scholarly journals «QUERY FEVER»: DOWN THE LINE EIGHTY YEARS

2017 ◽  
Vol 22 (4) ◽  
pp. 200-207
Author(s):  
Valery A. Malov ◽  
A. N Gorobchenko ◽  
N. M Gyulazyan ◽  
E. A Nemilostiva ◽  
N. N Kanshina ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Clinical Manifestations ◽  
Review Article ◽  
Diagnosis And Treatment ◽  
Pathogenetic Mechanisms ◽  
Modern Information ◽  
Chronic Course ◽  
Protective Systems

The review article coniders modern information on etiology, epidemiology of Q-fever, pathogenetic mechanisms promoting Coxiella burnetii bacteria to wear down the protective systems of the macroorganism and contribute to the development of the chronic course of the disease. Clinical manifestations of Q-fever in acute and chronic forms are considered in detail, problems of early diagnosis and treatment tactics are discussed.

scholarly journals A NEVER-ENDING STORY OF RHEUMATOID ARTHRITIS

2020 ◽  
pp. 10-17
Author(s):  
BALJIT K. ◽  
QADRIE Z. L. ◽  
AMIT B. ◽  
GAUTAM S. P.
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Diagnosis ◽  
Clinical Manifestations ◽  
Joint Stiffness ◽  
Review Article ◽  
Diagnosis And Treatment ◽  
Treat To Target ◽  
The Novel ◽  
Joint Tenderness ◽  
Loss Of Motion

There are distinct Rheumatic disorders, still Rheumatoid arthritis (RA) is believed to be very prevailing. RA is an empathic disorder described over integral redness, constant inflammation, and the existence of auto-antibodies. In RA, inflammation in joints, loss of motion of joint stiffness, joint tenderness are most common in patients. Deformity of joints can be prevented by early diagnosis and treatment. The extremity of the disease can be reduced by combining the drugs and improved weight more profiled than single medication. Treat-to-target progress results in a superior-conclusion in RA, and the ACR, EULAR, and other specialized systems have supported treat-to-target as a basic curative strategy for RA. The novel methods used in RA have upgraded the development of the disorder and maximum people helpful in cancellation of clinical manifestations if the identification of disorder takes place before time. This review article is written after studying most of the journal’s articles, which were published between 1997-2019.

scholarly journals The role of membrane-destabilizing processes in the pathogenesis and clinical manifestations of perinatal encephalopathy in children

2001 ◽  
Vol 82 (2) ◽  
pp. 137-138
Author(s):  
E. V. Levitina ◽  
G. A. Ivanichev ◽  
M. M. Minnibaev
Keyword(s):  
Nervous System ◽  
Early Diagnosis ◽  
Clinical Manifestations ◽  
Perinatal Period ◽  
Diagnosis And Treatment ◽  
Definition Of ◽  
Methods Of Treatment ◽  
All Diseases ◽  
Made In

2/3 of all diseases of the nervous system in children begin to develop in the perinatal period. In recent decades, great strides have been made in perinatal neurology in the development of criteria for early diagnosis and treatment of diseases. Further study of the biochemical foundations of perinatal lesions of the nervous system with the definition of objective markers of the severity of the lesion will reveal new links in its pathogenesis and develop more effective methods of treatment.

scholarly journals Development of High-Throughput Multiplex Serology to Detect Serum Antibodies against Coxiella burnetii

2021 ◽  
Vol 9 (11) ◽  
pp. 2373
Author(s):  
Rima Jeske ◽  
Larissa Dangel ◽  
Leander Sauerbrey ◽  
Dimitrios Frangoulidis ◽  
Lauren R. Teras ◽  
...  
Keyword(s):  
Coxiella Burnetii ◽  
High Throughput ◽  
Large Scale ◽  
Q Fever ◽  
Reference Group ◽  
Clinical Manifestations ◽  
Cost Effective ◽  
Population Monitoring ◽  
Increased Risk ◽  
Multiplex Serology

