scholarly journals RELATIONSHIPS BETWEEN INITIAL PROBING DEPTH AND CHANGES IN THE CLINICAL PARAMETERS FOLLOWING NON-SURGICAL PERIODONTAL TREATMENT IN CHRONIC PERIODONTITIS

2017 ◽  
Vol 0 (0) ◽  
Author(s):  
Süleyman Emre Meseli ◽  
Bahar Kuru ◽  
Leyla Kuru
Keyword(s):  
Chronic Periodontitis ◽  
Periodontal Treatment ◽  
Clinical Parameters ◽  
Probing Depth

scholarly journals Evaluation of Systemic Markers Related To Anemia of Chronic Disease in the Peripheral Blood of Smokers and Non-Smokers with Chronic Periodontitis

2008 ◽  
Vol 02 (02) ◽  
pp. 102-109 ◽  
Author(s):  
Ebru Olgun Erdemir ◽  
Rana Nalcaci ◽  
Osman Caglayan
Keyword(s):  
Chronic Disease ◽  
Cigarette Smoking ◽  
Chronic Periodontitis ◽  
Peripheral Blood ◽  
Clinical Parameters ◽  
Clinical Attachment Loss ◽  
Anemia Of Chronic Disease ◽  
Cell Parameters ◽  
Probing Depth ◽  
Age Range

ABSTRACTObjectives: The aim of this study was to investigate the effect of cigarette smoking on clinical parameters and signs anemia of chronic disease in chronic periodontitis patients.Methods: The study base consisted of 88 patients with chronic periodontitis including 45 volunteer current smokers with age range of 30-69 (45.5±8.5) and 43 volunteer non-smokers with age range of 32-61 years (45.8±7.9). The clinical parameters including plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment loss (CAL) were recorded and several red blood cell parameters were determined from peripheral blood samples.Results: In smokers, PI, PD and CAL were significantly higher than non-smokers (P<.05). The number of erythrocytes and the levels of hemoglobin, hematocrit and iron were lower in smokers compared to non-smokers (P<.05).Conclusions: In the present study, it is concluded that cigarette smoking may be effective on the signs of anemia of chronic disease in patients with chronic periodontitis. (Eur J Dent 2008;2:102-109)

scholarly journals Effect of non-surgical periodontal treatment on serum albumin levels in patients with chronic periodontitis

2018 ◽  
Vol 10 (1) ◽  
pp. 18-23
Author(s):  
Adileh Shirmohammadi ◽  
Masoumeh Faramarzi ◽  
Ashkan Salari ◽  
Mehrnoosh Sadighi Shamami ◽  
Amir Reza Babaloo ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Serum Albumin ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Statistical Significance ◽  
Serum Levels ◽  
T Test ◽  
Periodontal Treatment ◽  
Case Group ◽  
Clinical Parameters

Background. Albumin is a protein whose serum levels decrease in inflammatory conditions such as periodontal diseases. This study was undertaken to evaluate changes in serum albumin levels in patients with and without periodontal diseases prior and subsequent to non-surgical periodontal treatment and its relationship with clinical parameters of periodontal disease.Methods. Twenty patients diagnosed as having chronic periodontitis and 20 periodontally healthy subjects, referring to Tabriz Faculty of Dentistry, were selected. Serum albumin levels and clinical variables of periodontal disease (probing pocket depth, gingival index, bleeding index, clinical attachment level and plaque index) were determined before treatment and three months subsequent to non-surgical periodontal treatment. Data were subjected to descriptive statistical analyses (mean ± SD). Serum levels of albumin and clinical parameters were compared between the two groups with independent-samples t-test. Paired-samples t-test was applied to compare the variables before and after treatment in the case group. Statistical significance was defined at P<0.05.Results. The mean serum albumin level of chronic periodontitis patients (3.62±0.11 mg/dL) exhibited a significantly lower value compared to subjects who were periodontally healthy (4.17±0.29 mg/dL), with the serum albumin levels increasing significantly three months postoperatively (3.78±0.33 mg/dL), approaching the level in subjects who were periodontally healthy (P<0.05).Conclusion. Decreases and increases in serum albumin levels under the effect of periodontal disease and its treatment indi-cated an inverse relationship between the albumin levels of serum and chronic periodontitis.

