Occurrence of oral neoplasms and dysplastic lesions: retrospective study of a pathology service over a 19-years period

INTRODUCTION: The epidemiological survey of the maxillofacial pathologies is of fundamental importance to prevention and treatment of these lesions. OBJECTIVE: The aim of the present study was to collect and analyze histopathological reports of biopsies sent to the Pathology Department, School of Dentistry from EBMSP. METHODS: A retrospective study of biopsies realized from 2001 to 2019 was conducted and the diagnoses of oral neoplasms and epithelial dysplasias were collected and analyzed. Data related to sex and age of the patients, location of the lesions, and clinical and histopathological diagnosis were recovered. RESULTS: From the total of 3.068 biopsies received in this period, the oral neoplasms corresponded to 7,31% of this total. Patients of the female sex (55,3%) and individuals between 25 and 64 years of age (60,3%) were most affected by neoplasms. The most common diagnosis among benign neoplasms was the ameloblastoma (20,3%) and the squamous cells carcinoma (67,2%) was the most frequent diagnosis in the group of malignant neoplasms. The anatomical location most affected by the neoplasms was the jaw (36,7%). The epithelial dysplasias corresponded to 3,8% of the sample, with a higher occurrence in the male sex (50,8%) and the age group between 25 and 64 years (61%); the anatomical location most affected was the palate (22,8%), and the mild epithelial dysplasia (68,6%) was the most common diagnosis. CONCLUSION: The present study highlights the importance of the epidemiological surveys to prevention and treatment of the maxillofacial lesions and emphasizes the necessity of the appropriate filling out of biopsies files.

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Salivary Gland Tumors in Libyan Population: A 20- Years Retrospective Study

Khalij-Libya Journal of Dental and Medical Research ◽

10.47705/kjdmr.215107 ◽

2021 ◽

pp. 43-52

Author(s):

Mansora Hamad ◽

Salwa Ahmeida ◽

Samar Hamed ◽

Jamila Issawi

Keyword(s):

Salivary Gland ◽

Retrospective Study ◽

Pleomorphic Adenoma ◽

Minor Salivary Gland ◽

Pathological Finding ◽

Salivary Gland Tumors ◽

Radiology Department ◽

Benign Tumors ◽

Anatomical Location ◽

Histopathological Diagnosis

Background and objectives. Salivary gland tumors (SGT) are relatively uncommon. It pose considerable challenging in diagnosis because their histopathological features and behavior diversity. There are several epidemiological studies describe their incidence and frequency. The current study aims to investigate the diverse histological types and distribution clinical characters. Methods. A retrospective study was carried out in oral diagnosis, oral medicine, oral pathology and radiology department of faculty of dentistry at Benghazi university from 2000 to 2019. Information gathered contained the year of diagnosis, age, gender, site, symptoms and histopathological diagnosis. The data collected was analyzed with SPSS. Result. Of the total 60 salivary gland tumors, 25 (41.7%) was benign tumors in which the pleomorphic adenoma was the most common type (n=24, 96%), and malignant tumors account (n=35, 38.3%) with mucoepidermoid carcinoma is the most frequent (n=41, 40%). Female to male ratio was 1.3:1 with average age of 40.5 (range 11-94). About 91.1% of salivary gland tumors were diagnosed in minor salivary gland where most of cases occurred in palate by 8.9%. Major salivary glands were affected by 8.9% mostly in parotid gland (7.2%). Most of cases were diagnosed as painless swelling. Conclusion: Malignant salivary gland tumors more common the benign type with the palate is the principle anatomical location. Pleomorphic adenoma was the most common pathological finding with predominance of female over male.

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Frequency and Distribution of Biopsied Non-Dental Plaque-Induced Gingival Diseases in a Chinese Population According to the Classification of Gingival Health and Gingival Disease/Conditions

10.21203/rs.3.rs-308963/v1 ◽

2021 ◽

Author(s):

Xiaotian Li ◽

Jianyun Zhang ◽

Heyu Zhang ◽

Tiejun Li

Keyword(s):

