scholarly journals Immune related prognosis biomarkers for outcomes of joint preservation surgery in children with ischemic deformity of the proximal femur (preliminary results)

2020 ◽  
Vol 26 (4) ◽  
pp. 516-520
Author(s):  
M.P. Teplenky ◽  
◽  
M.V. Chepeleva ◽  
E.I. Kuznetsova ◽  
◽  
...  
Keyword(s):  
Proximal Femur ◽  
Immune Complexes ◽  
Immune Status ◽  
Circulating Immune Complexes ◽  
Immunological Parameters ◽  
Humoral Immune ◽  
Joint Preservation ◽  
Group I ◽  
Low Levels ◽  
Group Ii

Objective Assess the immune status of children with ischemic deformity of the proximal femur taking into account the treatment outcome. Material and methods Preoperative assessment of the immune status was performed for 16 adolescents with ischemic deformity of the proximal femur. Patients' age was 14.4 ± 0.45 years. Immunological parameters of 12 adolescents with satisfactory (group I) and 4 patients with poor (group II) anatomical and functional outcome of surgical treatment were compared. Peripheral blood lymphocyte typing was produced with laser cytometry assay, and IgA, IgM, IgG, IgE, IL-18, IFNγ and circulating immune complexes were quantified with enzyme-linked immunoassay. Results Сomparative analysis of preoperative immunological parameters showed statistically significant decline of Т-helper cells (СD3+СD4+), high levels of activated СD3+CD25 and СD3+HLADR T lymphocytes, low levels of activated NК cells (СD8dimCD38+) and IFNγ in group II. Humoral immune parameters indicated to low levels of IgA, IgM, IgG and higher levels of circulating immune complexes in group II relative to group I. Conclusion Preliminary data obtained suggest that cellular and humoral immune deficiency can be associated with unfavorable outcome of joint preservation procedure. Such immunological parameters as T lymphocytes subpopulation, immunoglobulins, circulating immune complexes and IFNγ can be used as significant prognostic factors for preoperative planning and postoperative rehabilitation of adolescents with ischemic deformity of the proximal femur.

scholarly journals Immunoglobulins G, A, M and circulatory immune complexes in patients with laryngeal carcinoma

2009 ◽  
Vol 56 (3) ◽  
pp. 45-49
Author(s):  
M.V. Dimitrijevic ◽  
V.Z. Djordjevic ◽  
N.A. Arsovic ◽  
P.D. Jeremic ◽  
N.A. Slijepcevic ◽  
...  
Keyword(s):  
Blood Serum ◽  
Immune Complexes ◽  
Laryngeal Carcinoma ◽  
Clinical Course ◽  
Malignant Tumors ◽  
Strong Association ◽  
Circulating Immune Complexes ◽  
Surgical Removal ◽  
Immunological Parameters ◽  
Humoral Immune

Introduction Malignant tumors of the head and neck represent 5% of all malignancies, of which the most common are tumors of the larynx and oral cavity. In the blood serum of patients with malignant tumors increased levels of immunoglobulins and circulating immune complexes have been detected, with a diverse relevance to the clinical course and prognosis of the disease. Aim Due to contradictory findings of the correlation between the humoral immune response and the clinical course of the disease, we examined 42 male patients with laryngeal carcinoma. All patients underwent surgery, of which 15 patients were treated postoperatively with radiotherapy. The changes in the levels of immunoglobulins and circulating immune complexes in the blood serum were recorded and evaluated. Results Analysis of the results showed an immunological disorder of an abnormal level of circulating immune complexes in the blood serum that normalized after the surgical removal of the tumor. The levels of immunoglobulins G and A were abnormal during the whole postoperative period of examination. Conclusion The normalizing of the levels of circulating immune complexes in the blood serum, after surgical removal of the tumor, shows a strong association between the two, and this could consequently mean that it could be used as a prognostic tool, particularly in correlation with other immunological parameters.

scholarly journals Role of Circulating Immune Complexes in the Pathogenesis of Canine Leishmaniasis: New Players in Vaccine Development

