The tolerability and clinical efficacy of “OKOMISTIN” in combination with “Oftalmoferon” in comparison to “Oftalmoferon” as monotherapy in the treatment of adenoviral eye diseases

Rationale. Adenovirus accounts for 48% to 62% of the cases of acute conjunctivitis [3, 4], and causes significant morbidity. Because of this, an important goal of clinical research is to find new medications which are effective in reducing the symptoms and which are easily tolerated. Objective. To estimate the tolerability and clinical efficacy of “Okomistin” in combination with “Oftalmoferon” in comparison to “Oftalmoferon” as monotherapy in the treatment of adenoviral eye diseases. Material and methods. 42 patients with adenoviral conjunctivitis were monitored. Their age ranged from19 to 59 years. Patients were divided into two groups: the main group and the control group. Patients of the main group received instillations of “Oftalmoferon” 6-8 times a day and those of “Okomistin” qid, patients of the control group - instillations of “Oftalmoferon” 6-8 times a day as monotherapy. Results. Combined use of “Okomistin” and “Oftalmoferon” significantly decreases the time of clinical recovery, is well tolerated, and does not cause toxic and allergic reactions. Conclusion. Combined use of “Okomistin” and “Oftalmoferon” in comparison to “Oftalmoferon” as monotherapy is more effective, but necessitates the use of ophthalmic lubricants.

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Evaluation of the clinical efficacy and safety of nitric oxide synthesized from room air in the postoperative period of cardiac surgery

Translational Medicine ◽

10.18705/2311-4495-2021-8-1-38-50 ◽

2021 ◽

Vol 8 (1) ◽

pp. 38-50

Author(s):

A. E. Bautin ◽

V. D. Selemir ◽

A. I. Shafikova ◽

K. Yu. Afanasyeva ◽

E. S. Kurskova ◽

...

Keyword(s):

Nitric Oxide ◽

Cardiac Surgery ◽

Side Effects ◽

Pulmonary Artery ◽

Clinical Efficacy ◽

Median Duration ◽

Postoperative Period ◽

Main Group ◽

Control Group ◽

Efficacy And Safety

Background. Inhaled nitric oxide is a highly selective pulmonary vasodilator, the potential benefits of which include reduced resistance and pressure in the pulmonary artery without systemic arterial hypotension, vasodilation in well-ventilated areas of the lungs, rapid onset of action, and a fairly low incidence of side effects in the therapeutic dose range. Objective. Тс estimate the clinical efficacy and safety of the method for synthesizing nitric oxide from room air in the postoperative period of cardiac surgery. Design and methods. A total of 110 patients were enrolled in the study: 55 patients were included in the main group (nitric oxide was synthesized from room air by AIT-NO-01 device), 55 patients were enrolled in the retrospective control group (nitric oxide was inhaled from the balloon). Inclusion criteria were: undergone heart surgery, mean pulmonary artery pressure (PAPm) ≥ 25 mm Hg., pulmonary artery wedge pressure (PAWP) ≤ 15 mm Hg. Results. After one hour of nitric oxide inhalation in the main group, there were a 35 % decrease in PVR and a 16 % decrease in PAPm. In the control group, there were a decrease in PVR by 40 % and decrease in PAPm by 19 %. Inhalation of nitric oxide did not affect the systemic circulation hemodynamics both in the main and in the control groups. The median duration of the mechanical ventilation (MV) was 7.3 (4.5; 13.8) h and the median length of stay (LOS) in the ICU was 23.2 (21.3; 46) h in the main group. In the retrospective control group, the median duration of MV was 8.2 (5; 14.1) h, and the length of ICU stay was 24 (22; 45.3) h; found no differences between the groups. Conclusion. Nitric oxide synthesized from room air significantly reduces PVR and PAPm in patients with precapillary pulmonary hypertension after cardiac surgery. There were no significant differences in the effect on a pulmonary circulation, clinical data and side effects between the methods of synthesis of nitric oxide from room air and dosing from balloons.

