scholarly journals Hypoxia and antihypoxants, focus on brain injury

2019 ◽  
Vol 17 (1) ◽  
pp. 7-16
Author(s):  
Petr D. Shabanov ◽  
Irina V. Zarubina
Keyword(s):  
Acute Hypoxia ◽  
Combined Treatment ◽  
Recovery Period ◽  
Craniocerebral Trauma ◽  
Anxiolytic Effect ◽  
The Body ◽  
Metabolic Disturbances ◽  
Early Recovery ◽  
The Individual ◽  
The Brain

Experiments on rats showed that the individual resistance of the body to acute hypoxia is of decisive importance in the early recovery period after mechanical craniocerebral trauma. Antihypoxant ethomersol administration (25 mg/kg, 3 days, intraperitoneally) following trauma decreased behavioral impairments in rats with different levels of resistance to acute hypoxia, restored the structure of individual behavior, and prevented metabolic disturbances in the brain. Monotherapy of consequences of craniocerebral trauma with antidepressant pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemithyl, an antihypoxant of benzimidazole structure, in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemithyl was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemithyl had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.

Evaluation of the activity of antihypoxants with an isothiourea structure in a model of hypercapnic hypoxia with a shutdown of the cerebral hemispheres

2021 ◽  
Vol 19 (1) ◽  
pp. 55-63
Author(s):  
Vera V. Marysheva ◽  
Vladimir V. Mikheev ◽  
Petr D. Shabanov
Keyword(s):  
Acute Hypoxia ◽  
Life Time ◽  
The Body ◽  
Cerebral Hemispheres ◽  
Antihypoxic Activity ◽  
Hypoxic Episode ◽  
Hypoxia With Hypercapnia ◽  
Hypercapnic Hypoxia ◽  
Outbred Mice ◽  
The Brain

PURPOSE: To study the effect of amtizol, 2-aminobenzthiazole (2-ABT) and 2-amino-4-acetylthiazolo[5,4-b]indole (BM-606) on the resistance of male outbred mice to acute hypoxia with hypercapnia under conditions of isolated functioning of one from the hemispheres, as well as both hemispheres of the brain. METHODS: A model of acute hypoxia with hypercapnia (canned hypoxia) was used in mice of the same mass, the lifespan of all animals was determined. Temporary shutdown of the cortex of one of the hemispheres or both hemispheres was achieved by epidural application of filter paper moistened with 25% potassium chloride solution, creating a spreading depression according to Leao. Amtizol, 2-aminobenzthiazole (2-ABT) and 2-amino-4-acetylthiazolo[5,4-b]indole (BM-606) at equimolar doses of 25, 32.5, and 50 mg/kg, respectively were used as pharmacological analyzers, the compounds were injected intraperitoneally 30 min before the hypoxic episode. RESULTS: It was shown that, in contrast to amtizol, 2-ABT and VM-606 increase the life time of experimental animals when any hemisphere is turned off. The use of drugs when both hemispheres were turned off revealed that amtizol has approximately equal effect on the brain and the rest of the body, in 2-ABT antihypoxic activity is 1/3 associated with the brain, in VM-606 exclusively with the brain. CONCLUSION: The experimental model used in this work makes it possible to quite easily evaluate the effect of either one drug or compare several drugs, their role in the functioning of the cerebral hemispheres, on which part of the sample highly resistant or low resistant to hypoxia they have the greatest effect.

Genealogy of the Cerebral Subject

Being Brains ◽  
2017 ◽  
Author(s):  
Fernando Vidal ◽  
Francisco Ortega
Keyword(s):  
Nineteenth Century ◽  
Functional Neuroimaging ◽  
The Body ◽  
Self Help ◽  
Brain Structure And Function ◽  
Cerebral Subject ◽  
The Individual ◽  
And Function ◽  
Cerebral Self ◽  
The Brain

The first chapter proposes to trace the distant roots of the cerebral subject to the late seventeenth century, and particularly to debates about the seat of the soul, the corpuscularian theory of matter, and John Locke’s philosophy of personal identity. In the wake of Locke, eighteenth century authors began to assert that the brain is the only part of the body we need to be ourselves. In the nineteenth century, this form of deterministic essentialism contributed to motivate research into brain structure and function, and in turn confirmed the brain-personhood nexus. Since then, from phrenology to functional neuroimaging, neuroscientific knowledge and representations have constituted a powerful support for prescriptive outlooks on the individual and society. “Neuroascesis,” as we call the business that sells programs of cerebral self-discipline, is a case in point, which this chapter also examines. It appeals to the brain and neuroscience as bases for its self-help recipes to enhance memory and reasoning, fight depression, anxiety and compulsions, improve sexual performance, achieve happiness, and even establish a direct contact with God. Yet underneath the neuro surface lie beliefs and even concrete instructions that can be traced to nineteenth-century hygiene manuals.

