scholarly journals Inter- and intraindividual approaches to study functional and somatic reactionsof individuals

2015 ◽  
Vol 8 (3) ◽  
pp. 47-61
Author(s):  
E.I. Rasskazova
Keyword(s):  
Quality Of Life ◽  
Functional Condition ◽  
Normative Sample ◽  
Individual Sensitivity ◽  
Empirical Relationships ◽  
Subjective Stress ◽  
Somatic Condition ◽  
Adult Participants ◽  
Approaches To Study

Paper is devoted to comparisons of inter- and intra-individual approaches to study functional and somatic reactions of individuals to subjective stress in the normative sample. Adult participants (N=79) appraised stress level, experienced somatic symptoms and filled the test of the differentiated assessment of a functional condition within four days in the evenings. In addition, illness frequency and quality of life were estimated. According to the results, appraisals of subjective stress levels, irritability, joints movements’ difficulties, headaches and symptoms that are rare in normative sample should not be averaged due to high variability. Application of the intra-individual approach in addition to the inter-individual one allows revealing cases of individual resistance and mobilization of a functional and somatic condition under the stress. Different patterns of the empirical relationships with illness frequency and quality of life are revealed depending on whether the average estimates of a stress and functioning, or individual sensitivity to a stress are measured.

scholarly journals Regulatory adaptive status in determining the effectiveness of nebivololum and sotalolum in patients with hypertensive disease and paroxysmal supraventricular tachycardia

2017 ◽  
Vol 14 (4) ◽  
pp. 20-26
Author(s):  
N M Nazhalkina ◽  
V G Tregubov ◽  
V M Pokrovsky
Keyword(s):  
Quality Of Life ◽  
Combination Therapy ◽  
Supraventricular Tachycardia ◽  
Positive Impact ◽  
Subjective Assessment ◽  
Functional Condition ◽  
Paroxysmal Supraventricular Tachycardia ◽  
Drug Regimens ◽  
Minute Walk

Objective. Compare the effectiveness of treatment with nebivololum or sotalolum in patients with paroxysmal supraventricular tachycardia (SVT) on a background of essential hypertension (EH) taking into account quantitative evaluation of the regulatory adaptive status (RAS). Materials and methods. 49 patients with paroxysmal SVT against the background of EH of stages II-III took part in the research, they were randomized into two groups for treatment with nebivololum (7.4±1.9 mg/day n=25) or sotalolum (162.5±46.2 mg/day n=24). As part of combination therapy, patients were administered lisinoprilum (14.4±4.4 and 14.3±4.7 mg/day), when required also atorvastatinum (15.9±4.1 mg/day, n=9 and 16.0±4.8 mg/day, n=10), acetylsalicylic acid (93.1±16.2 mg/day, n=14 и 94.1±16.5 mg/day, n=14). Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of brachiocephalic arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of quality of life. Results. Both drug regimens comparably improved structural and functional condition of the heart, controlled arterial hypertension, effectively suppressed paroxysms of SVT, improved the quality of life. At the same time, the use of nebivololum increased the RAS and increased exercise tolerance to a greater degree than the use of sotalolum. Conclusion. In patients with paroxysmal SVT against the background of EH of stages II-III, the use of nebivololum as part of combination therapy may be preferable to sotalolum due to its positive impact on the RAS.

scholarly journals The results of a comparative study effectiveness of therapy with nebivolol and sotalol in patients with ventricular arrhythmias.