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CLINICAL EFFICACY COMPARATIVE EVALUATION OF THE TREATMENT METHODS OF COMBINED DEFECTS AND DEFORMITIES OF THE ZIGOMA AND ORBIT

Ukrainian Dental Almanac ◽

10.31718/2409-0255.2.2021.14 ◽

2021 ◽

pp. 73-81

Author(s):

Yu.V. Chepurnyi ◽

D.M. Chernohorskyi ◽

O.I. Zhukovtseva ◽

A.V. Kopchak

Keyword(s):

Clinical Efficacy ◽

Main Group ◽

Patient Specific ◽

Control Group ◽

Traditional Methods ◽

Actual Problem ◽

Complex Anatomy ◽

And Control ◽

Methods Of Reconstruction

Introduction. Zigoma and orbital defects still become an actual problem of maxilla-facial surgery due to limited possibilities to precise restoration of their complex anatomy. Functional unity of zigoma and orbit in aspects of eyeball support and protection increases requirements to reconstructive precision. The total and subtotal defects are the most difficult for reconstruction when traditional methods of reconstruction demonstrate unconvincing efficiency. Complex anatomy of zigoma and orbit, as combination of convexities, depressions limited an application of free or vascularised bone transplants for precise 3D restoration of the face. Facing this, new possibilities of reconstructed were developed, based on CAD/CAM technologies. Application of patient specific implants (PSI), designed according personal anatomy of the patient and manufactured by additive technologies, open new modalities to reconstruction in orthognatic surgery, cranioplasty and others, demonstrated promising results. So, these achievements and experience possible could be implemented for zigoma reconstruction. The aim of the study was to evaluate and compare clinical efficacy of zigoma and orbital defect treatment with traditional methods of reconstruction. Materials and methods. To reach this purpose, fifty-one patients, who underwent reconstruction procedures regarding zigoma defects, were enrolled to retrospective study. All of them were clinically examined before and after surgery. CT examination was performed before, 1 week and 1 year after surgery in all cases. The patients, included to the study, were divided on two groups – main and control, equal concerning age, sex and anatomical-topographic patterns of the defects. The main group consisted of 27 patients, who underwent zigoma reconstruction with PSI. The rest of the patients, treated with traditional approach (free or vascularised bone grafting, reconstructive plates or reconstruction with temporal muscle), were included to control group. Clinical efficacy was evaluated applying esthetical estimation of experts according to ranking scale. Additionally, frequency of complication and precision of reconstruction according to CT were analysed. Orbital volume differences were calculated for cases of orbital reconstruction. Results. Comparative analysis of esthetical results revealed higher quality of reconstruction in a main group. The patients did not require any further surgical procedures in 66,7% of cases, in contrast, in a control group additional interventions were indicated or performed in 85,3% of patients (p<0,05). Mean rate of aesthetic estimation by experts were 3,15+1,2 in main group and 1,96+0,8 in control. Follow-up period was longer than 12 months for both main and control groups. Mean follow-up were 20,4 ±9,3 and 26,2 ± 13,5 months respectively. During follow-up any kind of complications were observed between the patients of the main group in 14,8% of cases as well in control – 54,2 % (p=0,01). The main complication between the patients of first group was exposure of the implants, which was noted only in 3 cases, and was caused mainly extension of soft tissues above the implant or compromised soft tissue covering due to incomplete vascularisation of the flaps. At the same time the most frequently observed complications of the main group were total or partial resorption of the grafts (two cases), implant exposure (n=7) and limitation of mouth opening. Additionally, deformity of the fixators with bone fragment displacement was noted in 25,0 % cases. Eyeball displacement was defined in 66,7% of all cases. Mean volume difference in main group was 1,5±0,7 см3, when between patients of control it was 2,3±1,2см3 (р=0,032). The frequency of diplopia was equal for both group. Conclusions. The main advantage of PSI application for zigoma reconstruction is the possibility of the precise 3D restoration of its complex anatomy, renewal of the correct position of the zigoma. Relatively to the clinical tasks, PSI could be used as fixator or endoprosthesis separately or with bone graft procedures. In some clinical situations separate application of PSI as endoprosthesis may be consider as effective alternative for free tissue transfer procedures.

