Hormonal contraception for women with type 1 diabetes

The investigation demonstrates the influence ofperoral combined contraceptives and preparations containing only progestagens on carbohydrate and lipid exchange and haemostatic system. The factors, which exert influence upon metabolic indices in women with type I insular diabetes, are estimated. The correlation between the intake of combined and containing only progestagens contraceptive preparations and the risk of tromboembolism is revealed. The indications and contraindications are defined for the prescription of peroral contraceptives in women with type I insular diabetes.

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The effects of exercise training versus intensive insulin treatment on skeletal muscle fibre content in type 1 diabetes mellitus rodents

Lipids in Health and Disease ◽

10.1186/s12944-021-01494-w ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

David P. McBey ◽

Michelle Dotzert ◽

C. W. J. Melling

Keyword(s):

Diabetes Mellitus ◽

Skeletal Muscle ◽

Type 1 Diabetes ◽

Exercise Training ◽

Muscle Fibre ◽

Lipid Content ◽

Fibre Type ◽

Insulin Treatment ◽

Type I

Abstract Background Intensive-insulin treatment (IIT) strategy for patients with type 1 diabetes mellitus (T1DM) has been associated with sedentary behaviour and the development of insulin resistance. Exercising patients with T1DM often utilize a conventional insulin treatment (CIT) strategy leading to increased insulin sensitivity through improved intramyocellular lipid (IMCL) content. It is unclear how these exercise-related metabolic adaptations in response to exercise training relate to individual fibre-type transitions, and whether these alterations are evident between different insulin strategies (CIT vs. IIT). Purpose: This study examined glycogen and fat content in skeletal muscle fibres of diabetic rats following exercise-training. Methods Male Sprague-Dawley rats were divided into four groups: Control-Sedentary, CIT- and IIT-treated diabetic sedentary, and CIT-exercised trained (aerobic/resistance; DARE). After 12 weeks, muscle-fibre lipids and glycogen were compared through immunohistochemical analysis. Results The primary findings were that both IIT and DARE led to significant increases in type I fibres when compared to CIT, while DARE led to significantly increased lipid content in type I fibres compared to IIT. Conclusions These findings indicate that alterations in lipid content with insulin treatment and DARE are primarily evident in type I fibres, suggesting that muscle lipotoxicity in type 1 diabetes is muscle fibre-type dependant.

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Type I Diabetes Mellitus

10.2310/im.4017 ◽

2019 ◽

Author(s):

Joseph I. Wolfsdorf ◽

Katharine Garvey

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Glycemic Control ◽

Type 1 Diabetes Mellitus ◽

Diabetic Ketoacidosis ◽

Autoimmune Diabetes ◽

Type I ◽

Insulin Deficiency ◽

Glucose Levels

Type 1 diabetes mellitus is characterized by severe insulin deficiency, making patients dependent on exogenous insulin replacement for survival. These patients can experience life-threatening events when their glucose levels are significantly abnormal. Type 1 diabetes accounts for 5 to 10% of all diabetes cases, with type 2 accounting for most of the remainder. This review details the pathophysiology, stabilization and assessment, diagnosis and treatment, disposition and outcomes of patients with Type 1 diabetes mellitus. Figures show the opposing actions of insulin and glucagon on substrate flow and plasma levels; plasma glucose, insulin and C-peptide levels throughout the day; the structure of human proinsulin; current view of the pathogenesis of Type 1 autoimmune diabetes mellitus; pathways that lead from insulin deficiency to the major clinical manifestations of Type 1 diabetes mellitus; relationship between hemoglobin A1c values at the end of a 3-month period and calculated average glucose levels during the 3-month period; different combinations of various insulin preparations used to establish glycemic control; and basal-bolus and insulin pump regimens. Tables list the etiologic classification of Type 1 diabetes mellitus, typical laboratory findings and monitoring in diabetic ketoacidosis, criteria for the diagnosis of Type 1 diabetes, clinical goals of Type 1 diabetes treatment, and insulin preparations. This review contains 10 figures, 9 tables, and 40 references. Keywords: Type 1 diabetes mellitus, optimal glycemic control, hypoglycemia, hyperglycemia, polyuria, polydipsia, polyphagia, HbA1c, medical nutrition therapy, Diabetic Ketoacidosis

