scholarly journals STRUCTURAL CHANGES OBSERVED IN MICE LIVER DUE TO CHRONIC EXPOSURE OF 1900-2200 MHZ RADIATIONS EMITTED FROM MOBILE PHONE

2019 ◽  
Vol 7 (1.3) ◽  
pp. 6254-6260
Author(s):  
Mugunthan N ◽  
◽  
Anbalagan J ◽  
Meenachi S ◽  
Rajanarayanan S ◽  
...  
Keyword(s):  
Mobile Phone ◽  
Chronic Exposure ◽  
Structural Changes ◽  
Mice Liver

scholarly journals Long term exposure of 900-1800 MHz mobile phone radiation on mice liver - A histological study

2016 ◽  
Vol 05 (04) ◽  
pp. 196-201
Author(s):  
N Mugunthan ◽  
K Shanmuga Samy ◽  
J Anbalagan ◽  
S Meenachi
Keyword(s):  
Mobile Phone ◽  
Structural Changes ◽  
Histological Study ◽  
Liver Parenchyma ◽  
Exposed Group ◽  
The Public ◽  
Radiation Induced ◽  
Mice Liver ◽  
Mobile Phone Radiation

Abstract Background and aims: Rapid developments in the telephone technology has made the communication faster and easier. The duration of the usage of mobile phones has also increased beyond the limits, which has raised the public concerns about their safety. This study was designed to investigate the long term exposure of 900 MHz to 1800 MHz mobile phone radiation induced structural changes in the mice liver at histological level. Materials & methods: After approval of institutional animal ethics committee, 36 mice were exposed to 20 (900-1800 MHz) mobile phone radiation, 48 minutes per day for a period of 30 to 180 days. The sham exposed group of 36 mice were kept under similar conditions without 20 exposure. The animals were sacrificed and the liver was removed after 1-6 months. The weight and volume of liver were recorded and the liver tissue was processed for histological study. The sections were studied under light microscope for structural changes. Two groups' data were compared and analyzed statistically. Results: Liver of 20 exposed groups showed the following findings in comparison to sham exposed group: Liver parenchyma and the periportal regions were infiltrated with lymphocytes, macrophages and neutrophil (mixed type of inflammation). Focal hemorrhages were found within the liver parenchyma. Hepatic sinusoids were congested and dilated. Many hepatocytes were swollen and showed pyknotic nuclei and vacuolations present in the cytoplasm. Conclusion: The long term exposure of ultra-high frequency radiation emitted from 20 cell phone can cause microscopic changes in the liver.

scholarly journals CHRONIC EXPOSURE TO BISPHENOL A PRODUCES MORPHOLOGICAL DERANGEMENTS IN LIVER, KIDNEY AND HEART IN RATS

2018 ◽  
Vol 26 (1) ◽  
Author(s):  
Mahendra K. Pant ◽  
Jayanti Pant ◽  
Shripad B. Deshpande
Keyword(s):  
Bisphenol A ◽  
Chronic Exposure ◽  
Food Packaging ◽  
Structural Changes ◽  
Histopathological Examination ◽  
Oral Route ◽  
Female Rats ◽  
Histopathological Study ◽  
Portal Triad ◽  
Study Results

Introduction: Bisphenol A (BPA), an estrogenic compound is used in the manufacturing of plastics and also as coating for the inner linings of food packaging containers. It is reported to be an endocrine disruptor and produce toxicity in various organs. Since BPA exposure mainly occurs in the form of oral ingestion in humans, the present study was performed to examine the effects produced by the chronic exposure to BPA orally on kidney, liver and heart in rats. Material & Methods: Adult female rats of Charles Foster strain were used for the study. The rats were divided into two groups (n=6 in each group). In group 1, the rats were provided with food and water ad libitum whereas the rats of group 2 were fed with BPA containing pellets (2 µg/kg body weight/day) for 30 days. Thereafter the heart, kidneys and liver were excised and processed for histopathological study. Results: The histopathological examination of the organs in BPA fed rats showed major structural changes which manifested as loss of normal cytoarchitecture in all the three organs. Further there was significant reduction in the number of glomeruli in kidneys, degenerative changes in liver in the form of damage to portal triad and in heart the intercalated discs were damaged. Conclusion: Chronic exposure to BPA by oral route produces renal toxicity as loss of glomeruli; hepatotoxicity as cytoarchitecture loss and cardiotoxicity as damage of intercalated disc changes.

