scholarly journals Mozart effect in patients with epilepsy

2021 ◽  
Vol 13 (3) ◽  
pp. 264-273
Author(s):  
Ya. B. Skiba ◽  
M. M. Odinak ◽  
A. Yu. Polushin ◽  
M. Yu. Prokudin ◽  
M. V. Selikhova ◽  
...  
Keyword(s):  
Epileptiform Activity ◽  
Epileptic Seizures ◽  
Musical Composition ◽  
Delayed Effect ◽  
Mozart Effect ◽  
Exclusion Criteria ◽  
Scientific Publications ◽  
Patients With Epilepsy

Objective: to analyze available publications assessing efficacy of the Mozart effect in patients with epilepsy.Material and methods. A search for scientific publications has been performed in PubMed, Scopus and eLibrary databases by retrieving inquiries "Mozart effect" and "epilepsy" in paper title, resume and keywords. As a result, 18 studies matching inclusion and exclusion criteria were selected. The data obtained were systematized into four categories: 1) whether a single listening of Mozart’s Sonata for Two Pianos in D major, K.448 affect interictal epileptiform activity (IEA) immediately during an event; 2) whether a repeated (course) of listening K.448 affect IEA; 3) is there a delayed effect on IEA after a single or repeated listening of K.448; 4) how does the Mozart effect act on rate of epileptic seizures during ongoing therapy course of listening K.448 or afterwards.Results. It was found that therapy with Mozart’s sonata K.448 may lower IEA index during a single listening of this musical composition and shortly afterwards. A lowered IEA index during a course listening of K.448 lasting for some time afterwards may be observed as well. Moreover, a repeated listening of K.448 may reduce rate of epileptic seizures within entire music course.Conclusion. The analysis revealed that there are currently some reasons to consider the Mozart effect as a means of neurostimulation impacting on rate of epileptic seizures and IEA.

scholarly journals Use of cannabidiol as a therapeutic method in epilepsy

2021 ◽  
Author(s):  
Mariana Soares ◽  
Ana Clara Mota Gonçalo ◽  
Kaline dos Santos Kishishita Castro ◽  
Victoria de Menezes Sá Lazera
Keyword(s):  
Cannabis Sativa ◽  
Epileptiform Activity ◽  
Neural Tissue ◽  
Epileptic Seizures ◽  
Cb1 Receptors ◽  
Study Results ◽  
Therapeutic Properties ◽  
Patients With Epilepsy ◽  
System Objective

Introduction: Cannabis sativa has several therapeutic properties and has been used for millennials for healing purposes. Among its benefits are analgesic, antiemetic and tranquilizing effects, acting strongly on the nervous system. Objective: This study aims to emphasize the importance of Cannabidiol as a therapeutic purpose for epilepsy, especially in Brazil, where its use is still controlled. Method: A systematic literature review, using bibliographic searches carried out in the electronic databases LILACS, PubMed and SciELO with the descriptors “cannabidiol” and “epilepsy”. Of 1645 searches found, 06 were used in the study. Results: Epileptic seizures can be generalized or partial and are determined by the affected area. The treatment for epilepsy are drugs that decrease the arousal capacity of neural tissue and a significant percentage of individuals cannot control them with traditional drugs alone. Endocannabinoids work in response to epileptiform activity, to activate CB1 receptors for excitatory neurons, to contain excess neuronal activity, which occurs during seizures. It is proven that patients who use it do not have toxic adverse effects. Conclusions: In Brazil, Cannabis is a controlled drug and the fact that it is imported, interfere in the treatment, who is interrupted while patient waits the new dosage. The importance of cannabidiol as a target for research and studies is verified, as it has ample potential in the treatment of epilepsy and reduces brain damage caused by it. In order that patients with epilepsy, have improvements in their quality of life.