2021 ◽  
Vol 9 (4) ◽  
pp. 712
Author(s):  
Cristina Cacheiro-Llaguno ◽  
Nuria Parody ◽  
Marta R. Escutia ◽  
Jerónimo Carnés
Keyword(s):  
Immune Complexes ◽  
Vaccine Development ◽  
Correct Diagnosis ◽  
Circulating Immune Complexes ◽  
Response To Treatment ◽  
Canine Leishmaniasis ◽  
Leishmania Infection ◽  
Serum Samples ◽  
Humoral Immune

During canine visceral leishmaniasis (CanL), due to Leishmania infantum (L. infantum), uncontrolled infection leads to a strong humoral immune response. As a consequence of the production of high antibody levels and the prolonged presence of parasite antigens, circulating immune complexes (CIC) are formed, which can be deposited in certain organs and tissues, inducing vasculitis, uveitis, dermatitis and especially glomerulonephritis and renal failure. A method to detect CIC and quantify their levels in serum samples from dogs infected with L. infantum has been recently described. It allowed demonstration of a correlation between CIC levels and disease severity. Thus, CIC measurement may be useful for diagnosis, assessment of disease progression and monitoring response to treatment. This is an interesting finding, considering that there remains an urgent need for identification of novel biomarkers to achieve a correct diagnosis and for optimal disease staging of dogs suffering from Leishmania infection. The objective of the present review is to shed light on the role of CIC in CanL, as well as to highlight their potential use not only as diagnostic and prognostic biomarkers but also as a valuable tool in vaccine development and new immunotherapy strategies to prevent or control disease outcome.

INFLUENCE OF OZONE THERAPY ON THE DYNAMICS OF HUMORAL IMMUNITY INDEXESIN OBSERVATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2021 ◽  
pp. 60-64
Author(s):  
А. М. ЖУКЕМБАЕВА ◽  
К.С. ЛАТКИНА ◽  
К. М. КАПАРОВА ◽  
А.К. КУАТ ◽  
Ж. К. АТХАН ◽  
...  
Keyword(s):  
Personal Data ◽  
Chronic Obstructive ◽  
Ozone Therapy ◽  
Immunological Parameters ◽  
Study Program ◽  
Obstructive Pulmonary Disease ◽  
Copd Exacerbations ◽  
Group I ◽  
Group Ii ◽  
Exacerbation Of Copd

Проведен анализ результатов изменений иммунологических показателей на фоне проводимого лечения обострения ХОБЛ, проведенного у 55 больных. Все больные, рассматриваемые в нашей работе, подписали письменное информированное согласие на участие в программе исследований и неразглашении личных данных. Установлено, что через 7 суток после начала лечения уровень IgM в сыворотке крови во II группе, где проводилась озонотерапия, был достоверно меньше, чем в I, что свидетельствовало о более быстрой регрессии воспалительного процесса во II группе (P< 0,05). При этом показатели HCT-индуцированного фагоцитоза, на фоне проводимой озонотерапии во II группе, были достоверно больше, чем в I, где озонотерапия не проводилась (P<0,05). То есть, резервы кислород зависимой фагоцитарной активности нейтрофилов во II группе на фоне проведения озонотерапии были более функционально активны. Особого внимания заслуживает то, что во II группе элиминация ЦИК происходила достоверно быстрее, чем в I (P< 0,05). Это свидетельствовало об эффективности применения озонотерапии при лечении обострения ХОБЛ. Таким образом, положительное влияние инфузионной озонотерапии на различные звенья воспаления при обострении ХОБЛ свидетельствуют о перспективности дальнейших исследований в этом направлении. The analysis of the results of changes in immunological parameters in the treatment of complications of COPD in 55 patients. All patients considered in our study signed a written informed consent to participate in the study program and not to disclose their personal data. Serum IgM levels in group II treated with ozone therapy 7 days after the start of treatment were significantly lower than in group I, indicating a more rapid regression of the inflammatory process in group II (P <0.05). At the same time, the incidence of HCT-induced phagocytosis in group II ozone therapy was significantly higher than in group I without ozone therapy (P <0.05). That is, in the context of ozone therapy, the reserves of oxygen-dependent phagocytic activity of neutrophils of group II were functionally active. Particular attention should be paid to the fact that the elimination of AIC in group II was faster than in group I (P <0.05). This demonstrated the effectiveness of ozone therapy in the treatment of COPD exacerbations. Thus, the positive effect of infusion ozone therapy at different stages of inflammation during the exacerbation of COPD indicates the prospects for further research in this area.

