scholarly journals C – reactive protein in saliva of non-smoking patients with periodontitis (a pilot study)

2021 ◽  
Author(s):  
Zerina Hadžić ◽  
Ivan Puhar
Keyword(s):  
Pilot Study ◽  
Test Group ◽  
Periodontal Therapy ◽  
Control Group ◽  
C Reactive Protein ◽  
Inflammatory Biomarker ◽  
Reactive Protein ◽  
Before And After ◽  
Oral Hygiene Instructions ◽  
And Control

Introduction: C-reactive Protein (CRP) as an inflammatory biomarker can be easily determined in saliva, but the values of salivary CRP in periodontitis are not well-studied. The aim of this study was to analyze and determine the values of salivary CRP in non-smokers with periodontitis stage 3 or 4 before and after supragingival and subgingival full-mouth periodontal therapy.Methods: Standard periodontal parameters and saliva samples were collected in 12 non-smoking patients. Patients in the test group (n = 6) underwent supragingival and subgingival full-mouth periodontal therapy, and the control group (n = 6) received only supragingival full-mouth therapy. Both groups received the same oral hygiene instructions in addition to therapy. After 3 months, re-registration of periodontal parameters and re-sampling of saliva for analysis of salivary CRP were done for both groups.Results: Statistical analysis revealed large differences in the values of clinical periodontal parameters and CRP levels in the test group after therapy. Values of salivary CRP in the test and control groups were lower 3 months the therapy; however, the results were not statistically significant. The correlation of clinical periodontal parameters and salivary CRP varied in both groups.Conclusion: Our pilot study reveals decreased concentrations of salivary C-reactive protein in non-smoking patients following non-surgical periodontal therapy. Further studies are needed to prove the reliability of salivary CRP as a biomarker for periodontitis.

scholarly journals Studying the Role of C-Reactive Protein in Patients with Sleeve Gastrectomy in Baghdad

2021 ◽  
Vol 3 (1) ◽  
pp. 55-60
Author(s):  
Mohammed Abbas Fadil ◽  
Raya Ezat Maroof ◽  
Moayed Abbas Fadil
Keyword(s):  
Sleeve Gastrectomy ◽  
Healthy Person ◽  
Control Group ◽  
C Reactive Protein ◽  
Serum Samples ◽  
Reactive Protein ◽  
Medical City ◽  
Healthy Control ◽  
And Control

Obesity and severe obesity are increasing serious health problems with an epidemic percentage in most countries. In Sleeve gastrectomy, a part of the stomach structure is removed, limiting its capacity by about two to three. A total of thirty blood samples were collected from patients with obesity and the result was compared with healthy person throughout the time from November 2019 to September 2020. Before sleeve gastrectomy and after more than 6 months of sleeve surgery, the sample was collected from the Medical City/Baghdad Teaching Hospital, the withdrawal was again taken at home to have pre and post sleeve gastrectomy, Patient age ranged between [20-46] years for obese patients and healthy control. Then the serum samples were obtained from patients and control group to screen for C-reactive protein by agglutination method. The result of the present study found that the positivity of CRP in pre-operation is higher than that of post-operative with high significance [P<0.005].

scholarly journals Treatment Success and User-Friendliness of An Electric Toothbrush App: A Pilot Study

2020 ◽  
Vol 8 (3) ◽  
pp. 97
Author(s):  
Viviane Humm ◽  
Daniel Wiedemeier ◽  
Thomas Attin ◽  
Patrick Schmidlin ◽  
Stefanie Gartenmann
Keyword(s):  
Pilot Study ◽  
Treatment Success ◽  
Test Group ◽  
Plaque Index ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
User Friendliness ◽  
Short Period ◽  
Electric Toothbrush ◽  
And Control

