The state of metabolism of carbohydrates, lipids, indicators of pro-inflammatory status and oxidative stress in obese patients receiving treatment for glandular hyperplasia of the endometrium

AbstractIron Overload Disorder (IOD) is a syndrome developed by captive browsing rhinoceroses like black rhinoceroses (Diceros bicornis) in which hemosiderosis settles in vital organs while free iron accumulates in the body, potentially predisposing to various secondary diseases. Captive grazing species like white rhinoceroses (Ceratotherium simum) do not seem to be affected. The pro-oxidant and pro-inflammatory properties of iron, associated with the poor antioxidant capacities of black rhinoceroses, could enhance high levels of inflammation and oxidative stress leading to rapid ageing and promoting diseases. In this prospective study, 15 black (BR) and 29 white rhinoceroses (WR) originating from 22 European zoos were blood-sampled and compared for their iron status (serum iron), liver/muscle biochemical parameters (AST, GGT, cholesterol), inflammatory status (total proteins, protein electrophoresis) and oxidative stress markers (SOD, GPX, dROMs). Results showed higher serum iron and liver enzyme levels in black rhinoceroses (P<0.01), as well as higher GPX (P<0.05) and dROM (P<0.01) levels. The albumin/globulin ratio was lower in black rhinoceroses (P<0.05) due to higher α2-globulin levels (P<0.001). The present study suggests a higher inflammatory and oxidative profile in captive BR than in WR, possibly in relation to iron status. This could be either a consequence or a cause of iron accumulation, potentially explaining rapid ageing and various diseases. Further investigations are needed to assess the prognostic value of the inflammatory and oxidative markers in captive black rhinoceroses, particularly for evaluating the impact of reduced-iron and antioxidant-supplemented diets.

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Relationship between inflammatory biomarkers and oxidative stress with uterine health in dairy cows with different dry period lengths1

Translational Animal Science ◽

10.1093/tas/txz040 ◽

2019 ◽

Vol 3 (2) ◽

pp. 607-619

Author(s):

Novi Mayasari ◽

Erminio Trevisi ◽

Annarita Ferrari ◽

Bas Kemp ◽

Henk K Parmentier ◽

...

Keyword(s):

Oxidative Stress ◽

Dairy Cows ◽

Negative Energy ◽

Inflammatory Biomarkers ◽

Early Lactation ◽

Dry Period ◽

Inflammatory Status ◽

Uterine Health ◽

Uterine Environment ◽

And Oxidative Stress

Abstract Earlier studies indicated that the inflammatory status of dairy cows in early lactation could not be fully explained by the negative energy balance (NEB) at that moment. The objective of the present study was to determine relationships between inflammatory biomarkers and oxidative stress with uterine health in dairy cows after different dry period lengths. Holstein–Friesian dairy cows were assigned to one of three dry period lengths (0-, 30-, or 60-d) and one of two early lactation rations (glucogenic or lipogenic ration). Cows were fed either a glucogenic or lipogenic ration from 10-d before the expected calving date. Part of the cows which were planned for a 0-d dry period dried themselves off and were attributed to a new group (0 → 30-d dry period), which resulted in total in four dry period groups. Blood was collected (N = 110 cows) in weeks −3, −2, −1, 1, 2, and 4 relative to calving to determine biomarkers for inflammation, liver function, and oxidative stress. Uterine health status (UHS) was monitored by scoring vaginal discharge (VD) based on a 4-point scoring system (0, 1, 2, or 3) in weeks 2 and 3 after calving. Cows were classified as having a healthy uterine environment (HU, VD score = 0 or 1 in both weeks 2 and 3), nonrecovering uterine environment (NRU, VD score = 2 or 3 in week 3), or a recovering uterine environment (RU, VD score = 2 or 3 in week 2 and VD score= 0 or 1 in week 3). Independent of dry period length, cows with NRU had higher plasma haptoglobin (P = 0.05) and lower paraoxonase levels (P < 0.01) in the first 4 weeks after calving and lower liver functionality index (P < 0.01) compared with cows with HU. Cows with NRU had lower plasma albumin (P = 0.02) and creatinine (P = 0.02) compared with cows with a RU, but not compared with cows with HU. Independent of UHS, cows with a 0 → 30-d dry period had higher bilirubin levels compared with cows with 0-, 30-, or 60-d dry period (P < 0.01). Cows with RU and fed a lipogenic ration had higher levels of albumin in plasma compared with cows with NRU and fed a lipogenic ration (P < 0.01). In conclusion, uterine health was related to biomarkers for inflammation (haptoglobin and albumin) and paraoxonase in dairy cows in early lactation. Cows which were planned for a 0-d dry period, but dried themselves off (0 → 30-d dry period group) had higher bilirubin levels, which was possibly related to a more severe NEB in these cows. Inflammatory biomarkers in dairy cows in early lactation were related to uterine health in this period.