scholarly journals Cognitive Impairments in Young Men Suffering from Epilepsy

2019 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Epileptiform Activity ◽  
Nervous Activity ◽  
Cognitive Disorders ◽  
Epileptic Seizures ◽  
Diagnostic Methods ◽  
Central System ◽  
Underlying Factor ◽  
Wide Range ◽  
Patients With Epilepsy

Epilepsy is a chronic disease of the central system with a wide range of neuropsychiatric disorders. Cognitive disorders are quite common with this disease and significantly reduce the quality of life of patients and their families. In approximately 35% of patients, despite treatment, various impairments of memory, attention and bradyphrenia persist in the interictal period. Causes of cognitive impairment in patients with epilepsy can be directly the underlying factor of epilepsy (genetic disease, structural brain defect, etc.), epileptic seizures, interictal epileptiform activity, side effects of antiepileptic drugs (AEDs). Modern neurophysiological and neuroimaging diagnostic methods allow us to identify new features of the course and progression of dysfunctions of higher nervous activity in epilepsy

scholarly journals Epilepsy combined with Wolf-Hirschhorn syndrome: a literature review and description of clinical cases

2019 ◽  
Vol 10 (4) ◽  
pp. 39-52
Author(s):  
M. B. Mironov ◽  
N. V. Chebanenko ◽  
S. O. Ayvazyan ◽  
S. A. Vladimirova ◽  
K. V. Osipova ◽  
...  
Keyword(s):  
Epileptiform Activity ◽  
Epileptic Seizures ◽  
Febrile Seizures ◽  
First Year ◽  
Eeg Activity ◽  
Epileptic Spasms ◽  
High Incidence ◽  
Clonic Seizures ◽  
First Year Of Life ◽  
Patients With Epilepsy

This article presents the anamnestic, clinical, electro-encephalographic and neuroimaging findings in 5 patients with epilepsy combined with Wolf-Hirschhorn syndrome (WHS). According to our data and the results of others, this combination has its specific characteristics. These include: a high incidence of epilepsy in patients with WHS (50-100% of cases), an early debut of seizures (mainly in the first year of life), fever-provoked seizures, and a variety of seizure types – focal paroxysms, bilateral tonic-clonic seizures, atypical febrile seizures, atypical absences and epileptic spasms. In addition, there may be frequent epileptic seizures tending toward status epilepticus, a slowing of the major EEG activity, a local EEG slowing (mainly in the posterior and bi-frontal areas), and regional / multiregional epileptiform activity. In more than 50% of cases, the diffuse peakwave activity is observed; the broad spectrum anti-epileptic drugs are highly efficient in 80% of cases. Based on this study, we propose recommendations for the management of patients with epilepsy combined with WHS.

Neurologist, 11 years’ experience, USA

2020 ◽  
pp. 63-67
Author(s):  
Markus Reuber ◽  
Gregg H. Rawlings ◽  
Steven C. Schachter
Keyword(s):  
Epileptiform Activity ◽  
Epileptic Seizures ◽  
Clinical Value ◽  
Interictal Eeg ◽  
Eeg Recordings ◽  
Patients With Epilepsy ◽  
Present Possibility ◽  
Epilepsy Monitoring

This chapter focuses on the clinical value of continued vigilance and neurologic follow-up after video-EEG (VEEG) confirmation of the diagnosis of Psychogenic Non-Epileptic Seizures (PNES), even when long-term EEG recordings over two separate admissions to an epilepsy monitoring unit have not captured any epileptiform activity. It has been shown that 19% of patients with epilepsy will not have interictal epileptiform abnormality during an admission for long-term VEEG monitoring. In particular, patients with extratemporal lobe epilepsies who have deep/mesial seizure foci and those with well-controlled epilepsies will be likely not to have epileptiform interictal EEG activity. In consideration of these observations, it has been advised that patients with PNES and non-epileptiform long-term EEG recordings should be followed by a neurologist for at least six months after discontinuation of antiepileptic drugs (AED). This consideration is due to the small but ever-present possibility of coexisting epilepsy as well as the observation that the risk of breakthrough epileptic seizures is highest during the initial six months after discontinuation of AEDs.

