scholarly journals Invasive potential of retroperitoneal well-differentiated liposarcomas depending on the extent of sclerosing component in the tumor

2020 ◽  
Vol 25 (2) ◽  
pp. 50-55
Author(s):  
A. Yu. Volkov ◽  
N. A. Kozlov ◽  
S. N. Nered ◽  
I. S. Stilidi ◽  
A. M. Stroganova ◽  
...  
Keyword(s):  
Long Term Results ◽  
Federal State ◽  
Invasive Potential ◽  
Morphological Marker ◽  
Favorable Prognosis ◽  
National Medical ◽  
Well Differentiated ◽  
Organ Invasion ◽  
Primary Retroperitoneal

Objective. To assess the influence of the extent of sclerosing component in the retroperitoneal well-differentiated liposarcoma (WDLPS) on the survival. Material and methods. The retrospective study included 111 patients with primary retroperitoneal WLPS who underwent radical surgical treatment in Federal State Budgetary Institution N.N. Blokhin National Medical Research Center of Oncology. Histological slides of all surgical specimens were reviewed by experienced pathologist and reclassified according to criteria of WHO (2013). Patients were divided into groups depending on the extent of the sclerosing component in the tumor and enrolled in intergroup analysis. We analyzed relationship between extent of the sclerosing component in the tumor and frequency of the pathologically confirmed visceral invasion. Also, we have analyzed the influence of the visceral invasion of WDLPS on the long-term results overall (OS) and recurrence-free (RFS) survival. Results. Pathologically confirmed visceral invasion was revealed in 17% of cases with the sclerosing component less 20%, and in 31% of cases with the sclerosing component more 20%. OS was significantly worse in the group of patients who suffered from WDLPS with visceral invasion than in the group of patients without visceral invasion (p = 0.009; logarithmic criterion). The median OS in the compared groups was 85 (95% CI, 84, 87) and 142 (95% CI, 109, 175) months, the 5-year OS rate was 41% and 86%, respectively. RFS was significantly worse in the group of patients with histologically confirmed visceral invasion than in the group without organ invasion (p = 0.001; logarithmic criterion). Median RFS in the compared groups was 26 (95% CI, 20, 32) and 57 (95% CI, 38, 76) months, 2-year RFS 33% and 85%, respectively. Conclusion. Results of the study demonstrate more aggressive behavior of WDLPS with increasing extent of the sclerosing component. We believe that semi-quantitative counting of sclerosing component in retroperitoneal WDLPS can serve as an effective morphological marker of a less favorable prognosis of the disease.

scholarly journals THE PROGNOSTIC SIGNIFICANCE OF MYXOID MATRIX IN RETROPERITONEAL WELL-DIFFERENTIATED LIPOSARCOMA

2021 ◽  
Vol 20 (1) ◽  
pp. 46-52
Author(s):  
A. Yu. Volkov ◽  
N. A. Kozlov ◽  
S. N. Nered ◽  
I. S. Stilidi ◽  
A. M. Stroganova ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Survival Rates ◽  
Prognostic Significance ◽  
Long Term Results ◽  
Rank Test ◽  
Federal State ◽  
Morphological Marker ◽  
Log Rank Test ◽  
Myxoid Matrix ◽  
Well Differentiated

Objective: to assess the influence of the myxoid matrix in retroperitoneal well-differentiated liposarcoma(WDLPS ) on the long-term results of surgical treatment of patients.Material and Methods. The study included 111 patients with primary retroperitoneal WDLPS who underwent radical surgical treatment in Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation. Histological slides of all surgical specimens were reviewed by experienced pathologist and reclassified according to criteria of WHO (2013) for histological subtypes of the WDLPS . Patients were divided into groups depending on presence or absence of the myxoid matrix in WDLPS and enrolled in intergroup analysis of overall (OS ) and recurrence-free (RFS) survival.Results. OS was significantly worse in the group of patients with the myxoid matrix in the tumor (p=0.002; log-rank test). The median OS was 142 (95 % CI , 108, 176) months in the group without the myxoid matrix, and 84 (95 % CI , 29, 139) months in the group with the myxoid matrix. The 5-year survival rates were 79 % and 44 % in the groups without myxoid matrix and with myxoid matrix, respectively. RFS was also significantly worse in the group of patients with the myxoid matrix than in the group of patients without the myxoid matrix (p=0.006; log-rank test). The median RFS was 55 (95 % CI , 38, 72) months in the WDLPS group without the myxoid matrix, and 31 (95 % CI , 15, 47) months in the WDLPS group with the myxoid matrix. The 2-year RFS rates were 75 % and 44 % in the groups without the myxoid matrix and with the myxoid matrix, respectively.Conclusion. The results of the study demonstrated that the presence of the myxoid matrix in WDLPS was associated with poor prognosis. We believe that the presence of the myxoid matrix in WDLPS can serve as an effective morphological marker of a less favorable prognosis for retroperitoneal WLPS .