Electronic and mobile health (eHealth/mHealth) are rapidly growing areas in medicine and digital technologies are gaining importance. In dentistry, digitalization is also an emerging topic, whereby more and more applications are being offered. As an example, using real-time feedback, digital application software (an app) was designed to help users brush their teeth more accurately. However, there is no data on the effectiveness and haptic of such apps. Therefore, a single-blinded, randomized controlled clinical trial was designed: twenty volunteers received an electric toothbrush with an associated app to assess whether the app-assisted toothbrushing is better than without. After a short period of familiarization with the electric toothbrush, plaque index (O‘Leary et al. 1972) was recorded and subjects were assigned to the test (with app; n = 10) or the control group (no app; n = 10). At the end of the 2-week pilot study period, plaque was again assessed and participants in the test group completed a questionnaire about the app’s user-friendliness. Statistical analysis revealed no significant differences between the test and control groups. The plaque index improved on average by 8.5% points in the test and 4.7% points in the control group. Fifty percent of the test group participants were of the opinion that they had achieved better cleaning results and would recommend the app to others, although the app contributed only marginally to increased plaque removal. However, such apps may nevertheless be helpful as motivational tools, especially when tracking and monitoring cleaning data. Therefore, more development and research on this topic is indicated.

scholarly journals Effect of non-surgical periodontal therapy on the levels of C-reactive protein: a pilot study

2011 ◽  
Vol 26 (1) ◽  
pp. 16-21
Author(s):  
Camila Oliveira Teixeira de Freitas ◽  
Isaac Suzart Gomes-Filho ◽  
Roberta Catapano Naves ◽  
Simone Seixas da Cruz ◽  
Carlos Antonio de Souza Teles Santos ◽  
...  
Keyword(s):  
Pilot Study ◽  
Protein A ◽  
Periodontal Therapy ◽  
C Reactive Protein ◽  
Reactive Protein

Pilot Study of Intraperitoneal Administration of Triamcinolone Acetonide for Cancerous Ascites in Patients With End-Stage Gynecological Cancer

2014 ◽  
Vol 24 (6) ◽  
pp. 1093-1097 ◽  
Author(s):  
Tadahiro Shoji ◽  
Eriko Takatori ◽  
Yuki Miura ◽  
Anna Takada ◽  
Hideo Omi ◽  
...  
Keyword(s):  
Pilot Study ◽  
Adverse Events ◽  
Triamcinolone Acetonide ◽  
Gynecological Cancer ◽  
Intraperitoneal Administration ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Before And After ◽  
End Stage ◽  
Abdominal Paracentesis

ObjectivePatients with end-stage cancer have poorly controlled ascites retention resulting due to cancerous peritonitis. We intraperitoneally administered triamcinolone acetonide (TA) to patients with end-stage gynecological cancer as a pilot study, and our treatment results are reported herein.Patients and MethodsWe enrolled 26 patients with end-stage gynecological cancer requiring frequent abdominal paracentesis for ascites drainage between April 2010 and September 2012. The volume of ascites drainage was 2000 to 3000 mL per drainage session, and TA at 10 mg/kg was intraperitoneally administered after drainage. We compared abdominal paracentesis intervals, performance status (PS), total protein level, albumin level, white blood cell count, changes in C-reactive protein (CRP) level, and adverse events before and after TA use.ResultsTriamcinolone acetonide was administered to 26 patients for a total of 59 times. The abdominal paracentesis intervals, PS, and mean (SD) of C-reactive protein before and after TA use were 13.2 (12.6) days and 21.9 (23.6) days (P = 0.0117), 2.4 (0.7) and 1.6 (1.1) (P < 0.0001), and 7.5 (5.2) mg/dL and 5.5 (5.0) mg/dL (P = 0.007), respectively. With regard to adverse events, abdominal pain of grade 2 was observed once (1.7%), but there were no other acute adverse events. Four subjects (15.4%) had intestinal perforation.ConclusionsIntraperitoneal administration of TA after drainage was considered to be a useful treatment, as it seems to extend paracentesis intervals and improve PS while maintaining quality of life for end-stage gynecological cancer patients with massive ascites.

scholarly journals INVESTIGATING THE EFFECT OF REFLEXOLOGY IN INTENSITY OF PAIN AND ANXIETY AMONG PATIENTS SUFFERING FROM METASTATIC CANCER IN ADULTS’ HEMATOLOGY WARD

2018 ◽  
Vol 11 (6) ◽  
pp. 401 ◽  
Author(s):  
Simin Jahani ◽  
Fatemeh Salari ◽  
Nasrin Elahi ◽  
Bahman Cheraghian
Keyword(s):  
Cancer Patients ◽  
Metastatic Cancer ◽  
Test Group ◽  
Control Group ◽  
Anxiety Management ◽  
Patients With Cancer ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
And Control