Dynamics of immunologic parameters in elder children with atopic dermatitis

1999 ◽  
Vol 80 (4) ◽  
pp. 253-255
Author(s):  
В. А. Shamov ◽  
A. G. Shamova ◽  
T. G. Malanicheva
Keyword(s):  
Atopic Dermatitis ◽  
Immune Complexes ◽  
Immune Status ◽  
Circulating Immune Complexes ◽  
Natural Killers ◽  
Cd8 Cells ◽  
Immunologic Parameters

In children aged 10 to 17 with atopic dermatitis the following changes are revealed: the decrease of the content of CD3+-cells, CD8+-cells, natural killers, CH50, the increase of immunoregulator index indicators, CD19+-cells, igg, ige circulating immune complexes. More pronounced disorders of the immune status are found in boys and girls aged 13 to 17 than in children aged 10 to 12. After the treatment the favourable dynamics of the indicators of CD8+-cells, immunoregulator index, concentration of igg, ige and circulating immune complexes is found.

Palliative treatment of unresectable pancreatico-biliary cancer by either gemcitabine or octreotide/imatinib: Impact on biomarkers of angiogenesis

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 15101-15101
Author(s):  
G. Treiber ◽  
T. Wex ◽  
P. Malfertheiner
Keyword(s):  
Pancreatic Cancer ◽  
Primary Outcome Measure ◽  
Ampullary Cancer ◽  
Secondary Outcome ◽  
Combination Group ◽  
Group I ◽  
Low Levels ◽  
Group Ii ◽  
Changes Over Time ◽  
The Impact

15101 Background: Gemcitabine represents standard Tx for unresectable cancers of the pancreas / distal biliary tract. Recent interest has focused on antiangiogenic properties in a mouse model of pancreatic cancer (JCI 2003); either VEGF or PDGF inhibition alone were less effective than the combination of both in terms of angiogenesis. In humans, imatinib (targeting PDGF) alone has been shown to be equivalent to gemcitabine in terms of survival (Cancer Lett. 2006;233:328–37), while most trials for octreotide (targeting IGF-1, VEGF) were disappointing. In HCC pts. we recently evaluated the impact of biomarkers on disease progression and survival (Cancer Res Clin Oncol 2006; 132:699–708). Methods: To investigate in a phase I/II trial the feasability of a combination (group I, n=11) of octreotide (30 mg im every 4 weeks, targeting VEGF-A) plus imatinib (400 mg po daily, targeting PDGF-B) vs gemcitable (group II, n=11, 1000mg/m2 weekly for 7/8 wks, then for 3/4 wks). Pts had either unresectable pancreatic cancer (n=18) or ampullary cancer (n=4). Primary outcome measure were changes in biomarkers (VEGF-A, PDGF-BB, soluble E-selectin, Ca19–9, CEA). Secondary outcome measures were TTP and OS. Results: 19/22 pts. had biomarker data available within the first 12 wks, changes over time are shwon in table . Median TTP was 109 vs 166 days (p<0.05) and median OS was 163 vs 325 days (p=NS) for group I vs II. Baseline Ca19–9 levels correlated with prognosis independent of Tx (p=0.05). In group I, high levels of PDGF-BB and VEGF-A levels at wk 12 but in group II, low levels of VEGF-A and s-E-selectin correlated with a better OS (p<0.05 each). TTP showed no correlations with biomarkers. Conclusions: The combination of octreotide plus imatinib is clinically less effective compared to gemcitabine. Although the absolute changes of angiogenesis markers are comparable between groups, chemotherapy compared to targeted therapy has a different impact on these in terms of survival. [Table: see text] No significant financial relationships to disclose.