scholarly journals Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Qianying Liu ◽  
Zhixin Lei ◽  
Anxiong Huang ◽  
Qinghua Wu ◽  
Shuyu Xie ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Chronic Exposure ◽  
Toxic Metabolites ◽  
Mice Liver

scholarly journals Negative Effects of Mobile Phone Addiction Tendency on Spontaneous Brain Microstates: Evidence From Resting-State EEG

2021 ◽  
Vol 15 ◽  
Author(s):  
Hao Li ◽  
Jingyi Yue ◽  
Yufeng Wang ◽  
Feng Zou ◽  
Meng Zhang ◽  
...  
Keyword(s):  
Mobile Phone ◽  
Phonological Processing ◽  
Resting State ◽  
Structural Changes ◽  
Negative Impact ◽  
Brain Regions ◽  
Withdrawal Symptoms ◽  
Negative Effects ◽  
Mobile Phone Addiction ◽  
The Brain

The prevalence of mobile phone addiction (MPA) has increased rapidly in recent years, and it has had a certain negative impact on emotions (e.g., anxiety and depression) and cognitive capacities (e.g., executive control and working memory). At the level of neural circuits, the continued increase in activity in the brain regions associated with addiction leads to neural adaptations and structural changes. At present, the spontaneous brain microstates that could be negatively influenced by MPA are unclear. In this study, the temporal characteristics of four resting-state electroencephalogram (RS-EEG) microstates (MS1, MS2, MS3, and MS4) related to mobile phone addiction tendency (MPAT) were investigated using the Mobile Phone Addiction Tendency Scale (MPATS). We attempted to analyze the correlation between MPAT and corresponding microstates and provide evidence to explain the brain and behavioral changes caused by MPA. The results showed that the total score of the MPATS was positively correlated with the duration of MS1, related to phonological processing and negatively correlated with the duration of MS2, related to visual or imagery processing, and MS4, related to the attentional network; the score of the withdrawal symptoms subscale was additionally associated with duration of MS3, related to the cingulo-opercular emotional network. Based on these results, we believe that MPAT may have some negative effects on attentional networks and sensory brain networks; moreover, withdrawal symptoms may induce some negative emotions.

scholarly journals Long term exposure of 900-1800 MHz mobile phone radiation on mice liver - A histological study

2016 ◽  
Vol 5 (4) ◽  
pp. 196
Author(s):  
N Mugunthan ◽  
KShanmuga Samy ◽  
J Anbalagan ◽  
S Meenachi
Keyword(s):  
Mobile Phone ◽  
Histological Study ◽  
Mice Liver ◽  
Mobile Phone Radiation

scholarly journals Chronic exposure of bisphenol S (BPS) affect hypothalamic-pituitary-testicular activities in adult male rats: possible in estrogenic mode of action

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Hizb Ullah ◽  
Faizan Ullah ◽  
Owais Rehman ◽  
Sarwat Jahan ◽  
Tayyaba Afsar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Exposure ◽  
Structural Changes ◽  
Gonadosomatic Index ◽  
Male Rats ◽  
Plasma Testosterone ◽  
Seminiferous Tubules ◽  
Sperm Production ◽  
Bisphenol S ◽  
Daily Sperm Production

Abstract Background The industrial revolution has resulted in increased synthesis and the introduction of a variety of compounds into the environment and their potentially hazardous effects have been observed in the biota. The present study was aimed to evaluate the potential endocrine-disrupting effects of chronic exposure to the low concentrations of bisphenol S (BPS) in male rats. Methods Weaning male Sprague-Dawley rats (22 days old) were either exposed to water containing 0.1% ethanol for control or different concentrations of BPS (0.5, 5, and 50 μg/L) in drinking water for 48 weeks in the chronic exposure study. After completion of the experimental period, animals were dissected and different parameters (hormone concentrations, histology of testis and epididymis, oxidative stress and level of antioxidant enzymes in the testis, daily sperm production (DSP), and sperm parameters) were determined. Results Results of the present study showed a significant alteration in the gonadosomatic index (GSI) and relative reproductive organ weights. Oxidative stress in the testis was significantly elevated while sperm motility, daily sperm production, and the number of sperm in epididymis were reduced. Plasma testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) concentrations were reduced and estradiol levels were high in the 50 μg/L-exposed group. Histological observations involved a significant reduction in the epithelial height of the testis along with disrupted spermatogenesis, an empty lumen of the seminiferous tubules, and the caput region of the epididymis. Conclusion These results suggest that exposure to 5 and 50 μg/L of BPS for the chronic duration started from an early age can induce structural changes in testicular tissue architecture and endocrine alterations in the male reproductive system which may lead to infertility in males.

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