scholarly journals Ovarian aromatase activity in polycystic ovarian syndrome

2014 ◽  
Vol 63 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Igor Pavlovich Nikolayenkov ◽  
Vladimir Vsevolodovich Potin ◽  
Marina Anatolyevna Tarasova ◽  
Natalya Nikolayevna Tkachenko ◽  
Maria Igorevna Yarmolinskaya ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Antral Follicle ◽  
Reproductive Age ◽  
Blood Levels ◽  
Aromatase Activity ◽  
Ovary Syndrome ◽  
Antral Follicles ◽  
Ovarian Syndrome

41 women with polycystic ovary syndrome (PCOS) and 15 healthy women of reproductive age were examined to evaluate ovarian aromatase activity. Aromatase activity was determined by the decrease of estradiol level after peroral intake of aromatase inhibitor letrosol. To examine aromatase activity of antral follicle (∆E2) was divided on the blood level of antimullerian hormone (AMH), which is corresponded to the number of antral follicles. Significant variations of aromatase activity of antral follicles in patients with PCOS were determined: in 34.1 % of women it was within physiological ranges, in 48.8 % of women it was decreased and in 17.1 % of women it was increased. Aromatase activity of antral follicles in patients with PCOS correlated with blood levels of estradiol (r = 0.67), estron (r = 0.27), free testosterone(r = 0.43), androstendion (r = 0.34) and body mass index (r = 0.30). Aromatase activity had reverse correlation with number of antral follicles. Athors suggest that the sensitivity of the ovaries to gonadotropinic stimulation is decreased in patients with PCOS and low aromatase activity.

scholarly journals Assessment of current methods of laboratory diagnosis of bacterial vaginosis

2014 ◽  
Vol 63 (1) ◽  
pp. 26-32
Author(s):  
Kira Valentinovna Shalepo ◽  
Veronika Victorovna Nazarova ◽  
Yulia Nicolaevna Menukhova ◽  
Tatiana Andreevna Rumyantseva ◽  
Alexander Evgenievich Guschin ◽  
...  
Keyword(s):  
Polycystic Ovary ◽  
Free Testosterone ◽  
Antral Follicle ◽  
Laboratory Diagnosis ◽  
Reproductive Age ◽  
Blood Levels ◽  
Aromatase Activity ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Antral Follicles

41 women with polycystic ovary syndrome (PCOS) and 15 healthy women of reproductive age were examined to evaluate ovarian aromatase activity. Aromatase activity was determined by the decrease of estradiol level after peroral intake of aromatase inhibitor letrosol. To examine aromatase activity of antral follicle (∆E2) was divided on the blood level of antimullerian hormone (AMH), which is corresponded to the number of antral follicles. Significant variations of aromatase activity of antral follicles in patients with PCOS were determined: in 34.1 % of women it was within physiological ranges, in 48.8 % of women it was decreased and in 17.1 % of women it was increased. Aromatase activity of antral follicles in patients with PCOS correlated with blood levels of estradiol (r = 0.67), estron (r = 0.27), free testosterone(r = 0.43), androstendion (r = 0.34) and body mass index (r = 0.30). Aromatase activity had reverse correlation with number of antral follicles. Athors suggest that the sensitivity of the ovaries to gonadotropinic stimulation is decreased in patients with PCOS and low aromatase activity.

scholarly journals The effect of progressive muscle relaxation on depression in polycystic ovarian syndrome

2018 ◽  
Vol 7 (8) ◽  
pp. 3029
Author(s):  
Jyoti Parle ◽  
Aishwarya D. Savant
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Muscle Relaxation ◽  
Progressive Muscle Relaxation ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Exclusion Criteria ◽  
Before And After ◽  
Muscle Groups ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Authors explored the effects of progressive muscle relaxation (PMR) on depression in females with polycystic ovarian syndrome (PCOS).Methods: In a 4-week study duration in which the intervention was for three times a week, 30 females which were selected according to the inclusion and exclusion criteria received a PMR protocol in which subjects were taught to contract and relax 16 muscle groups. The Becks Depression Inventory (BDI) was taken before and after the intervention as a depression analysis tool.Results: After 4 weeks of intervention, the patients showed significant improvement in depression (P < 0.05).Conclusions: In conclusion, this study suggests that PMR practice is effective in improving depression, in patients with PCOS.

scholarly journals Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Manal Madany Abdalqader ◽  
Shatha Sami Hussein
Keyword(s):  
Roc Analysis ◽  
Polycystic Ovarian Syndrome ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Ovary Syndrome ◽  
Significant Difference ◽  
Iraqi Women ◽  
Ovarian Syndrome ◽  
Control Study

