scholarly journals Optimization of drug supply for patients with malignant neoplasms in a region of the Russian Federation

2020 ◽  
Vol 12 (4) ◽  
pp. 300-308
Author(s):  
A. V. Nikitina ◽  
F. V. Gorkavenko ◽  
Y. S. Saybel ◽  
M. V. Avxentyeva ◽  
M. S. Sura ◽  
...  
Keyword(s):  
Russian Federation ◽  
Patent Protection ◽  
Malignant Tumors ◽  
Fold Increase ◽  
Drug Consumption ◽  
Malignant Neoplasms ◽  
Baseline Scenario ◽  
Base Level ◽  
The Russian Federation ◽  
The Difference

The aim was to assess the possibility of optimizing the costs of drugs for cancer patients in a subject of the Russian Federation considering the expiration of patent protection period.Materials and methods. The possibility of optimizing the costs of antitumor drugs was studied using a model of a hypothetical region with a population of 2 million. A gradual replacement of the reference drugs with expiring patent protection by generics or biosimilars over 5 years was simulated. Two replacement scenarios were analyzed: 1) maintaining the drug consumption at a stable level; 2) increasing the drug consumption to the level identified in a previous retrospective analysis of the pharmaceutical market. The baseline scenario implied that the drug purchases remained unchanged (in physical and monetary terms) at the level of 2018. We calculated the difference between the drug costs in the baseline scenario and the costs of the same drugs replaced with generics or biosimilars for a 5 year period.Results. By gradually replacing the reference drugs with generics or biosimilars in a region with a population of 2 million and keeping the costs of drugs for solid tumors at the 352.2 million rubles for 5 years (baseline scenario), 69.4 million rubles can be saved. That amount represents 19.7% of the base level if the drug consumption remains at the 2018 level. With an increase in the INN consumption after the release of generics/ biosimilars, no saving is expected; on the contrary, expenses will increase by 14.1% to 400 million rubles, although, an 8.45-fold increase in consumption is projected.Conclusion. With the appearance of generics / biosimilars for the treatment of solid malignant tumors, the possibility of fund saving depends on the increase in drug consumption.

scholarly journals SEGMENTATION OF TERRITORIES OF THE REPUBLIC OF BASHKORTOSTAN ON THE LEVEL OF MORTALITY FROM MALIGNANT NEOPLASMS

2019 ◽  
Vol 63 (1) ◽  
pp. 4-13
Author(s):  
P. A. Askarov ◽  
A. O. Karelin ◽  
I. A. Lakman ◽  
L. F. Rozanova ◽  
Zagira F. Askarova
Keyword(s):  
Cluster Analysis ◽  
Russian Federation ◽  
Malignant Tumors ◽  
Mortality Rates ◽  
Federal State ◽  
Malignant Neoplasms ◽  
Actual Problem ◽  
Republic Of Bashkortostan ◽  
The Russian Federation ◽  
The Republic

Malignant neoplasms are an actual problem due to their high prevalence, high level of disability, tendency to increase. The purpose of the study is the segmentation of the territories of the Republic of Bashkortostan (RB) by the level of mortality from malignant neoplasms (MN) as a whole by municipalities, as well as by gender and by localizations of malignant neoplasms. Material and methods. The data of official statistics of the Territorial body of the Federal State Statistics Service of the Republic of Belarus (Table C 51), Rosstat were analyzed. The study was conducted using k-means cluster analysis and rating, implemented in the Statistica system. Results. There is a significant increase in the death rate of the entire population of ZN in 41 municipalities. Analysis of standardized mortality rates shows that the mortality rate per 100 thousand of the population in the Republic of Belarus is lower than similar indicators in the Russian Federation. The exception is mortality in esophageal cancer, which is higher in both men and women than in the Russian Federation. It has been established that the regions of the fourth and fifth clusters are unfavorable in terms of mortality from MN. Discussion. Revealed a pronounced uneven distribution of the territory of the Republic of Belarus with a tendency to an increase in mortality from MN in many territories. It is possible that the main reasons for the increase in mortality rates are worsening socio-economic conditions, lower living standards, increased chemical stress in urbanized areas (air pollution), as well as insufficient promotion of healthy lifestyles among the population, preventive knowledge, and health problems. care, its poor quality. Conclusion. As a result of the analysis, it was possible to establish that cluster analysis allows us to identify areas that have similar problems related to the level and trends of mortality from malignant tumors.