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Insulin Resistance and Oxidative Stress Influence Colony-Forming Unit-Endothelial Cells Capacity in Obese Patients

Obesity ◽

10.1038/oby.2010.169 ◽

2011 ◽

Vol 19 (4) ◽

pp. 736-742 ◽

Cited By ~ 8

Author(s):

Ewa Miller-Kasprzak ◽

Pawet Bogdański ◽

Danuta Pupek-Musialik ◽

Pawet P. Jagodziński

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Endothelial Cells ◽

Obese Patients ◽

Colony Forming Unit ◽

And Oxidative Stress ◽

Stress Influence

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No Influence of Type 2 Diabetes on Chronic Inflammation and Oxidative Stress in Obese Patients

Notulae Scientia Biologicae ◽

10.15835/nsb619249 ◽

2014 ◽

Vol 6 (1) ◽

pp. 14-19

Author(s):

Adriana Florinela CĂTOI ◽

Alina Elena PÂRVU ◽

Adriana MUREŞAN ◽

Cristina BIDIAN ◽

Cornel CĂTOI ◽

...

Keyword(s):

Oxidative Stress ◽

Type 2 Diabetes ◽

Chronic Inflammation ◽

Cardiovascular Events ◽

Obese Patients ◽

Oxidative Stress Markers ◽

Stress Markers ◽

Per Se ◽

And Oxidative Stress

Obesity per se carries the features of chronic inflammation and oxidative stress that interrelate in a complex network and exert an important role in the onset of several complications such as type 2 diabetes, atherosclerosis and cardiovascular events. On the other hand, it seems that hyperglycemia per se as well as insulin resistance (independent of hyperglycemia), both induce increased oxidative stress. The aim of our study was to analyze proinflammatory and oxidative stress markers in obese patients with and without type 2 diabetes and to verify the hypothesis that type 2 diabetes associated with obesity would promote a higher chronic inflammation and oxidative stress state as compared to obesity alone. We found no differences between the two groups of patients regarding chronic inflammation and oxidative stress markers. Therefore we may conclude that there is no influence of type 2 diabetes on chronic inflammation and oxidative stress in obese patients.

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Hypocaloric Diet and Regular Moderate Aerobic Exercise Is an Effective Strategy to Reduce Anthropometric Parameters and Oxidative Stress in Obese Patients

Obesity Facts ◽

10.1159/000336526 ◽

2012 ◽

Vol 5 (1) ◽

pp. 12-22 ◽

Cited By ~ 10

Author(s):

Liliana Gutierrez-Lopez ◽

Jose Ruben Garcia-Sanchez ◽

Maria de Jesus Rincon-Viquez ◽

...

Keyword(s):

Oxidative Stress ◽

Aerobic Exercise ◽

Hypocaloric Diet ◽

Obese Patients ◽

Effective Strategy ◽

Anthropometric Parameters ◽

And Oxidative Stress

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Release of IL-1βTriggered by Milan Summer PM10: Molecular Pathways Involved in the Cytokine Release

BioMed Research International ◽

10.1155/2013/158093 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 28

Author(s):

Rossella Bengalli ◽

Elisabetta Molteni ◽

Eleonora Longhin ◽

Magne Refsnes ◽

Marina Camatini ◽

...