scholarly journals Evolution of humoral immunity effectors in four flocks of sheep with symptoms of contagious ecthyma, from Santău village, Romania

2021 ◽  
Vol 26 (2) ◽  
pp. 2361-2369
Author(s):  
ELISABETA-RAFILA MESTESANU ◽  
Keyword(s):  
Immune Complexes ◽  
Clinical Signs ◽  
Individual Characteristics ◽  
Circulating Immune Complexes ◽  
Contagious Ecthyma ◽  
Immunological Parameters ◽  
Secondary Infections ◽  
Welfare Implications ◽  
The Individual ◽  
Two Parameters

Contagious ecthyma or contagious pustular dermatitis is a debilitating condition located on the skin of sheep and goats, with a zoonotic character. Contagious ecthyma is a disease with economic and animal welfare implications, rarely being fatal if the host organism suffers from immunosuppression or if secondary infections occur. Similar to other members of the Poxviridae family, immunity to contagious ecthyma is mediated by both innate and adaptive immune responses. Following the invasion of the contagious ecthyma virus, immunoglobulins are mobilized that specifically bind to the contagious ecthyma virus to form immune complexes, which are then eliminated by defense system to protect tissues from damage. The level of circulating immune complexes and immunoglobulins can be quantified and can be an indicator of the stage of infection. In the present study we aimed to investigate whether there is a link between the individual characteristics (sex, age, severity of clinical signs) of sheep with orf symptoms and the evolution of circulating immune complexes and total immunoglobulins. In addition to these investigations, we aimed to follow the evolution of these immunological parameters compared to the evolution in clinically healthy animals. Investigations of the serum revealed that levels of these two parameters (total Ig and CIC), can be influenced by the individual characteristics of sheep affected by the contagious ectima and shows differences compared to clinically healthy animals.

scholarly journals Functional activity of the endothelium and immune status in atherosclerotic lesions of the aorto-iliac segment and revascularization

2020 ◽  
pp. 11-20
Author(s):  
Viktor A. Lazarenko ◽  
Elena A. Bobrovskaya ◽  
Vladimir N. Mishustin ◽  
Anna V. Mezentseva ◽  
Arina A. Petrova
Keyword(s):  
Blood Flow ◽  
Immune Status ◽  
Local Blood Flow ◽  
Systemic Blood Flow ◽  
Atherosclerotic Lesions ◽  
Group I ◽  
Tissue Plasminogen ◽  
Group Ii ◽  
Pai 1 ◽  
Lesion Class

Objective. The aim of the study is the evaluation of endothelial functional activity and immune status in systemic and local blood flow in atherosclerotic lesions of the aorto-iliac segment after open and endovascular interventions and establishing the relationship with the lesion class. Materials and methods. The study included 190 patients with lesions of the aorto-iliac segment. Depending on the type of surgical intervention, patients were divided into two groups: group I (n=97) - patients who underwent aorto-femoral bypass surgery, group II (n=93) - patients who underwent TRANS-balloon angioplasty with stenting of the iliac arteries. Results. Violations of the functional state of the endothelium and the immune status in the systemic and local blood flow, which do not correlate with the TASC II lesion class (TransAtlantic Inter-Society Consensus II), were revealed. There were differences in the factors of endothelial damage (in patients of group II before surgery, the level of homocysteine in the systemic blood flow, oxidized low-density lipoproteins in the systemic and local blood flow), hemostatic form of endothelial dysfunction (in group I, inhibitor of tissue plasminogen activator type I (PAI-1) in the systemic and tissue plasminogen activator (t-PA) in the local blood flow) and apoptosis (higher in group I in the systemic and local blood flow). During revascularization of the aorto-iliac segment, there were violations of the hemostatic form of endothelial dysfunction in group II with an increase in PAI-1 by 14.8% (p<0.001) in the systemic blood flow and by 1.9 times (p<0.001) in the revascularized arterial segment compared to group I. In group II after revascularization was significantly higher the immunoglobulins (Ig) class A in system and the circulating immune complexes, interleukins 1 (IL-1) in local blood flow and lower levels of IgM, interleukins 6 (IL-6), IL-1 in system and IgA, IgM, IL-6 in local blood flow compared with I group. Conclusion. The study of the features of the functional state of the endothelium and the immune status will optimize the management strategies of patients after various types of revascularization interventions on the aorto-iliac segment.

