Nutritional requirement at high-altitude with special emphasises to behaviour of gastro-intestinal tract and hormonal changes

2017 ◽  
Vol 2 (2) ◽  
pp. 120
Author(s):  
Naveen Shivanna ◽  
M. B. Anusha ◽  
K. R. Anilakumar
Keyword(s):  
Oxidative Stress ◽  
Partial Pressure ◽  
High Altitude ◽  
Acute Hypoxia ◽  
The Body ◽  
Nutritional Requirement ◽  
Hormonal Changes ◽  
Partial Pressure Of Oxygen ◽  
The Individual ◽  
Loss Of Appetite

<p>When people are exposed to the extreme environmental conditions, such as high altitude (HA) where there is decrease in temperature and partial pressure of oxygen induces fatigue, insomnia, loss of appetite and increased cardiac output. Hence there is need to improve the appetite through the diet and digestion clout of the individual. In the present review paper we have discussed the efficiency of digestion is compromised at HA. Also about, Hypoxia, resulting by decreased partial pressure of oxygen can be classified into acute hypoxia and chronic hypoxia based on the exposure time. There is increased formation of reactive oxygen species (ROS) due to less oxygen available in the air at HA which leads to oxidative stress. Lipid peroxidation caused by oxidative stress. Hypoxia is mediated through hypoxia inducible factors which maintain oxygen haemostasis in the body. At HA diet rich in carbohydrates have been found to be beneficial as it increases glucose metabolism. Requirement of nutrients such as vitamin A, vitamin E and vitamin C as well as micronutrients such as zinc, iron, selenium, copper and manganese will be required at HA. Hypoxia effect on the intestine leads to malabsorption and the lipid storage is stimulated and lipid catabolism is inhibited through β-oxidation.</p>

scholarly journals Hypoxia and antihypoxants, focus on brain injury

2019 ◽  
Vol 17 (1) ◽  
pp. 7-16
Author(s):  
Petr D. Shabanov ◽  
Irina V. Zarubina
Keyword(s):  
Acute Hypoxia ◽  
Combined Treatment ◽  
Recovery Period ◽  
Craniocerebral Trauma ◽  
Anxiolytic Effect ◽  
The Body ◽  
Metabolic Disturbances ◽  
Early Recovery ◽  
The Individual ◽  
The Brain

Experiments on rats showed that the individual resistance of the body to acute hypoxia is of decisive importance in the early recovery period after mechanical craniocerebral trauma. Antihypoxant ethomersol administration (25 mg/kg, 3 days, intraperitoneally) following trauma decreased behavioral impairments in rats with different levels of resistance to acute hypoxia, restored the structure of individual behavior, and prevented metabolic disturbances in the brain. Monotherapy of consequences of craniocerebral trauma with antidepressant pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemithyl, an antihypoxant of benzimidazole structure, in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemithyl was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemithyl had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.

scholarly journals The causes of absorption of oxygen by the lungs (Preliminary communication)

1910 ◽  
Vol 82 (556) ◽  
pp. 331-333
Keyword(s):  
Carbon Monoxide ◽  
Partial Pressure ◽  
Oxygen Pressure ◽  
Diffusion Theory ◽  
The Body ◽  
Mass Action ◽  
Arterial Oxygen ◽  
Partial Pressure Of Oxygen ◽  
Alveolar Air ◽  
Arterial Blood

It has for long been a subject of controversy among physiologists whether the absorption of oxygen through the walls of the lung alveoli into the blood occurs simply by diffusion or by an active physiological process analogus to glandular secretion. Pflüger, Fredericq, and, quite recently, Krogh, have brought forward experimental evidence in favour of the diffusion theory, while Bohr, and Haldane and Lorrain Smith have supported the secretory theory, which was originally suggested by Ludwig. If the partial pressure of oxygen is ever greater in the arterial blood leaving the lungs than in the air of the lung alveoli, it is clear that the simple diffusion theory must fall to the ground; and the experiments hitherto made have been designed to ascertain whether or not the oxygen pressure in the arterial blood is ever greater than in the alveolar air. Bohr, Fredericq, and Krogh have with this object employed improved forms of Pflüger’s well-known “aerotonometer,” the instrument finally devised by Krogh being very perfect of its king. Haldane and Lorrain Smith’s method depends upon the following facts:—When blood is brought into prolonged and intimate contact with a mixture of carbon monoxide and air the hæmoglobin of the blood-corpuscles combines partly with the oxygen and partly with the carbon monoxide, the final proportions (which can be easily and accurately determined) depending, in accordance with the laws of mass-action, on the relative partial pressures of the oxygen and carbon monoxide, and on a constant. Hence, if the final proportions, the constant, and the partial pressure of the carbon monoxide are known, the partial pressure of the oxygen can be accurately deduced. By supplying to an animal air containing a fixed proportion of carbon monoxide, until the final saturation of its hæmoglobin with carbon monoxide is reached, the partial pressure of oxygen in its arterial blood can be calculated on the same principle. If the arterial oxygen pressure is greater than that of the alveolar air the final saturation of the hæmoglobin with carbon monoxide will be less than that of blood saturated with the same air outside the body, and vice versâ . It is, of course, assumed that carbon monoxide diffuses freely through the body, since, apart from its property of combining with the hæmoglobin, it is, as was experimentally shown by Haldane, a physiologically indifferent gas, like nitrogen or hydrogen.

