Immediate, short- and long-term opposite effects of oestradiol-17β on glucose metabolism in rat adipocytes: relationship with the biphasic changes in body weight and food intake

1984 ◽  
Vol 101 (1) ◽  
pp. 13-19 ◽  
Author(s):  
A. Faure ◽  
M.-Th. Vergnaud ◽  
M.-Th. Sutter-Dub ◽  
B. Ch. J. Sutter
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Glucose Oxidation ◽  
The Other ◽  
Ovariectomized Rats ◽  
Insulin Effect ◽  
Short And Long Term ◽  
Dramatic Fall

ABSTRACT The changes in the effects of oestradiol-17β on body weight, food intake and [1-14C]glucose oxidation in adipocytes were followed in sham-operated, ovariectomized and adrenalectomized–ovariectomized rats to eliminate effects of endogenous progesterone and corticosterone. During the first 5 days oestradiol induced a dramatic fall in food intake and body weight concomitant with a decrease in glucose oxidation by adipocytes, when tested 12 h and 3 days after the beginning of treatment. In-vitro incubations with oestradiol showed that this was a direct effect of this hormone. On the other hand, from days 5 to 14 of treatment, body weight and food intake increased, though they were still lower than in sham-operated controls. On day 14, as values of treated rats tended to reach those of controls, glucose oxidation in adipocytes was stimulated by oestradiol treatment. An insulin effect was still observable and none of these effects was dependent on the adrenal gland. These biphasic changes in the parameters studied could be closely related; moreover, a relationship with other oestradiol actions on metabolism that are known to be corticosterone-dependent could be eliminated. J. Endocr. (1984) 101, 13–19

Level of satiety: in vitro energy metabolism in brain during hypophagic and hyperphagic body weight recovery

1989 ◽  
Vol 257 (6) ◽  
pp. R1322-R1327 ◽  
Author(s):  
T. R. Kasser ◽  
R. B. Harris ◽  
R. J. Martin
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Fatty Acid ◽  
Food Intake ◽  
Fatty Acid Oxidation ◽  
Glucose Oxidation ◽  
Area Postrema ◽  
Tube Feeding ◽  
Acid Oxidation

Rates of in vitro glucose and fatty acid oxidation were examined in four brain sites during hypophagic and hyperphagic recovery of normal body weight. Rats were fed 40, 100, or 160% of normal intake, via gastric intubation, for 3 wk. Another group of rats was starved until body weight loss was equivalent to weight loss in 40%-fed rats. Groups of rats were killed at the conclusion of tube feeding or fasting and at specific periods during recovery of body weight. Brain sites examined were the ventrolateral hypothalamus (VLH), ventromedial hypothalamus (VMH), a caudal brain stem site encompassing the area postrema-nucleus of the solitary tract (AP-NTS), and cortex. During recovery, rats previously fed 160% of normal intake (anorectic) maintained low rates of VLH fatty acid oxidation and were hypophagic until most excess fat was depleted. Conversely, rats previously fed 40% of normal intake (hungry) maintained high rates of VLH fatty acid oxidation and were hyperphagic until most deficient fat was repleted. Rats previously starved maintained high rates of VLH fatty acid oxidation during hyperphagic recovery, although levels of VLH fatty acid oxidation and food intake were initially low on refeeding. Rates of glucose oxidation in the brain sites examined did not relate well to energy balance status and the needed adjustments in food intake. The results indicated that the level of glucose oxidation in the VLH and AP-NTS responded to the level of energy immediately coming into the system (food intake).(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals How Important Is Eating Rate in the Physiological Response to Food Intake, Control of Body Weight, and Glycemia?

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1734
Author(s):  
Georgia Argyrakopoulou ◽  
Stamatia Simati ◽  
George Dimitriadis ◽  
Alexander Kokkinos
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Energy Intake ◽  
Normal Weight ◽  
Eating Rate ◽  
Effect Of Food ◽  
Short And Long Term ◽  
Normal Weight Obesity

The link between eating rate and energy intake has long been a matter of extensive research. A better understanding of the effect of food intake speed on body weight and glycemia in the long term could serve as a means to prevent weight gain and/or dysglycemia. Whether a fast eating rate plays an important role in increased energy intake and body weight depends on various factors related to the studied food such as texture, viscosity and taste, but seems to be also influenced by the habitual characteristics of the studied subjects as well. Hunger and satiety quantified via test meals in acute experiments with subsequent energy intake measurements and their association with anorexigenic and orexigenic regulating peptides provide further insight to the complicated pathogenesis of obesity. The present review examines data from the abundant literature on the subject of eating rate, and highlights the main findings in people with normal weight, obesity, and type 2 diabetes, with the aim of clarifying the association between rate of food intake and hunger, satiety, glycemia, and energy intake in the short and long term.