The issue of assessment of efficiency of works on land reclamation fisheries in inland waters of Russia

2021 ◽  
pp. 8-20
Author(s):  
Andrey Dmitrievich Bykov ◽  
Svetlana Yuryevna Brazhnik
Keyword(s):  
Fish Species ◽  
Land Reclamation ◽  
Long Term Results ◽  
Predatory Fish ◽  
Federal State ◽  
Inland Waters ◽  
Ecological Group ◽  
Spawning Grounds ◽  
Commercial Fish

The article considers the issue of assessing the long-term results of work on fisheries reclamation in inland waters of fisheries significance in Russia, carried out by the branches of the Federal State Budgetary Institution “Glavrybvod” on the state task in terms of their effectiveness. The relationship between dredging and clearing of watercourse beds and the dynamics of the number of producers of semi-navigable and non-aquatic fish in these rivers during spawning migrations has not been established. With long-term mowing of wetland vegetation in the shallow waters of reservoirs, deltas of large rivers and estuaries, there is no increase in their commercial fish productivity. A number of examples show the opposite effect of this type of work, which leads to a local deterioration of the ecological state of these reservoirs. At the same time, the repeatedly proven method of combating higher aquatic vegetation in the reservoirs of the south of Russia in low water conditions as biomelioration, based on the introduction of fish, consumers of autotrophic products by regional branches of the Federal State Budgetary Institution “Glavrybvod” is practically not used. When installing artificial spawning grounds in the littoral zone of reservoirs, regular ichthyological monitoring of the effectiveness of spawning on them is not carried out. There are no reliable data confirming the significant positive impact of artificial spawning grounds on the population dynamics of commercial fish species of the limnophilic ecological group under conditions of significant spring water level depletion in Russian reservoirs. When catching predatory and low-value fish species in water bodies, legal obstacles arise due to the fact that the volume of seizure of predatory fish includes commercial objects for which the ODE is established annually and their catch is already carried out according to industrial quotas.

scholarly journals Therapy intensification in high-risk neuroblastoma patients with poor response to standard induction: experience of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology

2019 ◽  
Vol 18 (4) ◽  
pp. 19-28
Author(s):  
T. V. Shamanskaya ◽  
D. Y. Kachanov ◽  
A. V. Dumacheva ◽  
M. V. Teleshova ◽  
D. V. Shevtcov ◽  
...  
Keyword(s):  
High Risk ◽  
Medical Research ◽  
Induction Therapy ◽  
Poor Response ◽  
Research Center ◽  
Long Term Results ◽  
Type I ◽  
Pediatric Hematology ◽  
National Medical

High-risk neuroblastoma (NB) is characterized by unsatisfactory treatment results and low probability of long-term survival despite the multimodal therapeutic approach (chemotherapy, surgical treatment, radiation therapy, autologous hematopoietic stem cell transplantation, etc.). One of the prognostic factors in this cohort of patients is the response to induction therapy. The article presents the experience of the intensification of induction therapy in 12 patients with high-risk NB with a poor response (mixed response, stable disease) to standard induction therapy who received treatment at Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, assessing its impact on the prognosis of the disease. The study was approved by the Independent Ethics Committee of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. Patients received an additional two courses of chemotherapy with the inclusion of a type I topoisomerase inhibitor topotecan (TCE – topotecan, cyclophosphamide, etoposide). This regimen of intensification of therapy has demonstrated its feasibility. The main grade 3–4 toxicity was hematologic. An improvement in response was achieved in 5/12 (41.6%) patients. However, long-term results of therapy remained unsatisfactory. The 3-year EFS was 16.7% (95% CI 0.0–37.8), the 3-year OS was 50.0% (95% CI 21.7–78.3). Thus, the intensification of therapy in patients with high-risk NB with a poor response to standard induction therapy did not improve treatment outcomes.

Features of clinical course, morphological diagnosis and prognosis factors for neuroendocrine neoplasms of rare localizations

2020 ◽  
pp. 54-60
Author(s):  
D. V. Abbasova ◽  
S. B. Polikarpova ◽  
N. A. Kozlov ◽  
Ye. V. Artamonova ◽  
V. Yu. Kirsanov ◽  
...  
Keyword(s):  
Prostate Gland ◽  
Survival Rates ◽  
Long Term Results ◽  
Neuroendocrine Neoplasms ◽  
High Survival ◽  
Diagnosis And Prognosis ◽  
National Medical ◽  
Static Data ◽  
Morphological Diagnosis

Currently, neuroendocrine neoplasms (NENs) of the gastroenteropancreat-ic and bronchopulmonary systems are well studied and the most common, the share of which is 73 and 25 % of cases, respectively. The remaining 2 % of cases are attributed to NEN of more rare localizations, the static registration of which is difficult due to their rarity, and clinical cases are presented by episodic descriptions of single observations. Such tumors include NEN of the prostate gland from 0.5 to 1.0 %, NEN of ovaries 0.5 %, NEN of the mammary gland from 0.3 to 0.5 %, NEN of the kidney (practically devoid of static data), bladder 0.48-1.00 %. The retrospective study included 92 patients with NEN of rare localizations who were examined and treated of the N. N. Blochin National Medical Research Center of Oncology from 1990 to 2019. Currently, there are no generally accepted methods of treatment for this group of patients due to the rarity of the pathology, and it is carried out according to the NEN of other localizations. NEN of rare localizations have high survival rates (the observation period was from a month to 14 years), both general and without progression and require long-term monitoring and observation. At the time of assessment of long-term results, 20 (21.8 %) patients died of progression, 12 (13.1 %) patients dropped out of observation. The rest were alive at the date of the last control.