scholarly journals Mechanisms of Action and Safety of Exercise in Patients with Epilepsy (Review)

2020 ◽  
Vol 100 (6) ◽  
pp. 81-91
Author(s):  
K.V. Petrov ◽  
M.M. Petrova ◽  
N.A. Shnayder ◽  
R.F. Nasyrova
Keyword(s):  
Physical Activity ◽  
Structural Changes ◽  
Epileptiform Activity ◽  
Epileptic Seizures ◽  
Well Being ◽  
Juvenile Myoclonic Epilepsy ◽  
Mechanisms Of Action ◽  
High Level ◽  
Patients With Epilepsy ◽  
The Brain

Juvenile myoclonic epilepsy (JME) is a common form of genetic generalized epilepsy. The patients’ intellect and physical development are not affected. However, epilepsy is characterized by a high level of social stigmatization. This is the reason for unjustified restrictions and low physical activity of patients. The review examines the mechanisms of action of exercise on the brain in epilepsy, including the benefits of exercise for preventing seizures. Physical activity in epilepsy provides mechanisms for protecting neurons associated with biochemical and structural changes, including the release of β-endorphins and neurosteroids, which can have an inhibitory effecton the occurrence of abnormal (paroxysmal) electrical activity in the brain. Epileptiform activity on the electroencephalogram may decrease or disappear during exercise, which may reduce the risk of recurrent epileptic seizures. Although exercise can cause epileptic seizures in some patients, the risk is less than 2–10% or lower in JME. Rehabilitation programs that promote exercise in adolescents andyoung patients with epilepsy should aim to improve their physical, psychological, and social well-being.

The use of progesterone during pregnancy in women with epilepsy as an alternative to the correction of doses of anticonvulsants

GYNECOLOGY ◽  
2020 ◽  
Vol 21 (6) ◽  
pp. 12-15
Author(s):  
Elena V. Tsallagova ◽  
Vasily O. Generalov ◽  
Timur R. Sadykov
Keyword(s):  
Clinical Remission ◽  
Epileptic Seizures ◽  
Progesterone Concentration ◽  
Teratogenic Effects ◽  
Safe Alternative ◽  
Patients With Epilepsy

Pregnancy is the most dangerous period in terms of interruption of even persistent and long-term remission. At the same time increasing the dose of anticonvulsant increases the risk of teratogenic effects. Aim. to assess the possibility of using progesterone to prevent relapse of epileptic seizures during pregnancy. Materials and methods. 38 pregnant patients with epilepsy with clinical remission before pregnancy, with relapse of epileptic seizures in I trimester of pregnancy, age 31.81.4 years. Dydrogesterone in a dose of 10 to 60 mg/day was prescribed after the relapse of remission. Anticonvulsant dosage was not changed. The blood progesterone concentration and EEG control was carried out. Results. During pregnancy, the level of progesterone in the blood gradually increased from 77.8 nmol/l at 78 weeks of pregnancy to 521.1 nmol/l at 3637 weeks of pregnancy, without exceeding the limits. EEG results did not deteriorate. None of the patients had seizures during pregnancy. Conclusion. Progesterone therapy is an adequate and safe alternative to increasing the dose of anticonvulsants in case of recurrent seizures during pregnancy.

scholarly journals Perception about Etiology of Epilepsy and Help-Seeking Behavior in Patients with Epilepsy

2021 ◽  
Author(s):  
Gautam Das ◽  
Samar Biswas ◽  
Souvik Dubey ◽  
Durjoy Lahiri ◽  
Biman Kanti Ray ◽  
...  
Keyword(s):  
Help Seeking ◽  
Tertiary Care ◽  
Epileptic Seizures ◽  
Treatment Seeking ◽  
Professional Help ◽  
Epileptic Patients ◽  
Seeking Behavior ◽  
Tertiary Care Centers ◽  
Patients With Epilepsy