Objective: Findings suggest dissatisfaction of half of the cancer patients regarding pain and anxiety management. This study aimed to determine the effect of reflexology on the intensity of pain and anxiety among patients with metastatic cancer hospitalized inadulthematology ward.  Methods: In this study, the samples were selected from adult hematology ward in Baghaei 2 hospital in Ahwaz, Iran, according to the inclusion criteria. They were then assigned into treatment and control groups. In the treatment group, reflexology protocol was performed following manual reflexology method by Fr Josef Eugster based on Ingham method on the patient’s bed. In the control group, sole touching was used as the placebo. Reflexology was performed for three days, 30 min per day. Spielberger questionnaire were provided to the samples and completed in the first and third days, and Spielberger questionnaire was provided to the samples and completed. The data obtained from this study were then analyzed by SPSS 20.Results: The two groups did not show a significant difference in terms of demographic characteristics (p>0.05). Based on the obtained results, it was found that in the test group, there was a significant difference between the mean intensity of pain before and after the treatment across all 3 days as well as the mean anxiety of the 1st and 3rd days (p<0.05). However, in the control group, there was no significant difference in terms of mean pain intensity before and after the treatment across 3 days (p>0.05). No significant difference was observed between the mean anxiety of the 1st and 3rd days either (p>0.05).Conclusion: Considering the findings of this research, it can be concluded that reflexology has a positive effect on mitigating the intensity of pain and anxiety in metastatic cancer patients. Therefore, it is recommended that nurses employed in cancer centers benefit from the findings of this research to further help patients with cancer. It is also suggested that further research be conducted on the effect of reflexology on the pain and anxiety of other patients.

scholarly journals A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement

2021 ◽  
Author(s):  
Zahra Alizadeh ◽  
Nastaran Keyhanian ◽  
Sara Ghaderkhani ◽  
Simin Dashti-Khavidaki ◽  
Raheleh Shokouhi Shoormasti ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Intervention Group ◽  
Control Group ◽  
Low Light ◽  
Reactive Protein ◽  
Significant Difference ◽  
Before And After ◽  
And Control ◽  
To Receive ◽  
Chest Ct Scan

No effective antiviral drugs and vaccines are available for the treatment of patients with severe coronavirus 2019 (COVID-19). Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for controlling inflammation. We did a randomized, single-blind study in Imam Khomeini Hospital between June 30, 2020, and August 5, 2020. Mild to moderate COVID-19 patients aged 25-65 years were eligible to enter the study based on chest CT scan, clinical symptoms, and physician diagnosis. The intervention group was prescribed 6 mg of oral melatonin for 2 weeks, which consumed half an hour before bedtime every night in low light conditions. Clinical symptoms and C-reactive protein (CRP) were measured before and after treatment in the melatonin received and control (regular medications) groups. Among screened patients with COVID-19, 14 patients were assigned to receive melatonin, and 17 patients were considered as controls. A significant difference (p=0.005) between CRP 1 and CRP 2 levels (before and after using melatonin) was found in the melatonin group while this difference (p=0.069) was not significant in the control group. Also, the percentage of recovery (based on symptoms) in patients who took melatonin was higher than that of patients in the control group (85.7% VS 47.1%).  The result of this study confirmed the effectiveness of melatonin in mild to moderate outpatients with COVID-19. More clinical trials on elderly, diabetic, obese patients and severe cases are suggested in future studies.   

scholarly journals Familial Combined Hyperlipidemia (FCH) Patients with High Triglyceride Levels Present with Worse Lipoprotein Function Than FCH Patients with Isolated Hypercholesterolemia

Biomedicines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 6
Author(s):  
Núria Puig ◽  
Inka Miñambres ◽  
Sonia Benítez ◽  
Pedro Gil ◽  
Margarida Grau-Agramunt ◽  
...  
Keyword(s):  
Statin Treatment ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Pla2 Activity ◽  
Familial Combined Hyperlipidemia ◽  
Control Groups ◽  
Reactive Protein ◽  
Before And After ◽  
Lipoprotein Composition ◽  
And Control