Dental Plaque ◽

Chinese Population ◽

Malignant Neoplasms ◽

Histopathological Diagnosis ◽

New Classification ◽

Screening Programs ◽

Gingival Health ◽

Common Diagnosis ◽

Gingival Diseases

Abstract Background: While inflammatory diseases such as gingivitis and periodontitis induced by dental plaque biofilms constitute the majority of gingival lesions, gingiva can also be affected by a variety of diseases that show etiologies different from bacterial biofilms. The aim of this study was to retrospectively analyze the frequency and distribution of non-dental plaque-induced gingival diseases (NDPIGDs) in a Chinese population. Methods: A total of 6859 samples of biopsied gingival diseases during the period of 2000-2019 were obtained from the Department of Pathology, Peking University Hospital of Stomatology. Lesions were categorized by histopathological diagnosis, pathological nature and the new classification of gingival health and gingival diseases/conditions. Demographic information, such as gender, location, and age, were also analyzed. Results: Among 6859 biopsied NDPIGD samples, the five most frequent diagnoses included oral squamous cell carcinoma (OSCC, n=2094), fibrous hyperplasia (n=2026), pyogenic granuloma (n=478), epithelial dysplasia (n=477), and epithelial hyperplasia/hyperkeratosis (n=436). All types could be grouped into nine categories according to their pathological characteristics. The most frequently common biopsied NDPIGDs category was “hyperplastic lesions” (n=2648, 38.61%), followed by “malignant neoplasms” (n=2275, 33.17%). The most common diagnosis types in each category were fibrous hyperplasia and OSCC. Of all NDPIGDs, most lesions could be categorized into the new classification of gingival health and gingival diseases/conditions; only 7.07% did not fit the current classification system. Conclusions: The present study represents the first report on the frequency and distribution of biopsied NDPIGDs in a Chinese population. Unlike previous studies, the most prevalent categories were “hyperplastic lesions” and “malignant neoplasms”. The proportion of “malignant neoplasms” and “oral potentially malignant disorders” was remarkably higher than in previous research. Nevertheless, the study provided epidemiological information for many NDPIGDs, which could be useful for future health policies as well as screening programs.

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Correlation of FNAC and histopathology in diagnosis of salivary gland lesions

Journal of Pathology of Nepal ◽

10.3126/jpn.v4i8.11593 ◽

2014 ◽

Vol 4 (8) ◽

pp. 654-657 ◽

Cited By ~ 2

Author(s):

S Koirala ◽

G Sayami ◽

AD Pant

Keyword(s):

Salivary Gland ◽

Preoperative Diagnosis ◽

Needle Aspiration ◽

University Teaching ◽

Malignant Neoplasms ◽

Histopathological Diagnosis ◽

Institute Of Medicine ◽

Needle Aspiration Cytology ◽

Sensitivity Specificity ◽

Diagnostic Pitfalls

Background: Value of fine needle aspiration cytology in preoperative diagnosis of salivary gland lumps has been established in various studies. This study aims to calculate sensitivity, specificity accuracy of FNAC, correlate FNAC findings with histopathology and find out reasons for common diagnostic pitfalls in FNAC.Materials and methods: This study was performed in 67 patients that presented with salivary gland lumps at Department of pathology, Tribhuvan University Teaching Hospital, Institute of medicine, Kathmandu, Nepal from January 2009 to June 2010. FNAC was performed and was correlated with histopathological diagnosis to judge the sensitivity, specificity and accuracy of FNAC.Results: Out of 36 cases there was cyto-histological correlation in 28 cases. Pleomorphic adenoma was the most frequent lesion in this study. Parotid gland was the most common site affected by salivary gland lesions. The sensitivity, specificity and accuracy for non-neoplastic lesions was 100%, 89.28%, 91.67%, for benign neoplasms was 100%, 86.95%, 91.67% and for malignant neoplasms was 57.14%, 100%, 83.33% respectively.Conclusion: FNAC is a useful tool in preoperative diagnosis of salivary gland lesions and can be crucial for the management of the patient. Aspiration and reporting of salivary gland lesions demands a competent pathologist who considers all the possible diagnostic pitfalls in mind.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11593 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 654-657

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Influence of preoperative corticosteroid treatment on rate of diagnostic surgeries in primary central nervous system lymphoma: a multicenter retrospective study

BMC Cancer ◽

10.1186/s12885-021-08515-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Florian Scheichel ◽

Franz Marhold ◽

Daniel Pinggera ◽

Barbara Kiesel ◽

Tobias Rossmann ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Retrospective Study ◽