Keyword(s):

Oxidative Stress ◽

Cardiovascular Diseases ◽

Fold Increase ◽

Molecular Pathways ◽

Cytokine Release ◽

Inflammatory Status ◽

Early Endosomes ◽

Dual Pathway ◽

Ros Formation ◽

And Oxidative Stress

Particulate matter (PM) exposure is related to pulmonary and cardiovascular diseases, with increased inflammatory status. The release of the proinflammatory interleukin- (IL-) 1β, is controlled by a dual pathway, the formation of inactive pro-IL-1β, through Toll-like receptors (TLRs) activation, and its cleavage by NLRP3 inflammasome. THP-1-derived macrophages were exposed for 6 h to 2.5 μg/cm2of Milan PM10, and the potential to promote IL-1βrelease by binding TLRs and activating NLRP3 has been examined. Summer PM10, induced a marked IL-1βresponse in the absence of LPS priming (50-fold increase compared to unexposed cells), which was reduced by caspase-1 inhibition (91% of inhibition respect summer PM10-treated cells) and by TLR-2 and TLR-4 inhibitors (66% and 53% of inhibition, resp.). Furthermore, summer PM10increased the number of early endosomes, and oxidative stress inhibition nearly abolished PM10-induced IL-1βresponse (90% of inhibition). These findings suggest that summer PM10contains constituents both related to the activation of membrane TLRs and activation of the inflammasome NLPR3 and that TLRs activation is of pivotal importance for the magnitude of the response. ROS formation seems important for PM10-induced IL-1βresponse, but further investigations are needed to elucidate the molecular pathway by which this effect is mediated.

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Evaluation the effects of pycnogenol (French maritime pine bark extract) supplementation on the inflammatory biomarkers, nutritional and clinical status in traumatic brain injury patients, in Intensive Care Unit; A Randomized Clinical Trial protocol

10.21203/rs.2.11720/v2 ◽

2019 ◽

Author(s):

Mahsa Malekahmadi ◽

Omid Moradi Moghaddam ◽

Sheikh Mohammed Shariful Islam ◽

Kiarash Tanha ◽

Mohsen Nematy ◽

...

Keyword(s):

Oxidative Stress ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Nutritional Status ◽

Organ Failure ◽

Intervention Group ◽

Control Group ◽

Base Line ◽

Inflammatory Status ◽

And Oxidative Stress

Abstract Background: Traumatic brain injury (TBI) is one of the major health and socioeconomic problems in the world. Immune-enhancing enteral formula has been proven to significantly reduce infection rate in TBI patient. One of the ingredients that can be used in immunonutrition formulas to reduce inflammation and oxidative stress is pycnogenol. Objective: surveying the effect of pycnogenol on the clinical, nutritional and inflammatory status of TBI patients. Methods: This is double-blind, randomized controlled trial . Block randomization will be used. Intervention group will receive pycnogenol supplementation of 150 mg for 10 days. Control group will receive placebo for the same duration. Inflammatory status (IL-6, IL- 1β, C-reactive protein) and oxidative stress status (Malondialdehyde, total antioxidant capacity), at the base line, at the 5 th day and at the end of the study (10 th day) will be measured. Clinical and nutritional status will be assessed three times during the intervention. SOFA (sequential organ failure assessment) questionnaire for assessment of organ failure will be filled out every other day. The mortality rate will be calculated within 28 days of the start of the intervention. Weight, body mass index and body composition will be measured. All analyses will be conducted by initially assigned study arm in an intention-to-treat analysis. Discussion: We expect that supplementation of 150 mg pycnogenol for 10 days will improve clinical and nutritional status and reduce the inflammation and oxidative stress of the TBI patients.

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