Abstract Objectives Patients with epilepsy and their family have diverse beliefs about the cause of their illness that generally determine their treatment-seeking behavior. In this study, our aim was to find out different beliefs about epilepsy that lead to different help-seeking patterns, which act as barrier to the intended modern medical management of epilepsy. Materials and Methods One hundred and fifty consecutive consenting patients accompanied by a reliable informant/family member fulfilling the International Classification of Epileptic Seizures (ICES), simplified version, were included. Demographic and clinical data of all the eligible subjects was collected. Perceived cause of illness and help-seeking pattern were explored from patient/informant by administering proper instruments. Results Respondents identified varied causes of epilepsy and explored multiple help-seeking options before reaching tertiary care centers. We observed that, generally, epileptic patients/relatives who had belief in causes like supernatural causes sought help from nonprofessional personnel and those attributed their symptom to bodily pathology had professional help-seeking. Conclusions The belief in supernatural causes not being conformed to the biomedical models of the epileptic disorders increases the treatment gap.

Comparison of Personality Characteristics on the Bear-Fedio Inventory Between Patients With Epilepsy and Those With Non-Epileptic Seizures

2012 ◽  
Vol 24 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Geoffrey Tremont ◽  
Megan M. Smith ◽  
Lyndsey Bauer ◽  
Michael L. Alosco ◽  
Jennifer D. Davis ◽  
...  
Keyword(s):  
Epileptic Seizures ◽  
Personality Characteristics ◽  
Patients With Epilepsy

scholarly journals Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy

2020 ◽  
Vol 78 (7) ◽  
pp. 424-429
Author(s):  
Ibrahim Halil YASAK ◽  
Mustafa YILMAZ ◽  
Murat GÖNEN ◽  
Metin ATESCELIK ◽  
Mehtap GURGER ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Epileptic Seizure ◽  
Epileptic Seizures ◽  
Healthy Individuals ◽  
Roc Curve Analysis ◽  
Remission Period ◽  
Significant Difference ◽  
Epileptic Attack ◽  
Patients With Epilepsy

ABSTRACT Objective: Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) enzyme levels were investigated in patients with epilepsy, epileptic seizure, remission period, and healthy individuals. Methods: Three main groups were evaluated, including epileptic seizure, patients with epilepsy in the non-seizure period, and healthy volunteers. The patients having a seizure in the Emergency department or brought by a postictal confusion were included in the epileptic attack group. The patients having a seizure attack or presenting to the Neurology outpatient department for follow up were included in the non-seizure (remission period) group. Results: The UCH-L1 enzyme levels of 160 patients with epilepsy (80 patients with epileptic attack and 80 patients with epilepsy in the non-seizure period) and 100 healthy volunteers were compared. Whereas the UCH-L1 enzyme levels were 8.30 (IQR=6.57‒11.40) ng/mL in all patients with epilepsy, they were detected as 3.90 (IQR=3.31‒7.22) ng/mL in healthy volunteers, and significantly increased in numbers for those with epilepsy (p<0.001). However, whereas the UCH-L1 levels were 8.50 (IQR=6.93‒11.16) ng/mL in the patients with epileptic seizures, they were 8.10 (IQR=6.22‒11.93) ng/mL in the non-seizure period, and no significant difference was detected (p=0.6123). When the UCH-L1 cut-off value was taken as 4.34 mg/mL in Receiver Operating Characteristic (ROC) Curve analysis, the sensitivity and specificity detected were 93.75 and 66.00%, respectively (AUG=0.801; p<0.0001; 95%CI 0.747‒0.848) for patients with epilepsy. Conclusion: Even though UCH-L1 levels significantly increased more in patients with epilepsy than in healthy individuals, there was no difference between epileptic seizure and non-seizure periods.

