scholarly journals A FIRST AUTOCHTNOUS HUMAN CASE OF THE LONGSTANDINDG MICROFILARAEMIA DUE TO DIROFILARIA REPENS IN RUSSIA AND A FIRST EXPERIENCE OF COMBINED THERAPY OF DIROFILARIASIS REPENS

2013 ◽  
Vol 18 (3) ◽  
pp. 47-52
Author(s):  
A. M Bronshteyn ◽  
N. A Malyshev ◽  
S. N Jarov ◽  
L. V Fedianina ◽  
A. A Frolova ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Combined Therapy ◽  
Human Case ◽  
Dirofilaria Repens ◽  
Connective Tissues ◽  
Internal Organs ◽  
First Report ◽  
Human Pathology ◽  
Russian Patient

A case of the longstandindg microfilaraemia due to Dirofilaria repens is presented as a 57-years-old female . This is the first report of the longstandindg microfilaraemia in a Russian patient due to infection of D. repens. The microfilariae of D. repens were detected due to multiple investigations of fresh drops of blood. The longstandindg microfilaraemia due to D. repens is discussed regarding their role in human pathology. As the larvae mature into adult wormes they migrate through blood vessels and the subdermal connective tissues causing pruritis, oedematous lesions on the skin, itching and pain as they pass beneath the conjunctivae and penetrate internal organs. The patient was successfully treated with doxycycline, albendazole and diethylcarbamazine.

scholarly journals Sustainable Development of Chitosan/Calotropis procera-Based Hydrogels to Stimulate Formation of Granulation Tissue and Angiogenesis in Wound Healing Applications

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3284
Author(s):  
Muhammad Zahid ◽  
Maria Lodhi ◽  
Zulfiqar Ahmad Rehan ◽  
Hamna Tayyab ◽  
Talha Javed ◽  
...  
Keyword(s):  
Wound Healing ◽  
Blood Vessels ◽  
Granulation Tissue ◽  
Chorioallantoic Membrane ◽  
Calotropis Procera ◽  
Connective Tissues ◽  
Blood Capillaries ◽  
Chick Chorioallantoic Membrane ◽  
Thaw Cycle ◽  
Freeze Thaw Cycle

The formation of new scaffolds to enhance healing magnitude is necessarily required in biomedical applications. Granulation tissue formation is a crucial stage of wound healing in which granulation tissue grows on the surface of a wound by the formation of connective tissue and blood vessels. In the present study, porous hydrogels were synthesized using chitosan incorporating latex of the Calotropis procera plant by using a freeze–thaw cycle to stimulate the formation of granulation tissue and angiogenesis in wound healing applications. Structural analysis through Fourier transform infrared (FTIR) spectroscopy confirmed the interaction between chitosan and Calotropis procera. Latex extract containing hydrogel showed slightly higher absorption than the control during water absorption analysis. Thermogravimetric analysis showed high thermal stability of the 60:40 combination of chitosan (CS) and Calotropis procera as compared to all other treatments and controls. A fabricated scaffold application on a chick chorioallantoic membrane (CAM) showed that all hydrogels containing latex extract resulted in a significant formation of blood vessels and regeneration of cells. Overall, the formation of connective tissues and blood capillaries and healing magnitude decreased in ascending order of concentration of extract.

scholarly journals LTBP1 promotes fibrillin incorporation into the extracellular matrix

2021 ◽  
Author(s):  
Matthias Przyklenk ◽  
Veronika Georgieva ◽  
Fabian Metzen ◽  
Sebastian Mostert ◽  
Birgit Kobbe ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Protein ◽  
Wide Spectrum ◽  
Extracellular Matrix Protein ◽  
Connective Tissues ◽  
Pathogenic Variants ◽  
Human Pathology ◽  
Fibrillin 1

LTBP1 is a large extracellular matrix protein and an associated ligand of fibrillin-microfibrils. Knowledge of LTBP1 functions is largely limited to its role in targeting and sequestering TGFβ growth factors within the extracellular matrix, thereby regulating their bioavailability. However, the recent description of a wide spectrum of phenotypes in multiple tissues in patients harboring LTBP1 pathogenic variants suggests a multifaceted role of the protein in the homeostasis of connective tissues. To better understand the human pathology caused by LTBP1 deficiency it is important to investigate its functional role in extracellular matrix formation. In this study, we show that LTBP1 coordinates the incorporation of fibrillin-1 and -2 into the extracellular matrix in vitro. We also demonstrate that this function is differentially exerted by the two isoforms, the short and long forms of LTBP1. Thereby our findings uncover a novel TGFβ-independent LTBP1 function potentially contributing to the development of connective tissue disorders.

