scholarly journals A Clinical Study on Anti-wrinkle Efficacy of a Cosmetics Containing Oligoarginine Conjugation of Palmitoyl-GHK peptide for Skin Penetrating

2021 ◽  
Vol 12 (5) ◽  
pp. 401-406
Author(s):  
Su-In Park, Soo Hyeon Heo, Jinseo Lee, Hoon Cha, Moon Sam Shin
Keyword(s):  
Clinical Trials ◽  
Adverse Event ◽  
Transepidermal Water Loss ◽  
Beneficial Effects ◽  
Test Product ◽  
Face Area ◽  
Crow’S Feet ◽  
Measurement Results ◽  
The Face ◽  
Skin Moisture

In this study, Arg 4 (R4) was conjugated with Pal-GHK to get palmitoyl heptapeptide, Pal-GHK‐R4 and wrinkle improvement clinical trials of cosmetics containing Pal-GHK‐R4 were conducted. As a result of total 21 subjects used the test products 4 weeks use on the face area; 1) measurement results of crow’s feet after 2 and 4 weeks of test products use, analysis value of crow’s feet statistically significantly decreased after 2 and 4 weeks of test products use compared to before use of products (p<0.05); 2) measurement results of skin moisturization after 2 and 4 weeks test products use, measured value of skin moisture content statistically significantly increased after 2 and 4 weeks use compared to before use of products (p<0.05); 3) measurement results of TEWL after 2 and 4 weeks use, measured value of TEWL statistically significantly decreased after 2 and 4 weeks use compared to before use of product(p<0.05); 4) there was no skin adverse event reported after using the products during the study period. Therefore, the test products containing both wrinkle improving and skin penetrating peptides, Pal-GHK‐R4 are considered to have beneficial effects on improvement of skin wrinkle, moisturization, transepidermal water loss(TEWL) after 2 and 4 weeks use of test product.

scholarly journals EFEKTIVITAS NATURAL FACE MASK DALAM MENINGKATKAN KELEMBABAN KULIT WAJAH

2019 ◽  
Vol 7 (3) ◽  
pp. 138
Author(s):  
Swaidatul Masluhiya AF ◽  
Hasminar Rachman Fidiastuti
Keyword(s):  
Face Mask ◽  
Significance Test ◽  
Water Evaporation ◽  
Dry Skin ◽  
Black Cumin ◽  
Face Area ◽  
Significant Difference ◽  
The Face ◽  
The Government ◽  
Skin Moisture

This study aimed to determine the effect of using natural masks to moisturize dry skin. This natural mask was made of ingredients that are safe to use and based on special formulations which include; bengkoang powder (2 grams), chocolate powder (1 gram), black cumin oil (0.6 ml), and honey (5 ml). This formulation was made so that the resultied mask formed paste stucture that can be directly applied. Masks were given to ten probandal women who have dry skin types and are 30-40 years old. Masks were used twice / week for six weeks (12 times usage). The instrument used to measure the moisture level of facial skin was a skin analyzer (HL-611) by directly attaching it to the face area and the results can be seen after 4-5 seconds. The data were analysed using ANOVA test 95% confidence interval and significance test using SPSS 15 for windows. The results showed that skin moisture values increased around 3.9% within 6 weeks of use, with a 0.8% increase at week 2, at week 4 there was an increase of 1.65% and at week 6 there was an increase in skin moisture by 1.4%. The moisture value of the skin on the face area (forehead, nose, chin, cheeks) showed no significant difference with almost the same value of humidity. It is recommended for dry skin types to use a face mask that contains oil as a skin lubricant and to protect water evaporation from the skin. It is necessary to do further testing on this natural mask so that safety on the skin can be guaranteed. It needs to be done so that the final product obtained meets the face mask safety quality standards set by the government. Keywords: Bengkuang; cocoa; black cumin; honey; natural mask.

A Single-Center Trial to Evaluate the Efficacy and Tolerability of Four Microneedling Treatments on Fine Lines and Wrinkles of Facial and Neck Skin in Subjects With Fitzpatrick Skin Types I-IV: An Objective Assessment Using Non-Invasive Devices and 0.33mm Microbiopsies

2021 ◽  
Author(s):  
Christine E Wamsley ◽  
Mikaela Kislevitz ◽  
Jennifer Barillas ◽  
Deniz Basci ◽  
Vishal Kandagatla ◽  
...  
Keyword(s):  
Gene Expression ◽  
Objective Assessment ◽  
Standard Of Care ◽  
Transepidermal Water Loss ◽  
Post Treatment ◽  
Non Invasive ◽  
Muscle Formation ◽  
The Face ◽  
High Resolution Ultrasonography ◽  
Elastin Gene