scholarly journals Non-functioning neuroendocrine tumors of the common hepatic duct: a case report and literature review

2017 ◽  
Vol 4 (3) ◽  
pp. 1101
Author(s):  
Maroun Abou-Jaoude ◽  
Haydar A. Nasser
Keyword(s):  
Neuroendocrine Tumors ◽  
Epigastric Pain ◽  
Hepatic Duct ◽  
Young Patients ◽  
Pancreatic Head ◽  
Long Term Results ◽  
Common Hepatic Duct ◽  
The Common ◽  
Well Differentiated

Extra-hepatic biliary tree neuroendocrine tumors are not common, accounting for about 0.1 % of all carcinoid tumors. Those affecting the common hepatic duct are very rare and their diagnosis is usually made post-operatively. Poorly differentiated tumors or neuroendocrine carcinomas are commonly seen in elderly, whereas well differentiated tumors, tend to occur in young patients, for whom surgery will lead to good long term results. About 100 cases have been reported in the English medical literature, showing good long term results after surgery for well differentiated (Grades 1 and 2) tumors. Herein, we report a case of an 18-year-old female, complaining from a dull epigastric pain related to a nodule compressing the common hepatic duct. After complete investigation, a laparotomy has been performed and showed a nodular tumor located in the common hepatic duct just above the insertion of the cystic duct with close contact with the pancreatic head distally. En bloc cholecystectomy with bile duct resection was performed and followed by a Roux-en-Y hepatico-jejunostomy. The pathology of the nodule came back to be a neuroendocrine tumor grade 2.

“Complex” hepatic echinococcosis

2021 ◽  
Vol 26 (4) ◽  
pp. 32-40
Author(s):  
A. B. Goncharov ◽  
Y. A. Kovalenko ◽  
Kh. A. Ayvazyan ◽  
R. Z. Ikramov ◽  
L. A. Marinova ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Lung Damage ◽  
Long Term Results ◽  
Tubular Structures ◽  
National Medical ◽  
Laparoscopic Intervention ◽  
Hepatic Echinococcosis ◽  
Isolated Liver ◽  
Observation Period

Aim. To study the long-term results of surgical treatment in patients with “complex” hepatic echinococcosis.Materials and methods. The results of surgical treatment of 118 patients with hepatic echinococcosis from 2015 to 2020 at the A.V. Vishnevsky National Medical Research Center of Surgery were analyzed. The term “complex” hepatic echinococcosis has been proposed. A comparative analysis of the number and type of complications and surgical interferences 2 groups of patients was carried out: 66 patients with hepatic echinococcosis, 52 patients with complex hepatic echinococcosis.Results. During the observation period, no any recurrence was recorded. 55 (44%) of 118 patients had complex hepatic echinococcosis. Isolated liver damage was found in 74% of cases, combined liver and lung damage in 20% cases and with other organs – in 6%. In most cases, pericystectomy was performed (82%), 8% of patients underwent atypical hepatectomy, 4% – segmental resection, 3% – laparoscopic intervention, 3% – hemihepatectomy. Postoperative complications were recorded in 22 (18,6%) of cases. Accumulations of bile and biliary fistulas formed in 45% of cases, pneumotothorax or hydrothorax – in 23%, wound abscess – in 18%, hematomas in the hepatectomy zone – in 14% of the cases.Conclusion. Surgical treatment of complex hepatic echinococcosis requires an individual approach to the choice of the operation option. Preference should be given to parenchyma-preserving radical operations. When the liver lobe is totally replaced with a hydatid cyst and in case of cystobiliary fistulas hemihepatectomy should be performed, and it is acceptable to leave the fibrous capsule on large tubular structures.

Reconstructive surgery of the operated stomach

2019 ◽  
Author(s):  
Дмитрий Ручкин ◽  
Dmitriy Ruchkin ◽  
Валентин Козлов ◽  
Valentin Kozlov
Keyword(s):  
Gastric Cancer ◽  
Surgical Treatment ◽  
Gastrointestinal Tract ◽  
Medical Research ◽  
Reconstructive Surgery ◽  
Gastric Surgery ◽  
Long Term Results ◽  
National Medical ◽  
Operated Stomach

The monograph formulated the concept of physiological reconstruction of the digestive tract during repeated operations on the stomach. The experience of surgical treatment of patients with diseases of the operated stomach and recurrent gastric cancer of the Department of reconstructive surgery of the esophagus and stomach Of the national medical research center of surgery named after A. V. Vishnevsky is presented. The immediate and long-term results of the original operations selected individually are highlighted. Special attention is paid to the study of motor and evacuation function of the gastrointestinal tract, to identify the frequency and severity of postgastrectomy and postgastresection syndromes after reconstructive interventions. For students and teachers, as well as anyone interested in the problems of gastric surgery.

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