scholarly journals Directly observed treatment increases drug compliance in lymphatic filariasis mass drug administration

2016 ◽  
Vol 35 (2) ◽  
pp. 119 ◽  
Author(s):  
Tutik Ida Rosanti ◽  
Sugeng Juwono Mardihusodo ◽  
Wayan T. Artama
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Compliance Rate ◽  
Drug Compliance ◽  
Chi Square ◽  
Significant Difference ◽  
Directly Observed Treatment ◽  
Chi Square Test ◽  
Household Heads

Backgroud. <br />Mass drug administration (MDA) has been one of the strategies for lymphatic filariasis elimination. Since the start of implementation in 2011 in Pekalongan, no study on MDA acceptability has yet been done. The objectives of the study were to determine the microfilaria rate (mf rate) and the risk factors of drug compliance in the MDA program. <br /><br />Methods<br />A longitudinal study was conducted at Pabean region, Pekalongan City. There were 90 household heads as subjects, who were selected by proportional cluster random sampling. Microfilaria rate (mf rate) was determined by finger blood examination. Drug compliance was measured using questionnaires and observation sheets. Drug compliance observers, filariasis counseling participation, and presence of filariasis patients were factors influencing drug compliance. <br /><br />Results<br />Mf rate in 2015 was 1.35% and drug compliance rate was 86.80%. Reasons for failing to take drugs were fear of side effects (50%), refusals (25%), laziness (16.7%), and perceiving the drug to be useless (8.3%). The chi-square test shows a significant difference between the presence of drug compliance observer and compliance (p=0.006). Filariasis counseling participation and presence of filariasis patients did not show a significant difference with drug compliance (p= 0.986).<br /><br />Conclusions<br />Families as the source of observers was associated with increased filariasis drug compliance. It is therefore essential to address the issues linked to low compliance to make the program more efficient and achieve the goal of filariasis elimination.

Non-compliance to Mass Drug Administration Associated with the Low Perception of the Community Members About their Susceptibility to Lymphatic Filariasis in Ankobra, Ghana

2020 ◽  
Vol 20 (2) ◽  
pp. 167-174
Author(s):  
Ilo Dicko ◽  
Yaya Ibrahim Coulibaly ◽  
Modibo Sangaré ◽  
Bismark Sarfo ◽  
Priscillia Awo Nortey
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Health Workers ◽  
Compliance Rate ◽  
Cross Sectional Study ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
Improve Compliance ◽  
Degree Of Association

Background: Lymphatic filariasis (LF) is a parasitic disease that has been targeted for elimination through the Mass Drug Administration (MDA.) Although the MDA started in the Ankobra community in Ghana in 2000, LF prevalence as reported in 2014 was relatively high (4.5%). Non-compliance to the MDA has been associated with the persistent LF prevalence in endemic regions. Objective: This study determined the factors associated with the non-compliance to the MDA among patients living in the Ankobra community, Ghana. Methods: A cross-sectional study using a one-stage cluster sampling method was used to collect data between June and July, 2017 in Ankobra. Questionnaires were used to collect data from health workers, the MDA drug distributors and study participants in Ankobra. Data analysis was performed using STATA 14. Logistic regression was used to measure the degree of association between the dependent (non-compliance) and independent variables. Non-compliance rate was defined as the percentage of individuals who self-reported that they did not actually swallow the drugs provided during the MDA. Results: The MDA coverage and non-compliance rates were 73.5% (147/200) and 33.33% (49/147) respectively. The main reason for non-compliance was fear of drug adverse events (75.51%, 37/49). Thought of “not being susceptible to LF” was significantly associated with the non-compliance (aOR= 2.83, [CI= 1.15, 6.98]). Conclusion: Health education about the susceptibility of residents getting LF disease in endemic community must be intensified to improve compliance to MDA medication ingestion and thus meet the Global Elimination of Lymphatic Filariasis by 2020.

scholarly journals Evaluation of coverage of mass drug administration programme conducted in Nalgonda district of Telangana state

2018 ◽  
Vol 5 (12) ◽  
pp. 5178
Author(s):  
Praveena Ganapa ◽  
Kishore Y. Jothula ◽  
Vishweswara Rao Guthi ◽  
P. Abhishek ◽  
V. Jyothi ◽  
...  
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Compliance Rate ◽  
Public Health Problem ◽  
Control Programme ◽  
Major Public Health Problem ◽  
Endemic District ◽  
Study Population ◽  
Coverage Rates