Imaging and the Human Brain Project: A Review

2002 ◽  
Vol 41 (04) ◽  
pp. 245-260 ◽  
Author(s):  
C. Rosse ◽  
J. F. Brinkley
Keyword(s):  
Human Brain ◽  
Physical Structure ◽  
Imaging Informatics ◽  
The Body ◽  
Human Brain Project ◽  
The Us ◽  
Physical Organization ◽  
The Subject ◽  
The Individual ◽  
The Brain

Summary Objectives: Survey current work primarily funded by the US Human Brain Project (HBP) that involves substantial use of images. Organize this work around a framework based on the physical organization of the body. Methods: Pointers to individual research efforts were obtained through the HBP home page as well as personal contacts from HBP annual meetings. References from these sources were followed to find closely related work. The individual research efforts were then studied and characterized. Results: The subject of the review is the intersection of neuroinformatics (information about the brain), imaging informatics (information about images), and structural informatics (information about the physical structure of the body). Of the 30 funded projects currently listed on the HBP web site, at least 22 make heavy use of images. These projects are described in terms of broad categories of structural imaging, functional imaging, and image-based brain information systems. Conclusions: Understanding the most complex entity known (the brain) gives rise to many interesting and difficult problems in informatics and computer science. Although much progress has been made by HBP and other neuroinformatics researchers, a great many problems remain that will require substantial informatics research efforts. Thus, the HPB can and should be seen as an excellent driving application area for biomedical informatics research.

scholarly journals Endocrine factors in the hypothalamic regulation of food intake in females: a review of the physiological roles and interactions of ghrelin, leptin, thyroid hormones, oestrogen and insulin

2011 ◽  
Vol 24 (1) ◽  
pp. 132-154 ◽  
Author(s):  
V. Somogyi ◽  
A. Gyorffy ◽  
T. J. Scalise ◽  
D. S. Kiss ◽  
G. Goszleth ◽  
...  
Keyword(s):  
Food Intake ◽  
Energy Expenditure ◽  
Thyroid Hormones ◽  
Energy Homeostasis ◽  
The Body ◽  
Feedback Information ◽  
Hypothalamic Regulation ◽  
The Individual ◽  
Desire To Eat ◽  
The Brain

Controlling energy homeostasis involves modulating the desire to eat and regulating energy expenditure. The controlling machinery includes a complex interplay of hormones secreted at various peripheral endocrine endpoints, such as the gastrointestinal tract, the adipose tissue, thyroid gland and thyroid hormone-exporting organs, the ovary and the pancreas, and, last but not least, the brain itself. The peripheral hormones that are the focus of the present review (ghrelin, leptin, thyroid hormones, oestrogen and insulin) play integrated regulatory roles in and provide feedback information on the nutritional and energetic status of the body. As peripheral signals, these hormones modulate central pathways in the brain, including the hypothalamus, to influence food intake, energy expenditure and to maintain energy homeostasis. Since the growth of the literature on the role of various hormones in the regulation of energy homeostasis shows a remarkable and dynamic expansion, it is now becoming increasingly difficult to understand the individual and interactive roles of hormonal mechanisms in their true complexity. Therefore, our goal is to review, in the context of general physiology, the roles of the five best-known peripheral trophic hormones (ghrelin, leptin, thyroid hormones, oestrogen and insulin, respectively) and discuss their interactions in the hypothalamic regulation of food intake.

scholarly journals Influencia del estrés en la Enfermedad de Alzheimer. // Stress influence in Alzheimer’s disease

Ciencia Unemi ◽  
2018 ◽  
Vol 10 (25) ◽  
pp. 123
Author(s):  
Maria Alejandra Vallejo-Johnson ◽  
Patricia Marcial-Velastegui
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Damage ◽  
The Body ◽  
Daily Routine ◽  
Stressful Situation ◽  
The Individual ◽  
Stress Influences ◽  
The Brain