Parathyroid gland before and after cisplatin treatment

1987 ◽  
Vol 45 ◽  
pp. 860-861
Author(s):  
S.K. Aggarwal ◽  
J.M. Fadool
Keyword(s):  
Parathyroid Gland ◽  
Wistar Rats ◽  
Antitumor Agent ◽  
The Body ◽  
Cross Linking ◽  
Limiting Factor ◽  
Hormonal Changes ◽  
Primary Mechanism ◽  
Before And After ◽  
Dna Strands

Cisplatin (CDDP) a potent antitumor agent suffers from severe toxic side effects with nephrotoxicity being the major dose-limiting factor, The primary mechanism of its action has been proposed to be through its cross-linking DNA strands. It has also been shown to inactivate various transport enzymes and induce hypocalcemia and hypomagnesemia that may be the underlying cause for some of its toxicities. The present is an effort to study its influence on the parathyroid gland for any hormonal changes that control calcium levels in the body.Male Swiss Wistar rats (Crl: (WI) BR) weighing 200-300 g and of 60 days in age were injected (ip) with cisplatin (7mg/kg in normal saline). The controls received saline injections only. The animals were injected (iv) with calcium (0.5 ml of 10% calcium gluconate/day) and were killed by decapitation on day 1 through 5. Trunk blood was collected in heparinized tubes.

Influence of stable iodine on the uptake of the thyroid – model vs. experiment

2001 ◽  
Vol 40 (01) ◽  
pp. 31-37 ◽  
Author(s):  
U. Wellner ◽  
E. Voth ◽  
H. Schicha ◽  
K. Weber
Keyword(s):  
Time Course ◽  
Compartment Model ◽  
The Body ◽  
Iodine Uptake ◽  
Model Calculations ◽  
Physiological Conditions ◽  
Iodine Supply ◽  
Predicted Values ◽  
The Individual ◽  
Stable Iodine

Summary Aim: The influence of physiological and pharmacological amounts of iodine on the uptake of radioiodine in the thyroid was examined in a 4-compartment model. This model allows equations to be derived describing the distribution of tracer iodine as a function of time. The aim of the study was to compare the predictions of the model with experimental data. Methods: Five euthyroid persons received stable iodine (200 μg, 10 mg). 1-123-uptake into the thyroid was measured with the Nal (Tl)-detector of a body counter under physiological conditions and after application of each dose of additional iodine. Actual measurements and predicted values were compared, taking into account the individual iodine supply as estimated from the thyroid uptake under physiological conditions and data from the literature. Results: Thyroid iodine uptake decreased from 80% under physiological conditions to 50% in individuals with very low iodine supply (15 μg/d) (n = 2). The uptake calculated from the model was 36%. Iodine uptake into the thyroid did not decrease in individuals with typical iodine supply, i.e. for Cologne 65-85 μg/d (n = 3). After application of 10 mg of stable iodine, uptake into the thyroid decreased in all individuals to about 5%, in accordance with the model calculations. Conclusion: Comparison of theoretical predictions with the measured values demonstrated that the model tested is well suited for describing the time course of iodine distribution and uptake within the body. It can now be used to study aspects of iodine metabolism relevant to the pharmacological administration of iodine which cannot be investigated experimentally in humans for ethical and technical reasons.

Pengembangan perangkat pembelajaran dengan menggunakan pendekatan keterampilan proses untuk meningkatkan hasil belajar mata pelajaran التربية الجسمية bagi siswa kelas XI IPA MAN I Kota Mojokerto

2017 ◽  
Vol 1 (1) ◽  
pp. 115
Author(s):  
Sudar Kajin
Keyword(s):  
Learning Outcomes ◽  
Learning Strategy ◽  
Bone Structure ◽  
The Body ◽  
Process Skills ◽  
Hormonal Changes ◽  
Learning Tools ◽  
Body Structure ◽  
Use Of Resources ◽  
The Look

Growth and development of the child have the nature of a thorough and intertwined relationships between components (health, nutrition, and environment). In general, child development can be grouped into three areas, namely cognitive, affective, and psychomotor, whereas biological growth which includes a change in the body structure. Body structure regarding the changes in bone structure, especially the long bones that have an impact on changes in body size, whereas changes in bodily functions is a result of hormonal changes that affect the physiological function .. The purpose of this development are: 1) Describe the product feasibility study التربية الجسمية for grade XI IPA at MAN I Mojokerto 2) Describe the development of learning tools using process skills can improve learning outcomes subjects التربية الجسمية class XI IPA at MAN I Mojokerto From the results of this development can be concluded: 1) results of expert validation and testing, the model approach process skills is fit for use for subjects of Physical Education, Sport and Health, because the products developed are not revised by experts but from the results of questionnaire of students stated that require revision are: (a) Improve the look model or change the learning strategy, and (b) improve the use of resources in implementing the model. 2) Product development learning tools using process skills can improve learning outcomes subjects التربية الجسمية class XI IPA at MAN I Mojokerto. From the class of the test increased learning completeness of Pre and Post Tests Tests are respectively 77.78% increase to 91.67%.