Background: Lymphatic filariasis has been a major public health problem in India. Government of India during 2004 initiated Mass Drug Administration (MDA) with annual single dose of DEC tablets to all the population living at the risk of filariasis. Nalgonda is endemic district where MDA programme is undertaken every year to eliminate lymphatic filariasis. The present study was undertaken to evaluate the coverage and compliance rates of the MDA programme conducted during January 2018.Methods: The guidelines of National Vector Borne Disease Control Programme (NVBDCP) were used to select a total of 129 households from four clusters (three rural and one urban). Each household was visited by a team and data was recorded on pre-structured questionnaire available in operational guidelines manual of NVBDCP. Data analyzed by SPSS version 22.Results: Total of 129 households were included in the study, Among the 523 study population, only 494 were eligible population to receive MDA. Current study shows that coverage rate was 79.84% and compliance rate was 84.6%. Fear of side effects was most common reason for noncompliance.Conclusions: Efforts should be made to improve coverage rates by involving more human resources, supervision and incentives. Though compliance rates were higher than required there is need to maintain these rates by IEC activities and community participation. 

scholarly journals Study on sustainable livelihoods of fishers from Chalan beel, Bangladesh

2020 ◽  
Vol 5 (3) ◽  
pp. 100-114
Author(s):  
SM Rezaul Karim ◽  
KM Abdul Halim ◽  
Md Asek Uddin ◽  
Most Farida Yeasmin ◽  
KM Hasanuzzaman ◽  
...  
Keyword(s):  
Statistical Tests ◽  
Age Groups ◽  
Physical Capital ◽  
Well Being ◽  
Point Of View ◽  
Chi Square ◽  
Significant Difference ◽  
Chi Square Test ◽  
Land Holdings ◽  
Household Heads

An assessment was carried out to observe the impacts of fish sanctuary on the livelihoods from fishers of Ruhul beel and Bamonji beel under Chalan beel in Pabna district of Bangladesh. Data were collected from selected sanctuary sites with prepared and pretested questionnaire and analyzed through statistical tests like ANOVA (Analysis of Variance), regression, correlation, Chi-square were used to identify the relationships between variables and significant differences/association among them. From physical capital point of view, it was found that 91.3% of fishermen’s houses were katcha, 6.52% were semi-pacca, and only 2.17% were pucca in case of Ruhul beel and in case of Bamonji beel 90.54% of fishermen’s houses were katcha, 8.11% were semi-pacca, and only 1.35% were pacca. There was no significant variation (ANOVA; P>0.05, Chi Square test; non-significant at 0.05 level) among the residences by well-being. From human capital, average age of the household heads (HHH) was 37.95(±) 1.354 for Ruhul beel respectively, whereas for Bamonji beel the average age were 38.05(±) 1.064. The medium aged group fishermen were dominant in Ruhul beel than Bamonji beel. There were no significant difference (P>0.05) found between the age groups by well-being. From income capital it was observed highest part of income were come from fishing contributing 64.89% (653.72±128.82 US$), 43.58% (431.89±74.66 US$) for Ruhul beel and Bamonji beel respectively. As per as natural and social capital, average used land holding was 0.274±0.136 ranging 0.065 ha to 0.534 ha for Ruhul beel and 0.228±0.305 ha ranging 0.040 to 0.267 ha for Bamonji beel. The average land holdings did not vary significantly (P>0.05) between the sites. Asian Australas. J. Biosci. Biotechnol. 2020, 5 (3), 100-114

scholarly journals Adverse reactions following mass drug administration with diethylcarbamazine in lymphatic filariasis endemic areas in the Northeast of Brazil

2012 ◽  
Vol 45 (6) ◽  
pp. 745-750 ◽  
Author(s):  
Ana Wládia Lima ◽  
Zulma Medeiros ◽  
Zailde Carvalho dos Santos ◽  
Gertrudes Monteiro da Costa ◽  
Cynthia Braga
Keyword(s):  
Lymphatic Filariasis ◽  
Adverse Drug Reactions ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Population Based ◽  
Drug Reactions ◽  
Cross Sectional ◽  
Significant Difference ◽  
Poor Treatment ◽  
Weight For Age

