scholarly journals Clinical and cytological characteristic of a condition of the oral cavity at pregnant women with various types of a diabetes mellitus

2016 ◽  
Vol 65 (6) ◽  
pp. 45-51 ◽  
Author(s):  
Ludmila Yu Orekhova ◽  
Anna A Aleksandrova ◽  
Ludmila A Aleksandrova ◽  
Ramila S Musaeva ◽  
Gulrukhsor Kh Tolibova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Pregnant Women ◽  
Inflammatory Diseases ◽  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Diabetes Mellitus Type 1 ◽  
Control Group ◽  
Type I ◽  
Liquid Based Cytology

Introduction. More and more researches dedicated to the communication of diseases of the oral cavity of pregnant women with diabetes. It is proved that the intensity of caries and inflammatory periodontal diseases (gingivitis and periodontitis) increase significantly during pregnancy, while the presence of comorbidities, such as diabetes, increase these indexes.Aim. The aim of the work was to study the dental status of pregnant women with diabetes.Materials and methods. The study compared women with gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes, to a control group of pregnant women without diabetes. In addition to clinical research methods, liquid-based cytology of the contents of the gingival sulcus was performed.Results. The results of clinical and laboratory studies have shown that inflammatory diseases of periodontium and teeth within pregnant women with diabetes are more common than within the pregnant women without this disease. It should be noted that the frequency of occurrence and severity of these diseases in the pregnant women with type I diabetes is higher than in the other groups.Conclusion. Pregnant women with diabetes are at risk for dental disease and require more attention from dentists, endocrinologists and obstetricians. The use of liquid-based cytology method helps in the diagnosis of inflammatory periodontal diseases.

scholarly journals ORAL CARE AND CHOICE OF MEDICINES FOR TREATING GINGIVITIS AND PERIODONTITIS IN CHILDREN WITH TYPE 1 DIABETES MELLITUS

2020 ◽  
Vol 20 (1) ◽  
pp. 199-204
Author(s):  
I.O. Kuz ◽  
O.V. Sheshukova
Keyword(s):  
Diabetes Mellitus ◽  
Inflammatory Diseases ◽  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Oral Care ◽  
Time Interval ◽  
Type I ◽  
Periodontal Tissues ◽  
Prophylactic Measures ◽  
Dental Appointment

The anatomical and physiological characteristics of a growing organism require a specific approach to the prevention and treatment of periodontal diseases. Not enough attention is paid toward improving the oral health of children suffering from diabetes mellitus, as well as therapeutic and prophylactic measures aimed at preserving teeth and preventing exacerbations of the inflammatory process in periodontal tissues. The results of clinical studies indicate a high prevalence of dental diseases in patients with type I diabetes mellitus; there are not enough reliable results of such indicators depending on the age and duration of this endocrine pathology, diabetic complications, hypoglycemic therapy taking into account metabolic control. Diagnosis of periodontal diseases is complicated by the peculiarities of the child’s psychological perception, caused by age-specific characteristics and the influence of common manifestations of inflammatory diseases. Children of primary school age often demonstrate increased motor activity, a hyperergic reaction even to minor negative feelings, the difficulty of adequate behaviour in an unfamiliar environment and a correct assessment of what is happening, being stressed due to the presence of many phobias associated with doctors and medical manipulations, communicative difficulties caused by staying in the spotlight, meeting new people, talking with adults. Teaching children must necessarily be accompanied by educating parents, since within limited time interval of dental appointment a doctor does not have the opportunity to fully monitor and consolidate the knowledge and skills the child has received, and this responsibility falls on parents. In this case, some attention should be paid to issues of skills, motivation as well as on the importance dental care aspects for the development of the dentofacial system, since in the vast majority of cases, parents are not enough aware on these issues. In addition to educating and fostering the motivation, it is necessary to control the level of knowledge, the frequency and quality of tooth brushing. For young children, it is necessary to do complete cleaning up the chewing group of teeth due to the low level of children’s manual skills.

scholarly journals FEATURES OF MICROBIOLOGICAL AND IMMUNE STATE IN PREGNANT WOMEN WITH INFLAMMATORY PERIODONTAL DISEASES AGAINST THE BACKGROUND OF GESTATIONAL DIABETES MELLITUS

