scholarly journals Modern therapeutic options in the treatment of bacterial vaginosis

2020 ◽  
Vol 69 (3) ◽  
pp. 39-45
Author(s):  
Evgeny F. Kira ◽  
Yulia V. Khalturina
Keyword(s):  
Bacterial Vaginosis ◽  
Therapeutic Options ◽  
Diagnosis And Treatment ◽  
Therapeutic Approaches ◽  
Advantages And Disadvantages ◽  
Modern Methods

This article reviews the pathogenetic aspects of bacterial vaginosis and modern methods of diagnosis and treatment of vaginal microbiocenosis disorders. The advantages and disadvantages of the available therapeutic approaches are discussed, and new opportunities and prospects in the treatment of bacterial vaginosis are highlighted.

CURRENT STATE OF THE PROBLEM OF DRAINAGE FOR NEUROGENIC BLADDER

2021 ◽  
pp. 30-38
Author(s):  
Игорь Александрович Артюхов ◽  
Владимир Васильевич Кузьменко ◽  
Андрей Владимирович Кузьменко ◽  
Тимур Асланбекович Гяургиев
Keyword(s):  
Urinary Tract ◽  
Neurogenic Bladder ◽  
Lower Urinary Tract ◽  
Advantages And Disadvantages ◽  
Economic Significance ◽  
Relevant Today ◽  
Modern Methods ◽  
Neurogenic Disorders ◽  
Neurogenic Dysfunction ◽  
Lower Urinary

Данный литературный обзор посвящен одной из актуальных проблем современной урологии - нейрогенной дисфункции мочевыводящих путей. Нейрогенная дисфункция нижних мочевыводящих путей является одной из важнейших проблем современной урологии, что обусловлено ее высокой распространенностью, частотой вторичных осложнений со стороны мочевыделительной системы и социально-экономической значимостью. Распространенность нейрогенного мочевого пузыря среди пациентов, перенесших острое нарушение мозгового кровообращения, варьирует от 15 % до 94 % и зависит от времени, прошедшего с момента сосудистого события. В статье представлены патофизиологические механизмы, лежащие в основе данной патологии, подробно рассмотрены современные методы дренирования нижних мочевыводящих путей, их преимущества и недостатки. К современным способам дренирования при нейрогенных расстройствах нижних мочевыводящих путей относят периодическую (интермиттирующую) катетеризацию, постоянную катетеризацию и надлобковую цистостомию. Анализ доступной литературы указывает на то, что частота осложнений, ассоциированных как с нейрогенной дисфункцией мочевого пузыря, так и с используемыми способами дренирования, продолжает оставаться достаточно высокой. Таким образом, проблема профилактики катетер-ассоциированных осложнений и улучшения качества жизни данной категории больных на сегодняшний день продолжает оставаться актуальной и требует проведения дальнейших исследований в данной области This literature review is devoted to one of the most pressing problems of modern urology - neurogenic urinary tract dysfunction. Neurogenic dysfunction of the lower urinary tract is one of the most important problems of modern urology, due to its high prevalence, frequency of secondary complications from the urinary system, and socio-economic significance. The prevalence of neurogenic bladder among patients who have experienced acute cerebrovascular accident varies from 15 % to 94 % and depends on the time elapsed since the vascular event. The article presents the pathophysiological mechanisms underlying this pathology, discusses in detail modern methods of drainage of the lower urinary tract, their advantages and disadvantages. Modern methods of drainage for neurogenic disorders of the lower urinary tract include periodic (intermittent) catheterization, permanent catheterization, and suprapubic cystostomy. Analysis of the available literature indicates that the frequency of complications associated with both neurogenic bladder dysfunction and the drainage methods used continues to be quite high. Thus, the problem of preventing catheter-associated complications and improving the quality of life of this category of patients continues to be relevant today and requires further research in this area

Multitarget therapeutic approaches for Alzheimer's and Parkinson's diseases: an opportunity or an illusion?

2021 ◽  
Author(s):  
Maria João Matos
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Diseases ◽  
Therapeutic Options ◽  
Therapeutic Approaches ◽  
Recent Information ◽  
Temporary Relief ◽  
Parkinson’S Diseases ◽  
Innovative Approaches

Alzheimer's and Parkinson's disease are the most prevalent neurodegenerative diseases and the leading causes of dementia worldwide. The etiology of these multifactorial pathologies is not completely known. The available therapeutic approaches can cause temporary relief of symptoms but cannot slow down their progression or cure them. Life-changing therapeutic solutions are urgently needed, as the number of people suffering from these pathologies has been increasing quickly over the last few decades. Several targets are being studied, and innovative approaches are being pursued to find new therapeutic options. This overview is focused on the most recent information regarding the paradigm of using multitarget compounds to treat both Alzheimer's and Parkinson's disease.