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INCREASING OF SURGICAL EFFICACY OF CYSTIC ECHINOCOCCOSIS OF LIVER IN PEDIATRIC SURGERY

Pediatrician (St Petersburg) ◽

10.17816/ped4162-64 ◽

2013 ◽

Vol 4 (1) ◽

pp. 62-64

Author(s):

Sergey Viktorovich Minaev ◽

Igor Nikolayevich Gerasimenko ◽

Nikolay Ivanovich Bykov

Keyword(s):

Cystic Echinococcosis ◽

Pediatric Surgery ◽

Main Group ◽

Control Group ◽

Medical Academy ◽

Combined Use ◽

Duration Of Hospitalization ◽

Residual Cavity ◽

State Medical Academy ◽

And Control

From 1990 until 2010 retrospective study was carried out to investigate the occurrence of cystic echinococcosis (CE) of liver in children at Stavropol Regional children hospital in clinical wards of Stavropol State Medical Academy. We treated 60 children from 3 to 15 years with hepatic CE. In 22 (36.7%) patients had hepatic CE, in 38 (63.3%) — combines CE of the liver and lungs. Patients were divided into two equal groups: main and control. In the main group was used omentoplastiсa of residual cavity after closed echinococсectomy. In the control group — capitonage. In main group performed pre-and postoperative chemotherapy with nemozol at a dose of 10–15mg/kg/day and wobenzym in the dose of 1 tablet per 6 kg of body weight three times per day. In the main group complications occurred in 6.7% of children. In the control group, the complication rate was 23.2%. The number of relapses in the control group was 6 cases, in the main group is not mentioned. Accordingly the combined use of omentoplastiсa of residual cavity after closed echinococсectomy with nemozol and polyenzyme therapy to avoid recurrence of the CE, as well as shorten the duration of hospitalization and number of postoperative complications in children.

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The Clinical Efficacy of Combined Use of the Metformin and the Atorvastatin in Patients with Osteoarthritis and Metabolic Syndrome

Journal of New Medical Technologies ◽

10.12737/13307 ◽

2015 ◽

Vol 22 (3) ◽

pp. 93-98

Author(s):

Васильева ◽

L. Vasileva ◽

Лахин ◽

D. Lakhin

Keyword(s):

Metabolic Syndrome ◽

Clinical Efficacy ◽

Analogue Scale ◽

Control Group ◽

Side Reactions ◽

Anthropometric Data ◽

The Metabolic Syndrome ◽

Combined Use ◽

Hypertensive Therapy ◽

Lipid Spectrum

The purpose was to evaluate the effectiveness of combined use of the Metformin and the Atorvastatin for the correction of the metabolic syndrome in patients with osteoarthritis. The study included 70 patients with osteoarthri-tis and metabolic syndrome, who were divided into 2 groups: control and basic. In the control group, the patients received only pathogenetic treatment of osteoarthritis and anti-hypertensive therapy. Patients of the main group also received the Metformin 500 mg x 2 times and the Atorvastatin 10 mg/day. The authors monitored biochemical, anthropo-metric indicators, assessed the severity of articular syndrome by calculation of the number of tender joints and swollen joints according to the index Richie. The intensity of articular syndrome was evaluated by the visual analogue scale, the authors determined the index WOMAC and Lequesne in both groups of patients 1-3, 7-10 days, 3, 6, and 12 months. On the background of combined use of these drugs has been able to achieve significantly positive changes in the characteristics of carbohydrate metabolism, lipid spectrum of blood, anthropometric data, as well as reducing the severity of pain and the number of swollen joints in the absence of side reactions. These results confirm the clinical efficacy of combined use of the Metformin and Atorvastatin not only for the metabolic syndrome, but for the articular status in osteoarthritis.