scholarly journals Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets

2021 ◽  
Vol 80 (2) ◽  
pp. 112-128
Author(s):  
Susan C Schwerin ◽  
Mitali Chatterjee ◽  
Elizabeth B Hutchinson ◽  
Francis T Djankpa ◽  
Regina C Armstrong ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Western Blot ◽  
Blood Vessels ◽  
Blast Injury ◽  
Preclinical Models ◽  
Blast Exposure ◽  
Blast Traumatic Brain Injury ◽  
Human Pathology ◽  
Military Conflicts ◽  
Therapeutic Protocols

Abstract Blast exposures are a hallmark of contemporary military conflicts. We need improved preclinical models of blast traumatic brain injury for translation of pharmaceutical and therapeutic protocols. Compared with rodents, the ferret brain is larger, has substantial sulci, gyri, a higher white to gray matter ratio, and the hippocampus in a ventral position; these attributes facilitate comparison with the human brain. In this study, ferrets received compressed air shock waves and subsequent evaluation of glia and forms of tau following survival of up to 12 weeks. Immunohistochemistry and Western blot demonstrated altered distributions of astrogliosis and tau expression after blast exposure. Many aspects of the astrogliosis corresponded to human pathology: increased subpial reactivity, gliosis at gray-white matter interfaces, and extensive outlining of blood vessels. MRI analysis showed numerous hypointensities occurring in the 12-week survival animals, appearing to correspond to luminal expansions of blood vessels. Changes in forms of tau, including phosphorylated tau, and the isoforms 3R and 4R were noted using immunohistochemistry and Western blot in specific regions of the cerebral cortex. Of particular interest were the 3R and 4R isoforms, which modified their ratio after blast. Our data strongly support the ferret as an animal model with highly translational features to study blast injury.

scholarly journals Dirofilaria Repens Infection of the Eye

2021 ◽  
Author(s):  
Karl Engelsberg ◽  
Jonas Bläckberg
Keyword(s):  
Clinical Outcome ◽  
Nordic Countries ◽  
Dirofilaria Repens ◽  
Surgical Removal ◽  
Good Clinical Outcome ◽  
First Report

Abstract We present the first report of a live subconjunctival Dirofilaria Repens in the Nordic countries. A woman had been in India five months before her symptoms started with redness and a foreign sensation in her eye. A worm that moved was found under her conjunctiva (film enclosed). She was instantly operated and the worm was removed (film enclosed). Surgical removal of the worm led to resolution of symptoms and a good clinical outcome.

Epithelioid Hemangioendothelioma Arising Within Mediastinal Myelolipoma: A WWTR1-Driven Composite Neoplasm

2019 ◽  
Vol 27 (6) ◽  
pp. 664-668
Author(s):  
Julio A. Diaz-Perez ◽  
Jaylou Velez-Torres ◽  
Oleksii Iakymenko ◽  
Nestor Villamizar ◽  
Andrew E. Rosenberg
Keyword(s):  
Endothelial Cells ◽  
Blood Vessels ◽  
Chimeric Protein ◽  
Epithelioid Hemangioendothelioma ◽  
Adrenal Myelolipoma ◽  
Vascular Neoplasm ◽  
First Report

In this article, we describe a case of conventional epithelioid hemangioendothelioma (EHE) arising within an extra-adrenal myelolipoma. This composite neoplasm arose in the mediastinum of a 51-year-old female. The tumor was composed of a large myelolipoma that contained nodules of EHE consisting of CD31-positive epithelioid endothelial cells that grew in solid cords and were enmeshed in a basophilic hyalinized stroma. Both EHE and myelolipoma are characterized genetically by alterations of WWTR1. We demonstrated the expression of CAMTA-1 chimeric protein by immunohistochemistry both in the neoplastic endothelial cells of EHE and some of the endothelial cells lining the blood vessels in the myelolipoma. To the best of our knowledge, this is the first report of a malignant vascular neoplasm arising in association with myelolipoma.

scholarly journals Human case of bacteremia due to Streptococcus suis serotype 5 in Japan: The first report and literature review

