Blood antioxidant capacity change in patients with the «dry» form of age-related macular degeneration treated with polarized polychromatic non-coherent light and dynamic electromyostimulation

Aim. To assess the antioxidant capacity in patients with the «dry» form of age-related macular degeneration before and after combined treatment with polarized polychromatic non-coherent light and dynamic electromyostimulation. Methods. Two groups of patients with the «dry» form of age-related macular degeneration were examined. 40 patients (80 eyes) from the main group were treated using combined treatment and 39 patients (78 eyes) in the group of control who were treated conventionally. The integral blood antioxidant capacity was measured by galvanometry. Results. Blood antioxidant capacity in healthy subjects is 26.0 kC/l. In patients of the main group blood antioxidant capacity before the treatment was equal to 22.81±0.27 kC/l, compared to 22.17±0.20 kC/l in control group (total mean value 22.49±0.27 kC/l). There was a relevant elevation of the blood antioxidant capacity at the late stages after the treatment - up to 12 months, compared to only 2 months in the control group. Visual acuity in patients of the main group before the treatment was 0.87±0.02, after the treatment was finished - 0.96±0,01 (p 0.001), 2 months after the treatment - 0.95±0.01 (p 0.001), 6 months after the treatment - 0.96±0.01 (p 0.001), 12 months after the treatment - 0.95±0.01 (p 0.001). Visual acuity in patients of the control group before the treatment was 0.91±0.02, after the treatment was finished - 0.95±0.02 (p 0.05), 2 months after the treatment - 0.94±0.02 (p 0.05), 6 months after the treatment - 0.92±0.02 (p 0.05). 12 months after the treatment the visual acuity deteriorated compared to the treatment start and was measured as 0.89±0.02. Conclusion. There is a decrease of blood antioxidant capacity (22.49±0.27 kC/l) in patients with the «dry» form of age-related macular degeneration; a relevant increase of blood antioxidant capacity and visual acuity can be observed up to 12 months after the treatment with polarized polychromatic non-coherent light and dynamic electromyostimulation.

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Electrophysiological parameters in patients with the «dry» form of age-related macular degeneration treated with polarized polychromatic non-coherent light and dynamic electromyostimulation

Kazan medical journal ◽

10.17816/kmj2119 ◽

2012 ◽

Vol 93 (6) ◽

pp. 961-965

Author(s):

F R Saifullina ◽

R Z Sharafieva ◽

V I Pogorel’tsev ◽

E A Abdulaeva

Keyword(s):

Macular Degeneration ◽

Wave Amplitude ◽

Light Stimulus ◽

Combined Treatment ◽

Red Light ◽

Age Related Macular Degeneration ◽

Control Group ◽

Coherent Light ◽

Age Related ◽

Wave Latency

Aim. To study the electrophysiological parameters in patients with the «dry» form of age-related macular degeneration before and after combined treatment with polarized polychromatic non-coherent light and dynamic electromyostimulation. Methods. Two groups of patients with the «dry» form of age-related macular degeneration were examined. Patients in the main group (40 patients, 80 eyes) were treated with a combination of polarized polychromatic non-coherent light and dynamic electromyostimulation, patients in the control group (39 patients, 78 eyes) were treated conventionally. Mean age of the patients was 71.3±1.1 years. All patients underwent standard ophthalmic examination. To assess the functional status of the macula, electroretinography was performed using the «Neuro-MVP» device (Ivanovo, Russia). A-wave amplitude and latency on the red light stimulus were examined. Results. A-wave amplitude on macular electroretinogram was 11.9% lower and A-wave latency was 20.8% higher in patients with age-related macular degeneration compared to healthy subjects. A statistically significant improvement of the A-wave amplitude and latency was observed on macular electroretinogram after the combined treatment. A-wave amplitude increased from 13.22±1.36 to 17.17±1.59 µV (p 0.01) after 2 months and up to 17.80±1.60 µV (p 0.05) after 6 months of treatment. A-wave latency decreased from 19.32±0.41 to 18.51±0.36 ms (p 0.01) after 2 months and down to 18.31±0.45 ms (p 0.05) after 6 months of treatment. There was a relevant increase in A-wave amplitude from 13.15±1.09 to 16.3±1.09 µV (p 0.01) and decrease in A-wave latency from 19.23±0.30 to 18.64±0.30 ms (p 0.05) in patients of the control group 2 months after the end of treatment. Conclusion. There were relevant increase in A-wave amplitude and decrease in A-wave latency observed on macular electroretinography after treatment. The proposed treatment method does not cause any complications and can be used as a treatment option in patients with allergic reactions to standard drugs.