Assessment of the Plasma/Serum IgG Test to Screen for Periodontitis

2012 ◽  
Vol 91 (12) ◽  
pp. 1190-1195 ◽  
Author(s):  
C. Kudo ◽  
K. Naruishi ◽  
H. Maeda ◽  
Y. Abiko ◽  
T. Hino ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Antibody Titer ◽  
Chronic Periodontitis ◽  
Characteristic Curve ◽  
Periodontal Treatment ◽  
Clinical Parameters ◽  
Periodontal Pathogens ◽  
Igg Antibody ◽  
Pocket Depth ◽  
Probing Pocket Depth

Chronic periodontitis is a silent infectious disease prevalent worldwide and affects lifestyle-related diseases. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens. Oral examination was performed, and IgG titers against periodontal pathogens were measured by ELISA in 1,387 individuals. The cut-off value of the IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed. The best cut-off value of IgG titer against Porphyromonas gingivalis for screening periodontitis was 1.682. Both clinical parameters and IgG titers decreased significantly under periodontal treatment. IgG titers of periodontitis patients were significantly higher than those of healthy controls, especially in those with sites of probing pocket depth over 4 mm. Multiplied cut-off values were useful to select patients with severe periodontitis. A blood IgG antibody titer test for Porphyromonas gingivalis is useful to screen hitherto chronic periodontitis patients (ClinicalTrials.gov number NCT01658475).

Antimicrobial Photodynamic Therapy Using a Chloro-Aluminum Phthalocyanine Adjuvant to Nonsurgical Periodontal Treatment Does Not Improve Clinical Parameters in Patients with Chronic Periodontitis

2019 ◽  
Vol 37 (11) ◽  
pp. 729-735
Author(s):  
Israel Alexandre de Araújo Sena ◽  
Davi Neto de Araújo Silva ◽  
Marcela Letícia da Silva Azevedo ◽  
Natália Teixeira da Silva ◽  
João Paulo Figueiró Longo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Chronic Periodontitis ◽  
Periodontal Treatment ◽  
Clinical Parameters ◽  
Antimicrobial Photodynamic Therapy ◽  
Aluminum Phthalocyanine

scholarly journals Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Ana Patricia Moreno Villagrana ◽  
José Francisco Gómez Clavel
Keyword(s):  
Chronic Periodontitis ◽  
Meta Analysis ◽  
Periodontal Treatment ◽  
Randomized Controlled Clinical Trials ◽  
Probing Depth ◽  
Nonsurgical Periodontal Therapy ◽  
Post Hoc ◽  
Systemic Antibiotics ◽  
Periodontal Probing ◽  
Attachment Level

The use of antibiotics in nonsurgical periodontal treatment is indicated in cases in which scaling and root planing present important limitations. However, their use is controversial due to the secondary effects associated with them and the disagreements regarding their prescription. The aim of this study is to determine the effectiveness of systemic antibiotics in the management of aggressive and chronic periodontitis. The study was based on a search of randomized, controlled clinical trials. Common data were concentrated and evaluated by means of an analysis of variance (ANOVA), and a meta-analysis of the results was performed. The meta-analysis (, 95% confidence interval, post hoc Bonferroni) determined that the supplementation of nonsurgical periodontal therapy with a systemic antibiotic treatment—amoxicillin with clavulanic acid and metronidazole or subantimicrobial dose doxycycline—provides statistically significant results in patients with aggressive or chronic periodontitis under periodontal treatment, whilst increasing the clinical attachment level of the gingiva and reducing periodontal probing depth.

scholarly journals Prospective Longitudinal Changes in the Periodontal Inflamed Surface Area Following Active Periodontal Treatment for Chronic Periodontitis