Existen diversos estudios que proponen las causas de la Enfermedad de Alzheimer (EA), las cuales pueden ser: biológicas, genéticas, cronológicas y ambientales, dentro de ésta última se encuentra el estrés como una influencia para el inicio de dicha patología. Según las distintas teorías del estrés, el sujeto, al encontrarse frente a una situación estresante, sufre diversos cambios en su cuerpo para sobrellevar dicho acontecimiento. El cerebro es el encargado de poner al cuerpo en alerta y en marcha para actuar frente a dicho cambio. El estrés prolongado conlleva a alteraciones en las vías cerebrales, específicamente un daño neuronal del hipocampo, el cual es el encargado de los recuerdos y memoria. Éste al verse afectado, repercute en la memoria del sujeto y por lo tanto empieza a fallar; el sujeto se ve en la incapacidad para recordar y realizar distintas actividades rutinarias. Mediante la investigación documental y encuestas a profesionales de la salud, se obtuvo información tanto del estrés como de la Enfermedad de Alzheimer para luego concluir en la influencia del mismo en el origen de la enfermedad. Se concluye que el estrés perenne repercute en la muerte de neuronas del hipocampo lo que conlleva a la EA. AbstractThere are different studies that propose that the causes of Alzheimer might be biological, genetic, chronological and environmental. Within the environmental aspects, the stress influences the beginning of this pathology. There are several studies that propose the causes of Alzheimer's disease (AD), which can be: biological, genetic, chronological and environmental, within the latter is the stress that influences the beginning of this pathology. According to different theories of stress, the individual, while facing a stressful situation, experiences many changes in the body in order to deal with this situation. The brain is in charge of alerting the body to protect itself against that change. The long-term stress alters the brain pathways, producing specifically a neuronal damage in the hippocampus that is responsible for memories and memory. This affects memory and therefore individual begins to fail, and then, the person cannot remember how to do the daily routine. Through bibliographical research and surveys applied to healthcare professionals, information was obtained on both stress and Alzheimer's disease to establish the influence of that condition on the disease. The study concludes that long-term stress affects the death of neurons in the hippocampus, which leads to AD.

scholarly journals On the nerves

1843 ◽  
Vol 4 ◽  
pp. 434-435
Keyword(s):  
Longitudinal Direction ◽  
The Body ◽  
Natural Temperature ◽  
The Will ◽  
Voluntary Motion ◽  
The Individual ◽  
Tubular Membranes ◽  
The Brain

The author gives the results of his examinations, both microscopical and chemical, of the structure and composition of the nerves; and concludes that they consist, in their whole extent, of a congeries of membranous tubes, cylindrical in their form, placed parallel to one another, and united into fasciculi of various sizes; but that neither these fasciculi nor the individual tubes are enveloped by any filamentous tissue; that these tubular membranes are composed of extremely minute filaments, placed in a strictly longitudinal direction, in exact parallelism with each other, and consisting of granules of the same kind as those which form the basis of all the solid structures of the body; and that the matter which fills the tubes is of an oily nature, differing in no essential respect from butter, or soft fat; and remaining of a fluid consistence during the life of the animal, or while it retains its natural temperature, but becoming granular or solid when the animal dies, or its temperature is much reduced. As oily substances are well known to be non-conductors of electricity, and as the nerves have been shown by the experiments of Bischoff to be among the worst possible conductors of this agent, the author contends that the nervous agency can be neither electricity, nor galvanism, nor any property related to those powers; and conceives that the phenomena are best explained on the hypothesis of undulations or vibrations propagated along the course of the tubes which compose the nerves, by the medium of the oily globules they contain. He traces the operation of the various causes which produce sensation, in giving rise to these undulations; and extends the same explanation to the phenomena of voluntary motion, as consisting in undulations, commencing in the brain, as determined by the will, and propagated to the muscles. He corroborates his views by ascribing the effects of cold in diminishing or destroying both sensibility and the power of voluntary motion, particularly as exemplified in the hybernation of animals, to its mechanical operation of diminishing the fluidity, or producing solidity, in the oily medium by which these powers are exercised.