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Change of electrical impedance measurements on brain in patients with the «dry» form of age-related macular degeneration treated with polarized polychromatic non-coherent light and dynamic electromyostimulation

Kazan medical journal ◽

10.17816/kmj2125 ◽

2012 ◽

Vol 93 (6) ◽

pp. 981-984

Author(s):

F R Saifullina ◽

R Z Sharafieva ◽

V I Pogorel’tsev ◽

E A Abdulaeva

Keyword(s):

Visual Acuity ◽

Macular Degeneration ◽

Cerebral Circulation ◽

Stress Ratio ◽

Combined Treatment ◽

Age Related Macular Degeneration ◽

Peak Amplitude ◽

Coherent Light ◽

Age Related ◽

Posterior Cerebral Circulation

Aim. To study the change of electrical impedance measurements in brain in patients with the «dry» form of age-related macular degeneration before and after combined treatment with polarized polychromatic non-coherent light and dynamic electromyostimulation. Methods. Two groups of patients with the «dry» form of age-related macular degeneration were examined. 40 patients (80 eyes) from the main group were treated using combined treatment and 39 patients (78 eyes) in the group of control who were treated conventionally. Results. Before the treatment, decreased blood flow in the internal carotid artery was found in 77.2%, and in the vertebral arteries in 82.2% of patients. Peak amplitude and the stress ratio index at rheoencephalography in the anterior cerebral circulation were 0.83±0.04 Ω and 27.46±0.40%, in the posterior cerebral circulation - 0.70±0.04 Ω and 23.78±0.35%. Peak amplitude values and the stress ratio index have improved significantly right after treatment and after 6 months in the main group compared to the control group. Mean visual acuity in the main group before treatment was 0.87±0.02, right after the treatment - 0.96±0.01 (p 0.001), 2 months after the treatment - 0.95±0.01 (p 0.001), 6 months after the treatment - 0.96±0.01 (p 0.001), 12 months after the treatment - 0.95±0.01 (p 0.001). In the control group mean visual acuity was 0.91±0.02 before the treatment, 0.95±0.02 (p 0.05) - right after the treatment. 2 months after the treatment - 0.94±0.02 (p 0.05), 6 months after the treatment - 0.92±0.02 (p 0.05). 12 months after the treatment mean visual acuity decreased and equaled 0.89±0.02. Decrease of anterior cerebral circulation was found in 77.2% of patients with the «dry» form of age-related macular degeneration, mean peak amplitude value was 0.83±0.04 Ω and the stress ratio index was 27.46±0.40%, decrease of posterior cerebral circulation was found in 82.2% of patients, mean peak amplitude value and the stress ratio index were 0.70±0.04 Ω and 23.78±0.35%. Conclusion. In patients with the «dry» form of age-related macular degeneration posterior cerebral circulation has improved significantly and visual acuity has improved 6 months after combined treatment with polarized polychromatic non-coherent light and dynamic electromyostimulation.

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Preservation of the Photoreceptor Inner/Outer Segment Junction in Dry Age-Related Macular Degeneration Treated by Rheohemapheresis

Journal of Ophthalmology ◽

10.1155/2015/359747 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 5

Author(s):

Eva Rencová ◽

Milan Bláha ◽

Jan Studnička ◽

Vladimír Bláha ◽

Miriam Lánská ◽

...

