scholarly journals MORBIDITY AND MORTALITY FROM MALIGNANT NEOPLASMS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS

2017 ◽  
Vol 4 (3) ◽  
pp. 33-50 ◽  
Author(s):  
O. P. Gretsova ◽  
A. A. Kostin ◽  
Yu. V. Samsonov ◽  
G. V. Petrova ◽  
M. Yu. Prostov ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Russian Federation ◽  
Malignant Tumors ◽  
Age Groups ◽  
Malignant Neoplasms ◽  
Cancer Register ◽  
Medicine Journal ◽  
The Russian Federation ◽  
First Time ◽  
Statistical Form

In this review we continue the publication of data on the problem of malignant neoplasms (MN) associated with human papillomavirus (HPV), in Russia. In a previous publication (Research’n Practical Medicine Journal 2016; 3(1): 66–78. DOI: 10.17709/2409-2231-2016-3-1-9) we at the first time presented the data on the incidence of malignant tumors associated with HPV in the Russian Federation for the period from 2009 to 2014. This article presents updated data on the incidence of in 2015, as well as data on mortality from the MN associated with HPV in Russia with the analysis of trends in men and women in different age groups. The statistics used in the article is calculated according to the annual state reporting documentation of the statistical form of the Ministry of health No. 7 and No. 35, forms 5 and Rosstat data, the combined database of the state of the cancer register of the Russian Federation.

MORBIDITY, MORTALITY AND RELIABILITY OF ACCOUNTING OF PATIENTS OF DIFFERENT AGE GROUPS WITH LIVER CANCER IN RUSSIA

2020 ◽  
pp. 240-245
Author(s):  
В. М. Мерабишвили ◽  
В. К. Гуркало ◽  
Э. Н. Мерабишвили
Keyword(s):  
Liver Cancer ◽  
Russian Federation ◽  
Malignant Tumors ◽  
Primary Liver Cancer ◽  
Age Groups ◽  
Federal District ◽  
Cancer Register ◽  
The North ◽  
The Russian Federation ◽  
North Western

Рак печени (РП) - тяжелейшая онкопатология. В России смертность превышает число первично-учтенных больных в среднем. Ежегодно в России регистрируют более 8 тыс. (8 810 - в 2018 г.) случаев рака печени и более 10 тыс. (10 018 - в 2018 г.) случаев смерти от этой причины. Использованы стандартные методы медицинской статистики, все зарегистрированные первичные случаи РП в России. Углубленная разработка материала проведена на основе базы данных Популяционного ракового регистра Северо-Западного Федерального округа РФ. Проанализированы данные всего комплекса доступной информации в целом по России. Установлен прирост заболеваемости РП населения России за 18 лет в «грубых» показателях и абсолютных числах на 20% и в стандартизованных - на 1,22%. У женщин отмечено снижение учтенных случаев РП на 4,55%. Смертность населения России в стандартизованных показателях снизилась за 18 лет практически на 3%. Превышение числа умерших над заболевшими от РП существенно возрастает в старших возрастных группах. Индекс достоверности учета (ИДУ) - это отношение абсолютных чисел или «грубых» показателей смертности населения к заболеваемости. Для всех злокачественных новообразований (ЗНО) величина в среднем по России составила 0,47, практически совпадающая со среднеевропейской. ИДУ у мужчин - 0,55, выше расчетных показателей для женщин - 0,40, что в первую очередь связано с более благоприятной структурой заболеваемости женщин ЗНО. Медиана выживаемости первичных больных РП составляет немногим более 3 мес. Пятилетняя выживаемость больных РП даже на ранних стадиях составляет у лиц моложе 60 лет с I стадией - 25,3%, старше 60 лет - только 17,2%, со II стадией - 17,9 и 11% соответственно. Liver cancer is a severe oncopathology. Mortality exceeds the number of primary-accounted patients in Russia on average. Every year in Russia more than eight thousand (8 810 in 2018) cases of liver cancer and more than 10 000 (10 018 in 2018) deaths from this cause are registered. Used Standard methods of medical statistics, all registered primary cases of liver cancer in Russia. In-depth development of the material was carried out on the basis of the database of the Population cancer register of the North-Western Federal district of the Russian Federation. The analysis of the data of the whole complex of available information in Russia as a whole is carried out. In-depth data development was carried out on the basis of the database of the Population cancer register of the North-Western Federal district of the Russian Federation. The increase in the incidence of liver cancer in Russia over 18 years in «rough» indicators and absolute numbers by 20 % and in standardized by 1,22 % was established. In women, there was a decrease in reported cases of liver cancer by 4,55 %. The mortality rate of the Russian population in standardized indicators has decreased by almost 3 % over 18 years. The excess of the number of deaths over those from liver cancer increases significantly in older age groups. The index of reliability of accounting is the ratio of absolute numbers or «rough» indicators of mortality to morbidity. For all malignant tumors, its value on average in Russia was 0,47, almost coinciding with the average European. The index of reliability of accounting for men is 0,55, higher than the calculated indicators for women - 0,40, which is primarily due to a more favorable structure of the incidence of malignant tumors in women. The median survival of primary liver cancer patients is a little more than three months. The fi ve-year survival rate of patients with liver cancer even in the early stages is in the first among persons younger than 60 years - 25,3 %, over 60 years - only 17,2 %, in the second, respectively, 17,9 and 11%.