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Health related quality of life among children with Type I diabetes, Assiut city, Egypt

Journal of Nursing Education and Practice ◽

10.5430/jnep.v7n10p73 ◽

2017 ◽

Vol 7 (10) ◽

pp. 73 ◽

Cited By ~ 2

Author(s):

Marzoka A. Gadallah ◽

Taghreed Abdul-Aziz M. Ismail ◽

Naglaa Saad Abdel Aty

Keyword(s):

Quality Of Life ◽

Type 1 Diabetes ◽

Health Insurance ◽

Type I Diabetes ◽

Type I ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Objective: Health related quality of life (HRQOL) is a multidimensional construct that includes physical and psychosocial functioning, has emerged as an important outcome in pediatric population with chronic health conditions. The study objectives are to measure the quality of life among children with type I diabetes compared to healthy peers and to determine factors affecting the QOL among children with type I diabetes.Methods: Analytic cross sectional study was conducted in Sidi Galal health insurance outpatient clinic for children with type 1 diabetes mellitus and a comparison group of healthy peers was taken from other outpatient clinics. A total of four hundred and twelve children, aged from 8-18 years with type 1 diabetes and four hundred and twelve healthy peers matched in age and sex were interviewed. Three tools were used for this study: Demographic questionnaire, Socio-economic scale, and Peds QL4.0 Generic Core Scale was used to measure HRQOL.Results: The mean age of studied children was 12.9 ± 3.2. More than 60% of children with diabetes had uncontrolled glycemic level and 60% of them were in low socio-economic level. Children with diabetes had significantly lower HRQOL than healthy children in all domains. Age, glycemic control status and birth order of the diabetic children showed no significance difference regarding the QOL. Disease duration affected only the emotional function of the QOL and females showed significantly higher score regarding school functioning. Social, school and the total QOL scores were significantly higher among children with highly educated mothers while father's education affected the emotional, school and total QOL scores. Children in the middle and high social class showed significantly higher scores regarding social, school and total QOL. Presence of diabetic parent positively affected the social functioning while had negative effect on the school function of children with type I diabetes.Conclusions and recommendations: Diabetes is negatively affecting all the QOL functioning of the children. We recommend that Integrated programs between child's home, school and health insurance clinics for educating and supporting children with diabetes to improve their HRQOL.

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Quality of Life in Romanian Children with Type 1 Diabetes: A Cross-Sectional Survey Using an Interdisciplinary Healthcare Intervention

Healthcare ◽

10.3390/healthcare8040382 ◽

2020 ◽

Vol 8 (4) ◽

pp. 382

Author(s):

Constanta Urzeală ◽

Aura Bota ◽

Silvia Teodorescu ◽

Mihaela Vlăiculescu ◽

Julien S Baker ◽

...

Keyword(s):

Quality Of Life ◽

Type 1 Diabetes ◽

Well Being ◽

Healthcare Intervention ◽

Type I ◽

Cross Sectional ◽

Significant Difference ◽

Interdisciplinary Healthcare

Background: The purpose of this study was to assess the quality of life in Romanian type 1 diabetes mellitus (T1DM) children attending an early interdisciplinary healthcare intervention. Hypothesis: engaging T1DM children in leisure sports leads to a better quality of life. Methods: This research embeds a cross-sectional observational study, incorporating some clinical characteristics relevant for diabetes management. The Kidscreen 27 questionnaire was issued to 100 T1DM children aged between 7 and 17 years. Parents completed the questionnaire. All subjects received interdisciplinary healthcare in the previous year. Statistics were performed using SPSS, v20. The required sample size of 100 subjects was obtained with a confidence interval of 95% and a sampling error of 0.009. The tests were two-sided, with a type I error set at 0.05. Results: Subjects reached an increased level of physical well-being, psychological well-being, autonomy, parent relationships, peer and social support, and school inclusion. There was a significant difference (p < 0.05) between children who practice leisure activities and children who only participated in physical education (PE) classes, regarding their physical well-being (t = 2.123). ANOVA demonstrated significant differences between age groups regarding physical well-being. Conclusion: The interdisciplinary healthcare intervention increased the efficiency of T1DM management with positive effects on life quality.