The causative agent of Q fever, the bacterium Coxiella burnetii (C. burnetii), has gained increasing interest due to outbreak events and reports about it being a potential risk factor for the development of lymphomas. In order to conduct large-scale studies for population monitoring and to investigate possible associations more closely, accurate and cost-effective high-throughput assays are highly desired. To address this need, nine C. burnetii proteins were expressed as recombinant antigens for multiplex serology. This technique enables the quantitative high-throughput detection of antibodies to multiple antigens simultaneously in a single reaction. Based on a reference group of 76 seropositive and 91 seronegative sera, three antigens were able to detect C. burnetii infections. Com1, GroEL, and DnaK achieved specificities of 93%, 69%, and 77% and sensitivities of 64%, 72%, and 47%, respectively. Double positivity to Com1 and GroEL led to a combined specificity of 90% and a sensitivity of 71%. In a subgroup of seropositives with an increased risk for chronic Q fever, the double positivity to these markers reached a specificity of 90% and a sensitivity of 86%. Multiplex serology enables the detection of antibodies against C. burnetii and appears well-suited to investigate associations between C. burnetii infections and the clinical manifestations in large-scale studies.

A CASE REPORT: KAZABACH-MERRITT SYNDROME (KMS)

Vestnik ◽  
2021 ◽  
pp. 73-77
Author(s):  
Г.Ж. Бодыков ◽  
Г.Н. Балмагамбетова ◽  
С.А. Лисогор ◽  
В.М. Шмонин
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Early Diagnosis ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Vascular Anomalies ◽  
Diagnosis And Treatment ◽  
Pediatric Practice

Синдром Казабаха - Мерритта в детской практике встречается крайне редко. Клинические проявления многообразны, что затрудняет своевременную диагностику и лечение данного заболевания. Цель: привлечь внимание неонатологов и педиатров к своевременной диагностике редких гематологических синдромов. Материалы и методы. Проведено расширенное обследование ребенка и тщательная дифференциальная диагностика с другими сосудистыми аномалиями. Результаты. На основании оценки анамнеза, клинико - лабораторных и инструментальных методов обследования установлен диагноз СКМ. Выводы. Постановка диагноза СКМ требует проведения расширенного обследования ребенка и тщательной дифференцировки с другими сосудистыми аномалиями. Kazabach-Merritt syndrome is extremely rare in pediatric practice. Clinical manifestations are diverse- and this fact complicates the early diagnosis and treatment of the disease.Purpose: to draw the attention of neonatologists and pediatricians to the early diagnosis of rare hematological syndromes.Materials and methods. An extended examination of the child and a thorough differential diagnosis with other vascular anomalies were carried out. Results. The KMS was diagnosed on the base of: the assessment of the anamnesis, clinical - laboratory and instrumental examination methods.Conclusion. The diagnosis of KMS requires an extended examination of the child and careful differentiation of other vascular anomalies.

scholarly journals Early Diagnosis and Treatment of Patients with Symptomatic Acute Q Fever Do Not Prohibit IgG Antibody Responses to Coxiella burnetii

2012 ◽  
Vol 19 (10) ◽  
pp. 1661-1666 ◽  
Author(s):  
C. C. H. Wielders ◽  
L. M. Kampschreur ◽  
P. M. Schneeberger ◽  
M. M. Jager ◽  
A. I. M. Hoepelman ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Phase I ◽  
Phase Ii ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Antibody Responses ◽  
Igg Antibody ◽  
Antibody Titers ◽  
Acute Q Fever

