An Analysis Of The Strategic Effect Of Lnformation System On The Lmmunity Enhancement Of Gallbladder Patients

This paper is to conduct a strategic analysis of the information system to improve the immunity system of gallbladder cancer patients. The subjects of the study were 146 people who visited internal medicine clinics located in Chungcheong Province from March 11 to May 13, 2019. The group of people who mediated the information system was classified as 53 people and those who did not mediated the information system were classified as 53 people. The change in patient condition was analyzed as t-test following the application of the information system. The application of the body’s immune system to the information system was measured at 4, 8, 12, 16, 20 and 24 weeks. The results of this study are as follows. First, LDL, a bad cholesterol decreased significantly after the information system was applied(t=3.72, p<.05). Second, the physical immunity continued to increase after the application of the information system. However, the body's immunity has tended to decline since the 16th. Therefore, to prevent the incidence of gallbladder cancer, diet management such as greasy and meat diet is required.

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Paradigm shift? Should a lymphadenectomy routinely be performed also among gallbladder cancer patients with T1a disease?

10.26226/morressier.59a6b347d462b80290b54db1 ◽

2017 ◽

Author(s):

Mathias Worni

Keyword(s):

Gallbladder Cancer ◽

Cancer Patients ◽

Paradigm Shift

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The patients’ perspective on coordinated action for cancer and AMR

European Journal of Public Health ◽

10.1093/eurpub/ckaa165.1153 ◽

2020 ◽

Vol 30 (Supplement_5) ◽

Author(s):

K Apostolidis

Keyword(s):

Quality Of Life ◽

Immune System ◽

Cancer Patients ◽

Cancer Treatments ◽

Unique Challenge ◽

Coordinated Action ◽

The Impact ◽

Patients Perspective

Abstract The speaker will present the perspective of the cancer patients, and the challenges they encounter across the spectrum of care and what measures they consider relevant in terms of prevention, diagnosis, treatment and, indeed, to raise awareness of the impact of AMR on rendering cancer treatments ineffective. She will elaborate on survivorship, and on the impact of AMR on the quality of life of patients, their carers, and families. Emphasis will be given on the implications of modern therapies, such as immunotherapy, representing a unique challenge in terms of better understanding the effect on overall health of patients, with the effect they have the immune system, further weakening the patient and leaving him/her exposed to infections potentially of higher risk than cancer itself.

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Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy

Cancer Biomarkers ◽

10.3233/cbm-210086 ◽

2021 ◽

pp. 1-11

Author(s):

Nontiya Homkham ◽

Pooriwat Muangwong ◽

Veeradej Pisprasert ◽

Patrinee Traisathit ◽

Rungarun Jiratrachu ◽

...

Keyword(s):

Head And Neck Cancer ◽

Immune System ◽

Cancer Patients ◽

Concurrent Chemoradiotherapy ◽

Absolute Lymphocyte Count ◽

Diet Group ◽

Cancer Therapies ◽

Dynamic Changes ◽

Regular Diet ◽

Over Time

BACKGROUND: Immune-enhancing nutrition (IMN) strengthens the systematic inflammatory response and the immune system. Neutrophil to lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) are affected during cancer therapies. OBJECTIVE: We carried out an analysis of the dynamic changes in NLR and ALC over time in cancer patients with or without IMN supplementation. METHODS: 88 cancer patients receiving concurrent chemoradiotherapy (CCRT) were randomized into regular diet group, and regular diet and IMN group.Generalized estimation equation models were used to assess associations between patient’s characteristics, IMN, and dynamic changes in NLR and ALC over time. RESULTS: NLR and ALC at preCCRT were significantly associated with dynamic changes in NLR (adjusted β= 1.08, 95% confidence interval [CI]: 0.64–1.52) and ALC (adjusted β= 0.41, 95% CI: 0.36–0.46). The magnitudes of the NLR and ALC changes through CCRT were lower in patients receiving IMN, although the differences were not statistically significant except ALC at the end of CCRT in head and neck cancer patients (P= 0.023). CONCLUSION: Dynamic negative changes in both markers were demonstrated throughout CCRT. There were non-significant trend in promising changes in both NLR and ALC values in the whole group in IMN supplementation.