Abstract Background While ablative techniques have been standard of care for the treatment of fine lines and wrinkles, microneedling is a minimally invasive alternative. Objectives The purpose of this study was to assess the efficacy of microneedling on facial and neck fine lines and wrinkles. Methods 35 subjects between 44 and 65 years old with Fitzpatrick skin types I-IV received four monthly microneedling treatments over the face and neck. Subjects returned one and three months post-treatment. At every visit, high-resolution ultrasonography, optical coherence tomography, transepidermal water loss and BTC-2000 were performed. 0.33mm microbiopsies were collected pre-treatment, before the fourth treatment and three months post-treatment. Results 32 subjects (93.75% female, 6.25% male) completed all seven visits. Facial dermal and epidermal density increased 101.86% and 19.28%, respectively from baseline at three months post-treatment. Facial elasticity increased 28.2% from baseline three months post-treatment. Facial attenuation coefficient increased 15.65% and 17.33% one and three months post-treatment. At study completion, blood flow 300µm deep decreased 25.8% in the face and 42.3% in the neck. Relative collagen type III and elastin gene expression was statistically higher three months post-treatment. However, total elastin protein levels unchanged compared to baseline. 58% of biopsies extracted three months post-treatment showed dermal muscle formation, compared to baseline 15.3%. Conclusions The results illustrate the effects of microneedling treatments. Non-invasive measurements and biopsy data showed changes in skin architecture and collagen/elastin gene expression suggesting skin rejuvenation, with new extracellular matrix production and muscle formation.

scholarly journals The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3081
Author(s):  
Mohammad Amin Atazadegan ◽  
Mohammad Bagherniya ◽  
Gholamreza Askari ◽  
Aida Tasbandi ◽  
Amirhossein Sahebkar
Keyword(s):  
Clinical Trials ◽  
Medicinal Plants ◽  
Vascular Endothelium ◽  
Animal Studies ◽  
Natural Compounds ◽  
Herbal Products ◽  
Mortality And Morbidity ◽  
Beneficial Effects ◽  
Serum Homocysteine ◽  
Prevention And Treatment

Background: Among non-communicable diseases, cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity in global communities. By 2030, CVD-related deaths are projected to reach a global rise of 25 million. Obesity, smoking, alcohol, hyperlipidemia, hypertension, and hyperhomocysteinemia are several known risk factors for CVDs. Elevated homocysteine is tightly related to CVDs through multiple mechanisms, including inflammation of the vascular endothelium. The strategies for appropriate management of CVDs are constantly evolving; medicinal plants have received remarkable attention in recent researches, since these natural products have promising effects on the prevention and treatment of various chronic diseases. The effects of nutraceuticals and herbal products on CVD/dyslipidemia have been previously studied. However, to our knowledge, the association between herbal bioactive compounds and homocysteine has not been reviewed in details. Thus, the main objective of this study is to review the efficacy of bioactive natural compounds on homocysteine levels according to clinical trials and animal studies. Results: Based on animal studies, black and green tea, cinnamon, resveratrol, curcumin, garlic extract, ginger, and soy significantly reduced the homocysteine levels. According to the clinical trials, curcumin and resveratrol showed favorable effects on serum homocysteine. In conclusion, this review highlighted the beneficial effects of medicinal plants as natural, inexpensive, and accessible agents on homocysteine levels based on animal studies. Nevertheless, the results of the clinical trials were not uniform, suggesting that more well-designed trials are warranted.

scholarly journals Monitoring Transepidermal Water Loss and Skin Wettedness Factor with Battery-Free NFC Sensor

Sensors ◽  
2020 ◽  
Vol 20 (19) ◽  
pp. 5549
Author(s):  
Syed Muhammad Ali ◽  
Wan-Young Chung
Keyword(s):  
Water Loss ◽  
Near Field ◽  
Experimental Tests ◽  
Transepidermal Water Loss ◽  
Comfort Level ◽  
Skin Wettedness ◽  
Moisture Content Level ◽  
Indoor And Outdoor Environments ◽  
Skin Moisture

The transepidermal water loss (TEWL) and the skin wettedness factor (SWF) are considered parts of a key perspective related to skincare. The former is used to determine the loss of water content from the stratum corneum (SC), while the latter is used to determine the human skin comfort level. Herein, we developed two novel approaches: (1) determination of the TEWL and the SWF based on a battery-free humidity sensor, and (2) the design of a battery-free smart skincare sensor device tag that can harvest energy from a near field communication (NFC)-enabled smartphone, making it a battery-free design approach. The designed skincare device tag has a diameter of 2.6 cm and could harvest energy (~3 V) from the NFC-enabled smartphone. A series of experimental tests involving the participation of eight and six subjects were conducted in vivo for the indoor and outdoor environments, respectively. During the experimental analysis, the skin moisture content level was measured at different times of the day using an android smartphone. The TEWL and SWF values were calculated based on these sensor readings. For the TEWL case: if the skin moisture is high, the TEWL is high, and if the skin moisture is low, the TEWL is low, ensuring that the skin moisture and the TEWL follow the same trend. Our smart skincare device is enclosed in a 3D flexible design print, and it is battery-free with an android application interface that is more convenient to carry outside than other commercially available battery-based devices.

scholarly journals Repurposing of Antimicrobial Agents for Cancer Therapy: What Do We Know?