Nutritional requirement at high-altitude with special emphasises to behaviour of gastro-intestinal tract and hormonal changes

2017 ◽  
Vol 2 (2) ◽  
pp. 120
Author(s):  
Naveen Shivanna ◽  
M. B. Anusha ◽  
K. R. Anilakumar
Keyword(s):  
Oxidative Stress ◽  
Partial Pressure ◽  
High Altitude ◽  
Acute Hypoxia ◽  
The Body ◽  
Nutritional Requirement ◽  
Hormonal Changes ◽  
Partial Pressure Of Oxygen ◽  
The Individual ◽  
Loss Of Appetite

<p>When people are exposed to the extreme environmental conditions, such as high altitude (HA) where there is decrease in temperature and partial pressure of oxygen induces fatigue, insomnia, loss of appetite and increased cardiac output. Hence there is need to improve the appetite through the diet and digestion clout of the individual. In the present review paper we have discussed the efficiency of digestion is compromised at HA. Also about, Hypoxia, resulting by decreased partial pressure of oxygen can be classified into acute hypoxia and chronic hypoxia based on the exposure time. There is increased formation of reactive oxygen species (ROS) due to less oxygen available in the air at HA which leads to oxidative stress. Lipid peroxidation caused by oxidative stress. Hypoxia is mediated through hypoxia inducible factors which maintain oxygen haemostasis in the body. At HA diet rich in carbohydrates have been found to be beneficial as it increases glucose metabolism. Requirement of nutrients such as vitamin A, vitamin E and vitamin C as well as micronutrients such as zinc, iron, selenium, copper and manganese will be required at HA. Hypoxia effect on the intestine leads to malabsorption and the lipid storage is stimulated and lipid catabolism is inhibited through β-oxidation.</p>

scholarly journals Protein intake in the early recovery period after exhaustive exercise improves performance the following day

2018 ◽  
Vol 125 (6) ◽  
pp. 1731-1742 ◽  
Author(s):  
Ove Sollie ◽  
Per B. Jeppesen ◽  
Daniel S. Tangen ◽  
Fredrik Jernerén ◽  
Birgitte Nellemann ◽  
...  
Keyword(s):  
Endurance Exercise ◽  
Recovery Period ◽  
Time Trial ◽  
Cycling Performance ◽  
The Body ◽  
Exhaustive Exercise ◽  
Mean Power ◽  
Early Recovery ◽  
Carbohydrate Ingestion ◽  
Elite Cyclists

The aim of the present study was to investigate the effect of protein and carbohydrate ingestion during early recovery from exhaustive exercise on performance after 18-h recovery. Eight elite cyclists (V̇o2max: 74.0 ± 1.6 ml·kg−1·min−1) completed two exercise and diet interventions in a double-blinded, randomized, crossover design. Participants cycled first at 73% of V̇o2max (W73%) followed by 1-min intervals at 90% of V̇o2max until exhaustion. During the first 2 h of recovery, participants ingested either 1.2 g carbohydrate·kg−1·h−1 (CHO) or 0.8 g carbohydrate + 0.4 g protein·kg−1·h−1 (CHO + PROT). The diet during the remaining recovery period was similar for both interventions and adjusted to body weight. After an 18-h recovery, cycling performance was assessed with a 10-s sprint test, 30 min of cycling at W73%, and a cycling time trial (TT). The TT was 8.5% faster (41:53 ± 1:51 vs. 45:26 ± 1:32 min; P < 0.03) after CHO + PROT compared with CHO. Mean power output during the sprints was 3.7% higher in CHO + PROT compared with CHO (1,063 ± 54 vs. 1,026 ± 53 W; P = 0.01). Nitrogen balance in the recovery period was negative in CHO and neutral in CHO + PROT (−82.4 ± 11.5 vs. 7.0 ± 15.4 mg/kg; P < 0.01). In conclusion, TT and sprint performances were improved 18 h after exhaustive cycling by CHO + PROT supplementation during the first 2 h of recovery compared with isoenergetic CHO supplementation. Our results indicate that intake of carbohydrate plus protein after exhaustive endurance exercise more rapidly converts the body from a catabolic to an anabolic state than carbohydrate alone, thus speeding recovery and improving subsequent cycling performance. NEW & NOTEWORTHY Prolonged high intensity endurance exercise depends on glycogen utilization and high oxidative capacity. Still, exhaustion develops and effective recovery strategies are required to compete in multiday stage races. We show that coingestion of protein and carbohydrate during the first 2 h of recovery is superior to isoenergetic intake of carbohydrate to stimulate recovery, and improves both endurance time-trial and 10-s sprint performance the following day in elite cyclists.