INTRODUCTION: The Global Programme to Eliminate Lymphatic Filariasis was launched with the goal of eliminating this disease via the annual mass drug administration (MDA) of a single dose of antifilarial drugs. Adverse drug reactions following MDA are a major factor of poor treatment adherence in several countries. This study assessed the occurrence of adverse drug reactions (ADRs) following the first round of mass treatment in two communities treated with different dosages of diethylcarbamazine (DEC) in the City of Recife, Brazil. METHODS: Population-based cross-sectional surveys were conducted in a random sample of the population living in both communities (Areas I and II). The dose of DEC recommended by the WHO (6mg/kg) was calculated based on the individual's weight-for-age. In Area II, weight differences between the genders were also considered when determining dosage. Data were obtained through interviews conducted in the first 12 to 48h and on the 5th day after MDA during household visits. RESULTS: A total of 487 and 365 individuals were interviewed in Areas I and II, respectively. The prevalence of ADRs in Area I (23.6; 95%CI: 19.1-29.5) was higher than in Area II (16.2; 95%CI:11.9-21.5)(p=0.0078). The prevalence of ADRs among females was higher than in males in Area I (p=0.0021). In Area II, no significant difference between the genders was observed (p=0.1840). Age was not associated with ADRs in either area. CONCLUSIONS: Adjusting MDA dosage schedules according to weight-for-age and sex may be may contribute to reduce the occurrence of adverse drug reactions in the population.

scholarly journals A systematic review and meta-analysis on the rate of human schistosomiasis reinfection

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243224
Author(s):  
Abdallah Zacharia ◽  
Vivian Mushi ◽  
Twilumba Makene
Keyword(s):  
Systematic Review ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Meta Analysis ◽  
Reinfection Rate ◽  
Chi Square ◽  
Urogenital Schistosomiasis ◽  
Intestinal Schistosomiasis ◽  
Human Schistosomiasis ◽  
Chi Square Test

While praziquantel mass drug administration is currently the most widely used method in the control of human schistosomiasis, it does not prevent subsequent reinfection hence persistent transmission. Towards schistosomiasis elimination, understanding the reinfection rate is crucial in planning for the future interventions. However, there is scarcity of information on the global reinfection rate of schistosomiasis. This systematic review and meta-analysis aimed at summarizing studies that estimated the reinfection rate of human schistosomiasis. Three data bases (PubMed, Hinari and Google Scholar) were thoroughly searched to retrieve original research articles presenting data on reinfection rate of human schistosomiasis. Study quality and risk of bias was assessed based on Joanna Briggs Institute critical appraisal checklist. Meta-analysis was conducted using statistical R version 3.6.2 and R Studio using “meta” and “metafor” packages. Random effect model was employed to estimate pooled reinfection rates. Heterogeneity was determined using Cochran’s Q (chi-square)–test and Higgins I2 statistics. A total of 29 studies met inclusion criteria to be included in this review. All studies had at least satisfactory (5–9 scores) quality. The overal mean and pooled reinfection rates of schistosomiasis were 36.1% (±23.3%) and 33.2% (95% CI, 26.5–40.5%) respectively. For intestinal schistosomiasis, the mean and pooled reinfection rates were 43.9% (±20.6%) and 43.4% (95% CI, 35.8–51.4%), and that for urogenital schistosomiasis were 17.6% (±10.8%) and 19.4% (95% CI, 12.3%– 29.2%) respectively. Cochran’s Q (chi-square)–test and Higgins I2 statistic indicated significant heterogeneity across studies (p-values < 0.001, I2 values > 95%). Results of subgroup analysis showed that, the type of Schistosoma species, participants’ age group, sample size and geographical area had influence on disparity variation in reinfection rate of schistosomiasis (p < 0.1). Despite the control measures in place, the re-infection rate is still high, specifically on intestinal schistosomiasis as compared to urogenital schistosomiasis. Achieving 2030 sustainable development goal 3 on good health and wellbeing intensive programmatic strategies for schistosomiasis elimination should be implemented. Among such strategies to be used at national level are repeated mass drug administration at least every six months, intensive snails control and health education.

scholarly journals Evaluation of coverage, compliance of mass drug administration and assessment of awareness about lymphatic filariasis in Tikamgarh district of Madhya Pradesh: a cross sectional study

2019 ◽  
Vol 6 (3) ◽  
pp. 1235
Author(s):  
Ram Kumar Panika ◽  
Rupesh Sahu
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Compliance Rate ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Major Public Health Problem ◽  
Sectional Study ◽  
Cross Sectional ◽  
Life Years