Diagnostic Delay ◽

Central Nervous System Lymphoma ◽

Corticosteroid Treatment ◽

Histopathological Diagnosis ◽

Significant Difference ◽

The Difference ◽

Immunocompetent Patients

Abstract Background Corticosteroid therapy (CST) prior to biopsy may hinder histopathological diagnosis in primary central nervous system lymphoma (PCNSL). Therefore, preoperative CST in patients with suspected PCNSL should be avoided if clinically possible. The aim of this study was thus to analyze the difference in the rate of diagnostic surgeries in PCNSL patients with and without preoperative CST. Methods A multicenter retrospective study including all immunocompetent patients diagnosed with PCNSL between 1/2004 and 9/2018 at four neurosurgical centers in Austria was conducted and the results were compared to literature. Results A total of 143 patients were included in this study. All patients showed visible contrast enhancement on preoperative MRI. There was no statistically significant difference in the rate of diagnostic surgeries with and without preoperative CST with 97.1% (68/70) and 97.3% (71/73), respectively (p = 1.0). Tapering and pause of CST did not influence the diagnostic rate. Including our study, there are 788 PCNSL patients described in literature with an odds ratio for inconclusive surgeries after CST of 3.3 (CI 1.7–6.4). Conclusions Preoperative CST should be avoided as it seems to diminish the diagnostic rate of biopsy in PCNSL patients. Yet, if CST has been administered preoperatively and there is still a contrast enhancing lesion to target for biopsy, surgeons should try to keep the diagnostic delay to a minimum as the likelihood for acquiring diagnostic tissue seems sufficiently high.

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Prevalence and pattern of neck masses in pediatric patient: in Aseer Central Hospital, KSA

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20174206 ◽

2017 ◽

Vol 3 (4) ◽

pp. 791

Author(s):

Jibril Yahya Hudise ◽

Khalid Ali Alshehri ◽

Radeif Eissa Shamakhey ◽

Ali Khalid Alshehri

Keyword(s):

Pediatric Patient ◽

Histopathological Examination ◽

Statistical Tests ◽

Age Groups ◽

Neck Mass ◽

Anatomical Location ◽

Histopathological Diagnosis ◽

Central Hospital ◽

Duct Cyst ◽

Neck Masses

Background: Neck masses are a common complaint in children worldwide, and constitute a major indication for surgical consultation in many pediatric surgical centers. Most of the neck masses in children are benign in their nature and clinical course. The broad spectrum of etiology of neck masses that ranged from congenital benign to acquired neoplastic lesions is varied and related to multiple factors. This retrospective study was done with the objective to assess the distribution of neck masses related to gender, age, pathology, and anatomical location of neck masses in Aseer Central Hospital. Methods: Medical records of 62 patients with neck masses were collected from the department of pathology at Aseer Central Hospital KSA. The cases were reviewed for data on gender, age, the type of origin tissue, the type of lesion, and the anatomical location. Comparison between genders, age groups, and tissue origins were performed. All statistical tests were performed with SPSS software. We exclude thyroid, parathyroid and salivary gland masses. Results: Over a period of 5 years, a total of 62 patients 53.2% and women 46.8% had neck masses resected for pathological assessments. The age of presentation was ranging from 1 to 14 years. 22.6% developed in (from 1 years to 5 years old), 38.7% developed in (6 to 10 years), and 38.7% developed, in (11 to 14 years). The histopathological diagnosis of the neck masses were congenital 40.3%, inflammatory 33.9%, and malignant tumor 25.8%. Conclusions: The differential diagnosis of the pediatric neck mass includes a wide array of congenital, inflammatory, benign and malignant lesions. The exact diagnosis may only be obtained by histopathological examination. In our study the most common masses in pediatric patient thyroglossal duct cyst, all midline masses are congenital.

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Epidemiological survey in oral health of the residents of the Teixeira Island, Paraná, Brazil

RSBO ◽

10.21726/rsbo.v1i4.548 ◽

2018 ◽

Vol 1 (4) ◽

pp. 219

Author(s):

Tiago Rodrigues Suizani ◽

Bruna Leal de Mello ◽

Luiza Foltran De Azevedo Koch ◽

Carolina Dea Bruzamolin ◽

Marilisa Carneiro Leão Gabardo

Keyword(s):

Oral Health ◽

Low Income ◽

Epidemiological Survey ◽

World Health ◽

Permanent Teeth ◽

Deciduous Teeth ◽

Oral Diseases ◽

Socioeconomic Condition ◽

Epidemiological Surveys ◽

Periodontal Index

Introduction: The epidemiological surveys aim to evaluate the distribution and state determinants or events in health in given populations. Objective: To conduct an epidemiological survey on the socioeconomic condition, use of dental services, referred oral morbidity, self-perception, and oral health of inhabitants of the Teixeira Island, Paraná, Brazil. Material and methods: The studyfollowed the statements of the World Health Organization and the Brazilian National Epidemiological Survey (SB Brazil 2010). Questionnaires were applied, and in the clinical examination the following data were collected: dental trauma, edentulism, fluorosis, caries in deciduous teeth (dmft), caries in permanent teeth (DMFT), Community Periodontal Index (CPI) and Loss of Periodontal Insertion Index (LPII). The data were analyzed with Statistical Package for Social Sciences software, version 21.0, and expresses in frequency tables. Results: Of the 108 inhabitants, 90 participated in the study. The socioeconomics conditions unfavorable were: low income and low schooling. The water supplying was not fluoridated. The perception of oral problems was reported by 82.2%; 48.9% declared to have had toothache in last the six months; the reason of search for care was predominantly for curative treatments. Almost 30% of the participants declared to be unsatisfied with their oral health. The values of DMFT and dmtf indexes were 13.9 and 1.2, respectively. The greater demand for maxillary prosthesis occurred in 39.7% of the sample, while 34.2% needed mandibular prosthesis. Conclusion: The oral diseases illnesses and need of treatment were evidenced in the sample, as well as risk factors that deserve attention of the public power.