scholarly journals Violência doméstica contra a mulher gestante

2017 ◽  
Vol 11 (12) ◽  
pp. 4999
Author(s):  
Naiany Monise Gomes Ramalho ◽  
Josefa Danielma Lopes Ferreira ◽  
Carla Lidiane Jácome de Lima ◽  
Thalys Maynnard Costa Ferreira ◽  
Sayonara Lays Umbelino Souto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Domestic Violence ◽  
Pregnant Women ◽  
Violence Against Women ◽  
Exclusion Criteria ◽  
Scientific Publications ◽  
Cross Sectional ◽  
Wide Range ◽  
Factores De Riesgo ◽  
Violencia Domestica

RESUMOObjetivo: analisar as publicações científicas sobre a violência doméstica contra a mulher gestante. Método: revisão integrativa, com buscas nas bases de dados MEDLINE, SCOPUS, LILACS e BDENF, usando os descritores em português e inglês violência doméstica, mulher grávida e Enfermagem. Foram identificados 536 artigos. Após critérios de inclusão e exclusão, obtiveram-se 16 estudos que compuseram a amostra. A apresentação dos resultados e a discussão final foram feitas de forma descritiva, além de estatística simples por porcentagem e apresentados sob a forma de figuras. Resultados: dos estudos incluídos na revisão, 18,8% foram publicados em 2007. Quanto ao tipo de estudo, 56,3% foram estudos de corte transversal. Os tipos de violência mais retratados foram o sexual, o físico e o psicológico. Todos os estudos relatavam os fatores de risco para a violência contra a mulher gestante. Conclusão: analisando os estudos, foi possível identificar uma ampla gama de fatores de risco encontrados na literatura e a falta de registros sobre a assistência de saúde à mulher grávida em situação de violência. Descritores: Enfermagem; Violência Doméstica; Mulher Grávida; Violência Contra a Mulher; Cuidados De Enfermagem; Fatores de Risco.ABSTRACTObjective: to analyze the scientific publications on domestic violence against pregnant women. Method: integrative review, with searches in the MEDLINE, SCOPUS, LILACS and BDENF databases, using the descriptors in Portuguese and English, domestic violence, pregnant women and Nursing. A total of 536 articles were identified. After inclusion and exclusion criteria, we obtained 16 studies that composed the sample. The presentation of the results and final discussion was done in a descriptive way, in addition to simple statistics by percentage and presented in the form of figures. Results: of the studies included in the review, 18.8% were published in 2007. Regarding the type of study, 56.3% were cross-sectional studies. The types of violence most portrayed were sexual, physical and psychological. All studies reported the risk factors for violence against pregnant women. Conclusion: analyzing the studies, it was possible to identify a wide range of risk factors found in the literature and the lack of records on health care for pregnant women in situations of violence. Descriptors: Nursing; Domestic Violence; Pregnant Woman; Violence Against Women; Nursing Care; Risk Factors.RESUMENObjetivo: analizar las publicaciones científicas sobre la violencia doméstica contra la mujer gestante. Método: revisión integrativa, con búsquedas en las bases de datos MEDLINE, SCOPUS, LILACS y BDENF, usando los descriptores en portugués e inglés violencia doméstica, mujer embarazada y Enfermería. Se identificaron 536 artículos. Después de criterios de inclusión y exclusión, se obtuvieron 16 estudios que compusieron la muestra. La presentación de los resultados y la discusión final fueron hechas de forma descriptiva, además de estadística simple por porcentaje y presentados bajo la forma de figuras. Resultados: de los estudios incluidos en la revisión, el 18,8% fueron publicados en 2007. En cuanto al tipo de estudio, el 56,3%, fueron estudios de corte transversal. Los tipos de violencia más retratados fueron el sexual, el físico y el psicológico. Todos los estudios relataban los factores de riesgo para la violencia contra la mujer embarazada. Conclusión: analizando los estudios, fue posible identificar una amplia gama de factores de riesgo encontrados en la literatura y la falta de registros sobre la asistencia de salud a la mujer embarazada en situación de violencia. Descriptores: Enfermería; La Violencia Doméstica; Mujer Embarazada; Violencia Contra la Mujer; Atención de Enfermería; Factores de Riesgo.

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