THE FIRST RESULTS OF THE ANALYSIS OF THE ACTIVITY OF THE CANCER SERVICE OF THE NORTH-WESTERN FEDERAL DISTRICT OF THE RUSSIAN FEDERATION, CONDUCTED ON THE BASIS OF THE CREATED POPULATION CANCER REGISTER OF THE FEDERAL DISTRICT

2020 ◽  
pp. 228-239
Author(s):  
В. М. Мерабишвили ◽  
А. М. Беляев
Keyword(s):  
Russian Federation ◽  
Cancer Incidence ◽  
Malignant Tumors ◽  
Survival Rates ◽  
Age Groups ◽  
Federal District ◽  
Cancer Service ◽  
The North ◽  
The Russian Federation ◽  
North Western

Полностью сформированная база данных Популяционного ракового регистра (БД ПРР) Северо-Западного Федерального округа Российской Федерации (СЗФО РФ) в феврале 2019 г. позволила существенно расширить возможности объективной оценки деятельности онкологической службы на более надежной основе аналитических материалов. В России впервые появилась возможность проводить эпидемиологические исследования злокачественных новообразований по редким локализациям опухолей, любым возрастным группам и расчеты показателей выживаемости больных. БД ПРР насчитывает более 1 млн наблюдений, включает все рубрики и подрубрики МКБ-10 по II классу - коды С00-96. В работе представлена динамика заболеваемости и смертности населения СЗФО РФ в сравнении со среднероссийскими показателями, достоверность учета и выживаемость больных злокачественными новообразованиями. Установлено увеличение онкологической заболеваемости в СЗФО РФ за 8 лет на 10,4% в стандартизованных показателях и снижение смертности населения в СЗФО РФ на 11,4% в тех же показателях. Рассчитана динамика пятилетней наблюдаемой выживаемости больных СЗФО РФ с учетом возрастных групп. Надежность БД ПРР СЗФО РФ подтверждается тем, что материалы трех административных территорий после тщательной проверки включены в монографию МАИР «Рак на 5 континентах», том XI (Санкт-Петербург, Архангельская обл. и Республика Карелия). The completely formed database of the Population Cancer Registry (PCR database) of the North-Western Federal district of the Russian Federation in February 2019 has significantly expanded the ability to objectively assess the activities of the cancer service on a more reliable basis of analytical materials. In Russia, for the first time, it was possible to conduct epidemiological studies of malignant tumors for rare tumor locations, any age groups, and calculations of patient survival rates. The PCR database has more than 1 million observations and includes all the headings and subheadings of ICD-10 for class II - codes C00-96. The article will present the dynamics of morbidity and mortality of the population of the northwestern Federal district of the Russian Federation in comparison with the national average, the reliability of accounting and survival of patients with malignant tumors. For 8 years, the growth of cancer incidence in the Northwestern Federal district of the Russian Federation by 10,4 % in standardized indicators and a decrease in population mortality in the Northwestern Federal district of the Russian Federation by 11,4 % in the same indicators. The dynamics of the 5-year observed survival rate of patients with Northwestern Federal district of the Russian Federation, taking into account age groups, is calculated. The reliability of the PCR database of the Northwestern Federal district of the Russian Federation is confirmed by the fact that the materials of 3 administrative territories are included in the IARC monograph «Cancer incidence in five continents. Vol. XI» (Saint-Petersburg, Arkhangelsk region and the Republic of Karelia).