Objective. Kisspeptin 1 might reflect increased androgen level in polycystic ovarian syndrome instead of other markers. Study Design. A case control study was performed in Al-Yarmouk Teaching Hospital from 1st of July 2016 to 1st of July 2017; it involved 87 women divided into two groups: 44 women diagnosed as PCOS, 22 women with BMI ≥ 25 kg/m2 and 22 women with BMI < 25 kg/m2, and another 43 women without PCOS, 22 women with BMI ≥ 25 kg/m2 and 21 women with BMI < 25 kg/m2. Hormonal, metabolic profiles, and hirsutism scores, as well as serum kisspeptin level, were assessed by using Human Kisspeptin 1(KISS-1) ELISA Kit. The blood samples between days 2 and 5 of menstrual cycle were drawn by an disposable sterile syringe and collected in EDTA containing tubes (as anticoagulant), and the hormonal profile was measured using a biotech ELISA reader. Result. Serum level of kisspeptin was significantly higher in PCOS compared to control (322.4 vs. 235.3 ng/L, respectively). There was no significant difference in age, BMI, and parity between control and PCOS; the frequency of hirsutism, acne, elevated LH, and increased free testosterone (fTT) were significantly higher in PCOS compared to control. Kisspeptin shows a direct significant correlation with hirsutism and fTT (r = 0.648, 0.238, respectively). In ROC analysis, kisspeptin had AUC (95% CI) = 0.874 (0.785–0.935) for predicting PCOS. Conclusion. Kisspeptin levels might be used as a marker for hyperandrogenemia in polycystic ovarian syndrome.

COMPLICATIONS OF PREGNANCY IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

2011 ◽  
Vol 22 (3) ◽  
pp. 188-206
Author(s):  
MALLIKA AZIZIA ◽  
PAUL HARDIMAN
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Polycystic Ovaries ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Ovarian Syndrome

Polycystic ovary syndrome (PCOS) is a common hormonal disorder affecting around 5–8% of women of reproductive age. It has a variable clinical spectrum including hyperandrogenism, menstrual abnormalities, polycystic ovaries and metabolic features like diabetes mellitus, obesity and dyslipidaemia. The manifestation of PCOS and its impact especially on reproductive function and pregnancy are profoundly affected by associated features of obesity/raised body mass index and metabolic syndrome.

scholarly journals Methodological approaches to the definition of ovarian aromatase in polycystic ovary syndrome

2016 ◽  
Vol 65 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Ekaterina M Timofeeva ◽  
Elena V Misharina ◽  
Igor P Nikolaenkov ◽  
Yanina A Samoylovich ◽  
Natalya N Tkachenko
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Aromatase Activity ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Antral Follicles ◽  
Methodological Approaches ◽  
Definition Of ◽  
Relative Deficiency

In order to study ovarian flavor ase activity in polycystic ovary syndrome (PCOS) examined 49 patients with PCOS and 33 healthy women of reproductive age. Aromatase activity determined using estradiol/number of antral follicles in both ovaries ratio (Е2/n). Values ovarian aromatase positively correlated (p < 0.05) with the results of its determination by a test with the aromatase inhibitor letrozole in PCOS. Reduced aromatase activity of antral follicles was present in 59 % of patients with PCOS. These data indicate that Е2/n ratio allows to evaluate ovarian aromatase and that an absolute or relative deficiency of ovarian aromatase underlies the pathogenesis of PCOS.

scholarly journals A Detailed Research on Detection of Polycystic Ovary Syndrome from Ultrasound Images of Ovaries

2019 ◽  
Vol 8 (2S11) ◽  
pp. 467-472
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Ultrasound Images ◽  
Time Analysis ◽  
Ovary Syndrome ◽  
Endocrine Disorder ◽  
Real Time Analysis ◽  
Ovarian Syndrome ◽  
Biochemical Abnormalities

A common endocrine disorder named polycystic ovarian syndrome (PCOS) usually occurs to several women’s during their reproductive age. This type of disease leads to infertility which represent with amenorrhea and hirsutism. The combination of clinical, endocrinological, and biochemical abnormalities are known to be PCOS which particularly related with the metabolism of estrogen and androgens. The periphery of ovaries is identified with the most common immature follicles which are less than 10mm. Analyzing this kind of situations in women is a major challenge which now doctors used ultrasound images which have the necessary details like number of follicles, size, and position. For real-time analysis of PCOS is a major task as follicles contains different sizes and highly connected with tissues and blood vessels which results in error prone. Several researchers have proposed different techniques for analyzing the PCOS using the ultrasound images of ovaries. In this study, we analyze the important factors and techniques used in detection of PCOS by using the ultrasound images taken from the women’s ovary and compared the results of existing works.

scholarly journals Prevalence of polycystic ovarian syndrome among selected group of Sudanese housewives with infertility disorders

2019 ◽  
Vol 2 (01) ◽  
Author(s):  
Mohammed A.Gafoor A.Gadir ◽  
Mohammed Omer Mohammed Hussein ◽  
Mosab Nouraldein Mohammed Hamad
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Clinical Symptoms ◽  
Polycystic Ovary ◽  
Pancreatic Beta Cell ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Cell Dysfunction ◽  
Increased Risk ◽  
Ovarian Syndrome

