scholarly journals Microsaccade generation requires a foveal anchor

2020 ◽  
Vol 12 (6) ◽  
Author(s):  
Jorge Otero-Millan ◽  
Rachel E Langston ◽  
Francisco Costela ◽  
Stephen L Macknik ◽  
Susana Martinez-Conde
Keyword(s):  
Visual Information ◽  
Visual Stimulation ◽  
Human Subjects ◽  
Covert Attention ◽  
Natural Scenes ◽  
Peripheral Stimulation ◽  
Free Viewing ◽  
Passive Viewing ◽  
Foveal Stimulation ◽  
Activation Map

Visual scene characteristics have the ability to affect various aspects of saccade and microsaccade dynamics. For example, blank visual scenes are known to elicit diminished saccade and microsaccade production, compared to natural scenes. Similarly, microsaccades are less frequent in the dark. Yet, the extent to which foveal and peripheral visual information contribute to microsaccade production remains unclear: because microsaccade are directed to covert attention locations as per the superior colliculus activation map, it follows that peripheral stimulation could suffice to produce regular microsaccade dynamics, even without foveal stimulation being present. Here we compared the characteristics of microsaccades generated in the presence or absence of foveal and/or peripheral visual stimulation, while human subjects conducted four types of oculomotor tasks (fixation, free-viewing, guided-viewing and fixation during passive viewing). Foveal information was either available, or made unavailable by the presentation of both solid and blurred scotomas. We found foveal stimulation to be critical for microsaccade production, and peripheral stimulation, by itself, to be insufficient to yield microsaccades. Our results indicate that a foveal visual anchor is necessary for microsaccade generation.   

Functional Organisation of Human Visual Cortex Revealed by fMRI

Perception ◽  
1997 ◽  
Vol 26 (1_suppl) ◽  
pp. 9-9 ◽  
Author(s):  
R B H Tootell ◽  
A M Dale ◽  
N Hadjikhani ◽  
A K Liu ◽  
S Marrett ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Visual Information ◽  
Visual Stimulation ◽  
Frequency Tuning ◽  
Human Subjects ◽  
Planar Imaging ◽  
Posterior Cortex ◽  
Human Visual Cortex ◽  
Wide Range ◽  
Functional Organisation

Until recently, comparatively little was known about the functional organisation of human visual cortex. Functional magnetic resonance imaging (fMRI), in conjunction with cortical flattening techniques and psychophysically relevant visual stimulation, has greatly clarified human visual-information processing. To date, we have completed cortical surface reconstructions (flattening), coupled with a wide range of visual stimulus testing, on 28 normal human subjects. Visual activation was acquired on a 1.5 T GE MR scanner with ANMR echo-planar imaging, with the use of a custom, bilateral, quadrature surface coil covering posterior cortex. Approximately ten visual cortical areas can now be functionally localised each with unique functional and topographical properties. The most well-defined areas are: V1, V2, V3, VP, V3A, V4v, MT, SPO, and perhaps MSTd. Most of the properties in these human areas are similar to those reported in presumably homologous areas of macaque, but distinctive species differences also appear to exist, notably in V3/VP, V4v, and V3A. Human areas showing prominant motion-selectivity include V3A, MT/MSTd, SPO, and a small area near the superior sylvian fissure. Retinotopic areas include V1, V2, V3, VP, V4v, and V3A. The human cortical magnification factor appears higher towards the fovea than in macaque, but, like macaque, preferred spatial frequency tuning varies inversely with eccentricity in all retinotopic areas in which sinusoidal gratings are effective stimuli.

scholarly journals A deep convolutional visual encoding model of neuronal responses in the LGN

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Eslam Mounier ◽  
Bassem Abdullah ◽  
Hani Mahdi ◽  
Seif Eldawlatly
Keyword(s):  
Firing Rate ◽  
Visual Information ◽  
Visual Stimulation ◽  
Neuronal Population ◽  
Neuronal Firing ◽  
Electrode Arrays ◽  
Deep Convolutional Neural Networks ◽  
Firing Rates ◽  
Spatiotemporal Representation