scholarly journals Formation features of humoral immunity in newborn calves in case of including haylage with bio-preservative into the diet of cows

2021 ◽  
Vol 273 ◽  
pp. 02008
Author(s):  
Anna Karamaeva ◽  
Larisa Bakaeva ◽  
Natalia Soboleva ◽  
Sergey Karamaev
Keyword(s):  
Blood Serum ◽  
Milk Yield ◽  
Humoral Immunity ◽  
Immune Status ◽  
The Body ◽  
Group Iii ◽  
First Feeding ◽  
Group I ◽  
Newborn Calves ◽  
Group Ii

The peculiarities of the formation of colostrum in the udder of cows and the immune status in the body of calves in the first hours and days after birth, when included in the diet of cows, haylage from eastern goat’s rue prepared with the use of bio-preservatives “Silostan” (group II) and “GreenGrass 3 × 3”(Group III). The study of colostrum of the first milk yield showed that feeding cows with silage with the bio-preservative “Silostan” contributed to an increase in the content of immunoglobulins by 4.0% (Р<0,001), with bio-preservative “GreenGras 3 × 3” - by 5.3% (Р<0,001). After drinking the first portion of colostrum, immunoglobulins appear in the blood serum of calves after 2 hours. After 6 hours, the content of immunoglobulins in the blood serum of calves of group II was 21.9% higher than in group I (haylage without preservative) (P < 0.05), group III - by 27.1% (P <0.001). The proportion of calves with an immunoglobulin content 6 hours after the first feeding with colostrum not more than 6.0 mg / ml, decreased in group II by 12.0%, in group III - by 20.0%.

scholarly journals The influence of genetic and immunologic factors on indicators of innate immunity daughters

2019 ◽  
pp. 63-66
Author(s):  
M. A. Eryomina ◽  
I. Yu. Ezdakova
Keyword(s):  
Animal Health ◽  
Immunological Parameters ◽  
Significant Relationships ◽  
Group I ◽  
Reference Type ◽  
Immunological Factors ◽  
Milking Frequency ◽  
Group Ii ◽  
Negative Relationships ◽  
Type Parameter

The aim of the research is to study the influence of genetic and immunological factors of bulls on the immunological parameters of daughters at razdoe (from the first lactation to the second). The object of research was cows-daughters of bulls, previously evaluated by genetic and immunological indicators. It was revealed based on the survey findings that in the cows in group II in the period of the second lactation, the lymphocyte and basophil concentrations decreased by 9.23% (р0.05) and 1.54% (р0.05), respectivley, while the monocyte concentration increased by 6.23% (р0.001). It may be related with an increase in the animal body compensatory responses at the reference-type parameter of the neutrophils phagocytic activity reduced by 10.7% (р0.05) and 14.6% (р0.05) for the animals in group I and group II, respectively. With respect to the animals in group II, the negative relationships between the lymphcyte and monocyte counts in the first lactation and the neutrophil and eosinophil counts in the second lactation, comprising -0.501 (р0.05) and -0.567 (р0.05), respectively, were ascertained. The less quantity of the significant relationships in group I can indicate the less intense state of the immune system in the daughters of the bull sires, which are characterized with the steady-state genetic and immunological parameters, in the period of increasing the milking frequency early in lactation (from the first to second lactations), what can serve as an additional criterion, given the consolidation in the offspring of sires stable indicators of animal health.

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