scholarly journals MORBIDITY AND MORTALITY FROM MALIGNANT NEOPLASMS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS

2017 ◽  
Vol 4 (3) ◽  
pp. 33-50 ◽  
Author(s):  
O. P. Gretsova ◽  
A. A. Kostin ◽  
Yu. V. Samsonov ◽  
G. V. Petrova ◽  
M. Yu. Prostov ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Russian Federation ◽  
Malignant Tumors ◽  
Age Groups ◽  
Malignant Neoplasms ◽  
Cancer Register ◽  
Medicine Journal ◽  
The Russian Federation ◽  
First Time ◽  
Statistical Form

In this review we continue the publication of data on the problem of malignant neoplasms (MN) associated with human papillomavirus (HPV), in Russia. In a previous publication (Research’n Practical Medicine Journal 2016; 3(1): 66–78. DOI: 10.17709/2409-2231-2016-3-1-9) we at the first time presented the data on the incidence of malignant tumors associated with HPV in the Russian Federation for the period from 2009 to 2014. This article presents updated data on the incidence of in 2015, as well as data on mortality from the MN associated with HPV in Russia with the analysis of trends in men and women in different age groups. The statistics used in the article is calculated according to the annual state reporting documentation of the statistical form of the Ministry of health No. 7 and No. 35, forms 5 and Rosstat data, the combined database of the state of the cancer register of the Russian Federation.

scholarly journals Stages of development of the system of objective assessment of the cancer service of Russia, the northwestern Federal district of the Russian Federation (morbidity, mortality, reliability of accounting, primary mortality, median survival, observed and relative survival of patients with malignant neoplasms). Part I.

2021 ◽  
Author(s):  
Vakhtang M. Merabishvili ◽  
Alexey M. Belyaev
Keyword(s):  
Russian Federation ◽  
Malignant Tumors ◽  
Objective Assessment ◽  
Relative Survival ◽  
Federal District ◽  
Cancer Registries ◽  
Malignant Neoplasms ◽  
Historical Outline ◽  
The Russian Federation

The first part of the study includes a brief historical outline on the creation of an objective system for assessing the activities of the oncological service in Russia and the Northwestern Federal District of the Russian Federation.Dynamic series of all types of indicators of the populations morbidity and mortality have been presented, an increasing process of reliability and improvement of the quality of registration of primary patients with malignant tumors has been shown.In Russia, aswell as in the Northwestern Federal District of the Russian Federation, standardized indicators of the malignant tumorsincidence remain at a relatively low level. In the world ranking of Cancer Registries, the Russian Federation is on 300th place among 450 others.The mortality rate of the population in most localizations isrecorded above the average European indicators.

Malignant mesothelioma in the Russian Federation

2020 ◽  
pp. 646-646
Author(s):  
E. V. Kovalevskiy ◽  
S. V. Kashanskiy ◽  
I. M. Tskhomariia
Keyword(s):  
Malignant Mesothelioma ◽  
Russian Federation ◽  
Preventive Measures ◽  
Convincing Evidence ◽  
Malignant Neoplasms ◽  
Asbestos Fibers ◽  
The Russian Federation

One of the malignant neoplasms, which is associated with exposure to only one factor - asbestos fibers, is malignant mesothelioma. At the same time, today there is already convincing evidence of its polyetiology. This indicates the urgent need to expand research in this direction in order to develop targeted preventive measures.