ABSTRACTLittle is known about the effect of timing of antibiotic treatment on development of IgG antibodies following acute Q fever. We studied IgG antibody responses in symptomatic patients diagnosed either before or during development of the serologic response toCoxiella burnetii. Between 15 and 31 May 2009, 186 patients presented with acute Q fever, of which 181 were included in this retrospective study: 91 early-diagnosed (ED) acute Q fever patients, defined as negative IgM phase II enzyme-linked immunosorbent assay (ELISA) and positive PCR, and 90 late-diagnosed (LD) acute Q fever patients, defined as positive/dubious IgM phase II ELISA and positive immunofluorescence assay (IFA). Follow-up serology at 3, 6, and 12 months was performed using IFA (IgG phase I and II). High IgG antibody titers were defined as IgG phase II titers of ≥1:1,024 together with IgG phase I titers of ≥1:256. At 12 months, 28.6% of ED patients and 19.5% of LD patients had high IgG antibody titers (P= 0.17). No statistically significant differences were found in frequencies of IgG phase I and IgG phase II antibody titers at all follow-up appointments for adequately and inadequately treated patients overall, as well as for ED and LD patients analyzed separately. Additionally, no significant difference was found in frequencies of high antibody titers and between early (treatment started within 7 days after seeking medical attention) and late timing of treatment. This study indicates that early diagnosis and antibiotic treatment of acute Q fever do not prohibit development of the IgG antibody response.

scholarly journals Feline corneal sequestration

2001 ◽  
Vol 31 (3) ◽  
pp. 553-556
Author(s):  
Arianne Pontes Oriá ◽  
Ana Maria Barros Soares ◽  
José Luiz Laus ◽  
Francisco de Assis Dórea Neto
Keyword(s):  
Clinical Manifestations ◽  
Review Article ◽  
Diagnosis And Treatment ◽  
Domestic Cats ◽  
Ocular Pain

Corneal sequestration is a disease unique to domestic cats, clinically characterized by chronicity; signs of ocular pain with the development of a dark brown to black, opaque, oval, paracentral or central corneal plaque. The purpose of this review article was to approach and discuss about the etiology, clinical manifestations, diagnosis, and treatment of the corneal sequestrum.

scholarly journals INFECTIOUS ENDOCARDITIS WITH COXIELLA BURNETII

2017 ◽  
Vol 20 (4) ◽  
pp. 190-193
Keyword(s):  
Aortic Valve ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Clinical Manifestations ◽  
Cardiac Decompensation ◽  
Unpasteurized Milk ◽  
Appropriate Treatment ◽  
First Choice ◽  
Proper Diagnosis ◽  
Inflammatory Syndrome

Q fever is caused by an anthropozoonosis determined by the pathogen Coxiella burnetii, a gram-negative bacterium with intracellular growth. The occurrence of infection in the human species takes place through inhalation of contaminated aerosols or dust from infected domestic animals (cattle, sheep, goats) and more rarely through ingestion of unpasteurized milk, infected mite or inter-human transmission. The endocardium is one of the main infection sites, especially in the context of the long-term development of the disease, and cardiac decompensation often leads to death in absence of a proper diagnosis and appropriate treatment (1).We present the case of a patient of the male sex aged 37 years without personal pathologic history known admitted in “St. Parascheva” Clinical Hospital for Infectious Diseases Iasi complaining of productive cough, fatigue, shortness of breath with moderate effort and pain in the left scapulohumeral joint with irradiation in the left upper limb. Clinical examination objectified digital clubbing, systolic/diastolic murmurs throughout the precordium area and hepato-splenomegaly, while laboratory tests revealed the presence of inflammatory syndrome, cholestasis and hepatic cytolysis. Echocardiography shows a hyperechogenic entity at the level of the aortic valve, as well as a severe valve disorder. The diagnosis of infective endocarditis is established on aortic valve and therapy with first-choice antibiotics, consisting of triple combination of cefotaxime, amikacin and vancomycin, is initiated. Blood cultures taken upon admission were negative, while positive serological phase I and II tests for C. burnetii urged the indication of changing therapy with doxycycline and trimethoprim sulfamethoxazole (in the absence of hydroxychloroquine). Subsequently he underwent aortic valve replacement. The particularities of this case consisted in atypical clinical manifestations, the absence of fever and epidemiological context suggestive for Q fever.