Short- and long-term estrogen depletions produce sex dependent changes in food intake and body weight

2009 ◽  
Vol 65 ◽  
pp. S224
Author(s):  
Mariko Nakata ◽  
Maiko Kobayashi ◽  
Kazuhiro Sano ◽  
Mumeko Tsuda ◽  
Katsumi Toda ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Short And Long Term

scholarly journals Effects of short- and long-term feeding of zinc oxide-supplemented diets on the mature, female domestic fowl with special reference to tissue mineral content

1986 ◽  
Vol 55 (2) ◽  
pp. 333-349 ◽  
Author(s):  
N. Jackson ◽  
S. W. Gibson ◽  
M. H. Stevenson
Keyword(s):  
Zinc Oxide ◽  
Body Weight ◽  
Food Intake ◽  
Domestic Fowl ◽  
Mineral Content ◽  
Mature Female ◽  
Egg Number ◽  
Short And Long Term ◽  
Pancreas Weight

1. In Expt 1, the effects on laying hens of diets supplemented with zinc oxide providing up to 20 gadded zinc/kg were compared. In Expt 2 the diets contained up to 6 g added Zn/kg.2. In both experiments, food intake, body-weight, egg number, and liver, oviduct and ovary weights/kg body-weight were significantly reduced by added ZnO; gizzard weight/kg body-weight was significantly increased. In Expt 2, pancreas weight was significantly reduced by added ZnO.3. Liver, kidney and pancreatic Zn and iron concentrations were significantly elevated in both experiments.4. In both experiments, liver, kidneys and pancreatic copper concentrations gave quadratic responses to added ZnO.

scholarly journals The Pice Effects of Competition from Parallel Imports and Therapeutic Alternatives: Using Dynamic Models to Estimate the Causal Effect on the Extensive and Intensive Margins

2021 ◽  
Author(s):  
David Granlund
Keyword(s):  
Dynamic Models ◽  
Causal Effect ◽  
The Other ◽  
Causal Effects ◽  
Parallel Imports ◽  
Extensive And Intensive Margins ◽  
Price Effects ◽  
Short And Long Term ◽  
Therapeutic Alternatives

AbstractThis paper studies responses to competition with the use of dynamic models that distinguish between short- and long-term price effects. The dynamic models also allow lagged numbers of competitors to become valid and strong instruments for the current numbers, which enables studying the causal effects using flexible specifications. A first parallel trader is found to decrease prices of exchangeable products by 7% in the long term. On the other hand, prices do not respond to the first competitor that sells therapeutic alternatives; but competition from four or more competitors that sell on-patent therapeutic alternatives decreases prices by about 10% in the long term.

Polyacrilonytrile versus Cuprophan Membranes for Hemodialysis: Evaluation of Efficacy and Biocompatibility by Platelet Aggregation Studies

1981 ◽  
Vol 4 (5) ◽  
pp. 218-222 ◽  
Author(s):  
M. Berrettini ◽  
U. Buoncristiani ◽  
P. Parise ◽  
E. Ballatori ◽  
G.G. Nenci
Keyword(s):  
Platelet Count ◽  
Platelet Aggregation ◽  
Term Effect ◽  
The Other ◽  
Long Term Effect ◽  
Short And Long Term ◽  
Extracorporeal Dialysis ◽  
Uremic Patients

The short- and long-term effect of hemodialysis with two different membranes — cuprophan and polyacrilonytrile — on platelet aggregation has been investigated in 12 uremic patients undergoing extracorporeal dialysis, passing from one treatment to the other. Cuprophan membranes failed to correct the defective platelet aggregation of uremia, and their thrombogenicity was documented by a fall in platelet count and further impairment of platelet aggregation during dialysis. On the contrary, polyacrilonitryle membranes showed the capacity to correct completely but transiently the platelet aggregation, without changes in platelet count. The results indicate that polyacrilonytrile membranes show a better biocompatibility toward platelets than cuprophan membranes.

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