The new in monitoring of provision of cancer care in the Russian Federation

2019 ◽  
Vol 2019 (4) ◽  
pp. 35-37
Author(s):  
Наталья Стадченко ◽  
Natal'ya Stadchenko
Keyword(s):  
Russian Federation ◽  
Treatment Guidelines ◽  
Malignant Tumors ◽  
Patient Specific ◽  
Insurance Fund ◽  
Medical Aid ◽  
Proven Case ◽  
The Russian Federation ◽  
Positive Results ◽  
Made In

The Federal Compulsory Medical Insurance Fund created the system of a monitoring of medical aid provided for the oncology patients, which allows realizing control over execution of the treatment guidelines on every stage. Changes been made in the governing documents, aimed at development of patient-specific records of provided medical aid at suspicion on the malignant tumors or in proven case of the malignant tumors. The article presents the data on control and expert activities demonstrating positive results of that work.

TREATMENT OF NICOTINE DEPENDENCE IN PATIENTS WITH ONCOLOGICAL DISEASES

2020 ◽  
Vol 66 (1) ◽  
pp. 7-12
Author(s):  
Petr Yablonskiy ◽  
Olga Sukhovskaya ◽  
I. Kulikov
Keyword(s):  
Smoking Cessation ◽  
Russian Federation ◽  
Withdrawal Syndrome ◽  
Malignant Tumors ◽  
Behavioral Therapy ◽  
Tobacco Consumption ◽  
The United States ◽  
Nicotine Addiction ◽  
World Health ◽  
The Russian Federation

Worldwide, tobacco use is a major behavioral risk factor for cancer. A comparative study conducted in 2017 showed that 7.10 million deaths were associated with smoking. Tobacco consumption not only increases the risk of developing various forms of cancer, but also reduces life expectancy after suffering a cancer, and increases the risk of relapse. In patients with lung cancer who underwent lung resection, smoking increased the risk of nosocomial mortality by three times and significantly increased the incidence of pulmonary complications. In addition to the localization and stage of cancer, abstinence from tobacco consumption has been noted as the strongest predictor of survival in cancer patients. In the United States, National Recommendations for Comprehensive Cancer Treatment (NCCN) included recommendations for the treatment of nicotine addiction, including 12 weeks of behavioral therapy (including telephone counseling) in combination with smoking cessation drugs for all patients receiving treatment in oncological clinics. Treatment of nicotine addiction has proven cost-effective: in particular, it has been shown for a smoking cessation program prior to surgical resection of the lung. Principles 5 A are recommended by the World Health Organization (WHO) to assist in the smoking cessation. There are national guidelines in other countries. In the Russian Federation, clinical guidelines “Tobacco addiction syndrome, tobacco withdrawal syndrome in adults” were adopted. Given the significant impact of smoking on the prognosis of cancer, the treatment of nicotine addiction should be an integral part of the treatment of malignant tumors. The most effective treatment is the combination of pharmacotherapy and cognitive-behavioral therapy. Teaching behavioral methods to overcome the withdrawal syndrome can be conducted by calling the to Quitline, organized by the Ministry of Health of the Russian Federation.

MORBIDITY, MORTALITY AND RELIABILITY OF ACCOUNTING OF PATIENTS OF DIFFERENT AGE GROUPS WITH LIVER CANCER IN RUSSIA

2020 ◽  
pp. 240-245
Author(s):  
В. М. Мерабишвили ◽  
В. К. Гуркало ◽  
Э. Н. Мерабишвили
Keyword(s):  
Liver Cancer ◽  
Russian Federation ◽  
Malignant Tumors ◽  
Primary Liver Cancer ◽  
Age Groups ◽  
Federal District ◽  
Cancer Register ◽  
The North ◽  
The Russian Federation ◽  
North Western