2021 ◽  
Vol 10 (6) ◽  
pp. 1165
Author(s):  
Yoshiaki Nomura ◽  
Toshiya Morozumi ◽  
Atsushi Saito ◽  
Atsutoshi Yoshimura ◽  
Erika Kakuta ◽  
...  
Keyword(s):  
Surface Area ◽  
Chronic Periodontitis ◽  
Periodontal Treatment ◽  
Periodontal Pocket ◽  
Clinical Parameters ◽  
Periodontal Pathogens ◽  
Mixed Effect ◽  
Longitudinal Changes ◽  
Prospective Longitudinal ◽  
Mixed Effect Modeling

Periodontal disease is a chronic inflammatory disease of the periodontal tissue. The periodontal inflamed surface area (PISA) is a proposed index for quantifying the inflammatory burden resulting from periodontitis lesions. This study aimed to investigate longitudinal changes in the periodontal status as evaluated by the PISA following the active periodontal treatment. To elucidate the prognostic factors of PISA, mixed-effect modeling was performed for clinical parameters, tooth-type, and levels of periodontal pathogens as independent variables. One-hundred-twenty-five patients with chronic periodontitis who completed the active periodontal treatment were followed-up for 24 months, with evaluations conducted at 6-month intervals. Five-times repeated measures of mean PISA values were 130+/−173, 161+/−276, 184+/−320, 175+/−417, and 209+/−469 mm2. Changes in clinical parameters and salivary and subgingival periodontal pathogens were analyzed by mixed-effect modeling. Plaque index, clinical attachment level, and salivary levels of Porphyromonas gingivalis were associated with changes in PISA at the patient- and tooth-level. Subgingival levels of P. gingivalis and Prevotella intermedia were associated with changes in PISA at the sample site. For most patients, changes in PISA were within 10% of baseline during the 24-month follow-up. However, an increase in the number of bleeding sites in a tooth with a deep periodontal pocket increased the PISA value exponentially.

scholarly journals Evaluation of NLRP3 and IL-18 Levels after Periodontal Therapy

2021 ◽  
Author(s):  
Shahrzad Shahbeik ◽  
Ferial Taleghani ◽  
Mandana Sattari ◽  
Mahyar Mahvash Mohammadi ◽  
Mohammadreza Moravej
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Pearson Correlation ◽  
Treatment Phase ◽  
Periodontal Treatment ◽  
Enzyme Linked Immunosorbent Assay ◽  
Clinical Parameters ◽  
Periodontal Pathogens ◽  
Mean Values ◽  
Before And After

The progression of periodontitis depends on interactions between the periodontal pathogens and the host immune cytokines, including interleukin (IL)-1β and IL-18. Production of IL-1β is regulated by NOD-like receptors family pyrin domain containing 3 (NLRP3). This study aimed to evaluate the effect of periodontal treatment on the concentrations of IL-18 and NLRP3 in patients with chronic periodontitis. In this experimental study, 18 patients with chronic periodontitis and a mean age of 46.2±8.95 years, were included. The gingival crevicular fluid (GCF) was collected at the beginning of the study, 4 weeks after non-surgical (phase I), and 4 weeks after surgical periodontal treatment. The levels of NLRP3 and IL-18 were measured; using an enzyme-linked immunosorbent assay. Pearson correlation test was used to analyze the concentration of NLRP3 and IL-18 before and after the treatments with CAL and PD. There was a significant association between the level of NLRP3 and the mean values of PD and CAL before treatment. After each treatment phase, a significant decrease was observed in the NLRP3 level. There was no significant relationship between IL-18 and clinical parameters before and after periodontal treatments. Given the possible association between the level of NLRP3 and clinical parameters, we suggest it as a possible indicator of inflammation in chronic periodontitis and an index for evaluating the treatment outcome.

scholarly journals Clinical and Biological Effects of Adjunctive Photodynamic Therapy in Refractory Periodontitis

2019 ◽  
Vol 10 (2) ◽  
pp. 139-145
Author(s):  
Rola Al Habashneh ◽  
Mohammad A Mashal ◽  
Yousef Khader ◽  
Rana Qudah
Keyword(s):  
Photodynamic Therapy ◽  
Gingival Crevicular Fluid ◽  
Biological Effects ◽  
Gingival Recession ◽  
Periodontal Treatment ◽  
Control Group ◽  
Clinical Parameters ◽  
Biological Parameters ◽  
Probing Depth ◽  
Crevicular Fluid