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EFFECTIVENESS OF THE COMBINED USE OF ROBOTIC KINESIOTHERAPY AND BOTULINUM THERAPY IN THE COMPLEX REHABILITATION OF CHILDREN WITH CEREBRAL PALSY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i9.26541 ◽

2018 ◽

Vol 11 (9) ◽

pp. 360

Author(s):

Balgayeva Maira ◽

Bulekbayeva Sholpan

Keyword(s):

Cerebral Palsy ◽

Motor Function ◽

Muscle Tone ◽

Botulinum Toxin Type A ◽

Main Group ◽

Control Group ◽

Spastic Diplegia ◽

Gross Motor ◽

Gross Motor Function ◽

Combined Use

Objective: The objective of this study is to evaluate the effectiveness of combined use of robotic kinesiotherapy and botulinum therapy in the complex rehabilitation of children with spastic diplegia.Methods: In the research, 162 children were participated in the age from 4 to 6 years with spastic diplegia. The main group was carried out using robotic kinesiotherapy with the help of the Lokomat complex and intramuscular injection of botulinum toxin type A (BtA), as a part of complex rehabilitation. Children from the control group received rehabilitative treatment with traditional methods.Results: During the comparative study of groups, higher results were obtained in the main group, where average according to Gross Motor Function Measure 88 increased from 69.99 to 76.41 with a difference of 6.42 points (p=0.0001). In the control group, this indicator increased from 67.01 to 69.41 with a difference of 2.4 points. In the main group, a moderate coupling was noticed between overall motor activity improvement and muscle tone improvement (rs=0.411, p=0.001). Herewith, the correlation was pronounced more with children of the III level in Gross Motor Function Classification System (rs=0.483, p=0.002) in comparison with the II development level (rs=0.304, p=0.042).Conclusion: Research results indicated that the children with spastic diplegia have significant improvement in motor characteristics when the combined applying of robotic walking and botulinum therapy compared with conventional therapy. In our opinion, the data obtained allow to recommend this method as one of the perspective methods of rehabilitation treatment for children with spastic forms of cerebral palsy.

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Experience in the use of physical factors during the recovery of the renal parenchyma after percutaneous nephroscopy

Fizioterapevt (Physiotherapist) ◽

10.33920/med-14-2108-07 ◽

2021 ◽

pp. 68-71

Author(s):

V. N. Gornostaev ◽

R. A. Gurtskoy ◽

V. V. Shulzhenko

Keyword(s):

Postoperative Period ◽

Recovery Period ◽

Polarized Light ◽

Early Postoperative Period ◽

Main Group ◽

Renal Parenchyma ◽

Control Group ◽

Physical Factors ◽

Ozone Therapy ◽

Combined Use

The article reflects the results of the use of physical factors to restore the renal parenchyma in the early postoperative period after percutaneous nephroscopy in patients with urolithiasis. Material and methods: the study included 80patients with concretions of the renal pelvis after percutaneous nephroscopy (45men and 35women, average age — 46 years), who were divided into 2 comparable groups: groupI (main group) — 40 patients who underwent intravenous laser blood irradiation (ILBI) and ozone therapy — 6 procedures in the preoperative period, and polarized light and ILBI — 6 procedures in the early postoperative period; groupII (control group), which served as a background in the main group, were prescribed non-steroidal anti-inflammatory drugs after the surgery, taking into account bacterial urine culture. Inclusion criteria: patients with urolithiasis aged 28 to 62 years; indications for percutaneous nephroscopy. Exclusion criteria: concomitant diseases; compliance; pregnancy; acute inflammatory kidney diseases; abnormalities of the upper urinary tract. Results: The combined use of ILBI, ozone therapy and polarized light in the pre- and early postoperative period in patients with urolithiasis after percutaneous nephrolithotripsy allowed improving clinical, laboratory, subjective and objective indicators, as well as shortening the recovery period of the renal parenchyma, which was confirmed by the data of ultrasound studies in the dynamics in the form of a significant reduction in the recovery period of the index of renal vessels resistance and reduction of edema of the renal parenchyma. As a result of the application of the developed complex, the total bed-day of patients’ stay in the hospital decreased, and there was a rapid recovery of capacity to work. Conclusion: The developed method of the combined use of ILBI, ozone therapy and polarized light in the pre- and early postoperative period in patients with urolithiasis after percutaneous nephrolithiasis is pathogenetically justified and highly effective, which allows us to recommend it for wide use in urological practice.