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A Retrospective Study Comparing Radiological to Histopathological Diagnosis After Laparoscopic Cholecystectomy for Suspected Cholecystitis

Cureus ◽

10.7759/cureus.10817 ◽

2020 ◽

Author(s):

Anupam K Gupta ◽

Joseph Farshchian ◽

Nir Hus

Keyword(s):

Laparoscopic Cholecystectomy ◽

Retrospective Study ◽

Histopathological Diagnosis

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(A Clinicopathological Aspects of Resectable Pancreatic Neoplasm)

Gevher Nesibe Journal, IESDR ◽

10.46648/gnj.274 ◽

2021 ◽

Vol 6 (15) ◽

pp. 39-44

Author(s):

Şeref Dokcu ◽

Mehmet Ali Çaparlar ◽

Salim Demirci

Keyword(s):

Pancreatic Cancer ◽

Survival Analysis ◽

Survival Rates ◽

Pancreatic Neoplasm ◽

Population Based ◽

Clinicopathological Features ◽

Categorical Variables ◽

Malignant Neoplasms ◽

Continuous Variables ◽

Common Diagnosis

Aim Pancreatic cancer is one of the deadliest malignant neoplasms. As with many malignant neoplasms, survival rates depend on the histopathological type of cancer, its stage, tumor size, and treatment. In this study, we aimed to classify pancreatic cancer according to clinicopathological features and histological subtypes. Material and method The data of all adult patients diagnosed and treated for pancreatic neoplasm in our clinic were collected retrospectively from the hospital's computerized database and medical files. Patients were categorized according to their clinicopathological features. Chi-square test and Fisher's exact test were used for between-group comparisons, and t-test was used for independent samples for quantitative data. Data were expressed as mean ± SD for continuous variables and numbers and percentages for categorical variables. A value of p<0.05 was considered significant. Results The mean age of the patients was 60.5 years, 70.8% were male. There were five types of tumors defined histopathologically, and the most common diagnosis was adenocarcinoma (76.9%). The most common localization of the tumor was head and neck (44.4%). Whipple surgery was performed predominantly in 69.2% of patients, and distal pancreatectomy in 29.0%. Postoperative complications were observed in more than one third (34%) of the patients. The main complications were pancreatic cyst (16.3%). In the survival analysis performed with the Kaplan-Meier test, median survival of 30.5 months, and overall survival (OS) at 1.2 and 5 years were 67.8%, 40.5%, and 16.6%, respectively. Discussion However, survival analysis results were optimistic compared to population-based studies as all patients had resectable tumors.

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Assessment of quality of life in patients with advanced oral cancer who underwent mandibulectomy with or without bone reconstruction

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.64.08.710 ◽

2018 ◽

Vol 64 (8) ◽

pp. 710-716

Author(s):

Jose Roberto Netto Soares ◽

Fernando Luiz Dias ◽

Roberto Rego Monteiro de Araujo Lima ◽

Ullyanov Bezerra Toscano ◽

Ana Carolina Pastl Pontes ◽

...

Keyword(s):

Quality Of Life ◽

Surgical Treatment ◽

Oral Cavity ◽

Clinical Stage ◽

Malignant Neoplasms ◽

Anatomical Location ◽

Bone Reconstruction ◽

Vital Functions ◽

The Mean

INTRODUCTION Malignant neoplasms of the head and neck, due to its anatomical location, can cause significant alterations in vital functions related to feeding, communication and social interaction of the affected patients. Objective To analyze the quality of life of patients with advanced malignant neoplasms of the oral cavity and submitted to radical operations with curative intent. Material and methods 47 patients with oral cavity squamous cell carcinoma (SCC), in stages III and IV, underwent surgical treatment with segmental mandibulectomy and complementary radiotherapy. The patients were submitted to the quality of life questionnaires after a minimum time of six months after the surgical treatment. Results Of the 183 patients, only 47 (25.7%) were able to answer the questionnaire and were included as the sample of the study. The majority of patients selected were male (39; 82.9%). The mean age was 64.4 years. The majority of the patients presented clinical stage IV (83%) and were submitted to adjuvant radiotherapy (95.4%). The mean score obtained after the questionnaires were applied was 64.6. The worst scores were found in swallowing and chewing. Conclusion There were no statistically significant differences in the domains of quality of life between the two groups studied (with bone reconstruction versus no bone reconstruction). Patients interviewed 2 years or more after treatment presented higher scores (p = 0.02).