2020 ◽  
Vol 75 (3) ◽  
pp. 83-86
Author(s):  
Ye.I. Alexandrov ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Oral Cavity ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Periodontal Diseases ◽  
Main Group ◽  
Control Group ◽  
Periodontal Health ◽  
Periodontal Tissues

90 pregnant women with inflammatory periodontal diseases, aged 27 to 35 years were examined. The main group consisted of 60 pregnant women with gestational diabetes mellitus and the control one consisted of 30 patients with physiological pregnancy. All patients were examined before providing treatment and preventive measures at 14–15 weeks of pregnancy and after them at 37–38 weeks. Studies have shown deterioration in periodontal health, oral hygiene and increase in contamination of the oral cavity in patients of the main group as compared with patients of the control group. The use of the anti-inflammatory succinic acid based preparation is effective for inflammatory periodontal diseases in pregnant women with gestational diabetes. The improvement of periodontal tissues health was confirmed by the posttreatment indices of hygiene, immunoglobulins, microbiocenosis and periodontal indices that promote normalization of the oral cavity.

scholarly journals Perinatal and neonatal outcomes of pregestational diabetes mellitus: a retrospective study

2021 ◽  
Author(s):  
Giampiero Capobianco ◽  
Alessandra Gulotta ◽  
Giulio Tupponi ◽  
Francesco Dessole ◽  
Giuseppe Virdis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pregnant Women ◽  
Gestational Hypertension ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Control Group ◽  
Growth Disorders ◽  
Pregestational Diabetes ◽  
Increased Risk ◽  
History Of

Abstract BackgroundThe aim of the study was to evaluate maternal-foetal and neonatal clinical outcomes in a group of patients with pregestational diabetes mellitus (PGDM) such as diabetes mellitus type 1 (DM1), diabetes mellitus type 2 (DM2), and maturity onset diabetes of the young (MODY).MethodsOverall, 174 pregnant women, nulliparous and multiparous, with single pregnancy were enrolled. The selected patients were divided into two groups: PGDM (42 with DM1, 14 with DM2, and 2 with MODY); 116 patients with a negative pathological history of diabetes mellitus were the control.ResultsWe reported an incidence of preterm delivery of 55.2% in the PGDM group, of 59.5% in the DM1 group, and 42.9% in the DM2 group VS. 6% in the controls. Foetal growth disorders, such as intrauterine growth retardation, small for gestational age, and foetal macrosomia were found in 19% and 3.6% in the case and in the control group, respectively. A relationship between DM2 and gestational hypertension was found.Conclusionspatients with PGDM are at increased risk of perinatal and neonatal complications in comparison with pregnant women without PGDM.

ESTIMATION OF THE CLINICAL EFFICIENCY OF THE APPLICATION OF LASER TECHNOLOGIES FOR SANITATION OF THE ORAL CAVITY IN INFLAMMATORY - DESTRUCTIVE DISEASES OF THE PERIODONT IN PATIENTS WITH TYPE I AND II DIABETES MELLITU

2020 ◽  
pp. 82-87
Author(s):  
Vyrmaskin S.I.
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Periodontal Diseases ◽  
High Energy ◽  
Type I ◽  
Erbium Laser ◽  
Surgical Method ◽  
Periodontal Tissues ◽  
Laser Technologies ◽  
Dental Laser

The study is devoted to the study of inflammatory and destructive periodontal diseases against the background of type 1 and 2 diabetes mellitus. The search and development of new approaches to the rehabilitation of periodontal tissues in patients with diabetes mellitus are aimed at stabilizing the pathological process in the oral cavity. The use of high-energy lasers in practice leads to a persistent bactericidal effect in target tissues and a reduction in the regeneration time in the postoperative period. Erbium laser with a wavelength of 2940 nm was used as a cutting tool according to the manufacturer's instructions in the recommended mode. The clinical efficacy of the dental laser in comparison with the conventional surgical method is shown on the basis of the quantitative results of the evaluation of the effect generally accepted in evidence-based medicine. The expediency of combining patients with different types of diabetes mellitus into a general group has been determined. A number of indices in the groups with gingivitis and periodontitis were analyzed. A randomized, open, comparative in parallel groups clinical study of the effectiveness of debridement of foci of periodontal infection in patients with type I and II diabetes mellitus using an erbium laser in comparison with the surgical method was carried out. The paper presents conclusions on the reduction of the unfavorable outcome of inflammatory-destructive periodontal diseases when using laser technologies. The results of evaluating the effectiveness of the use of a dental laser open the prospect for including this method of sanitation of gum tissue in the scheme of complex treatment of inflammatory and destructive periodontal disease.