scholarly journals Incidence of malignant neoplasms at radiation-hazardous facilities

2021 ◽  
Vol 100 (2) ◽  
pp. 154-158
Author(s):  
Aleksandr P. Biryukov ◽  
El’vira P. Korovkina ◽  
Igor’ P. Korenkov ◽  
Aleksandr R. Tukov ◽  
Sergej E. Okhrimenko ◽  
...  
Keyword(s):  
Russian Federation ◽  
Age Groups ◽  
Federal State ◽  
Malignant Neoplasms ◽  
Social Rehabilitation ◽  
Present Information ◽  
Icd 10 ◽  
Personal Level ◽  
The Russian Federation ◽  
Annual Mortality

Introduction. Authors present information on the results of social and hygienic monitoring of personnel’s health status at hazardous radiation facilities and the assigned contingent of healthcare institutions of Russia’s FMBA. The main causal patterns of the influence of risk factors on morbidity and mortality from malignant neoplasms (MNO) among employees of enterprises and the attached contingent of organizations served by healthcare institutions of the FMBA of Russia were revealed. Material and methods. The object of the study was the data on malignant neoplasms obtained from the Federal State Budgetary Institution FTSITEP FMBA of Russia and the Branch Medical and Dosimetric Register of the A.I. Burnazyan FMBA of Russia for 2012-2016. Comparative data of official medical statistics on the incidence of malignant neoplasms and mortality from them in the contingent served by FMBA hospitals, according to the nosological forms of ICD-10 and age groups with similar indices in Russia as a whole, were studied and analyzed (“NMITs Radiology” of the Ministry of Health of Russia). Results. An increase in the incidence of malignant neoplasms in Russia’s FMBA for 2012-2016 (328.4-359.6) and the Russian Federation (367.3-408.6) was noted. 9, which is significantly less than the all-Russian indices (201.0-201.6). The annual mortality rate in 2016 was lower in Russia’s FMBA patients (17.7%) than in the Russian Federation (23.3%). The five-year survival rate in Russia’s FMBA was close to that in the Russian Federation (49.9-54.3%.) It was noted that the largest number of cancer cases was observed in the older age groups: 40-59 years: 23.3-26.6%; 60-85 years: 72.2-68.3%, the same as in the Russian Federation. Conclusion. The research results can become the basis for the development of measures for medical and social rehabilitation of employees of enterprises and organizations served by medical and preventive institutions of the FMBA of Russia and the assigned contingent. In the area of the location of hazardous radiation facilities, constant monitoring and analysis of indicators of cancer incidence, carried out at a personal level using register technologies, is required.

scholarly journals SEGMENTATION OF TERRITORIES OF THE REPUBLIC OF BASHKORTOSTAN ON THE LEVEL OF MORTALITY FROM MALIGNANT NEOPLASMS