AbstractThe Lateral Geniculate Nucleus (LGN) represents one of the major processing sites along the visual pathway. Despite its crucial role in processing visual information and its utility as one target for recently developed visual prostheses, it is much less studied compared to the retina and the visual cortex. In this paper, we introduce a deep learning encoder to predict LGN neuronal firing in response to different visual stimulation patterns. The encoder comprises a deep Convolutional Neural Network (CNN) that incorporates visual stimulus spatiotemporal representation in addition to LGN neuronal firing history to predict the response of LGN neurons. Extracellular activity was recorded in vivo using multi-electrode arrays from single units in the LGN in 12 anesthetized rats with a total neuronal population of 150 units. Neural activity was recorded in response to single-pixel, checkerboard and geometrical shapes visual stimulation patterns. Extracted firing rates and the corresponding stimulation patterns were used to train the model. The performance of the model was assessed using different testing data sets and different firing rate windows. An overall mean correlation coefficient between the actual and the predicted firing rates of 0.57 and 0.7 was achieved for the 10 ms and the 50 ms firing rate windows, respectively. Results demonstrate that the model is robust to variability in the spatiotemporal properties of the recorded neurons outperforming other examined models including the state-of-the-art Generalized Linear Model (GLM). The results indicate the potential of deep convolutional neural networks as viable models of LGN firing.

scholarly journals Conscious perception and perceptual echoes: a binocular rivalry study

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Canhuang Luo ◽  
Rufin VanRullen ◽  
Andrea Alamia
Keyword(s):  
Binocular Rivalry ◽  
Visual Information ◽  
Visual Stimulation ◽  
Brain Regions ◽  
Travelling Wave ◽  
Alpha Power ◽  
Conscious Perception ◽  
Impulse Response Functions ◽  
Band Frequency ◽  
Underlying Mechanisms

Abstract Alpha rhythms (∼10Hz) in the human brain are classically associated with idling activities, being predominantly observed during quiet restfulness with closed eyes. However, recent studies demonstrated that alpha (∼10Hz) rhythms can directly relate to visual stimulation, resulting in oscillations, which can last for as long as one second. This alpha reverberation, dubbed perceptual echoes (PE), suggests that the visual system actively samples and processes visual information within the alpha-band frequency. Although PE have been linked to various visual functions, their underlying mechanisms and functional role are not completely understood. In this study, we investigated the relationship between conscious perception and the generation and the amplitude of PE. Specifically, we displayed two coloured Gabor patches with different orientations on opposite sides of the screen, and using a set of dichoptic mirrors, we induced a binocular rivalry between the two stimuli. We asked participants to continuously report which one of two Gabor patches they consciously perceived, while recording their EEG signals. Importantly, the luminance of each patch fluctuated randomly over time, generating random sequences from which we estimated two impulse-response functions (IRFs) reflecting the PE generated by the perceived (dominant) and non-perceived (suppressed) stimulus, respectively. We found that the alpha power of the PE generated by the consciously perceived stimulus was comparable with that of the PE generated during monocular vision (control condition) and higher than the PE induced by the suppressed stimulus. Moreover, confirming previous findings, we found that all PEs propagated as a travelling wave from posterior to frontal brain regions, irrespective of conscious perception. All in all our results demonstrate a correlation between conscious perception and PE, suggesting that the synchronization of neural activity plays an important role in visual sampling and conscious perception.

Retinal input influences pace of neurogenesis but not cell-type configuration of the visual forebrain

2021 ◽  
Author(s):  
Shachar Sherman ◽  
Koichi Kawakami ◽  
Herwig Baier
Keyword(s):  
Visual Information ◽  
Visual Stimulation ◽  
Ganglion Cells ◽  
Neuronal Cell ◽  
Cell Types ◽  
Vertebrate Brain ◽  
Relative Contribution ◽  
Retinal Input ◽  
And Migration ◽  
The Brain