Iron Metabolism in the Human Body and Setting its Hygienic Limits for Drinking Water. Review. Part 2

2020 ◽  
Vol 99 (5) ◽  
pp. 504-508
Author(s):  
Natalija A. Egorova ◽  
N. V. Kanatnikova
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Iron Overload ◽  
Iron Metabolism ◽  
Subcutaneous Tissue ◽  
Allergic Diseases ◽  
The Body ◽  
Urogenital System ◽  
High Iron Content ◽  
Labile Iron Pool

Iron is an assential element for the growth, division, differentiation and functioning of any cell in the body. Iron is virtually important for human and danger at the same time, because with excessive accumulation it causes oxidative stress with formation of highly active oxygen radicals and reactive form of nitrogen that can destroy cell membranes, proteins, nucleic acids, reduce cell viability, with, according to modern concepts, can contribute to the development of many diseases (cardiovascular, rheumatic, gastrointestinal, neurodegenerative, oncological, metabolic and others), and also accelerate the aging process. Part 1 of this review discussed the issues of iron metabolism in human, including its regulation at the cellular and systemic levels, the intake, transport, use, accumulation and export of iron in cells, the role of the labile iron pool in the cytoplasm of cells and plasma non-transferrin bound iron. Data are provided on the causes, frequency and significance of iron overload in the formation of free radicals and the development of oxidative stress. Part 2 of the review provides information on diseases associated with iron overload as well as information on ferroptosis - a new type of iron-dependent regulated cell death. Attention is paid to the works of domestic authors, where it was found that prolonged use of drinking water with a high iron content is unfavorable for the population and leads to an increase in the overall incidence, the development of the diseases of the blood, skin and subcutaneous tissue, musculoskeletal system, digestive system, urogenital system, and allergic diseases. Separate publications are cited on the possibility of a negative effect of iron at concentrations in water of 0.3 mg/l and lower. The material of the review emphasizes the preventive significance of caution attitude to regulating iron in the water in the Russian Federation, where 1/3 of the population uses iron-containing water for drinking, and substantiate the feasibility of establishing a hygienic limit for iron in water not higher than 0.3 mg/l.

Interaction of H2O, O2 and H2 with Proton Conducting Oxides Based on Lanthanum Scandates

2019 ◽  
pp. 88-100
Author(s):  
A. S. Farlenkov ◽  
N. A. Zhuravlev ◽  
Т. A. Denisova ◽  
М. V. Ananyev
Keyword(s):  
Water Vapor ◽  
Partial Pressure ◽  
Gas Phase ◽  
Molecular Hydrogen ◽  
Proton Magnetic Resonance ◽  
Partial Pressure Of Oxygen ◽  
Proton Conducting ◽  
Conducting Oxides ◽  
Temperature Range ◽  
Apparent Level

The research uses the method of high-temperature thermogravimetric analysis to study the processes of interaction of the gas phase in the temperature range 300–950 °C in the partial pressure ranges of oxygen 8.1–50.7 kPa, water 6.1–24.3 kPa and hydrogen 4.1 kPa with La1–xSrxScO3–α oxides (x = 0; 0.04; 0.09). In the case of an increase in the partial pressure of water vapor at a constant partial pressure of oxygen (or hydrogen) in the gas phase, the apparent level of saturation of protons is shown to increase. An increase in the apparent level of saturation of protons of the sample also occurs with an increase in the partial pressure of oxygen at a constant partial pressure of water vapor in the gas phase. The paper discusses the causes of the observed processes. The research uses the hydrogen isotope exchange method with the equilibration of the isotope composition of the gas phase to study the incorporation of hydrogen into the structure of proton-conducting oxides based on strontium-doped lanthanum scandates. The concentrations of protons and deuterons were determined in the temperature range of 300–800 °C and a hydrogen pressure of 0.2 kPa for La0.91Sr0.09ScO3–α oxide. The paper discusses the role of oxygen vacancies in the process of incorporation of protons and deuterons from the atmosphere of molecular hydrogen into the structure of the proton conducting oxides La1–xSrxScO3–α (x = 0; 0.04; 0.09). The proton magnetic resonance method was used to study the local structure in the temperature range 23–110 °C at a rotation speed of 10 kHz (MAS) for La0.96Sr0.04ScO3–α oxide after thermogravimetric measurements in an atmosphere containing water vapor, and after exposures in molecular hydrogen atmosphere. The existence of proton defects incorporated into the volume of the investigated proton oxide from both the atmosphere containing water and the atmosphere containing molecular hydrogen is unambiguously shown. The paper considers the effect of the contributions of the volume and surface of La0.96Sr0.04ScO3–α oxide on the shape of the proton magnetic resonance spectra.

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