2019 ◽  
Vol 63 (1) ◽  
pp. 4-13
Author(s):  
P. A. Askarov ◽  
A. O. Karelin ◽  
I. A. Lakman ◽  
L. F. Rozanova ◽  
Zagira F. Askarova
Keyword(s):  
Cluster Analysis ◽  
Russian Federation ◽  
Malignant Tumors ◽  
Mortality Rates ◽  
Federal State ◽  
Malignant Neoplasms ◽  
Actual Problem ◽  
Republic Of Bashkortostan ◽  
The Russian Federation ◽  
The Republic

Malignant neoplasms are an actual problem due to their high prevalence, high level of disability, tendency to increase. The purpose of the study is the segmentation of the territories of the Republic of Bashkortostan (RB) by the level of mortality from malignant neoplasms (MN) as a whole by municipalities, as well as by gender and by localizations of malignant neoplasms. Material and methods. The data of official statistics of the Territorial body of the Federal State Statistics Service of the Republic of Belarus (Table C 51), Rosstat were analyzed. The study was conducted using k-means cluster analysis and rating, implemented in the Statistica system. Results. There is a significant increase in the death rate of the entire population of ZN in 41 municipalities. Analysis of standardized mortality rates shows that the mortality rate per 100 thousand of the population in the Republic of Belarus is lower than similar indicators in the Russian Federation. The exception is mortality in esophageal cancer, which is higher in both men and women than in the Russian Federation. It has been established that the regions of the fourth and fifth clusters are unfavorable in terms of mortality from MN. Discussion. Revealed a pronounced uneven distribution of the territory of the Republic of Belarus with a tendency to an increase in mortality from MN in many territories. It is possible that the main reasons for the increase in mortality rates are worsening socio-economic conditions, lower living standards, increased chemical stress in urbanized areas (air pollution), as well as insufficient promotion of healthy lifestyles among the population, preventive knowledge, and health problems. care, its poor quality. Conclusion. As a result of the analysis, it was possible to establish that cluster analysis allows us to identify areas that have similar problems related to the level and trends of mortality from malignant tumors.

Analysis of the level and structure of the incidence of the population of the KHMAO

2021 ◽  
Vol 22 (3) ◽  
pp. 82-89
Author(s):  
T. V. Razumova ◽  
◽  
T. V. Zuyevskaya ◽  
P. I. Pavlov ◽  
E. V. Sadrieva ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Russian Federation ◽  
Age Groups ◽  
Circulatory System ◽  
Federal District ◽  
Malignant Neoplasms ◽  
Number Of Patients ◽  
Working Age ◽  
The Russian Federation ◽  
Khanty Mansi Autonomous