Clinical and pharmacological rationale for principles of therapy for bacterial vaginosis

2021 ◽  
Vol 20 (3) ◽  
pp. 134-145
Author(s):  
N.B. Lazareva ◽  
◽  
E.V. Rebrova ◽  
A.Yu. Ryazanova ◽  
E.V. Shikh ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Metabolic Pathways ◽  
Disease Recurrence ◽  
Gardnerella Vaginalis ◽  
Adherence To Treatment ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Structural Differences ◽  
Single Use ◽  
Low Incidence

Metronidazole and clindamycin have been the main medications for the treatment of bacterial vaginosis (BV) for 60 years. Despite the available arsenal of therapeutic agents, the frequency of disease recurrence remains high, and therefore the search for new therapeutic approaches remains relevant. In 2017, the FDA (Food and Drug Administration, USA) approved the use of secnidazole for the treatment of BV. As a member of the 5-nitroimidazole group, secnidazole differs structurally from metronidazole and tinidazole by radical groups attached to the annular nitrogen next to the nitro group. Structural differences may explain physicochemical and biochemical differences (e.g., tissue distribution, metabolic pathways) between these agents within the same pharmacological class of 5-nitroimidazoles. Secnidazole has the longest half-life compared to other medications in this group, which can significantly increase adherence to treatment, due to the possibility of achieving a clinical effect after a single use and a low incidence of adverse drug reactions, comparable to placebo. Key words: bacterial vaginosis, gardnerella vaginalis, lactobacilli, metronidazole, secnidazole

scholarly journals To help patients with hypothalamic-pituitary disorders {patient’s school)

1997 ◽  
Vol 43 (2) ◽  
pp. 32-34
Author(s):  
G. A. Melnichenko ◽  
T. I. Romantsova ◽  
V. A. Chernogolov ◽  
M. G. Pavlova
Keyword(s):  
Pituitary Hormones ◽  
Diagnosis And Treatment ◽  
Previous Issue ◽  
Modern Methods ◽  
Excessive Secretion

In the previous issue of the magazine, we talked about how the lack of pituitary hormones manifests itself and what modern methods of diagnosis and treatment of these conditions exist. Today we continue the story about the disease of the hypothalamic-pituitary system and dwell on the symptoms of excessive secretion of pituitary hormones.

scholarly journals Rehabilitation of patients after acute cerebrovascular accident followed by hemodynamically significant stenoses of the brachiocephalic arteries

2020 ◽  
pp. 25-29
Author(s):  
A. G. Shapovalova ◽  
V. G. Rapovka ◽  
A. O. Sobolevskaya ◽  
T. N. Negoda
Keyword(s):  
Carotid Arteries ◽  
Atherosclerotic Lesion ◽  
Cerebral Stroke ◽  
Cerebrovascular Accidents ◽  
Advantages And Disadvantages ◽  
Acute Cerebrovascular Accident ◽  
Modern Methods ◽  
Epidemiological Significance ◽  
Brachiocephalic Arteries

The literature data is presented covering epidemiological significance of acute cerebrovascular accidents (CVA) in‑ cidence in patients with brachiocephalic arteries lesion. The role of atherosclerotic lesion of carotid arteries in the develop‑ ment of ischemic cerebral stroke is shown. The basic methods for diagnosis of carotid arteries lesion has been analyzed as well as their availability and informative value. A comparative analysis of modern methods for surgical treatment of athero‑ sclerotic lesion of carotid arteries such as carotid endarterectomy (classic and eversion), endovascular procedure has been done. The main advantages and disadvantages of these treatment methods, indications and contraindications for their use are described. The timing of cerebral revascularization in the acute and delayed periods of ischemic stroke was estimated. The role of bilateral lesion of the carotid territory is shown as well as approaches to the treatment strategy of such patients.

scholarly journals MODERN METHODS OF THE TREATMENT OF ESOPHAGEAL STRICTURES IN BULLOUS EPIDERMOLYSIS CHILDREN

2019 ◽  
Vol 21 (1) ◽  
pp. 54-61
Author(s):  
Artem V. Tupylenko ◽  
M. M. Lokhmatov ◽  
N. N. Murashkin ◽  
V. I. Oldakovskiy
Keyword(s):  
Esophageal Stenosis ◽  
Optimal Method ◽  
Advantages And Disadvantages ◽  
Endoscopic Gastrostomy ◽  
Treatment And Prevention ◽  
Fluoroscopic Control ◽  
Esophageal Strictures ◽  
Modern Methods ◽  
Peg Tube ◽  
Surgical Operations

The review presents modern approaches to the treatment and prevention of the benign esophageal stenosis in epidermolysis bullosa (EB) children. There are discussed advantages and disadvantages of such main methods as conservative, intraluminal recanalization, and surgical operations used in the treatment of esophageal strictures in EB patients. The features of anesthesia in BE patients are described. Balloon dilatation of esophageal strictures under endoscopic or fluoroscopic control has been shown to be the optimal method of treating patients. In severe BE children with refractory esophageal stenosis, developmental delay, and nutritional status disorders, to perform hyperalimentation by virtue of the percutaneous endoscopic gastrostomy (PEG) tube is recommended.