2018 ◽  
Vol 95 (11) ◽  
pp. 1050-1056
Author(s):  
V. G. Tregubov ◽  
Iosif Z. Shubitidze ◽  
S. G. Kanorskii ◽  
V. M. Pokrovsky
Keyword(s):  
Quality Of Life ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Essential Hypertension ◽  
Combination Therapy ◽  
Ventricular Arrhythmias ◽  
Positive Impact ◽  
Functional Condition ◽  
Grading System

Aim. Compare the effectiveness of nebivolol and sotalol in patients ventricular arrhythmias (VA) given its impact on the regulatory adaptive status (RAS). Material and methods. 60 patients with VA of grade I-IV based on the В.Lown grading system, I-II groups based on J.T. Bigger grading system against the background of essential hypertension and/or coronary heart disease took part in the research, they were randomized into two groups for treatment with nebivolol (6,5 ± 2,1 mg/day) and sotalol (166,7 ± 49,4 mg/day). As part of combination therapy, patients were administered lisinopril (13,7 ± 4,5 mg/day and 14,0 ± 4,6 mg/day), acetylsalicylic acid when required (92,9 ± 18,2 mg/day and 95,5 ± 15,1 mg/day), atorvastatin (16,5 ± 4,7 mg/day and 15,7 ± 5,1 mg/day) in addition to nebivolol and sotalol, respectively. Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of common carotid arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of quality of life. Results. Both drug regimens comparably improved structural and functional condition of the heart, increased controlled arterial hypertension, effectively suppressed ventricular arrhythmia, improved the quality of life. Nebivolol positively affected the RAS and increased exercise tolerance more. Conclusion. In patients with VA against the background of essential hypertension and/or coronary heart disease as part of combination therapy the use of nebivolol may be preferable to sotalol due to its positive impact on the RAS.

scholarly journals Glucocorticosteroids for people with alcoholic hepatitis (Cochrane review)

2019 ◽  
Vol 91 (8) ◽  
pp. 52-66
Author(s):  
Chavdar S Pavlov ◽  
Daria L Varganova ◽  
Giovanni Casazza ◽  
Emmanuel Tsochatzis ◽  
Dimitrinka Nikolova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adverse Events ◽  
Alcoholic Hepatitis ◽  
Health Related Quality ◽  
Serious Adverse Events ◽  
Adult Participants ◽  
All Cause Mortality ◽  
Related Quality ◽  
Health Related

Alcoholic hepatitis (AH) is a form of alcoholic liver disease. Glucocorticosteroids (GCS) are used as anti - inflammatory drugs for people with alcoholic hepatitis. Aim. To assess the benefits and harms of GCS in people with AH. Material and methods. We identified trials through electronic searches in Cochrane Hepato-Biliary's (CHB) Controlled Trials Register, CENTRAL, MEDLINE, Embase, LILACS, and Science Citation Index Expanded. We considered for inclusion randomised clinical trials (RCTs) assessing GCS versus placebo/no intervention in adult participants with AH. We allowed co - interventions in the trial groups if they were similar. We followed Cochrane methodology, CHB Group methodology using Review Manager 5 and Trial Sequential Analysis(TSA) to perform meta - analysis (M-A), assessed bias risk of the trials, certainty of evidence using GRADE. Results and discussion. Sixteen trials fulfilled the inclusion criteria. Fifteen trials provided data for analysis (927 participants received GCS, 934 - placebo/no intervention). The GCS were administered to adult participants at different stages of AH orally or parenterally for a median of 28 days. There was no evidence of effect of GCCs on our primary outcomes all - cause mortality up to 3 months following randomisation (RR 0.90, 95% CI 0.70-1.15; n=1861), on health - related quality of life (MD - 0.04 points; 95% CI -0.11-0.03; n=377; trial = 1) (EQ-5D-3L scale), on the occurrence of serious adverse events during treatment (RR 1.05, 95% CI 0.85-1.29; n=1861). We found no evidence of a difference between the intervention groups. The risk of bias was high in all the trials except one. The certainty of evidence was very low or low. One of the trials seems to be not industry - funded. Conclusion. We found no evidence of a difference between GCS and placebo or no intervention on all - cause mortality, health - related quality of life, and serious adverse events during treatment. We cannot exclude increases in adverse events and cannot rule out significant benefits and harms of GCSs. Future trials ought to report depersonalised individual participant data.

scholarly journals The Association Between Different Kinds of Exercise and Quality of Life in the Long Term. Results of a Randomized Controlled Trial on the Elderly