Рак печени (РП) - тяжелейшая онкопатология. В России смертность превышает число первично-учтенных больных в среднем. Ежегодно в России регистрируют более 8 тыс. (8 810 - в 2018 г.) случаев рака печени и более 10 тыс. (10 018 - в 2018 г.) случаев смерти от этой причины. Использованы стандартные методы медицинской статистики, все зарегистрированные первичные случаи РП в России. Углубленная разработка материала проведена на основе базы данных Популяционного ракового регистра Северо-Западного Федерального округа РФ. Проанализированы данные всего комплекса доступной информации в целом по России. Установлен прирост заболеваемости РП населения России за 18 лет в «грубых» показателях и абсолютных числах на 20% и в стандартизованных - на 1,22%. У женщин отмечено снижение учтенных случаев РП на 4,55%. Смертность населения России в стандартизованных показателях снизилась за 18 лет практически на 3%. Превышение числа умерших над заболевшими от РП существенно возрастает в старших возрастных группах. Индекс достоверности учета (ИДУ) - это отношение абсолютных чисел или «грубых» показателей смертности населения к заболеваемости. Для всех злокачественных новообразований (ЗНО) величина в среднем по России составила 0,47, практически совпадающая со среднеевропейской. ИДУ у мужчин - 0,55, выше расчетных показателей для женщин - 0,40, что в первую очередь связано с более благоприятной структурой заболеваемости женщин ЗНО. Медиана выживаемости первичных больных РП составляет немногим более 3 мес. Пятилетняя выживаемость больных РП даже на ранних стадиях составляет у лиц моложе 60 лет с I стадией - 25,3%, старше 60 лет - только 17,2%, со II стадией - 17,9 и 11% соответственно. Liver cancer is a severe oncopathology. Mortality exceeds the number of primary-accounted patients in Russia on average. Every year in Russia more than eight thousand (8 810 in 2018) cases of liver cancer and more than 10 000 (10 018 in 2018) deaths from this cause are registered. Used Standard methods of medical statistics, all registered primary cases of liver cancer in Russia. In-depth development of the material was carried out on the basis of the database of the Population cancer register of the North-Western Federal district of the Russian Federation. The analysis of the data of the whole complex of available information in Russia as a whole is carried out. In-depth data development was carried out on the basis of the database of the Population cancer register of the North-Western Federal district of the Russian Federation. The increase in the incidence of liver cancer in Russia over 18 years in «rough» indicators and absolute numbers by 20 % and in standardized by 1,22 % was established. In women, there was a decrease in reported cases of liver cancer by 4,55 %. The mortality rate of the Russian population in standardized indicators has decreased by almost 3 % over 18 years. The excess of the number of deaths over those from liver cancer increases significantly in older age groups. The index of reliability of accounting is the ratio of absolute numbers or «rough» indicators of mortality to morbidity. For all malignant tumors, its value on average in Russia was 0,47, almost coinciding with the average European. The index of reliability of accounting for men is 0,55, higher than the calculated indicators for women - 0,40, which is primarily due to a more favorable structure of the incidence of malignant tumors in women. The median survival of primary liver cancer patients is a little more than three months. The fi ve-year survival rate of patients with liver cancer even in the early stages is in the first among persons younger than 60 years - 25,3 %, over 60 years - only 17,2 %, in the second, respectively, 17,9 and 11%.

scholarly journals Immigration from the CIS countries to Russia in the context of the economic crisis in the Russian Federation

2018 ◽  
Vol 9 (4) ◽  
pp. 677-694
Author(s):  
Agnieszka Piekutowska ◽  
Monika Fiedorczuk
Keyword(s):  
Economic Crisis ◽  
Russian Federation ◽  
Labour Force ◽  
Gdp Per Capita ◽  
Russian Economy ◽  
Foreign Labour ◽  
The Russian Federation ◽  
Per Capita ◽  
The Difference ◽  
Cis Countries