General Paralysis: its Unsolved Problems

1924 ◽  
Vol 70 (288) ◽  
pp. 33-47 ◽  
Author(s):  
R. M. Stewart
Keyword(s):  
Scientific Progress ◽  
The Body ◽  
General Paralysis ◽  
Close Relationship ◽  
Arsenical Compounds ◽  
Latent Interval ◽  
The Individual ◽  
Special Strain ◽  
The Brain ◽  
Gain Access

There is probably no disease in regard to which our views have undergone so radical a change during the past few years as general paralysis of the insane, and none in which the discovery of the causative agent has been followed by so rapid a revolution in standpoint. Although almost from the time of its definition, more than a century ago, the essentially organic nature of the disease and its close relationship to syphilis have been universally recognized, it has required many years of patient study to free it from the hypotheses which have been invoked to explain its obscurities, and, as always happens in scientific progress, in the process of unravelling the knotty problems of this disease, we discover that there are new obstacles and difficulties to be overcome. Is the Spirochóte pallida alone responsible for the genesis of general paralysis? When does it gain access to the nervous system, and how? Is there a special strain of spirochóte, or must the individual resistance of the infected person be considered the deciding factor in the development of the disease? What is the meaning of the long latent interval before the onset of symptoms? What determines the peculiar distribution of the lesions in general paralysis, and is there some particular place in the brain from which the spirochæte starts its wandering? What is the significance of the absence of spirochætes in other organs of the body, and why does the cerebro-spinal fluid contain no organisms at a time when the brain contains millions? Why do tabes, general paralysis and optic atrophy, supposedly of similar origin, not occur in conjunction more frequently? Why is it that arsenical compounds fail to effect a cure?

scholarly journals Vegetative State from the Perspective of Islamic Law

2019 ◽  
Vol 19 (3&4) ◽  
pp. 102
Author(s):  
Hossein Shamsi Gooshki ◽  
Seyyed Hassan Abedian Kalkhoran ◽  
Seyyed Mohammad Mahdi Ahmadi ◽  
Abolfazl Khoshi ◽  
Hassan Goodarzi
Keyword(s):  
Cerebral Cortex ◽  
Brain Death ◽  
Brain Function ◽  
Islamic Law ◽  
Criminal Responsibility ◽  
Vegetative State ◽  
The Body ◽  
Judicial Affairs ◽  
The Individual ◽  
The Brain

<p>The death of the cerebral cortex is a particular type of brain death that occurs after the destruction of the cerebral cortex (the hemispheres of the brain). It is said that the individual has gone through a vegetative state. This cortex is responsible for controlling voluntary activities of the body. This condition is caused by a coma (anesthesia), and sometimes the individual remains in this state for several years. Although the person looks awake, his/her eyes are open and has some involuntary movements, there is no signs of mental and cognitive function. Moreover, the individual is physically in a state of dementia. Coma is a state in which a person cannot be awakened and does not respond to any stimulation including pain. Generally it lasts few days to a few weeks, after which some patients gradually recover, but some permanently lose all brain function (brain death), while others evolve to a vegetative state (VS). Patients in VS are unconscious and unaware of their surroundings, but they continue to have a sleep-wake cycle and can have periods of consciousness. They are able to breathe spontaneously, retain their gag, cough, sucking, and swallowing reflexes. They often look fairly “normal” to families and friends who hope and pray for their full recovery. Laws and regulations in Islamic countries originate from popular jurisprudence. Therefore, by arguing that the well-known principles of Islam are necessarily legitimate, the phenomenon of vegetative state has been recognized. Jurisprudents have conflicting opinions on brain deaths and these perspectives cannot be considered as a widespread legal basis at the level of macro policy for administrative, medical and judicial affairs. In criminal law, maniac has no criminal responsibility because the punishment is not in line with the purpose of punishment. Consequently, restrictions will be imposed on the patients. Therefore, it can be concluded that a person with vegetative state is compatible with the insanity.</p>

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