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3193
Author(s):  
Christina Pfab ◽  
Luisa Schnobrich ◽  
Samir Eldnasoury ◽  
André Gessner ◽  
Nahed El-Najjar
Keyword(s):  
Clinical Trials ◽  
Antimicrobial Agents ◽  
Large Body ◽  
Drug Repurposing ◽  
Extensive Discussion ◽  
Attrition Rates ◽  
Beneficial Effects ◽  
Stage Of Development ◽  
Development Costs ◽  
Approved Drugs

The substantial costs of clinical trials, the lengthy timelines of new drug discovery and development, along the high attrition rates underscore the need for alternative strategies for finding quickly suitable therapeutics agents. Given that most approved drugs possess more than one target tightly linked to other diseases, it encourages promptly testing these drugs in patients. Over the past decades, this has led to considerable attention for drug repurposing, which relies on identifying new uses for approved or investigational drugs outside the scope of the original medical indication. The known safety of approved drugs minimizes the possibility of failure for adverse toxicology, making them attractive de-risked compounds for new applications with potentially lower overall development costs and shorter development timelines. This latter case is an exciting opportunity, specifically in oncology, due to increased resistance towards the current therapies. Indeed, a large body of evidence shows that a wealth of non-cancer drugs has beneficial effects against cancer. Interestingly, 335 drugs are currently being evaluated in different clinical trials for their potential activities against various cancers (Redo database). This review aims to provide an extensive discussion about the anti-cancer activities exerted by antimicrobial agents and presents information about their mechanism(s) of action and stage of development/evaluation.

Face Image Segmentation Using Color Information and Saliency Map

2011 ◽  
Vol 55-57 ◽  
pp. 77-81
Author(s):  
Hui Ming Huang ◽  
He Sheng Liu ◽  
Guo Ping Liu
Keyword(s):  
Image Segmentation ◽  
Human Skin ◽  
Skin Color ◽  
Saliency Map ◽  
Face Image ◽  
Color Information ◽  
Attention Model ◽  
Face Area ◽  
Face Region ◽  
The Face

In this paper, we proposed an efficient method to address the problem of color face image segmentation that is based on color information and saliency map. This method consists of three stages. At first, skin colored regions is detected using a Bayesian model of the human skin color. Then, we get a chroma chart that shows likelihoods of skin colors. This chroma chart is further segmented into skin region that satisfy the homogeneity property of the human skin. The third stage, visual attention model are employed to localize the face region according to the saliency map while the bottom-up approach utilizes both the intensity and color features maps from the test image. Experimental evaluation on test shows that the proposed method is capable of segmenting the face area quite effectively，at the same time, our methods shows good performance for subjects in both simple and complex backgrounds, as well as varying illumination conditions and skin color variances.

Treatment With Pantethine

2011 ◽  
Vol 16 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Zoltán Horváth ◽  
László Vécsei
Keyword(s):  
Clinical Trials ◽  
Acyl Carrier Protein ◽  
Pantothenic Acid ◽  
Acid Oxidation ◽  
Moderating Effects ◽  
Current Increase ◽  
Beneficial Effects ◽  
Slowing Down ◽  
Clinical Observations ◽  
Theoretical Considerations

The current increase in cardiovascular and cerebrovascular morbidity is a growing burden for society. Consideration must therefore be given to compounds capable of slowing down these pathological processes without significant adverse effects. The natural vitamins pantetheine/pantothenic acid are major precursors of coenzyme A and acyl carrier protein, which are essential for fatty acid oxidation and participate in the metabolism of cholesterol and carbohydrates and in at least 70 other enzymatic processes. Following a number of theoretical considerations and clinical observations, various clinical studies have revealed that they possess significant beneficial effects. In particular, they demonstrate useful moderating effects on vascular pathological processes, lowering lipid levels, and inhibiting platelet functions and lipid peroxidation. Although they are natural, well-tolerated therapeutic agents, few controlled clinical trials have been conducted. The available data suggest the need for larger clinical trials and possible use of pantetheine/pantothenic acid as adjuvant therapy.

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