Lipoprotein characteristics were analyzed in familial combined hyperlipidemia (FCH) patients before and after statin treatment. Twenty-six FCH patients were classified according to the presence (HTG group, n = 13) or absence (normotriglyceridemic (NTG) group, n = 13) of hypertriglyceridemia. Fifteen healthy subjects comprised the control group. Lipid profile, inflammation markers, and qualitative characteristics of lipoproteins were assessed. Both groups of FCH subjects showed high levels of plasma C-reactive protein (CRP), lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and apolipoprotein J. Statins reverted the increased levels of Lp-PLA2 and CRP. Lipoprotein composition alterations detected in FCH subjects were much more frequent in the HTG group, leading to dysfunctional low-density lipoproteins (LDL) and high-density lipoproteins (HDL). In the HTG group, LDL was smaller, more susceptible to oxidation, and contained more electronegative LDL (LDL(-)) compared to the NTG and control groups. Regarding HDL, the HTG group had less Lp-PLA2 activity than the NTG and control groups. HDL from both FCH groups was less anti-inflammatory than HDL from the control group. Statins increased LDL size, decreased LDL(-), and lowered Lp-PLA2 in HDL from HTG. In summary, pro-atherogenic alterations were more frequent and severe in the HTG group. Statins improved some alterations, but many remained unchanged in HTG.

scholarly journals The Effect of Eight Weeks of Massage on Blood Pressure, Heart Rate and C-Reactive Protein in Women With Hypertension

2020 ◽  
Vol 23 (3) ◽  
pp. 398-411
Author(s):  
Shahnaz Shahrjerdi ◽  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Control Group ◽  
Common Disease ◽  
Medical Sciences ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Massage Group ◽  
Quasi Experimental ◽  
And Control

Background and Aim: Hypertension is a common disease and universal that can cause cardiovascular disease and kidney damage. The purpose of this study was to determine the effect of an eight-weeks massage on blood pressure (systolic and diastolic), heart rate and C-reactive protein in women with hypertension.  Methods & Materials: In this quasi-experimental study, 44 volunteer women with Mean±SD age of 42.12±5.31years were selected from women referred to Arak Oil Company specialized polyclinic with hypertension. Four women excluded from the study for some reason, and the rest were divided into experimental and control groups. In massage group massage was done for three sessions per week, 45-60 minutes in each session, on the back and upper limbs for eight weeks. Data analysis was conducted using dependent and independent t-test by SPSS V. 25 statistical software at the significant level of (P≤0.05). Ethical Considerations: This study (Code: 92-160-26) was approved in Research Ethics Committee of Arak University of Medical Sciences. Results: The results showed that eight weeks of massage reduced blood pressure (P=0.001), the heart rate (P=0.001), and C-reactive protein (P=0.001) in women with hypertension compared to the control group (P=0.62). Conclusion: The findings of this study showed that massage for eight weeks is an efficient and appropriate method to improve systolic and diastolic blood pressure, heart rate, and C-reactive protein in patients with hypertension.

Expression of Nod-Like Receptor Protein 3 (NLRP3) in Peripheral Blood Mononuclear Cells of Patients with Sepsis

2020 ◽  
Vol 10 (2) ◽  
pp. 271-275
Author(s):  
Ying Li ◽  
Yongshan Tang
Keyword(s):  
Immune Responses ◽  
Mononuclear Cells ◽  
Receptor Protein ◽  
Control Group ◽  
C Reactive Protein ◽  
Peripheral Blood Mononuclear ◽  
Reactive Protein ◽  
Adaptive Immune ◽  
Caspase 1 ◽  
Before And After

Sepsis is a common clinical disease. The NLRP3 inflammasome is a multiprotein complex that is involved in both innate and adaptive immune responses. However, the expression of NLRP3 in patients with sepsis has not been elucidated. 98 patients with sepsis before and after treatment were selected and 106 healthy volunteers were used as the control group. PBMCs were isolated from each group to measure NLRP3 and Caspase 1 level Real time PCR. The expression of serum procalcitonin (PCT), C-reactive protein (CRP), IL-1β and IL-18 was analyzed by ELISA. NLRP3 and Caspase 1 level was significantly increased in sepsis patients before treatment with increased secretion of IL-1β and IL-18 in serum and elevated level of PCT and CRP (P < 0.05). NLRP3, Caspase 1 expression, IL-1β and IL-18 secretion were positively correlated with serum PCT and CRP in patients with sepsis (P < 0.05). After treatment, NLRP3 and Caspase 1 mRNA expression was significantly decreased and serum IL-1β and IL-18 secretion was significantly decreased (P < 0.05). NLRP3 is increased in sepsis and IL-1β and IL-18 secretion is elevated, implying the involvement of NLRP3 in the occurrence and development of sepsis.

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