Keyword(s):

Visual Acuity ◽

Macular Degeneration ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Treated Group ◽

Plasma Viscosity ◽

Age Related Macular Degeneration ◽

Control Group ◽

Macular Function ◽

Age Related

Aim. To evaluate the long-term effect of rheohemapheresis (RHF) treatment of age-related macular degeneration (AMD) on photoreceptor IS/OS junction status.Methods. In our study, we followed 24 patients with dry AMD and drusenoid retinal pigment epithelium detachment (DPED) for a period of more than 2.5 years. Twelve patients (22 eyes) were treated by RHF and 12 controls (18 eyes) were randomized. The treated group underwent 8 RHF standardized procedures. We evaluated best-corrected visual acuity, IS/OS junction status (SD OCT), and macular function (multifocal electroretinography) at baseline and at 2.5-year follow-up.Results. RHF caused a decrease of whole-blood viscosity/plasma viscosity at about 15/12%. BCVA of treated patients increased insignificantlyP=0.187from median 74.0 letters (56.2 to 81.3 letters) to median 79.0 letters (57.3 to 83.4 letters), but it decreased significantly from 74.0 letters (25.2 to 82.6 letters) to 72.5 letters (23.4 to 83.1 letters) in the control groupP=0.041. The mfERG responses in the region of eccentricity between 1.8° and 7° were significantly higher in treated patientsP=0.04.Conclusions. RHF contributed to sparing of photoreceptor IS/OS junction integrity in the fovea, which is assumed to be a predictive factor for preservation of visual acuity.

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THE HOMING TRIAL: A RETROSPECTIVE PILOT STUDY ON THE EFFICACY OF PERSONALIZED BIOIDENTICAL HORMONE, DIETARY SUPPLEMENT AND NUTRITION CARE PLANS FOR AGE-RELATED MACULAR DEGENERATION (AMD)

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i4.1886 ◽

2021 ◽

Vol 5 (4) ◽

Author(s):

George W. Rozakis ◽

Brian A. Bakke

Keyword(s):

Oxidative Stress ◽

Gene Expression ◽

Visual Acuity ◽

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Control Group ◽

Care Plans ◽

Age Related ◽

Dry Amd ◽

Wet Amd

The objective of the Hormones, Oxidative stress, Methylation, Inflammation and Gene expression (HOMING) trial was to assess the efficacy of personalized bio identical hormone, dietary supplement and nutritional care plans on dry and wet Age-related Macular Degeneration (AMD) outcomes. We evaluated 220 Age-related Macular Degeneration (AMD) patients that followed a personalized clinical care plan for up to 9 months. The care plans consisted of bio identical hormones, dietary supplements and nutrition recommendations with the objective to improve lab and clinical measurements linked to oxidative stress, inflammation and gene expression. Serum concentrations of CRP, HbA1c and homocysteine responded favorably to the HOMING protocol with full program compliance. Sixty percent (42/70) of wet AMD patients reported improvement in visual acuity and/or a reduction in the frequency of anti-VEGF injections during the study period. Forty eight percent (44/92) of dry AMD patients reported improvement in visual acuity during the study period. Nine percent (4/45) patients reported improvement in visual acuity in the dry AMD control group and no (0/13) wet AMD patients in the control group reported improvement. Six percent (4/70) of wet AMD patients reported that their vision declined and/or that their F frequency increased during the study period. Five percent (4/92) of dry AMD patients reported that their vision was worse. Keywords: Bio identical Hormones, Oxidative stress, Methylation, Inflammation, Gene Expression, Nutrition and AMD.

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EVALUATION OF THE DATA OF EFFECTIVENESS OF TREATMENT OF AGE-RELATED MACULAR DEGENERATION BY THE METHOD OF INTEGRATION OF ANGIOGENESIS INHIBITORS INTO THE BACK SUBTENON SPACE ON THE VISCOUS MEDIA

Medical academic journal ◽

10.17816/maj18289-95 ◽

2018 ◽

Vol 18 (2) ◽

pp. 89-95

Author(s):

R V Gaybaryan ◽

A N Epikhin ◽

U N Epikhina ◽

U F Bondarenko ◽

N A Epikhin

Keyword(s):