Purpose of the study: assessment of the level and structure of the incidence of the population to determine the main categories of diseases most common in the Khanty-Mansi Autonomous Okrug-Yugra, as well as making a territorial comparison of the incidence of the population. Materials and research methods: statistical materials from the annual collection “Health of the population of the Khanty-Mansi Autonomous Okrug-Yugra and the activities of medical organizations” and data of statistical reporting on the incidence of the population from the Medstat program were used, in particular, the primary morbidity of the population of the Khanty-Mansi Autonomous Okrug-Yugra in different age groups, the general incidence the population of different age groups of the Khanty-Mansi Autonomous Okrug-Yugra. The analysis used indicators such as primary morbidity, general morbidity, one-year mortality (died within the first year from the date of diagnosis) in malignant neoplasms. Results. The primary morbidity of the population in the Khanty-Mansi Autonomous Okrug-Yugra tends to grow in all age groups. The indicators of primary morbidity of the population of the Khanty-Mansi Autonomous Okrug-Yugra in 2018 are 17.1% higher than in the Russian Federation and 12.2% higher than in the Ural Federal District. In the structure of primary morbidity, the first place is taken by diseases of the respiratory system, the second place in the structure of the primary morbidity of people over working age is taken by diseases of the circulatory system, and the third place is by diseases of the genitourinary system. The overall incidence rate of the entire population is 1896 per 1000 population. In 2018, 41.2 cases of tuberculosis per 100 thousand of the population were detected for the first time in the Khanty-Mansi Autonomous Okrug-Yugra (in the Ural Federal District – 61.6, in the Russian Federation – 44.4 per 100 thousand of the population). This pathology tends to decrease and compared with 2017 decreased by 10.2% (the Russian Federation decreased by 8.1%, the Ural Federal District – 2.1%). The number of patients with newly diagnosed HIV infection in 2018 decreased by 1.5% compared to 2017 and amounted to 82.3 per 100 thousand population, which is higher than in the Russian Federation (58.5), but lower. than in the Ural Federal District (108.2) per 100 thousand population. Since 2012, there has been a tendency towards an increase in the incidence of malignant neoplasms, but the detection rate of malignant neoplasms at stages III-IV has not changed since 2015 and is 39.5%, which is higher than in the Russian Federation (38.5%). Conclusion: the primary morbidity in the Khanty-Mansi Autonomous Okrug-Yugra in 2018 is 17.1% higher than in the Russian Federation. In the first place are diseases of the respiratory system (48.4%, of which in children – 66.4, and in persons of older working age – 22.2%). In second place in children is infectious pathology, and in people of working age – diseases of the genitourinary system. The second place in morbidity in older people of working age is diseases of the circulatory system. The district has a high level of infectious and parasitic diseases. The number of patients with newly diagnosed tuberculosis is lower than in the Ural Federal District and the Russian Federation. The number of patients with HIV infection is higher than in the Russian Federation, but lower than in the Ural Federal District. There is a tendency towards an increase in the number of malignant neoplasms. The number of neoplasms is lower than in the Ural Federal District and the Russian Federation. In the Khanty-Mansi Autonomous Okrug-Yugra, there is a positive trend in the reduction of socially significant diseases, such as tuberculosis, HIV infection, STIs, alcoholism, drug addiction, injuries and an increase in overall morbidity, including malignant neoplasms, which indicates the availability of medical care, health literacy of the population and carrying out appropriate preventive work.

scholarly journals Structure of Oncological Pathology and Survival of Patients with Malignant Tumors of the Eye and Adnexa (C69) Taking into Account Sex, Age and Histological Characteristics (Population Study)

2021 ◽  
Vol 18 (3) ◽  
pp. 578-583
Author(s):  
V. M. Merabishvili ◽  
E. N. Merabishvili
Keyword(s):  
Survival Rate ◽  
Russian Federation ◽  
Malignant Tumors ◽  
Federal District ◽  
Histological Structure ◽  
Cancer Register ◽  
The North ◽  
Anti Cancer ◽  
The Russian Federation ◽  
North Western

Objective. In February 2019, we completed work on creating a unified database of the population cancer registry of the NorthWestern Federal district of the Russian Federation. The development of data on the material of a large area significantly increases the reliability of the material under study, especially for RARE localities of malignant tumors, which include tumors of the eye and and adnexa.For the first time in Russia to present an analysis of the effectiveness of anti-cancer activities in relation to malignant tumors of the eye and adnexa (C69) at the Federal district level with calculations of 5-year survival rates of patients taking into account sex, age and histological structure of tumors.Methods. The development of the 5-year survival rate of patients with malignant tumors of the eye (C69) included information from the database created by us Population cancer register of all administrative territories of the North-Western Federal district of Russia for the period from 1999 to 2013, more than 1000 observations (1022).Results. The study revealed a positive dynamics of survival in patients of the North-Western Federal district of Russia with malignant tumors of the eye. The 5-year survival rate increased among males from 58.8 to 63.1 %, and among females from 64.7 to 69.6 %. A significant overestimation of the proportion of early stages among primary patients with malignant tumors of the eye and adnexa (C69) was found, which may be due to medical errors. Calculations of patient survival (with careful tracking of the deceased) allow us to get a more objective picture.Conclusion. Excellent achievements in the treatment of patients of advanced research centers and institutes can be welcomed only if similar successes are recorded at the population level and are available to all patients. Our in-depth development of population data in the Federal district confirmed the success in the treatment of patients with the malignant tumors of the eye and adnexa (C69), and the patterns we found first in the database of the Population cancer register of St. Petersburg, and now in the North-Western Federal district of the Russian Federation. Similar studies in other Federal districts could be an important component in the planning, monitoring and evaluation of anti-cancer measures in relation to the malignant tumors of the eye and adnexa (C69).