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T-Cell Immunity to the Folate Receptor Alpha Is Prevalent in Women With Breast or Ovarian Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2006.05.9311 ◽

2006 ◽

Vol 24 (26) ◽

pp. 4254-4261 ◽

Cited By ~ 44

Author(s):

Keith L. Knutson ◽

Christopher J. Krco ◽

Courtney L. Erskine ◽

Karin Goodman ◽

Linda E. Kelemen ◽

...

Keyword(s):

Ovarian Cancer ◽

Immune System ◽

T Cell ◽

Cancer Patients ◽

Folate Receptor ◽

Prediction Algorithm ◽

Amino Terminus ◽

Folate Receptor Alpha ◽

Receptor Alpha ◽

Healthy Donors

Purpose Studies have demonstrated that the generation of immunity to tumor antigens is associated with improved prognosis for many cancers. A candidate antigen is the folate receptor alpha (FRα), which is overexpressed in breast and ovarian cancers. Our goal in this study was to attain a better understanding of the extent of endogenous FRα immunity. Methods Using a CD4+ T cell epitope prediction algorithm, we predicted promiscuous epitopes of FRα, and tested for immunity in 30 breast (n = 17) or ovarian (n = 13) cancer patients and 18 healthy donors using enzyme-linked immunospot analysis. Results Fourteen peptides were predicted, seven each from the carboxy- and amino-terminus halves of the protein. More than 70% of patients demonstrated immunity to at least one FRα peptide. Patients responded to an average of 3 ± 0.5 peptides, whereas healthy donors responded to 1 ± 0.4 peptides (P = .004). Five peptides were recognized by more than 25% of patients. Responses to three peptides were higher (P < .05) in patients than in healthy donors, suggesting augmented immunity. Compared with healthy individuals, patients developed higher immunity to the amino-terminus half of the receptor (P = .03). There was no difference between each group in the responses to nonspecific (P = .2) and viral stimuli (P = .5). Lastly, patients demonstrated elevated levels of FRα antibodies consistent with a coordinated immune response. Conclusion These findings demonstrate that the FRα is a target of the immune system in breast and ovarian cancer patients. Understanding which antigens are targeted by the immune system may be important for prognosis or immune-based therapies.

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Explainable Transformer-Based Neural Network forthe Prediction of Survival Outcomes in Non-SmallCell Lung Cancer (NSCLC)

10.1101/2021.10.11.21264761 ◽

2021 ◽

Author(s):

Gustavo Arango ◽

Elly Kipkogei ◽

Etai Jacob ◽

Ioannis Kagiampakis ◽

Arijit Patra

Keyword(s):

Immune System ◽

Precision Medicine ◽

Cancer Patients ◽

Patient Survival ◽

Response To Therapy ◽

Survival Models ◽

Attractive Alternative ◽

Survival Prediction ◽

Molecular Features ◽

Clinical Measurements

In this paper, we introduce the Clinical Transformer - a recasting of the widely used transformer architecture as a method for precision medicine to model relations between molecular and clinical measurements, and the survival of cancer patients. Although the emergence of immunotherapy offers a new hope for cancer patients with dramatic and durable responses having been reported, only a subset of patients demonstrate benefit. Such treatments do not directly target the tumor but recruit the patient immune system to fight the disease. Therefore, the response to therapy is more complicated to understand as it is affected by the patients physical condition, immune system fitness and the tumor. As in text, where the semantics of a word is dependent on the context of the sentence it belongs to, in immuno-therapy a biomarker may have limited meaning if measured independent of other clinical or molecular features. Hence, we hypothesize that the transformer-inspired model may potentially enable effective modelling of the semantics of different biomarkers with respect to patient survival time. Herein, we demonstrate that this approach can offer an attractive alternative to the survival models utilized incurrent practices as follows: (1) We formulate an embedding strategy applied to molecular and clinical data obtained from the patients. (2) We propose a customized objective function to predict patient survival. (3) We show the applicability of our proposed method to bioinformatics and precision medicine. Applying the clinical transformer to several immuno-oncology clinical studies, we demonstrate how the clinical transformer outperforms other linear and non-linear methods used in current practice for survival prediction. We also show that when initializing the weights of a domain-specific transformer by the weights of a cross-domain transformer, we further improve the predictions. Lastly, we show how the attention mechanism successfully captures some of the known biology behind these therapies