Introduction: To date, no novel treatment approach is available for optimum outcomes regarding refractory periodontitis. The aim of the present study was to assess the efficiency of photodynamic therapy (PDT) in treating patients diagnosed with refractory periodontitis and compare the clinical and biological outcomes of conventional periodontal treatment with or without adjunctive PDT in these patients, by assessing clinical parameters (plaque index [PI], gingival recession [GR], bleeding on probing [BOP], periodontal probing depth [PPD] and clinical attachment level [CAL]) as well as biological parameters (IL-1β) in the gingival crevicular fluid (GCF). Methods: Sixteen patients within the age of 30 to 60 years, with a mean age of 40 years old, diagnosed with refractory periodontitis were included. In this split mouth design study, 2 quads (1 upper + 1 lower) from the same patient were randomly treated with (scaling and root planing [SRP]+PDT) together. The other 2 quadrants (1 upper + 1 lower) were treated by SRP only and selected to serve as controls. Clinical parameters including PI, GR, BOP, PPD and CAL and biological parameters (IL-1β) in the GCF were measured at baseline, then at, 2 and 6 months after therapy. Results: A statistically significant reduction in several clinical parameters as, BOP (P < 0.001), PI (P < 0.001), PPD (P < 0.001) and CAL (P < 0.001) in quadrant treated with SRP and adjunctive PDT when compared to control group treated with SRP alone was observed and both therapies showed non-statistically significant differences in the reduction of IL-1β level. Conclusion: The inclusion of PDT as an adjunctive measure to nonsurgical conventional periodontal treatment seems to be a useful therapeutic measure in refractory periodontitis treatment.

scholarly journals Comparison of cefixime and amoxicillin plus metronidazole in the treatment of chronic periodontitis

2016 ◽  
Vol 73 (6) ◽  
pp. 526-530 ◽  
Author(s):  
Smiljka Dukic ◽  
Stevo Matijevic ◽  
Dragana Dakovic ◽  
Tatjana Cutovic
Keyword(s):  
Chronic Periodontitis ◽  
Control Group ◽  
Clinical Parameters ◽  
Group Iii ◽  
Group I ◽  
Probing Depth ◽  
Significant Clinical Improvement ◽  
Causal Treatment ◽  
Clinically Significant ◽  
Attachment Level

Introduction/Aim. Despite significant advances in current medicine and improvement of overall health education, chronic periodontitis is still a widespread disease. Losing teeth is the most serious complication of this particular illness. The aim of this study was to examine patients with chronic periodontitis in order to evaluate the efficacy of non-surgical therapy and combination of amoxicillin and metronidazole compared with cefixime, which has not been so far used for the treatment of this disease. Methods. Adult patients with chronic periodontitis (n = 90) underwent non-surgical periodontal treatment (zero-day) and then randomly divided into three groups. The group I served as a control, the group II was additionally treated with the combination of amoxicillin and metronidazole (for 7 days), while the group III was treated with cefixime (also for 7 days). To assess the condition of periodontium before and seven days after the therapy, four clinical parameters were used: gingival index (GI), bleeding on probing (BOP), probing depth (PD) and clinical attachment level (CAL). Results. On the day 7 after the beginning of the therapy, we found that all the three groups of patients had statistically significant clinical improvement of three parameters: GI, BOP and PD, but not of the CAL. However, the improvement of PD was only statistically, but not clinically significant. The improvement in the control group of patients on the day 7 was 19% in BOP and 28% in GI; this improvement was statistically highly significant after the addition of amoxicillin plus metronodazole (71% in BOP and 77% in GI) or cefixime (62% in BOP and 82% in GI). Compared to the combination of amoxicillin and metronidazole, cefixim was statistically significantly more effective for GI (p < 0.05), while for the other three clinical parameters their effects were equal. Conclusion. The conjunction of amoxicillin plus metronidazole or cefixime to the causal treatment of patients with chronic periodontitis led to statistically significant improvement in efficacy in relation to GI and BOP parameters, while cefixime was statistically significantly more efficient than the combination of amoxicillin and metronidazole for GI.

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