Analysis of anti-inflammatory toothpastes efficiency among patients with diabetes mellitus and chronic generalized periodontitis

2020 ◽  
Vol 25 (1) ◽  
pp. 47-53
Author(s):  
L. Yu. Orekhova ◽  
R. S. Musaeva ◽  
E. S. Loboda ◽  
E. V. Grinenko ◽  
A. V. Chuprinina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Oral Hygiene ◽  
Periodontal Diseases ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Periodontal Tissues ◽  
Patients With Diabetes ◽  
Anti Inflammatory

Relevance. Inflammatory periodontal diseases (IPD) on the background of microangiopathy among patients with diabetes mellitus (DM) are considered one of the main complications. Reduced resistance of periodontal tissues and trophic disorders due to changes in capillary walls leads to development of inflammatory processes with the destruction of gingival joint. The presence of diabetes mellitus in patients with chronic generalized periodontitis requires not only conservative periodontal therapy by a dentist, but also constant maintenance therapy, which consists in the ability of patient to maintain satisfactory oral hygiene and the use of therapeutic and prophylactic toothpastes.Purpose. To evaluate the effectiveness of using toothpastes with anti-inflammatory components among pa-tients with chronic generalized periodontitis and type 1 diabetes after professional oral hygiene complex.Materials and methods. The examination of 60 patients with diabetes mellitus type 1 and chronic generalized periodontitis at the age of 20 to 50 years was conducted. All patients underwent a questionnaire on the presence of complaints about state of the oral cavity and a comprehensive dental examination with definition of basic dental indices. Then, a complex of professional oral hygiene with individual hygiene training was carried out. Patients were divided into groups depending on the prescribed paste with anti-inflammatory components. Repeated examination was carried out after 1 month.Results. In 1 month after conservative therapy was carried out, improvement of all indexes in all groups, improvement of the acid-base state of the oral fluid was found. Patients themselves noted a better way change in state of oral cavity tissues. The best dynamics after treatment complex was observed in the 1st group.Conclusion. Hygienic and periodontal condition of the oral cavity among patients with diabetes mellitus type 1 was initially at a rather low level. It has been revealed that complex of professional oral hygiene and prescription of therapeutic and prophylactic toothpaste improve periodontal status of patients with diabetes.

Evaluation of Bone Mineral Density in Children with Type I Diabetes Mellitus and Relationship to Serum Levels of Osteopontin

Drug Research ◽  
2017 ◽  
Vol 67 (09) ◽  
pp. 527-533 ◽  
Author(s):  
Forough Saki ◽  
Abdolkarim Sheikhi ◽  
Gholam Omrani ◽  
Hamid Karimi ◽  
Mohammad Dabbaghmanesh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Negative Correlation ◽  
Healthy Subjects ◽  
Type I Diabetes ◽  
Serum Levels ◽  
Control Group ◽  
Type I ◽  
Mineral Density

Abstract Type I diabetes mellitus (T1DM) patients are at risk of osteoporosis and fracture due to the osteoblast and osteoclast malfunction. Osteopontin (OPN) as the major non-collagenous bone matrix protein is produced by osteoblasts and osteoclasts and involve in bone resorption, formation and remodeling. To evaluate the serum levels of OPN, bone mineral density (BMD) and correlation in patients with T1DM this study was designed. In this case-control study, 87 children with T1DM and 87 age/sex-matched healthy subjects were enrolled. Blood samples were tested for OPN levels by ELISA. Dual energy X-ray absorptiometry was used to measure BMD. The mean levels of BMD in patients was significantly lower than control group (p<0.0001). There was no significant difference between patients and healthy subjects regarding the levels of OPN. However, in patients with high levels of OPN (mean+1.5 standard deviation) the BMD was significantly lower than other patients (p<0.0001). Totally there was a negative correlation between serum levels of OPN and BMD in patients with T1DM (p<0.016). These results indicated that the BMD in T1DM is less than healthy children and elevated level of OPN in patients could be associated with low BMD. A linear negative correlation between serum OPN and total BMD of T1DM patients compared to control group was noticed in this study indicating that the amount of serum OPN could be effective on BMD and a good predicting factor for osteoporosis in patients.