2014 ◽  
Vol 10 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Gioia Mura ◽  
Federica Sancassiani ◽  
Gian Mario Migliaccio ◽  
Giorgia Collu ◽  
Mauro Giovanni Carta
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Controlled Trial ◽  
Vigorous Physical Activity ◽  
Normative Sample ◽  
Randomized Controlled ◽  
Activity Program ◽  
Over Time

Introduction: Quality of Life (QoL) tends to decrease with age. Exercise has been shown to be effective in improving some psychosocial features related to QoL. We carried out a randomized controlled trial to verify the long-term efficacy of an intensive fitness program versus a lighter program on the QoL of an elderly sample, compared to QoL of a large normative sample. Methods: Participants aged ≥65 years were randomly assigned in a 1:1 fashion either to a vigorous physical activity program group (VAG) or to a postural gymnastic group (PGG). Depressive symptoms were screened by PHQ-9. QoL assessment was done by SF-12. Multivariate analysis of variance (MANOVA) was conducted to test differences between the two groups over time. Comparison with the normative sample was carried out by means of ANOVA 1-way. Results: Both VAG and PGG showed low PHQ9 scores at the beginning and at the end of the trial, indicating the absence of depressive symptoms. At the end of the study, both groups had a higher level of QoL, measured by means of SF-12, than the normative standardized sample. While SF-12 scores for both groups decreased slightly 12 weeks after the end of the trial, only the VAG group maintained significantly-higher scores than those of the normative sample. Conclusions: A vigorous physical activity program group might be associated with better maintenance of results over time as compared to a postural gymnastic program. These results require future confirmation by further studies on large samples.

SOCIO-DEMOGRAPHIC AND MEDICO-BIOLOGICAL FACTORS AS PROGNOSTIC INDICATORS OF QUALITY OF LIFE IN EARLY CHILDHOOD

2021 ◽  
Vol 55 (1 (254)) ◽  
pp. 75-84
Author(s):  
Siranush А. Mkrtchyan ◽  
Razmik А. Dunamalyan ◽  
Lilit E. Gukasyan ◽  
Marine А. Mardiyan
Keyword(s):  
Quality Of Life ◽  
Medical Science ◽  
Risk Groups ◽  
Health Condition ◽  
Family Type ◽  
Prognostic Indicators ◽  
Artificial Nutrition ◽  
Biological Factors ◽  
Somatic Condition

Patient’s quality of life (QL) measures are endowed with independent predictive value and these factors are considered to be more distinct than patient’s general somatic condition for predicting patient’s health condition. However, the number of researches devoted to QL prediction in the field of medical science is low. The aim of research is evaluation of predictive measure of QL of early aged children. Prospective observational study was carried out. The objects of the research were 2362 early age children (3months-3years old) from pediatric polyclinics of Yerevan. QL of children was evaluated with the international questionnaire “QUALIN”. Wald’s analytical method has been applied for predictive evaluation of QL criteria and formation of risk group. For the analysis and evaluation of the statistical material used SPSS Statistics software package. In social-hygienic factors more important were: family type, conflicts in family, disabled child and frequent morbidity families, presence of artificial nutrition since birthday. Among medico-biological factors the presence of two or more diseases in neonatal period, low and high levels of physical development, weight deficit and obesity, child’s health group and respiratory, nervous and digestive system diseases were more significant. In terms of predictive evaluation of QL, it can be stated that a number of medico-biological and socio-hygienic factors affect the overall formation of QL. By means of predictive evaluation of QL one can originally set apart targeted risk groups and if the score of predictive evaluation is +13 and higher, implement health measures, which may provide with improvements of QL criteria.