Polycystic ovary syndrome (PCOS), also recognized as the Stein-Leventhal syndrome, is one of the most widespread endocrinopathies between women of reproductive age. Hyperinsulinemia in mixture with pancreatic beta cell dysfunction consequences in an increased risk of numerous illnesses, counting type 2 diabetes, hypertension, dyslipidemia, endothelial dysfunction, atherosclerosis and cardiovascular diseases. Insulin also stimulates the theca cells of the ovary to create excessive testosterone, which is accountable for the clinical symptoms of hyperandrogenism

scholarly journals An Overview of Harmful Effects of Polycystic Ovary Syndrome

2021 ◽  
pp. 1-5
Author(s):  
Anisa Iftikhar ◽  
Keyword(s):  
Patient Management ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Metabolic Effects ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Harmful Effects ◽  
Hormone Imbalance ◽  
Ovarian Syndrome

PCOS, a hormone imbalance that causes infertility, obesity etc. Polycystic ovarian syndrome (PCOS) is the most frequent endocrinopathy among women of reproductive age. It is the most common female endocrine disorder with prevalence rates ranging from 4% to 18%. There are many associated condition with PCOS like obesity, many types of cancer, infertility, cardiac diseases etc. It is confirm that women who have this syndrome are at risk more than other women. The treatment of PCOS is determined by whether a woman wishes to become pregnant or not. If pregnancy is not a goal, then weight loss, oral contraceptives, and the diabetes medication. It should also include all metabolic effects and potential problems. More study and knowledge of the biology of PCOS will lead to better treatment outcomes and patient management.

scholarly journals Is serum amylase normal in women with polycystic ovarian syndrome?

2014 ◽  
Vol 11 (4) ◽  
pp. 1583-1591
Author(s):  
Baghdad Science Journal
Keyword(s):  
Insulin Resistance ◽  
Metabolic Disorders ◽  
Polycystic Ovarian Syndrome ◽  
Serum Amylase ◽  
Amylase Activity ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Reproductive Age Women ◽  
Ovarian Syndrome

Background : Polycystic ovary syndrome (PCOS) is the most common cause of infertility in reproductive-age women , it is an important harbinger of metabolic disorders. It has been reported that hyperamylasemia can be used as marker of ovarian cancer patients . The current study was conducted to evaluate amylase activity and to estimate the correlation of this enzyme with insulin and insulin resistance in PCOS patients. Methods: This study was conducted on forty five patients with PCOS in comparison to twenty five women as control. Fasting blood sample was taken from each subject and analyzed for amylase activity , FSH,LH, Insulin , proteins, and blood sugar , meanwhile insulin resistance was determined by HOMA-IR index. Results: The results of the study showed a significant increase (p

scholarly journals Serum free testosterone levels in polycystic ovarian syndrome patients and its correlation with clinical hyperandrogenism in Pakistan

2020 ◽  
Vol 14 (03) ◽  
pp. 132-135
Author(s):  
Tahir Ullah Khan ◽  
Naseer Nazeer Memon ◽  
Amna Riaz ◽  
Zohaib Ahmed Khan ◽  
Sundus Mariyum Haroon ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Reproductive Age ◽  
Fisher Exact Test ◽  
Polycystic Ovaries ◽  
Cross Sectional ◽  
Serum Free ◽  
Testosterone Levels ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) is the most frequent pathology among women of reproductive age characterized by menstrual irregularities, hyperandrogenism and polycystic ovaries on ultrasound. Evidence suggests that high androgen levels are the fundamental factor in the pathogenesis of PCOS. The objectives of the present study was to determine serum free testosterone levels in polycystic ovarian syndrome patients, and observe its correlation with clinical hyperandrogenism. Patients and methods: This cross-sectional study was conducted at Jinnah Allama Iqbal Institute of Diabetes and Endocrinology Lahore, Pakistan from 15th May 2019 to 15th November 2019. The study included 140 patients of PCOS diagnosed as per Rotterdam criteria. Serum testosterone levels were determined in these patients by ELISA method. Ferriman-Gallwey (FG) score was used to assess severity of clinical hyperandrogenism in the form of hirsutism. Patients were categorized into three groups, mild (FG score 8-15), moderate (FG score 15-25) and severe (FG score >25). Correlation between clinical (hirsutism) and biochemical hyperandrogenism (serum free testosterone levels) was assessed using Fisher exact test. Data was analyzed using SPSS version 25. Results: Biochemical hyperandrogenism in the form of raised free testosterone levels was present in 46 (32.9%) PCOS patients. Out of 12 patients having Ferriman Gallwey score >25, 10 (83.3%) had biochemical hyperandrogenism. Out of 70 patients having Ferriman Gallwey score 15-25, 22 (31.4%) had biochemical hyperandrogenism whereas out of 58 patients having Ferriman Gallwey score 8-15, only 14 (24.1%) patients had biochemical hyperandrogenism. Conclusion: Prevalence of biochemical hyperandrogenism in PCOS patients in our studied population was significantly low when compared to the population studied worldwide making it less reliable as diagnostic tool in this part of the world. Also there was significant positive correlation between free testosterone levels and degree of hirsutism which means that diagnostic accuracy of free testosterone in PCOS patients is considerably high in those having clinical hyperandrogenism.

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