Background: Lymphatic filariasis is the second leading cause of disability worldwide accounting for more than 5 million disability adjusted life years annually. It has been a major public health problem in India which leads to irreversible chronic manifestations which are responsible for considerable economic loss and severe physical disability to the affected individuals. Mass drug administration (MDA) means administration of diethylcarbamazine and albendazole tablets to all people (excluding children <2 years, pregnant women, seriously ill persons) in endemic areas once in a year. The objective of the study was to assess coverage, compliance of MDA and awareness about lymphatic filariasis in Tikamgarh district of Madhya Pradesh.Methods: Cross-sectional study was conducted and total 120 households were surveyed in four randomly selected clusters of Tikamgarh district of Madhya Pradesh.Results: Out of total 743 persons 678 (91.25%) persons were eligible for MDA. Coverage rate was 86.57% and compliance rate was 74.27%. The main reason for non-compliance was not having the concerned disease (55.78%) followed by fear of side effect (22.31%). Only 40.83% among the surveyed families were aware about MDA and only 45.83% respondents had heard about lymphatic filariasis.Conclusions: There is coverage and compliance gap and awareness about the lymphatic filariasis and MDA program is limited. Drug compliance need to be improved and awareness need to be raised. MDA program should not be confined to tablet distribution only and due importance should be given to compliance rate.

scholarly journals Evaluation of coverage and compliance to mass drug administration for lymphatic filariasis elimination in two endemic districts of Karnataka

2019 ◽  
Vol 6 (8) ◽  
pp. 3583
Author(s):  
Anwith H. Shivalingaiah ◽  
Ravikumar K. ◽  
Sunil M. Gurupadaswamy
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Compliance Rate ◽  
Household Survey ◽  
Cross Sectional Study ◽  
Coverage Rate ◽  
Cross Sectional ◽  
Effective Coverage ◽  
Multi Stage

Background: Lymphatic filariasis is a debilitating and disfiguring disease causing significant socioeconomic burden. India is endemic for filariasis which includes Kalaburagi and Yadgir districts in Karnataka. India has the target for filariasis elimination by 2020 and mass drug administration [MDA] is a strategy for elimination. The objective of the study was to evaluate the coverage and compliance of mass drug administration against lymphatic filariasis.Methods: The study was a cross sectional study conducted during the month of October 2018 in Kalaburagi and Yadgir districts. The study subjects included all the residents of cluster except subjects aged below 2 years and pregnant women. Multi stage sampling was used and three clusters from rural area and one cluster from urban area from each district. Data collection was done by household survey after informed consent using a standard questionnaire.Results: A total population of 1,963 subjects residing in 399 houses of two districts was included. Majority of the study subjects 1517 (77.27%) were in the age group of more than 15 years with predominantly males 984(50.12%). The coverage rate and compliance rate of MDA was 83.17% and 92.46% in Kalaburagi district and 86.71% and 86.98% in Yadgir district respectively. The effective coverage rate and coverage compliance gap was 76.89% and 7.53% in Kalaburagi district, 75.42% and 13.01% in Yadgir district. Incomplete dose of MDA was consumed by 17 subjects in Kalaburagi district and 21 subjects in Yadgir district.Conclusions: The effective MDA coverage in both the study districts is below 85% which is not satisfactory.

scholarly journals Mass Drug Administration for Lymphatic Filariasis Elimination in Two Districts of North Karnataka: Coverage and Compliance Assessment

Healthline ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 94-99
Author(s):  
Huluvadi Shivalingaiah Anwith ◽  
S R Suhas ◽  
Seema K S ◽  
Karishma P S ◽  
K Ravi Kumar ◽  
...  
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Compliance Rate ◽  
Household Survey ◽  
Control Programme ◽  
Coverage Rate ◽  
Cross Sectional ◽  
Effective Coverage ◽  
All Diseases