The inclusion of happiness in multidimensional studies of the quality of life

2019 ◽  
Vol 64 (1) ◽  
pp. 52-57
Author(s):  
Wiesława Gierańczyk ◽  
Marzena Leszczyńska
Keyword(s):  
Quality Of Life ◽  
European Social Survey ◽  
Subjective Quality Of Life ◽  
Social Survey ◽  
Gross National Happiness ◽  
Economic Problems ◽  
National Welfare ◽  
Approaches To Study ◽  
Definition Of

The objective of the article is to present the complexity and diversity of methodical approaches to study the quality of life, including the category of happiness. An attempt was made to quantify the subjective quality of life based on Polish research, among others, Social Cohesion Research (BSS, conducted since 2011), European Survey of Living Conditions (EU-SILC, since 2005) and Social Diagnosis (DS, from 2000) and international research, among others Gross National Happiness (GNH, from 1972), European Quality of Life Survey (EQLS, since 2003), European Social Survey (ESS, since 2002) and Measurement of National Welfare, implemented by the Office for Nation-al Statistics in Great Britain (ONS, from 2010). The analyzes carried out show that the researchers did not accept one valid definition of happiness; there is also no one way to measure it. Common approaches to studying the problems of happiness include the conviction that the quality of life and the sense of happiness of citizens are the same priority as measurable economic problems.

scholarly journals Radionuclide study in gastroparesis: Is it still relevant?

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Mohamad Shahrir Abdul Rahim ◽  
Ibrahim Lutfi bin Shuaib ◽  
Sazilah binti Ahmad Sarji
Keyword(s):  
Quality Of Life ◽  
Clinical Symptoms ◽  
Gastrointestinal Symptoms ◽  
Mechanical Obstruction ◽  
Radionuclide Scintigraphy ◽  
Radionuclide Study ◽  
Approaches To Study ◽  
High Index Of Suspicion

The incidence of gastroparesis in Malaysia is not well documented. Gastroparesis may present with various combinations of debilitating sign and symptoms that decrease quality of life and increases morbidity. It is diagnosed based on clinical symptoms and exclusion of the obstruction. There should be a high index of suspicion in patients who present with symptoms to avoid missing the diagnosis. There are various approaches to study the gastric motility. Here’s a case of a young adult woman with type 1 diabetes mellitus suffering severe gastrointestinal symptoms. In this case, radionuclide scintigraphy is used as one of the investigation to confirm the diagnosis of gastroparesis. Radionuclide scintigraphy remains a hallmark in the diagnosis of gastroparesis after excluding mechanical obstruction.

scholarly journals Beneficial effects of spa treatment on functional status and quality of life of patients with rheumatoid arthritis

2008 ◽  
Vol 136 (7-8) ◽  
pp. 391-396 ◽  
Author(s):  
Dusan Mustur ◽  
Vladislava Vesovic-Potic ◽  
Nada Vujasinovic-Stupar ◽  
Tatjana Ille
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Functional Status ◽  
Climatic Factors ◽  
Short Form ◽  
Functional Condition ◽  
Spa Therapy ◽  
Physical Factors ◽  
Sf 36

INTRODUCTION Rheumatoid arthritis (RA) is a chronic constantly deteriorating disease of unpredictable clinical course, with exacerbations, remissions and damaged joints. It leads to the loss of self-sufficiency, independence in performing many daily activities, decrease of working ability and invalidity. Beside physical factors, which are regarded as most responsible for the poorer quality of life of RA patients, psychological changes are also significant, such as the feeling of helplessness, hopelessness and depression. The goal of the treatment of patients with RA is to decrease illness symptoms, slow down the development of illness progression, improvement of physical functioning and provision of expert help to the RA patients to adapt to life. OBJECTIVE The aim of the study was to assess the influence of spa therapy on the functional condition and life quality of RA patients. METHODS The study involved 69 patients with RA (51 female and 18 male, on average aged 55.2?11.4 years, with illness duration 12.5?7.5 years), and were a part of a cohort from Norway, suffering of inflammatory rheumatism. All the patients came for four-week rehabilitation at the Institute for Physical Medicine, Rehabilitation and Rheumatology "Dr. Simo Milosevic" in Igalo, Montenegro. The RA patients underwent treatment with mud compresses, mud, mineral and pearl baths, as well as with underwater shower massage (balneotherapy) kinesitherapy and certain forms of electrotherapy with analgesic effects. The evaluation was done on admission and after completed physical therapy when we assessed RA patients' functional condition and quality of life. The functional condition was determined using the Modified Health Assessment Questionnaire (MHAQ), and the quality of life using the Medical Outcomes Study Short Form 36-item Questionnaire (SF-36), which encompassed eight life domains. RESULTS After completion of 28-dayspa therapy, RA patients showed a significant improvement in functional condition. Their quality of life was significantly improved in all dimensions of SF-36 Questionnaire (p<0.01), and the functional status (MHAQ score) was also significantly better (p<0.01). CONCLUSION Balneotherapy, together with climatic factors in Igalo, leads to a significant improvement of functional status and quality of life in patients suffering from RA.