The brain is assembled during development by both innate and experience-dependent mechanisms1-7, but the relative contribution of these factors is poorly understood. Axons of retinal ganglion cells (RGCs) connect the eye to the brain, forming a bottleneck for the transmission of visual information to central visual areas. RGCs secrete molecules from their axons that control proliferation, differentiation and migration of downstream components7-9. Spontaneously generated waves of retinal activity, but also intense visual stimulation, can entrain responses of RGCs10 and central neurons11-16. Here we asked how the cellular composition of central targets is altered in a vertebrate brain that is depleted of retinal input throughout development. For this, we first established a molecular catalog17 and gene expression atlas18 of neuronal subpopulations in the retinorecipient areas of larval zebrafish. We then searched for changes in lakritz (atoh7-) mutants, in which RGCs do not form19. Although individual forebrain-expressed genes are dysregulated in lakritz mutants, the complete set of 77 putative neuronal cell types in thalamus, pretectum and tectum are present. While neurogenesis and differentiation trajectories are overall unaltered, a greater proportion of cells remain in an uncommitted progenitor stage in the mutant. Optogenetic stimulation of a pretectal area20,21 evokes a visual behavior in blind mutants indistinguishable from wildtype. Our analysis shows that, in this vertebrate visual system, neurons are produced more slowly, but specified and wired up in a proper configuration in the absence of any retinal signals.

Responses to Moving Visual Stimuli in Pretectal Neurons of the Small-Spotted Dogfish (Scyliorhinus canicula)

2008 ◽  
Vol 99 (1) ◽  
pp. 200-207 ◽  
Author(s):  
Olivia Andrea Masseck ◽  
Klaus-Peter Hoffmann
Keyword(s):  
Visual Information ◽  
Visual Stimulation ◽  
Semicircular Canals ◽  
Neuronal Responses ◽  
Vertical Movements ◽  
Scyliorhinus Canicula ◽  
Random Dot Patterns ◽  
Pretectal Area ◽  
Corpus Geniculatum Laterale ◽  
Sensitive Direction

Single-unit recordings were performed from a retinorecipient pretectal area (corpus geniculatum laterale) in Scyliorhinus canicula. The function and homology of this nucleus has not been clarified so far. During visual stimulation with a random dot pattern, 45 (35%) neurons were found to be direction selective, 10 (8%) were axis selective (best neuronal responses to rotations in both directions around one particular stimulus axis), and 75 (58%) were movement sensitive. Direction-selective responses were found to the following stimulus directions (in retinal coordinates): temporonasal and nasotemporal horizontal movements, up- and downward vertical movements, and oblique movements. All directions of motion were represented equally by our sample of pretectal neurons. Additionally we tested the responses of 58 of the 130 neurons to random dot patterns rotating around the semicircular canal or body axes to investigate whether direction-selective visual information is mapped into vestibular coordinates in pretectal neurons of this chondrichthyan species. Again all rotational directions were represented equally, which argues against a direct transformation from a retinal to a vestibular reference frame. If a complete transformation had occurred, responses to rotational axes corresponding to the axes of the semicircular canals should have been overrepresented. In conclusion, the recorded direction-selective neurons in the Cgl are plausible detectors for retinal slip created by body rotations in all directions.

scholarly journals Refixation control in free viewing: a specialized mechanism divulged by eye-movement-related brain activity

2018 ◽  
Vol 120 (5) ◽  
pp. 2311-2324 ◽  
Author(s):  
Andrey R. Nikolaev ◽  
Radha Nila Meghanathan ◽  
Cees van Leeuwen
Keyword(s):  
Eye Movement ◽  
Visual Information ◽  
Direct Evidence ◽  
Search Task ◽  
Visual Search Task ◽  
Brain Activity ◽  
Movement Control ◽  
Planning Stage ◽  
Eye Fixations ◽  
Free Viewing

In free viewing, the eyes return to previously visited locations rather frequently, even though the attentional and memory-related processes controlling eye-movement show a strong antirefixation bias. To overcome this bias, a special refixation triggering mechanism may have to be recruited. We probed the neural evidence for such a mechanism by combining eye tracking with EEG recording. A distinctive signal associated with refixation planning was observed in the EEG during the presaccadic interval: the presaccadic potential was reduced in amplitude before a refixation compared with normal fixations. The result offers direct evidence for a special refixation mechanism that operates in the saccade planning stage of eye movement control. Once the eyes have landed on the revisited location, acquisition of visual information proceeds indistinguishably from ordinary fixations. NEW & NOTEWORTHY A substantial proportion of eye fixations in human natural viewing behavior are revisits of recently visited locations, i.e., refixations. Our recently developed methods enabled us to study refixations in a free viewing visual search task, using combined eye movement and EEG recording. We identified in the EEG a distinctive refixation-related signal, signifying a control mechanism specific to refixations as opposed to ordinary eye fixations.

