Cardiomyocyte injury: mechanism of doxorubicin toxicity effects

An unusually severe case of toxicity accompanied by activated sludge filamentous bulking was observed at the wastewater treatment plant Sao Paulo-Barueri. Treatment efficiency of the plant, operated without major problems for more than five years before, was significantly hindered for almost six months. Occurrence of toxic shocks was confirmed partly directly but mostly indirectly by inhibition of nitrification and biological phenomena related to toxicity. Several measures adopted, including the recycled activated sludge chlorination, are described in the paper.

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Toxic effects of sub lethal concentration of dioctyl phthalate on the histology of liver of Clarias batrachus (Linn.).

International Journal of Bioassays ◽

10.21746/ijbio.2016.09.0017 ◽

2016 ◽

Vol 5 (09) ◽

pp. 4874

Author(s):

Manisha Satpathi* ◽

Ravinder Singh

Keyword(s):

Acute Toxicity ◽

Light Microscopy ◽

Dioctyl Phthalate ◽

Clarias Batrachus ◽

Fresh Water Fish ◽

Histopathological Changes ◽

Histological Changes ◽

Water Fish ◽

Toxicity Effects ◽

Plastic Products

Dioctyl phthalate (DOP) commonly used as plasticizer enters into aquatic environment from the industries manufacturing plastic products, PVC resins, cosmetics and many other commercial products. Therefore, this study was designed to evaluate the acute toxicity effects of Dioctyl phthalate on fresh water fish Clarias batrachus. The 96 hour LC50 of Dioctyl phthalate in Clarias batrachus was estimated as 14.5ml/L. Histopathological changes in liver of Clarias batrachus were determined by exposing them to a fraction of LC50(1/5th) dose with every change of water for 30 days.The liver of Clarias batrachus was excised at every interval of 30 days and histological changes of liver were studied under light microscopy. Liver tissues showed abnormalities. Centrilobular vacuolation, necrosis, eccentric nuclei and enlarged nuclei, Centrilobular degeneration of hepatocytes were observed in liver tissue of fish.

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Toxicity effects of procymidone, iprodione and their metabolite of 3,5-Dichloroaniline to zebrafish

Chemosphere ◽

10.1016/j.chemosphere.2021.129577 ◽

2021 ◽

pp. 129577

Author(s):

Qi Lai ◽

Xiaofang Sun ◽

Lianshan Li ◽

Da Li ◽

Minghua Wang ◽

...

Keyword(s):

Toxicity Effects

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Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp

Scientific Reports ◽

10.1038/s41598-021-96226-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jerónimo Laiolo ◽

Priscila Ailin Lanza ◽

Oscar Parravicini ◽

Cecilia Barbieri ◽

Daniel Insuasty ◽

...

Keyword(s):

Multidrug Resistance ◽

Molecular Complexes ◽

Binding Mode ◽

Reversal Agents ◽

Structure Activity Relationships ◽

Structure Activity ◽

Doxorubicin Toxicity ◽

Key Residues ◽

Nanomolar Range ◽

Experimental Structure

AbstractP-gp-associated multidrug resistance is a major impediment to the success of chemotherapy. With the aim of finding non-toxic and effective P-gp inhibitors, we investigated a panel of quinolin-2-one-pyrimidine hybrids. Among the active compounds, two of them significantly increased intracellular doxorubicin and rhodamine 123 accumulation by inhibiting the efflux mediated by P-gp and restored doxorubicin toxicity at nanomolar range. Structure–activity relationships showed that the number of methoxy groups, an optimal length of the molecule in its extended conformation, and at least one flexible methylene group bridging the quinolinone to the moiety bearing the pyrimidine favored the inhibitory potency of P-gp. The best compounds showed a similar binding pattern and interactions to those of doxorubicin and tariquidar, as revealed by MD and hybrid QM/MM simulations performed with the recent experimental structure of P-gp co-crystallized with paclitaxel. Analysis of the molecular interactions stabilizing the different molecular complexes determined by MD and QTAIM showed that binding to key residues from TMH 4–7 and 12 is required for inhibition.

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Assessment of the toxicity effects of nicotine on sperm and IVF and the potential protective role of silymarin—an experimental study in mice

Middle East Fertility Society Journal ◽

10.1186/s43043-020-00025-4 ◽

2020 ◽

Vol 25 (1) ◽

Author(s):

Mohammad Rahimi-Madiseh ◽

Mohsen Mohammadi ◽

Amin Hassanvand ◽

Reza Ahmadi ◽

Maasume Shahmohammadi ◽

...

Keyword(s):

Experimental Study ◽

Protective Role ◽

Toxicity Effects

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