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Retrospective Study of Mammary Lesions in Bitches - Uberlândia, MG, Brazil

Acta Scientiae Veterinariae ◽

10.22456/1679-9216.80788 ◽

2017 ◽

Vol 45 (1) ◽

pp. 8

Author(s):

Mariana Batista Andrade ◽

Ednaldo Carvalho Guimarães ◽

Arlinda Flores Coleto ◽

Nicolle Pereira Soares ◽

Alessandra Aparecida Medeiros-Ronchi

Keyword(s):

Retrospective Study ◽

Tumor Size ◽

Hormone Receptors ◽

Malignant Tumors ◽

Histological Grade ◽

Mammary Tumors ◽

Mammary Glands ◽

Malignant Neoplasms ◽

The Mean ◽

Inguinal Glands

Background: Mammary tumors are a type of neoplasia that are most commonly found in female dogs and are mostly malignant. The aim of this study, performed in the Laboratory of Veterinary Pathology of the Federal University of Uberlândia (LVP-FUU) from 2004 to 2014, was to determine the prevalence of mammary tumors in bitches and to verify the relationship between the epidemiological factors (age and breed) and clinicopathological aspects (ulceration, tumor size, and malignancy) in the occurrence of tumors.Materials, Methods & Results: A retrospective study was carried out using histopathological information retrieved from the LPV-UFU database. We collected the information on age and breed of female dogs, as well as about the location, macroscopic aspects, and histological diagnosis of mammary lesions. Only female dogs were considered for this study; a total of 911 histopathological protocols (with only one diagnosis) were analyzed along with 36 protocols that presented more than one diagnosis of mammary tumor. The age of animals ranged from one to 20 years, and the mean age was 9.99 years. The most affected breeds of dogs were: Cross breed (39.56% - 288/728) and Poodle (20.19% - 147/728). The inguinal glands were most affected by the malignant tumors (P < 0.05). A prevalence of tumors bigger than 5 cm in diameter (T3) was observed in the elderly animals (P = 0.0154) and in the inguinal mammary glands (P = 0.044). Simple carcinoma was the most frequent histological type.Discussion: Research shows that more than 40% of the tumors in bitches are located in the mammary glands, emphasizing the importance of this type of neoplasia in female dogs. Mammary tumors develop more frequently in the middle-aged and elderly bitches, with the highest occurrence being in the age range of 8 and 10 years, corroborating our observation in the present study that the mean age of bitches was 9.99 years. In this survey, a higher incidence was observed in mongrel bitches compared to that in the Poodle breed. Some authors affirm that there is no racial predisposition for the occurrence of this pathology; however, a compilation of data suggests a predisposition of at least 10 breeds, with the involvement of an as yet unidentified genetic component. Of these, six breeds (Poodle, Cocker Spaniel, Pointer, Maltese, Yorkshire Terrier, and Dachshund) were found to be predisposed to mammary tumors in this study. The percentage (49.23%) of malignant tumors found in the inguinal glands is consistent with the findings reported in literature, and might be associated with a greater amount of parenchyma, abundance of hormone receptors in these glands, and vascularization provided by the caudal superficial epigastric artery and vulvar branches of external pudendal artery. Tumor size is considered to be a prognostic factor and tumors ≤ 3 cm in diameter (T1) have a better prognosis. Consequently, the prevalence of tumors ≥ 5 cm in diameter (T3) in elderly animals is probably related to malignancy of the lesions, because tumors usually progress to a worse histological grade with time. The higher occurrence of T3 in inguinal glands might be related to the abundance of parenchyma and/or hormonal receptors in them. As in the present study, data from literature refer to the superiority of malignant histological types, with prevalence varying between 68 and 91%. When prolonged, the time between the onset of tumor and clinical evaluation may be a determinant in the progression from benign to malignant tumors. Among the malignant neoplasms, simple carcinoma was observed to be prevalent, followed by mixed tumors with carcinoma, in agreement with the results of several studies. It is concluded that mammary tumors are more prevalent in older mongrel dogs and Poodle. Attention should be paid to inguinal mammary tumors, because these are mainly malignant.

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