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Infrequent mismatch repair protein loss in gallbladder cancer patients in Japan

Virchows Archiv ◽

10.1007/s00428-016-2043-5 ◽

2016 ◽

Vol 470 (1) ◽

pp. 109-112

Author(s):

Hiroshi Yoshida ◽

Kazuaki Shimada ◽

Nobuyoshi Hiraoka

Keyword(s):

Gallbladder Cancer ◽

Cancer Patients ◽

Mismatch Repair ◽

Protein Loss ◽

Repair Protein ◽

Mismatch Repair Protein

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Influence of physical activity on the immune system in breast cancer patients during chemotherapy

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-017-2573-5 ◽

2018 ◽

Vol 144 (3) ◽

pp. 579-586 ◽

Cited By ~ 9

Author(s):

Thorsten Schmidt ◽

Walter Jonat ◽

Daniela Wesch ◽

Hans-Heinrich Oberg ◽

Sabine Adam-Klages ◽

...

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Immune System ◽

Cancer Patients ◽

Breast Cancer Patients

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Oncology education for Canadian internal medicine residents: the value of participating in a medical oncology elective rotation

Current Oncology ◽

10.3747/co.25.3934 ◽

2018 ◽

Vol 25 (3) ◽

pp. 213

Author(s):

N.A. Nixon ◽

H. Lim ◽

C. Elser ◽

Y.J. Ko ◽

R. Lee-Ying ◽

...

Keyword(s):

Internal Medicine ◽

End Of Life ◽

Cancer Patients ◽

Online Survey ◽

Medical Oncology ◽

Comfort Level ◽

Cancer Knowledge ◽

Self Directed Learning ◽

Oncology Education ◽

Before And After

Background Despite the high incidence and burden of cancer in Canadians, medical oncology (mo) rotations are not mandatory in most Canadian internal medicine (im) residency training programs.Methods All im residents scheduled for a mo rotation at 4 Canadian teaching cancer centres between 1 January 2013 and 31 December 2015 were invited to complete an online survey before and after their rotation. The survey was designed to evaluate perceptions of oncology, comfort in managing cancer patients, and basic oncology knowledge.Results The survey was completed by 68 im residents pre-rotation and by 48 (71%) post-rotation. Cancer-related learning was acquired mostly from mo physicians in clinic (35%). Self-directed learning, didactic teaching, and resident or fellow teaching accounted for 31%, 26%, and 10% respectively of learning acquisition. Comfort level in dealing with cancer patients and patients at end of life improved to 4.0/5 from 3.2/5 (p < 0.001) and to 4.0/5 from 3.6/5 (p = 0.003) respectively. Mean knowledge assessment score improved to 83% post-rotation from 76% pre-rotation (p = 0.003), with the greatest increase observed in general knowledge of common malignancies. The 3 topics ranked as most important to learn during a mo rotation were oncologic emergencies, common complications of treatment, and approach to diagnosis of cancer.Conclusions A rotation in mo improves the perceptions of im residents about oncology and their comfort level in dealing with cancer patients and patients at end of life. Overall cancer knowledge is also improved. Given those benefits, im residency programs should encourage most of their residents to complete a mo rotation.

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