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Assessment of 25(OH)D status in patients with genital endometriosis and clinical efficacy of cholecalciferol in the treatment of the disease

Journal of obstetrics and women s diseases ◽

10.17816/jowd62883 ◽

2021 ◽

Vol 70 (4) ◽

pp. 125-133

Author(s):

Alexandra S. Denisova ◽

Maria I. Yarmolinskaya ◽

Natalia N. Tkachenko

Keyword(s):

Vitamin D ◽

Clinical Efficacy ◽

Combined Therapy ◽

Depression Scale ◽

Pain Syndrome ◽

Disease Prevalence ◽

Main Group ◽

Control Group ◽

Mcgill Pain Questionnaire ◽

Emotional Status

AIM: The aim of this study was to determine the 25(OH)D status in patients with genital endometriosis compared to the control group and to analyze the clinical efficacy of cholecalciferol implication as a combined targeted therapy of the disease. MATERIALS AND METHODS: The main group included 440 patients with genital endometriosis (mean age 33.75.8 years) with various degrees of disease prevalence. The control group consisted of 30 women with the normal ovulatory menstrual cycle (mean age 26.33.1 years) in whom gynecological pathology was not revealed. Peripheral blood (PB) 25(OH)D level was assessed in all the participants included into the study. In 49 women from the main group, the level of 25(OH)D in the peritoneal fluid (PF) was determined. Comparative evaluation of the clinical efficacy of cholecalciferol intake in combination with gonadotropin-releasing hormone agonist (aGnRH) 3.75 mg injections or with dienogest 2 mg oral administration, as well as monotherapy in comparison with standard hormone-modulating treatment was carried out. Prior to the start of treatment, the patients had pain syndrome of varying severity, which was evaluated using the McGill Pain Questionnaire with the Visual Analogue Scale for pain. The psycho-emotional status was assessed using the Hospital Anxiety and Depression Scale. The Excel, Statistica 10, and Jamovi software programs were used to process the obtained data. RESULTS: The level of 25(OH)D in PB of patients with endometriosis was significantly lower compared to the control group (p 0.001). Women with Grades III and IV genital endometriosis were characterized by lower PB 25(OH)D levels compared to the patients with Grades I and II of the disease, but the difference was not statistically significant. Relationships were revealed between 25(OH)D levels in the PB and PF (p 0.001), as well as PF 25(OH)D level and the disease prevalence (p = 0.004). Significantly more pronounced pain reduction and stabilization of the psycho-emotional status were observed in patients receiving combined therapy with cholecalciferol. CONCLUSIONS: Insufficient level of vitamin D and vitamin D deficiency can be considered as factors that play a role in the progression of genital endometriosis. The use of cholecalciferol in combination with aGnRH 3.75 mg or dienogest 2 mg may more effectively reduce the severity of pain and stabilize the psycho-emotional status in patients with genital endometriosis compared to standard hormone-modulating therapy.

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Comparative Analysis of the Clinical Efficacy of Intrastromal Keratoplasty using a Digital Marking Device in Patients with Keratoconus

Ophthalmology in Russia ◽

10.18008/1816-5095-2020-1-42-48 ◽

2020 ◽

Vol 17 (1) ◽

pp. 42-48

Author(s):

A. V. Tereshchenko ◽

I. G. Trifanenkova ◽

E. N. Vishnyakova ◽

S. K. Dem’yanchenko ◽

E. А. Nikolaev

Keyword(s):