Introduction: Lymphatic filariasis or elephantiasis is the most debilitating and disfiguring scourge among all diseases which imposes severe social and economic burden. Currently an estimated 63crores people are at a risk of filariasis in 256 endemic districts across 16 states and 5 union territories in India. National filarial control programme is operational since 1955 in India and the current goal is achieving elimination of filariasis by 2020through Mass Drug Administration (MDA). Objective: To assess the coverage, compliance and causes for noncompliance of MDA in the study districts. Method: A cross sectional descriptive study was conducted in October 2019 and January 2020 in Koppal and Bidar districts respectively. Randomly four clusters were selected, three from rural area and one from urban area. All the residents of a cluster were included except subjects aged below 2 years and pregnant women. Data collection was done by household survey using a standard questionnaire. Results: Total populations of 2043 subjects residing in 480 houses were included. The coverage rate was95.44 &94.73% with compliance rate of 91.61% &93.12% in Koppal & Bidar districts, respectively. The effective coverage rate was 87.44 %& 88.2% in Koppal & Bidar districts respectively. Drug consumption by DOT was 95.1% in Koppal&85.8% in Bidar district. Conclusions: The coverage& compliance of MDA was found to be satisfactoryas it was >65%.Consumption of MDA by DOT to be more emphasized to reduce coverage compliance gap and increase the effective coverage rate.

scholarly journals Mid-term assessment of mass drug administration for elimination of lymphatic filariasis: in Bundelkhand region of Madhya Pradesh

2019 ◽  
Vol 6 (2) ◽  
pp. 750
Author(s):  
Ram K. Panika ◽  
Rakesh K. Mahore
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Compliance Rate ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Active Involvement ◽  
Change Communication ◽  
Disability Adjusted Life ◽  
Life Years

Background: Lymphatic filariasis is a vector borne parasitic disease caused by lymphatic dwelling nematode parasite. It is one of the world's leading causes of permanent and long-term disability with an estimated 5.1 million disability adjusted life years (DALYs) are lost due to this disease. The National Health Policy 2002 aims at Elimination of Lymphatic filariasis by 2015 through Annual Mass Drug Administration (MDA) of single dose of DEC. Objective was to assess coverage and compliance of MDA Program and awareness about lymphatic filariasis in Chhatarpur district of Madhya Pradesh.Methods: Cross-sectional Study was conducted. Total 120 households were surveyed in four selected clusters of Chhatarpur district of MP.Results: Out of total 835 persons only 94.37% persons were eligible and 47 (5.62%) were not eligible for MDA for MDA. Coverage rate was 90.22% and compliance rate was 75.24%. The main reason for non-compliance was not having the concerned disease 34.38 % followed by fear of side effect (24.90%). Only 37.5% among the surveyed families were aware about MDA. Majority of respondent 21 (46.66%) acquired knowledge from health workers.Conclusions: The compliance of MDA program was low and the awareness about the lymphatic filariasis in the study population was limited in Chhatarpur district. Poor compliance of MDA is attributed to inadequate consumption of drugs due to poor awareness among eligible population. For elimination of lymphatic filariasis active involvement of community is very essential. It can be made possible through behavior change communication and health education of people.

scholarly journals Coverage and compliance of mass drug administration for elimination of lymphatic filariasis in Khammam district

2018 ◽  
Vol 5 (12) ◽  
pp. 5121
Author(s):  
Rajeshwar Rao Alwala ◽  
Chandrasekhar Reddy Bolla ◽  
Shankar Reddy Dudala ◽  
Y. Pravin Raju ◽  
Raston Mondal ◽  
...  
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Compliance Rate ◽  
Population Based ◽  
Economic Problem ◽  
Coverage Rate ◽  
Systematic Sampling ◽  
Cross Sectional ◽  
Effective Coverage

Background: Lymphatic filariasis (LF) is an important public health and socio-economic problem in the world and it was identified as one of the six diseases, which could be targeted for elimination /eradication. Annual mass drug administration of DEC with selective vector control could result in the effective elimination of infection by interruption of transmission. The present study aimed to find the coverage and compliance of mass drug administration (MDA) of diethyl-carbamazine (DEC) for elimination of lymphatic filariasis (LF) in Khammam district in November 2009.Methods: Cross-sectional, population-based, house-to-house survey was conducted after the round of MDA with DEC. Multi-stage systematic sampling method was used and four clusters were selected with 30 houses in each. A pretested questionnaire was used to interview the study participants. The data collected was analyzed and coverage rate, compliance rate and effective coverage rate were calculated.Results: The coverage rate was 65.54% with variation across different areas. The compliance with drug ingestion was 71.14%. The effective coverage (46.63%) was much below the target (85%) which has to be targeted by intensive information, education and communication (IEC). Side effects of DEC were minimum, transient and drug-specific.Conclusions: The coverage, compliance, and effective coverage rates were found to be lower than the target, which need to be intensified by extensive IEC. 

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