scholarly journals Gene Therapy for Pancreatic Diseases: Current Status

2018 ◽  
Vol 19 (11) ◽  
pp. 3415 ◽  
Author(s):  
Kenya Kamimura ◽  
Takeshi Yokoo ◽  
Shuji Terai
Keyword(s):  
Pancreatic Cancer ◽  
The Body ◽  
Therapeutic Options ◽  
Current Status ◽  
Endocrine Tumors ◽  
Therapeutic Approaches ◽  
Islet Cell Tumors ◽  
Pancreatic Diseases ◽  
Gene Therapies ◽  
New Strategies

The pancreas is a key organ involved in digestion and endocrine functions in the body. The major diseases of the pancreas include pancreatitis, pancreatic cancer, cystic diseases, pancreatic divisum, islet cell tumors, endocrine tumors, diabetes mellitus, and pancreatic pain induced by these diseases. While various therapeutic methodologies have been established to date, however, the improvement of conventional treatments and establishment of novel therapies are essential to improve the efficacy. For example, conventional therapeutic options, including chemotherapy, are not effective against pancreatic cancer, and despite improvements in the last decade, the mortality rate has not declined and is estimated to become the second cause of cancer-related deaths by 2030. Therefore, continuous efforts focus on the development of novel therapeutic options. In this review, we will summarize the progress toward the development of gene therapies for pancreatic diseases, with an emphasis on recent preclinical studies and clinical trials. We aim to identify new areas for improvement of the current methodologies and new strategies that will lead to safe and effective gene therapeutic approaches in pancreatic diseases.

Benign Prostatic Hyperplasia (BPH): Therapeutic Options

1994 ◽  
Vol 61 (3) ◽  
pp. 192-196
Author(s):  
N. Caruso
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Endoscopic Surgery ◽  
Benign Prostatic Hypertrophy ◽  
Prostatic Hyperplasia ◽  
Prostatic Hypertrophy ◽  
Therapeutic Options ◽  
Invasive Therapy ◽  
Advantages And Disadvantages ◽  
Symptomatic Form

Researchers' interest in the last few years has been concentrated on finding a medical, if possible, or at least “mini-invasive” therapy for benign prostatic hypertrophy (BPH), which can be used for the symptomatic form instead of open or endoscopic surgery. The various therapeutic options are reviewed, underlining their advantages and disadvantages.

scholarly journals A Yeast-Based Model for Hereditary Motor and Sensory Neuropathies: A Simple System for Complex, Heterogeneous Diseases

2020 ◽  
Vol 21 (12) ◽  
pp. 4277 ◽  
Author(s):  
Weronika Rzepnikowska ◽  
Joanna Kaminska ◽  
Dagmara Kabzińska ◽  
Katarzyna Binięda ◽  
Andrzej Kochański
Keyword(s):  
Molecular Mechanisms ◽  
Genetic Diagnosis ◽  
Clinical Manifestations ◽  
Model System ◽  
Research Field ◽  
Therapeutic Approaches ◽  
Rare Disorders ◽  
Advantages And Disadvantages ◽  
Pathogenic Variants ◽  
Disease Subtypes

Charcot–Marie–Tooth (CMT) disease encompasses a group of rare disorders that are characterized by similar clinical manifestations and a high genetic heterogeneity. Such excessive diversity presents many problems. Firstly, it makes a proper genetic diagnosis much more difficult and, even when using the most advanced tools, does not guarantee that the cause of the disease will be revealed. Secondly, the molecular mechanisms underlying the observed symptoms are extremely diverse and are probably different for most of the disease subtypes. Finally, there is no possibility of finding one efficient cure for all, or even the majority of CMT diseases. Every subtype of CMT needs an individual approach backed up by its own research field. Thus, it is little surprise that our knowledge of CMT disease as a whole is selective and therapeutic approaches are limited. There is an urgent need to develop new CMT models to fill the gaps. In this review, we discuss the advantages and disadvantages of yeast as a model system in which to study CMT diseases. We show how this single-cell organism may be used to discriminate between pathogenic variants, to uncover the mechanism of pathogenesis, and to discover new therapies for CMT disease.

scholarly journals Vaccine and Therapeutic Options To Control Chikungunya Virus

2017 ◽  
Vol 31 (1) ◽  
Author(s):  
Ann M. Powers
Keyword(s):  
Vector Control ◽  
Future Development ◽  
Chikungunya Virus ◽  
Therapeutic Options ◽  
Protective Measures ◽  
Vector Borne Diseases ◽  
Advantages And Disadvantages ◽  
Vector Borne ◽  
And Control ◽  
Integrated Vector Control

SUMMARYBeginning in 2004, chikungunya virus (CHIKV) went from an endemic pathogen limited to Africa and Asia that caused periodic outbreaks to a global pathogen. Given that outbreaks caused by CHIKV have continued and expanded, serious consideration must be given to identifying potential options for vaccines and therapeutics. Currently, there are no licensed products in this realm, and control relies completely on the use of personal protective measures and integrated vector control, which are only minimally effective. Therefore, it is prudent to urgently examine further possibilities for control. Vaccines have been shown to be highly effective against vector-borne diseases. However, as CHIKV is known to rapidly spread and generate high attack rates, therapeutics would also be highly valuable. Several candidates are currently being developed; this review describes the multiple options under consideration for future development and assesses their relative advantages and disadvantages.

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