P771Metoprolol succinate efficacy in patients with chronic heart failure on the background of obesity: genetic aspects of individual sensitivity and tolerability

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
I Gasanov ◽  
O Medentseva ◽  
I Rudyk ◽  
V Galchinskaya
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Heart Rate ◽  
Chronic Heart Failure ◽  
Left Ventricle ◽  
Control Group ◽  
Individual Sensitivity ◽  
Cyp2d6 Gene ◽  
Metoprolol Succinate

Abstract Background The cornerstone of modern cardiology is the problem of comorbidity, the combination of chronic heart failure (CHF) with obesity as well. Efficacy of treatment with beta-blockers in different patients varies significantly, partly depending on genotypically determined features of its metabolization with enzymes. Purpose To improve the CHF treatment with metoprolol succinate efficacy in patients with obesity by detection of genetic aspects of individual sensitivity and tolerability. Methods A prospective randomized dynamic (1 year) study was conducted involving 127 patients with CHF II–III stages at the age of 32–87 years; they were distributed into main group with combination of CHF and obesity (73 patients) and control group with only CHF (54 patients). The examination included an assessment of CYP2D6 gene 1846G/A polymorphism, clinical symptoms, quality of life (by Minnesota questionnaire), 6-minute walk test data, doppler echocardiography, heart rate variability, serum insulin, N-terminal prohormone of brain natriuretic peptide (NT-proBNP). Metoprolol succinate was administered according to a standard regimen with dose titration every 2 weeks from 12.5 to 100–200 mg. The critical p-level was 0.05. Results An association of “unfavorable” allele A with an increase in body weight was found (p=0.05). As a result of treatment, better indicators of the clinical status were found in control group (6 [5; 7] versus 7 [6; 8] points in obese patients, p=0.05) and quality of life in patients with genotype GG than the GA genotype (p<0,05). The use of metoprolol succinate in patients with GG genotype is associated with more pronounced positive dynamics of treatment efficacy. In contrast to the carriers of the GA genotype, in patients with the GG genotype there were an increase in left ventricle ejection fraction (by 21.5% versus 9.3%, p<0.01) and the reduction of the left ventricle end-diastolic size (p=0.02). The GG genotype carriers significantly increased the amount of exercise tolerance (p<0.05), and showed a more pronounced improvement in quality of life (p<0.03) and the clinical state (p=0.05), as well as the normalization of the vegetative balance (LF/HF index). The level of serum NT-proBNP in the GG genotype was lower than in patients with GA genotype (p=0.05). At the same time, patients with a GA genotype showed a more pronounced decrease in heart rate compared to those with a GG genotype (p<0.05). In carriers of the GA genotype, a tendency to a greater incidence of side effects compared with the GG genotype (bradycardia 42.0% vs. 28.0%, p<0,05; cold extremities 44.0% vs. 32.0%, p<0.05, fatigue 39.0% vs. 31.0%, p<0.05, headache 32.0% vs. 24.0%, p<0,10, drowsiness 38,0% vs. 27,0%, p<0,05). Conclusions It is useful to take into account the CYP2D6 gene 1846G/A polymorphism in order to improve the CHF treatment with metoprolol succinate in patients with obesity.

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