scholarly journals A CASE OF Q FEVER IN NON-ENDEMIC AREAS

2012 ◽  
Vol 17 (6) ◽  
pp. 38-40
Author(s):  
A. A. Nafeev ◽  
V. V. Bezik
Keyword(s):  
Coxiella Burnetii ◽  
Q Fever ◽  
Geographical Area ◽  
Clinical Manifestations ◽  
Epidemiological Data ◽  
Definite Diagnosis ◽  
Serological Tests ◽  
Acute Case ◽  
The Subject ◽  
Endemic Areas

Coxiellosis (Q-fever) is a systemic natural focal zooanthroponosis disease, which has a very wide geographical area. A variety of clinical manifestations and the absence of pathognomonic signs of illness forces to use for making a definite diagnosis complex of techniques including epizootological, epidemiological data, clinical manifestations, and certainly the results of several serological tests designed to detect antibodies to Coxiella burnetii. There is presented a description of an acute case of Q - fever in a child in the subject, characterized as trouble-free of Coxiellosis from 70-ies of the last century.

scholarly journals Research Trends and Hotspots of Q Fever Research: A Bibliometric Analysis 1990-2019

2022 ◽  
Vol 2022 ◽  
pp. 1-14
Author(s):  
Muhammad Farooq ◽  
Aman Ullah Khan ◽  
Hosny El-Adawy ◽  
Katja Mertens-Scholz ◽  
Iahtasham Khan ◽  
...  
Keyword(s):  
Bibliometric Analysis ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Research Output ◽  
Knowledge Exchange ◽  
Clinical Manifestations ◽  
Laboratory Diagnosis ◽  
Research Collaborations ◽  
Collection Data ◽  
Essential Resource

Q fever is a worldwide distributed zoonosis caused by Coxiella burnetii, a Gram-negative bacterium. Despite existence of large amount of research data on the developments related to Q fever, no bibliometric analysis of this subject is available to our knowledge. Bibliometric studies are an essential resource to track scholarly trends and research output in a subject. This study is aimed at reporting a bibliometric analysis of publications related to Q fever (2,840 articles published in the period 1990-2019) retrieved from Science Citation Index Expanded, an online database of Clarivate Analytics Web of Science Core Collection. Data was retrieved using keywords “Q fever” or “Coxiella burnetii” in title, abstract, and author keywords to describe important research indicators such as the kind and language of articles, the most important publications, research journals and categories, authors, institutions, and the countries having the most significant contribution to this subject. Finally, the emerging areas in field of diagnosis, host range, and clinical presentation were identified. Word cluster analysis of research related to Q fever revealed that major focus of research has been on zoonosis, seroprevalence, laboratory diagnosis (mainly using ELISA and PCR), clinical manifestations (abortion and endocarditis), vectors (ticks), and hosts (sheep, goat, and cattle). This bibliometric study is intended to visualize the existing research landscape and future trends in Q fever to assist in future knowledge exchange and research collaborations.

Application of Aptamer-based Hybrid Molecules in Early Diagnosis and Treatment of Diabetes Mellitus: From the Concepts Towards the Future

2019 ◽  
Vol 15 (4) ◽  
pp. 309-313 ◽  
Author(s):  
Sepideh Ahmadi ◽  
Navid Rabiee ◽  
Mohammad Rabiee
Keyword(s):  
Diabetes Mellitus ◽  
Early Diagnosis ◽  
Review Article ◽  
Diagnosis And Treatment ◽  
Future Perspective ◽  
Dna And Rna ◽  
Hybrid Molecules ◽  
Prevention And Treatment ◽  
Potential Factor ◽  
Treatment Of Diabetes

Aptamers have several positive advantages that made them eminent as a potential factor in diagnosing and treating diseases such as their application in prevention and treatment of diabetes. In this opinion-based mini-review article, we aimed to investigate the DNA and RNA-based hybrid molecules specifically aptamers and had a logical conclusion as a promising future perspective in early diagnosis and treatment of diabetes.

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