Macular Degeneration ◽

Angiogenesis Inhibitors ◽

Viscous Medium ◽

Main Group ◽

Age Related Macular Degeneration ◽

Control Group ◽

Age Related ◽

Viscous Media ◽

The Mean ◽

Pathological Focus

Aim of the research. Study of clinical efficacy of treatment of wet form of age-related macular degeneration by using the method of introduction of the inhibitor of angiogenesis into the back s ubtenon s pace on the viscous media. Material and methods of the study. The first group (main group) included 41 patients (43 eyes) with wet form of age-related macular degeneration (AMD). All patients in this group were injected in the back subtenon space 7.5-12.5 mg of an angiogenesis inhibitor on a viscous medium (1.0 ml of 2% solution of hydroxypropylmethyl cellulose). The second group (control group) consisted of 30 patients (30 eyes) with wet form of AMD, for this group a retrospective analysis of dynamics of morpho-functional indices after intravitreal injections of angiogenesis inhibitors according to standard methods (1.25 mg) was carried out. The observance time period amounted to 12 months. Results. When comparing the effectiveness of treatment, the mean best-corrected visual acuity (BCVA) improved significantly in both groups after treatment. Also, according to data of the optical coherence tomography (OCT), the mean central retinal thickness (CRT), the extent, height of pathological changes, the area of the pathological focus and the relative volume of the pathological focus were significantly reduced as a result of treatment. No significant differences were found between the groups (all p>0.05). In accordance with results of the evaluation, the effect duration at subtenon method of administrations amounted to 2-2.5 months, at intravitreal method it amounted to 1-1.5 months. The number of administrations in the 12 months of observation in the main group amounted to 2.8 injections per patient on average, and in the control group it amounted to 4.2 injections. Conclusion: Subtenon injections of the inhibitor of angiogenesis into the back subtenon space gives the positive effect in the treatment of wet form of age-related macular degeneration, and its application on viscous medium has a prolonged effect.

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A comparative analysis of the course of wet age-related macular degeneration in eyes with incipient cataract and in eyes after phacoemulsification

Ophthalmology journal ◽

10.17816/ov2014427-32 ◽

2014 ◽

Vol 7 (4) ◽

pp. 27-32

Author(s):

Yuriy Sergeyevich Astakhov ◽

Nikita Yur’yevich Dal’ ◽

Natal’ya Viktorovna Chistyakova

Keyword(s):

Visual Acuity ◽

Macular Degeneration ◽

Retinal Thickness ◽

Treated Group ◽

Age Related Macular Degeneration ◽

Central Retinal Thickness ◽

Control Group ◽

Age Related ◽

Significant Difference ◽

Wet Amd

Many patients with wet age-related macular degeneration (AMD) also have a cataract in the same eye. Because there is a theoretical risk of progression of the degenerative processes in the macular area after surgical lens removal, this raises some ethical, clinical and economical questions for ophthalmologists. The purpose of the study was to compare the course of wet AMD in eyes with incipient cataract and the course in eyes after surgical cataract removal. Materials and methods: 135 eyes with wet AMD, 48 eyes - treated group - were subjects to phacoemulsification during the study, 87 eyes - control group - with incipient cataract without indications for surgery. Regular visits every 1.5 months during 2 years of follow-up with visual acuity testing, central retinal thickness analysis by optical coherence tomography (OCT). Anti-VEGF injections were performed according to a PRN regimen. Results: there was no statistically significant difference in visual acuity, central retinal thickness, intravitreal injection frequency between both groups during the study period. Conclusions: No influence of phacoemulsification on the wet AMD course was found.

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A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration

Nutrients ◽

10.3390/nu13041253 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1253

Author(s):

Alfredo García-Layana ◽

Sergio Recalde ◽

Maria Hernandez ◽

Maximino J. Abraldes ◽

João Nascimento ◽

...

Keyword(s):