Evaluation of α-klotho level in insulin dependent diabetes mellitus (IDDM) children

2020 ◽  
Vol 33 (6) ◽  
pp. 761-765
Author(s):  
Fariba Tarhani ◽  
Ghobad Heidari ◽  
Alireza Nezami
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Sandwich Elisa ◽  
Serum Levels ◽  
Dependent Diabetes Mellitus ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Type I ◽  
And Control

AbstractObjectivesReduced levels of α-Klotho is associated with the pathogenesis of various diseases including diabetes. In type I diabetes, decrease in Klotho leads to apoptosis of β-cells of pancreases. The aim of this study was to evaluate the levels of α-Klotho in type I diabetic pediatric patients.MethodsIn this cross-sectional single centered study, 46 patients presenting type I diabetes mellitus (case group) and 78 control group under the age of 12, referred to our clinic were included in our study. Serum levels of soluble Klotho were measured by sandwich ELISA in case and control groups. Statistical analysis was conducted for the data recorded via questionnaire.ResultsMean age of the patients in the case and control group was 7.65 ± 3.09 and 7 ± 2.37, respectively. Type I diabetes patients had a significant reduction in the levels of serum Klotho, as compared to controls (p<0.001). However, gender and age-based comparison between patient and control group was not significant.ConclusionsThis study reports a significant decrease in the serum levels of α-Klotho in type 1 diabetic patients. Low levels of Klotho can be associated with diabetic nephropathy and other comorbidities in these patients.

scholarly journals Correction of dyslipidemia with combined use of beta-sitosterol and polyprenyl phosphates in dogs with type 1 diabetes mellitus

2019 ◽  
Vol 2019 (5) ◽  
pp. 12-15
Author(s):  
Вячеслав Анников ◽  
Vyacheslav Annikov ◽  
Александр Наровлянский ◽  
Aleksandr Narovlyanskiy ◽  
Александр Санин ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Type I Diabetes ◽  
Control Group ◽  
Type I ◽  
Upper Limit ◽  
Combined Use ◽  
Polyprenyl Phosphates

This study considers the efficiency of use of a combined drug based on beta-sitosterol and polyprenyl phosphates in dogs with type I diabetes mellitus complicated by hyperlipidemia. It was shown that after 1 month of the therapy, there was a significant decrease of the level of cholesterol, triglycerides and glucose vs. control animals. After 2 months of the therapy, in the control group the level of cholesterol and triglycerides was at the upper limit of the norm, which can lead to an exacerbation of the disease in future.

scholarly journals Triglycerides Predict Plasma Fibronectin in Children with Type I Diabetes Mellitus Rather than Diabetes

2002 ◽  
Vol 45 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Ayşe Binnur Erbağcı ◽  
Mehmet Tarakçıoğlu ◽  
Ahmet Erbağcı ◽  
Mehmet Gözübüyük ◽  
Necat Yılmaz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Plasma Cholesterol ◽  
Endothelial Activation ◽  
Type I Diabetes Mellitus ◽  
Control Group ◽  
Type I ◽  
Plasma Fibronectin ◽  
Diabetic Children ◽  
Adhesive Proteins

