characteristics of initiation of RNA synthesis and the elongation of RNA chains on rat ventral-prostate chromatin by RNA polymerase B were investigated by two methods. 1. Initiation was carried out under low-salt conditions with three ribonucleoside triphosphates, and elongation was begun in the absence of reinitiation by the addition of the fourth ribonucleoside triphosphate and increasing the salt concentration. 2. Stable initiation complexes were formed by preincubation of enzyme with template at 37 degrees C, elongation was started by the addition of all four ribonucleoside triphosphates and reinitiation or spurious RNA synthesis was prevented by rifamycin AF/013. The latter method gave more reliable results. The dependence of those parameters on the androgenic status of the animal was studied. During the first 24h after castration, elongation was mainly affected, whereas after 72h a smaller number of initiation sites for RNA polymerase B on chromatin was evident. Considerable diurnal variations in the various parameters were observed. Changes in the relative concentrations of the chromatin-associated proteins were also observed after castration. In the rat ventral-prostate gland androgenic steroids may not only influence one stage of the transcriptional process, but may affect many factors involved in the control of gene expression.

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