Visual Acuity ◽

Fatty Acid ◽

Macular Degeneration ◽

Fatty Acid Profile ◽

Differential Effect ◽

Intervention Group ◽

Age Related Macular Degeneration ◽

Control Group ◽

Relevant Effect ◽

Age Related

The purpose of this study is evaluate the efficacy and safety of medicinal products containing the original Age-Related Eye Disease group (AREDS) formulation at doses approved in Europe (EU, control group; n = 59) with a product that adds DHA, lutein, zeaxanthin, resveratrol and hydroxytyrosol to the formula (intervention group; n = 50). This was a multicenter, randomized, observer-blinded trial conducted in patients aged 50 years or older diagnosed with unilateral exudative Age related Macular Degeneration AMD. At month 12, the intervention did not have a significant differential effect on visual acuity compared with the control group, with an estimated treatment difference in Early Treatment Diabetic Retinopathy Study (ETDRS) of −1.63 (95% CI −0.83 to 4.09; p = 0.192). The intervention exhibited a significant and, in most cases, relevant effect in terms of a reduction in some inflammatory cytokines and a greater improvement in the fatty acid profile and serum lutein and zeaxantin concentration. In patients with unilateral wet AMD, the addition of lutein, zeaxanthin, resveratrol, hydroxytyrosol and DHA to the AREDS EU recommended doses in the short-term did not have a differential effect on visual acuity compared to a standard AREDS EU formula but, in addition to improving the fatty acid profile and increasing carotenoid serum levels, may provide a beneficial effect in improving the proinflammatory and proangiogenic profile of patients with AMD.

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The impact of saffron (Crocus sativus) supplementation on visual function in patients with dry age-related macular degeneration

Italian Journal of Medicine ◽

10.4081/itjm.2016.758 ◽

2016 ◽

Vol 10 ◽

Cited By ~ 5

Author(s):

Abbas Riazi ◽

Yunes Panahi ◽

Ali Agha Alishiri ◽

Mohammad Ahmad Hosseini ◽

Ali Akbar Karimi Zarchi ◽

...

Keyword(s):

Visual Acuity ◽

Macular Degeneration ◽

Contrast Sensitivity ◽

Visual Function ◽

Low Vision ◽

Age Related Macular Degeneration ◽

Crocus Sativus ◽

Control Group ◽

Age Related ◽

The Impact

The aim was to evaluate the impact of saffron supplementation on visual function in patients with dry age-related macular degeneration (ARMD). Fifty-four participants, 23 male and 31 female, with dry ARMD were assigned to one of the following two groups. The treatment group (n=29) consumed 50 mg saffron daily during a 3- month period, while 25 subjects served as the control group. Visual acuity, contrast sensitivity, and retinal thickness were measured at the beginning and at the end of the study. Quality of life was evaluated using the Melbourne Low Vision Index (MLVI) before and after treatment. Significant increases in visual acuity and contrast sensitivity were found in the saffron group but not in the control group. Changes in macular thickness were not statistically different between the two groups. Short-term consumption of saffron may slow down the progression of disease and improve visual function, especially contrast sensitivity, in patients with dry ARMD.

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Influence of vitrectomyon the progressionof wet age related macular degeneration

Ophthalmology journal ◽

10.17816/ov2014413-21 ◽

2014 ◽

Vol 7 (4) ◽

pp. 13-21

Author(s):

Yuriy Sergeyevich Astakhov ◽

Gassan Basharovich Shaar ◽

Nikita Yur’yevich Dal’

Keyword(s):

Visual Acuity ◽

Treatment Group ◽

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Control Group ◽

Posterior Hyaloid ◽

Age Related ◽

One Year ◽

Wet Amd

Purpose. To study the effects of vitrectomy on the course of wet age-related macular degeneration (AMD). Materials and methods. 99 patients (99 eyes) with wet AMD associated with vitreo-macular adhesion or posterior hyaloid traction were included in the study. During the first 6 months, all patients received anti-VEGF treatment according to a PRN regimen. Then, they were divided into two groups: in 45 patients vitrectomy was performed and 54 patients did not receive surgical treatment. The follow-up period duration was one year. Results. At the beginning of the study, visual acuity was 0.27 ± 0.17 in the control group, and 0.17 ± 0.15 in the treatment group. Most prominent differences in visual acuity between the two groups were observed during the first 6 months (visual acuity in the treatment group before surgery was 0.12 ± 0.1) (p < 0.01 and p < 0.001), at the same time during the following 6 follow-up months, this difference decreased (p < 0.05 and p < 0.01). 1 year from the study start, visual acuity in the control group was 0.24 ± 0.17, and 0.17 ± 0.13 in the treatment one. Conclusions. Vitrectomy surgery in patients with wet AMD in association with vitreo-macular adhesion or posterior hyaloid traction does not exacerbate the disease course, stabilizes visual functions and improves the quality of life.

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