scholarly journals Tachyons but Not Photons Might Generate Conscious Dreams

2019 ◽  
Author(s):  
Ahmad Yousef
Keyword(s):  
Eye Movements ◽  
Visual Information ◽  
Human Subjects ◽  
Visual Awareness ◽  
Human Eye ◽  
Rapid Eye Movements ◽  
Cognitive Vision ◽  
Human Awareness

We had learnt from cognitive vision that involuntarily visual awareness should be generated by exogenous stimuli; but not indigenous! Given the complexity of understanding the reasons behind the rapid eye movements during vivid dreams; dreams that carry highly bizarre information; dreams that disallow the human subjects to have control over what they see; these types of dreams should be therefore reside under the umbrella of the “involuntary human awareness”. We therefore suggest possibilities of physical particles that could carry the visual information of these extraordinary exogenous stimuli; particles that should be able to invade the human’s eyes while they are closed; particles that have the ability to move the eye rapidly aiming for perfect transformation of the visual information. The present research aims to talk about these particles, proposes scenarios of how human eye & retina deal with them.

Differences in Inter-Hemispheric Variance in Brain Responses of Attentive and Inattentive Human Subjects

1973 ◽  
Vol 36 (3_suppl) ◽  
pp. 1099-1102 ◽  
Author(s):  
Daniel N. Robinson ◽  
Robert Strandburg
Keyword(s):  
Human Subjects ◽  
Evoked Responses ◽  
Brain Responses ◽  
Passive Viewing ◽  
Light Flashes

Human Ss were exposed to light flashes under passive viewing conditions and under conditions calling for discriminative responses. Average evoked responses and the variances of these AERs were recorded from corresponding areas of the two hemispheres. The major finding is that, under attentive viewing, the two hemispheres respond with nearly equivalent variance whereas, under passive viewing, inter-hemispheric variance is markedly asymmetrical. Implications are discussed briefly.

Interhemispheric Transmission of Visuomotor Information in Humans: fMRI Evidence

2002 ◽  
Vol 88 (2) ◽  
pp. 1051-1058 ◽  
Author(s):  
M. Tettamanti ◽  
E. Paulesu ◽  
P. Scifo ◽  
A. Maravita ◽  
F. Fazio ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Visual Information ◽  
Human Subjects ◽  
Conduction Time ◽  
Clear Cut ◽  
Cortical Areas ◽  
Poffenberger Paradigm ◽  
Interhemispheric Transmission ◽  
Hemispheric Activation ◽  
Normal Human

Normal human subjects underwent functional magnetic resonance imaging (fMRI) while performing a simple visual manual reaction-time (RT) task with lateralized brief stimuli, the so-called Poffenberger's paradigm. This paradigm was employed to measure interhemispheric transmission (IT) time by subtracting mean RT for the uncrossed hemifield-hand conditions, that is, those conditions not requiring an IT, from the crossed hemifield-hand conditions, that is, those conditions requiring an IT to relay visual information from the hemisphere of entry to the hemisphere subserving the response. The obtained difference is widely believed to reflect callosal conduction time, but so far there is no direct physiological evidence in humans. The aim of our experiment was twofold: first, to test the hypothesis that IT of visuomotor information requires the corpus callosum and to identify the cortical areas specifically activated during IT. Second, we sought to discover whether IT occurs mainly at premotor or perceptual stages of information processing. We found significant activations in a number of frontal, parietal, and temporal cortical areas and in the genu of the corpus callosum. These activations were present only in the crossed conditions and therefore were specifically related to IT. No selective activation was present in the uncrossed conditions. The location of the activated callosal and cortical areas suggests that IT occurs mainly, but not exclusively, at premotor level. These results provide clear cut evidence in favor of the hypothesis that the crossed-uncrossed difference in the Poffenberger paradigm depends on IT rather than on a differential hemispheric activation.

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