Research background: A series of changes towards the greater openness to the influx of foreign labour force made in recent years in the Russian Federation prompts for analysis of immigration to this country as adopted solutions in the field of the migration policy affect other regions of destination (e.g. EU). Liberalisation of access of migrants to the Russian labour market is a part of a wider problem: competition (on an international scale) for an influx of foreign labour force. In this context, it is worth examining how the crisis which affected the Russian economy influenced the scale of immigration to Russia from the main sending countries, i.e. the countries of the Commonwealth of Independent States (CIS). Purpose of the article: The aim of the article is to show the impact of the crisis which affected the Russian economy in recent years on the scale of immigration from the CIS countries to Russia. The main hypothesis is as follows: the factor explaining immigration from the CIS countries to Russia is the difference in the level of income measured by GDP per capita (PPP) between the sending state and the country of destination. Such studies have not been undertaken so far and, due to the role of factors inherent in the concept of post-imperial migration, it becomes relevant to examine whether the factors shaping migration (including the differences in the level of income) recognised in the neoclassical theory of migration are important in explaining the flows in this area. Methods: In order to check the relationship between immigration and the economic crisis in Russia, the analysis of correlation and regression was used. Findings & Value added: It has been shown that despite the decline in GDP in Russia, immigration from the CIS countries to Russia is not decreasing. Therefore, it is a dependence different from the assumptions of the neoclassical economy according to which the reduction of differences in the level of income between the sending state and the country of destination reduces the scale of international migrations. As it has been shown, the scale of migration to Russia may not be explained by the difference in the level of GDP per capita in all CIS countries and, inter alia, political factors, conflicts or naturalisation processes become more important in shaping the scale of migration to Russia.

scholarly journals THE DISABILITY OF CITIZEN OF ELDERLY AGE IN THE RUSSIAN FEDERATION

2019 ◽  
Vol 61 (6) ◽  
pp. 292-299
Author(s):  
Marina A. Shurgaya
Keyword(s):  
Social Support ◽  
Health Care ◽  
Russian Federation ◽  
Disabled Persons ◽  
Regional Differentiation ◽  
Malignant Neoplasms ◽  
Urogenital System ◽  
Elderly Age ◽  
Gender Characteristics ◽  
The Russian Federation

During the period of health care reforming, study of a true picture of population health and medical social needs in particular age-gender groups, including elderly age, is a necessary condition for planning development of health care, social support and scientific substantiation of prevention programs. The article presents the results of comparative analysis of indices of disability of main age groups of adult population of the Russian Federation during 2005-2016. The methods of study: documentary, data sampling, statistical and graphic techniques. The volume of study made up to 34,840,933 individuals aged from 18 years and older, recognized as disabled, including disabled persons of elderly age - 12,971,062 individuals. The established characteristics of primary and repeated disability of citizen of elderly age in the Russian Federation (gender characteristics, nosological structure, regional differentiation) are covered that reflect demographic tendencies of aging of population. The dynamics of disability of citizen of elderly age during long term period (2005-2016) testifies alteration of ratio between primary and repeated established cases of disability. In 2005 overwhelming exceeding of primary recognized as disabled persons over repeatedly recognized was marked: 81.2% against 18.9%. In 2016 in total contingent of the examined the disabled persons with repeatedly established disability prevailed: 62.7% against 37.3%. During the period of observation, the level of repeatedly established disability among citizen of elderly age increased up to 74,5% (R2 = 0,546), whereas in contingents of young and middle age is marked a stable tendency to decreasing of value of indicator (R2 = 0,934, R2 = 0,5873 correspondingly). The citizen of elderly age prevails in the structure of disability due to malignant neoplasms, diseases of blood circulation system, diseases of musculoskeletal system and connective tissue, diseases of eye, ear and mastoid bone, diseases of endocrine, nervous and urogenital system. In connection with high invalidation, the elderly category of population is in need of significant medical social support. The development of activities targeted to medical social rehabilitation of citizen of elderly age it is appropriate considering regional differentiation of the subjects in the Russian Federation related to prevalence of disability and also gender characteristics of disability.

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