IDCases ◽  
2016 ◽  
Vol 6 ◽  
pp. 36-38 ◽  
Author(s):  
Daisuke Taniyama ◽  
Mayu Sakurai ◽  
Tetsuya Sakai ◽  
Takahide Kikuchi ◽  
Takashi Takahashi
Keyword(s):  
Literature Review ◽  
Streptococcus Suis ◽  
Human Case ◽  
First Report ◽  
Serotype 5 ◽  
Suis Serotype

XXV.—The Anatomy of a Fœtal African Elephant, Elephas africanus (Loxodonta africana). Part II. The Body Muscles

1928 ◽  
Vol 55 (3) ◽  
pp. 609-642 ◽  
Author(s):  
Nellie B. Eales
Keyword(s):  
Weak Solution ◽  
Blood Vessels ◽  
Royal Society ◽  
Loxodonta Africana ◽  
African Elephant ◽  
The Body ◽  
Internal Organs

In the Transactions of the Royal Society of Edinburgh, Vol. LIV, Part III, No. 11, 1926, the author published an account of the anatomy of the head of an African Elephant fœtus, 21 cms. in length. The present paper deals with the voluntary muscles (except those already described) of the same fœtus. The author intends to prepare later an account of the skeleton and internal organs, so that a complete description of the anatomy of this rare specimen will be available.The section which treats of the head will henceforward be referred to as Part I; the present paper, therefore, becomes Part II.The body muscles were investigated under the Zeiss Binocular Dissecting Microscope, and the work was facilitated by rapid staining with a weak solution of saffranin. Owing to long preservation, the muscles, nerves, and blood-vessels of the specimen were quite colourless. The saffranin gave a certain amount of differentiation which lasted for several hours, and the advantage of the method is that the colour disappears entirely when the specimen is put back into the store jar between one working period and the next.

scholarly journals When the disease goes beyond the skin, changes in the skin can be a sign of systemic disease

2020 ◽  
Vol 19 (3) ◽  
pp. 95-104
Author(s):  
L. A. Khachatryan ◽  
D. M. Nikolaeva ◽  
A. P. Shcherbakov
Keyword(s):  
Blood Vessels ◽  
Heart Defects ◽  
Systemic Disease ◽  
Neck Region ◽  
Coarctation Of The Aorta ◽  
Infantile Hemangioma ◽  
Internal Organs ◽  
Skin Changes ◽  
Arterial Blood ◽  
Cranial Fossa

Infantile hemangioma may be accompanied by malformations of internal organs and blood vessels. In 1996 PHACE syndrome was defined as a disease which is characterized by the association of segmental infantile hemangioma with localization in the head/neck region and the presence of malformations in the posterior cranial fossa, abnormalities of arterial blood vessels including coarctation of the aorta, heart defects, as well as malformations of the eyes and central nervous system. This article presents a clinical case of a child who was diagnosed this syndrome at the age of 1.5 months based on the presence of segmental hemangioma, as well as large and small criteria specific for this disease. In addition to the main symptoms, the child had an accompanying pathology: Wolff–Parkinson–White syndrome. Therapy with non-selective b-blockers and polychemotherapy allowed stopping already developed and prevent possible complications associated with this syndrome. Parents gave their consent to use information about the child, including fotos, in the article.

Physiology of the Internal Organs

2017 ◽  
Author(s):  
Jingduan Yang ◽  
Daniel A. Monti
Keyword(s):  
Small Intestine ◽  
Chinese Medicine ◽  
Body Fluids ◽  
The Body ◽  
Connective Tissues ◽  
Internal Organs ◽  
Physiological Functions ◽  
Human Organs

This chapter provides a detailed description of the concepts of internal human organs from a Chinese medicine perspective, including two additional organs: Pericardium and San Jiao (cavities of chest, abdomen, and pelvic). It describes in detail the manifestation (Xiang) of physiological functions of solid organs (Zang) such as the Heart, Liver, Lungs, Spleen, Kidneys, and Pericardium, and hollow organs (Fu) such as Small Intestine, Larger Intestine, Gallbladder, Bladder, Stomach, and San Jiao. It teaches the functions that overlap largely with modern medical physiology as well as the additional functions due to the energetic connections of each internal organ with the rest of the body, including their specific impacts on sensory faculties, connective tissues, body gestures and movements, and body fluids. This chapter emphasizes that the internal organs in acupuncture and Chinese medicine should be perceived not only as structural and biochemical centers but also as energetic centers.

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