scholarly journals Difficulties of diagnosing acute intermittent porphyria in clinical practice

2016 ◽  
Vol 97 (6) ◽  
pp. 975-978 ◽  
Author(s):  
K L Zagidullina ◽  
N A Popova ◽  
E E Astashina

Acute intermittent porphyria is an inherited metabolic disease with autosomal dominant inheritance pattern. The pathogenesis of the disease includes disturbed function of vegetative regulation. Attacks of acute intermittent porphyria are rare, sometimes are fatal, but in practice they often remain undiagnosed. Significant difficulties are attributed to unspecific clinical manifistations of acute intermittent porphyria. The patients initially visit surgeons with a clinical presentation of acute abdomen. As a result porphyrinogenic diagnostic and remedial procedures are administered including anesthetics and laparoscopy with anesthesia, which worsen the attack and prognosis. Porphyria being an orphan disease and polymorphism of clinical presentation, absence of medications for its treatment in health care facilities in Russian Federation cause challenges for physicians. The article deals with clinical observation of two patients with a diagnosis of acute intermittent porphyria first made in the neurology department. A 53-year old female was brought in to the neurology department by an ambulance in obtundation after a series of generalized tonoclonic spasms with hyperthermia. A 21-year old female was admitted to the surgical department due to intensive epigastric pain, nausea, repeated episodes of vomiting, an episode of diarrhea and significant general fatigue causing impossibility to move. Presented clinical cases reflect a general situation when for a long period of time the patients were wrongfully admitted to different departments, and cover a problem of late and untimely diagnosis of the disease.

1979 ◽  
Vol 135 (3) ◽  
pp. 269-272 ◽  
Author(s):  
David M. Ndetei ◽  
Joseph Muhangi

SummaryOne hundred and forty patients seen in a suburban walk-in walk-out clinic over a period of 30 days were studied. Twenty-eight (20 per cent) of them were found to be primarily psychiatrically disabled, 83 (59.3 per cent) primarily physically disabled and the diagnosis of the rest (20.7 per cent) was uncertain. The psychiatric patients were found to be suffering from anxiety and depressive states. Their sex, age, education, economic status, symptomatology and duration of the illness were analysed.The findings suggest among other things that the prevalence of psychiatric disorders in the rural setting in Kenya is high and therefore calls for a proportionate provision of mental health care facilities. They also suggest that anxiety and depression in African patients are masked by somatic symptoms, often leading to unnecessary delays in diagnosis and management.


2012 ◽  
Vol 21 (3) ◽  
pp. 75-84
Author(s):  
Venkata Vijaya K. Dalai ◽  
Jason E. Childress ◽  
Paul E Schulz

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.


Crisis ◽  
2003 ◽  
Vol 24 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Lourens Schlebusch ◽  
Naseema B.M. Vawda ◽  
Brenda A. Bosch

Summary: In the past suicidal behavior among Black South Africans has been largely underresearched. Earlier studies among the other main ethnic groups in the country showed suicidal behavior in those groups to be a serious problem. This article briefly reviews some of the more recent research on suicidal behavior in Black South Africans. The results indicate an apparent increase in suicidal behavior in this group. Several explanations are offered for the change in suicidal behavior in the reported clinical populations. This includes past difficulties for all South Africans to access health care facilities in the Apartheid (legal racial separation) era, and present difficulties of post-Apartheid transformation the South African society is undergoing, as the people struggle to come to terms with the deleterious effects of the former South African racial policies, related socio-cultural, socio-economic, and other pressures.


2017 ◽  
Vol 23 (2) ◽  
Author(s):  
JAMIL AHMED KHAN ◽  
RAJINDER PAUL

Poonch district of Jammu and Kashmir is a reservoir of enormous natural resources including the wealth of medicinal plants. The present paper deals with 12 medicinal plant species belonging to 8 genera of angiosperms used on pneumonia in cattle such as cows, sheep, goats and buffaloes in different areas of Poonch district. Due to poverty and nonavailability of modern health care facilities, the indigenous people of the area partially or fully depend on surrounding medicinal plants to cure the different ailments of their cattles. Further research on modern scientific line is necessary to improve their efficacy, safety and validation of the traditional knowledge.


Author(s):  
Agel Vidian Krama ◽  
Nurul Qamilah

Location Hospital and Health Center in Bandar Lampung and the District Pesawaran not currently mapped by conventional or digital. And there is no data base that provides information about the location and distribution of hospitals and health centers in Bandar Lampung City, and the uneven number of health facilities to ensure the availability of health services for all citizens, by optimizing existing health care facilities. Contributions utilization of spatial studies in the health field is used for mapping and modeling of health in order to facilitate access, provision of efficiency and planning of health services in order to take policy related to determining the location of health facilities. The research method uses spatial model approach with descriptive research type and analysis through the use of Huff Model. The results of the regionization shows the coverage area of hospital services serving 33 points in the District Pesawaran and 24 point Population in Bandar Lampung with the spread of regionization is divided into 3 regions. Keywords: Health Service, Regionalization


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