Fibronectins are adhesive proteins considered as markers of endothelial activation. Plasma fibronectin levels in diabetes mellitus (DM) have been found to be associated with atherosclerotic risk factors. This study was carried out to investigate plasma fibronectin and its relation with serum lipids, apolipoproteins AI, B100 and lp(a) in diabetic children. 35 children (19F/16M) with type I DM and 30 non-diabetic age and gender-matched controls were enrolled. Apolipoprotein and fibronectin concentrations were determined with nephelometric methods. Plasma fibronectin levels of the children with type I DM and the control group are not statistically different. HbA1c and triglycerides concentration are found to be significant predictors of plasma fibronectin in diabetic children, while effect of plasma cholesterol, apolipoprotein AI, B100 and lp(a) are insignificant. Diabetic children with triglycerides 1.13 mmol/l have elevated plasma fibronectin (median, 25th–75th percentiles; 29.6, 8.3–40.8 mg/dL) compared to the diabetic ≥19.9, 8.6–30.7 mg/dL, p<0,05) and non-diabetic children (16.6, 12.7–32.4 mg/dL, p<0.01) with triglycerides<1.13mmol/L. On the other hand plasma fibronectin concentrations of diabetic and non-diabetic children with high triglycerides are not significantly different. In conclusion our data does not support the concept that plasma fibronectin is elevated in type I diabetes mellitus at least in children, but high plasma triglycerides secondary to diabetes or not is associated with higher FNp concentrations which may have implications on atherogenesis. Plasma cholesterol, apolipoproteins AI, B100 and lp (a) are not significant determinants of FNp in type I diabetic children.

scholarly journals Clinical evaluation of complex treatment and prevention of generalized periodontitis in patients with type I diabetes mellitus with cardiomyopathy

2021 ◽  
Vol 25 (3) ◽  
pp. 424-427
Author(s):  
R. Y. Shkrebnyuk ◽  
V. T. Dyryk ◽  
O. M. Vynogradova ◽  
N. I. Bodnaruk ◽  
O. V. Zubachyk
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Control Group ◽  
Type I ◽  
Periodontal Tissue ◽  
Prevention Measures ◽  
Traditional Treatment ◽  
Periodontal Tissues ◽  
Treatment And Prevention

Annotation. Diabetes mellitus is an acute problem, as evidenced by the large number of people suffering from this disease, and the tendency to significantly increase the incidence rate. The most serious complications of diabetes include cardiomyopathy, the pathogenetic aspects of which are being actively studied. Widespread inflammatory-dystrophic periodontal disease and an increase in the proportion of generalized periodontitis in patients with diabetes mellitus complicated by cardiomyopathy, makes the problem of effective treatment and prevention of this pathology among the most relevant. The purpose of the study: clinical evaluation of complex treatment and prevention of generalized periodontitis in patients with type I diabetes mellitus with cardiomyopathy according to the developed algorithm. Comprehensive treatment and prevention measures were performed in 127 patients with generalized periodontitis on the background of type I diabetes mellitus with cardiomyopathy, of which 82 patients were the main group, where treatment was carried out using our proposed treatment and prevention algorithm. The control group, in which treatment was carried out according to protocol methods, consisted of 45 patients. Clinical visual examination and determination of paraclinical indices were performed on day 30 after treatment. Statistical calculation of digital values was performed on a Pentium II computer using the statistical software package “Statgraphic 2.3” and “Microsoft Excel 2000”, the significance of changes was evaluated by t-test. As a result of the research it was found that on average, 30 days after treatment, in the main group where we used the proposed pharmacotherapy, “normalization” of periodontal tissues was studied in 26.83 % of patients, “improvement” – in 30.49 % of patients’ treatment was ineffective in 42.68 % of patients, with a reliability of p>0.05. In patients of the control group, where traditional treatment and prevention measures were used to treat generalized periodontitis, on average, “normalization” of periodontal tissue was recorded in 17.78 % of patients, “improvement” of periodontal tissue was found in 28.89 % of patients. Treatment was ineffective in 53.33 % of patients. Thus, as a result of research, it can be argued that in patients with generalized periodontitis on the background of type I diabetes mellitus complicated by cardiomyopathy, whose treatment was carried out using our treatment and prevention algorithm, which included local measures and general appointments, significantly improved periodontal tissues, as confirmed by clinical observation. In the control group, where traditional treatment regimens were used, the treatment of generalized periodontitis was ineffective. In further studies, it is planned to study the microbiome of the oral cavity in patients with generalized periodontitis on the background of type I diabetes mellitus complicated by cardiomyopathy.

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