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Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

Journal of Experimental Medicine ◽

10.1084/jem.20082622 ◽

2008 ◽

Vol 205 (13) ◽

pp. 2953-2957 ◽

Cited By ~ 25

Author(s):

Pierre Bougnères ◽

Alain-Jacques Valleron

Keyword(s):

Type 1 Diabetes ◽

Early Onset ◽

Type I Diabetes ◽

Metabolic Changes ◽

Data Driven ◽

Metabolic Phenotype ◽

Type I ◽

Β Cell ◽

New Era

A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and β cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality.

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Type-I Interferons Inhibit Interleukin-10 Signaling and Favor Type 1 Diabetes Development in Nonobese Diabetic Mice

Frontiers in Immunology ◽

10.3389/fimmu.2018.01565 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 5

Author(s):

Marcos Iglesias ◽

Anirudh Arun ◽

Maria Chicco ◽

Brandon Lam ◽

C. Conover Talbot ◽

...

Keyword(s):

Type 1 Diabetes ◽

Interleukin 10 ◽

Type I Interferons ◽

Type I ◽

Diabetic Mice ◽

Nonobese Diabetic ◽

Diabetes Development ◽

Nonobese Diabetic Mice

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Clustering of Cases of Type 1 Diabetes Mellitus Occurring 2-4 Years After Vaccination is Consistent with Clustering After Infections and Progression to Type I Diabetes Mellitus in Autoantibody Positive Individuals

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem.2003.16.4.495 ◽

2003 ◽

Vol 16 (4) ◽

Cited By ~ 5

Author(s):

J.B. Classen ◽

D.C. Classen

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Type I Diabetes ◽

Type I Diabetes Mellitus ◽

Type I

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Functional defects in adenylyl cyclase signaling mechanisms of insulin and relaxin in skeletal muscles of rat with streptozotocin type 1 diabetes

Open Life Sciences ◽

10.2478/s11535-006-0035-1 ◽

2006 ◽

Vol 1 (4) ◽

pp. 530-544 ◽

Cited By ~ 21

Author(s):

Alexander Shpakov ◽

Ludmila Kuznetsova ◽

Svetlana Plesneva ◽

Alexander Kolychev ◽

Vera Bondareva ◽

...

Keyword(s):

Type 1 Diabetes ◽

Adenylyl Cyclase ◽

Skeletal Muscles ◽

Glycogen Synthase ◽

Type I Diabetes ◽

Functional Coupling ◽

Type I ◽

Stimulatory Action ◽

Functional Disturbance

AbstractFunctional disturbance in the novel adenylyl cyclase signaling mechanism (ACSM) of insulin and relaxin action in rat streptozotocin (STZ) type I diabetes was studied on the basis of the authors’ conception of molecular defects in hormonal signaling systems as the main causes of endocrine diseases. Studying the functional state of molecular components of the ACSM and the mechanism as a whole, the following changes were found in the skeletal muscles of diabetic rats compared with control animals: 1) increase of insulin receptor binding due to an increase in the number of insulin binding sites with high and low affinity; 2) increase of the basal adenylyl cyclase (AC) activity and the reduction of AC-activating effect of non-hormonal agents (guanine nucleotides, sodium fluoride, forskolin); 3) reduction of ACSM response to stimulatory action of insulin and relaxin; 4) decrease of the insulin-activating effect on the key enzymes of carbohydrate metabolism, glycogen synthase and glucose-6-phosphate dehydrogenase. Hence, the functional activity of GTP-binding protein of stimulatory type, AC and their functional coupling are decreased during experimental type 1 diabetes that leads to the impairment of the transduction of insulin and relaxin signals via ACSM.

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