Visual Acuity ◽

Comparative Analysis ◽

Clinical Efficacy ◽

Functional Results ◽

Main Group ◽

Vector Analysis ◽

Control Group ◽

Postoperative Astigmatism ◽

Uncorrected Visual Acuity ◽

Observation Period

Purpose — to perform a comparative analysis of the clinical efficacy of intrastromal keratoplasty (ISKP) in patients with keratoconus during surgery with and without Verion digital marking device.Patients and methods. 37 patients (50 eyes) with corneal astigmatism up to -5.0 diopters were included in the study. These patients were operated with the femtolaser method of ISKP with implantation of corneal segments. The average age of the patients was 27.96 ± 3.40 years. The observation period is from 3 to 12 months. All patients were divided into two groups depending on the surgical technique: Verion-assisted, using a digital marking device and taking into account the angle of cyclotorsia, or standard, without taking into account the angle of cyclotorsia. The first main group included 28 eyes (56 %), the second control group included 22 eyes (44 %) accordingly.Results. The functional results after ISKP in both groups were quite good. Stabilization of functional parameters and keratometric data was noted in the postoperative period, by 3 months. Patients of the main group showed a statistically significant (p < 0.05) increase in average uncorrected visual acuity to 0.50 ± 0.16, and visual acuity with maximum correction to 0.70 ± 0.12 (p < 0.05). The average keratometry of the weak meridian decreased to 44.3 ± 1.4 diopters, the average keratometry of the strong meridian decreased to 50.8 ± 3.2 diopters. Patients in the control group showed a statistically significant (p < 0.05) increase in average uncorrected visual acuity to 0.45 ± 0.12, and visual acuity with maximum correction to 0.60 ± 0.17. The average values of keratometry of the weak meridian decreased to 45.3 ± 1.8 diopters, the average values of keratometry of the strong meridian decreased to 51.8 ± 2.2 diopters. The results of the vector analysis reliably indicate a significantly higher accuracy of the Verion-assisted ISKP. Which is confirmed by the achieved indicators of the “success” index, the calculated astigmatism vector close to the actual postoperative astigmatism vector, the smaller the magnitude of the astigmatism axis difference vector compared to the control.Conclusion. The use of the Verion-assisted intrastromal technique for keratoconus reduces the risk of erroneous positioning of the corneal segments in the tunnel during transferring diagnostic data to the operating room. Taking into account the angle of cyclotorsia during cutting into the intrastromal tunnel increases the effective correction of the cylindrical component of refraction, which is confirmed by the main coefficients of the vector analysis by N. Alpins.

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MOTOR REHABILITATION OF INVALIDS WITH INFRINGEMENT OF LOCOMOTOR FUNCTION DUE TO RESIDUAL PHENOMENA OF STROKE

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2013-2-128-134 ◽

2013 ◽

Vol 12 (2) ◽

pp. 128-134

Author(s):

G. M. Tsirkin ◽

O. A. Jafarova ◽

V. A. Voroninskiy ◽

M. M. Shperling

Keyword(s):

Body Image ◽

Adaptive Capacity ◽

Medical Therapy ◽

Clinical Efficacy ◽

Cost Effective ◽

Main Group ◽

The Body ◽

Control Group ◽

Motor Rehabilitation ◽

Locomotor Function

This paper demonstrates the clinical efficacy of multiparametric biofeedback in patients aged 45 to 60 years with residual phenomena after stroke with 1 to 5 years prescription. Comparison was made according to the international scale. Patients in the control group and the main group were selected at random.It was shown that the use of multiparametric biofeedback allows to reduce spasticity, restore body image and improve hemodynamics, increase adaptive capacity of the body, improve coordination. At the sa me time, when compared with medical therapy of spasticity, this technology is an order higher cost-effective.

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Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

Russian Osteopathic Journal ◽

10.32885/2220-0975-2019-3-4-97-105 ◽

2020 ◽

pp. 97-105

Author(s):

E. N. Simakova ◽

O. V. Stenkova

Keyword(s):

Intraocular Pressure ◽

Drug Therapy ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Randomized Study ◽

Main Group ◽

Control Group ◽

Open Angle ◽

Complex Treatment ◽

Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

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