scholarly journals Stages of development of the system of objective assessment of the cancer service of Russia, the northwestern Federal district of the Russian Federation (morbidity, mortality, reliability of accounting, primary mortality, median survival, observed and relative survival of patients with malignant neoplasms). Part I.

2021 ◽  
Author(s):  
Vakhtang M. Merabishvili ◽  
Alexey M. Belyaev
Keyword(s):  
Russian Federation ◽  
Malignant Tumors ◽  
Objective Assessment ◽  
Relative Survival ◽  
Federal District ◽  
Cancer Registries ◽  
Malignant Neoplasms ◽  
Historical Outline ◽  
The Russian Federation

The first part of the study includes a brief historical outline on the creation of an objective system for assessing the activities of the oncological service in Russia and the Northwestern Federal District of the Russian Federation.Dynamic series of all types of indicators of the populations morbidity and mortality have been presented, an increasing process of reliability and improvement of the quality of registration of primary patients with malignant tumors has been shown.In Russia, aswell as in the Northwestern Federal District of the Russian Federation, standardized indicators of the malignant tumorsincidence remain at a relatively low level. In the world ranking of Cancer Registries, the Russian Federation is on 300th place among 450 others.The mortality rate of the population in most localizations isrecorded above the average European indicators.

scholarly journals Optimization of drug supply for patients with malignant neoplasms in a region of the Russian Federation

2020 ◽  
Vol 12 (4) ◽  
pp. 300-308
Author(s):  
A. V. Nikitina ◽  
F. V. Gorkavenko ◽  
Y. S. Saybel ◽  
M. V. Avxentyeva ◽  
M. S. Sura ◽  
...  
Keyword(s):  
Russian Federation ◽  
Patent Protection ◽  
Malignant Tumors ◽  
Fold Increase ◽  
Drug Consumption ◽  
Malignant Neoplasms ◽  
Baseline Scenario ◽  
Base Level ◽  
The Russian Federation ◽  
The Difference

The aim was to assess the possibility of optimizing the costs of drugs for cancer patients in a subject of the Russian Federation considering the expiration of patent protection period.Materials and methods. The possibility of optimizing the costs of antitumor drugs was studied using a model of a hypothetical region with a population of 2 million. A gradual replacement of the reference drugs with expiring patent protection by generics or biosimilars over 5 years was simulated. Two replacement scenarios were analyzed: 1) maintaining the drug consumption at a stable level; 2) increasing the drug consumption to the level identified in a previous retrospective analysis of the pharmaceutical market. The baseline scenario implied that the drug purchases remained unchanged (in physical and monetary terms) at the level of 2018. We calculated the difference between the drug costs in the baseline scenario and the costs of the same drugs replaced with generics or biosimilars for a 5 year period.Results. By gradually replacing the reference drugs with generics or biosimilars in a region with a population of 2 million and keeping the costs of drugs for solid tumors at the 352.2 million rubles for 5 years (baseline scenario), 69.4 million rubles can be saved. That amount represents 19.7% of the base level if the drug consumption remains at the 2018 level. With an increase in the INN consumption after the release of generics/ biosimilars, no saving is expected; on the contrary, expenses will increase by 14.1% to 400 million rubles, although, an 8.45-fold increase in consumption is projected.Conclusion. With the appearance of generics / biosimilars for the treatment of solid malignant tumors, the possibility of fund saving depends on the increase in drug consumption.

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