Early signs of airflow restriction and cardiovascular damage in conditionally healthy smokers

2021 ◽  
Vol 31 (1) ◽  
pp. 57-65
Author(s):  
V. A. Nevzorova ◽  
E. A. Kondrashova ◽  
D. Yu. Bogdanov ◽  
Zh. V. Bondareva
Keyword(s):  
Risk Factors ◽  
Left Ventricle ◽  
Longitudinal Strain ◽  
Myocardial Dysfunction ◽  
Blood Pressure Measurement ◽  
Myocardial Damage ◽  
Combustion Products ◽  
Noncommunicable Diseases ◽  
Smoking Intensity ◽  
Brachiocephalic Arteries

Tobacco smoking is one of the most widespread and at the same time difficult to control risk factors for chronic noncommunicable diseases, which make the most significant contribution to the mortality. Smoking intensity, development of airflow restrictions, and damage to vascular endothelium are connected to the accelerated development of atherosclerosis. At the same time, there is no evidence of a possible relationship between the development of myocardial dysfunction and exposure to tobacco combustion products. It is of interest to study the incidence of airflow restrictions, arterial hypertension, and markers of early damage to target organs - the brachiocephalic arteries (BCA) and myocardium, in so-called relatively healthy smoking individuals. The aim of the study was to describe the incidence of airflow restrictions, hypertension, the state of the brachiocephalic arteries, and indicators of global and regional longitudinal strain of the left ventricle (GLSLV and RLSLV) in actively smoking conditionally healthy individuals. Methods. 100 active smokers were examined (smoking person index or ICH > 10 (17 ± 2 packs/year)) at the mean age of 48,80± 0,68years. 55% of the patients were male. The diagnosis of COPD was made based on spirometry values before and after the test with bronchodilators (400 mcg of salbutamol) (FEV1/FVC < 70% and FEV1 increase <12% of the initial values). Blood pressure measurement, duplex scanning of brachiocephalic arteries, transthoracic echocardiography with GLSLV and RLSLV with 17-segment division by Strain method were performed in all patients. Results. COPD was diagnosed in 35% of the patients, hypertension - in 45%. Evaluation of BCA showed increased thickness of intimamedia complex in the patients with hypertension (р= 0.002) and a significantly higher degree of stenosis and number of plaques in patients with concomitant COPD and hypertension. Type 1 diastolic dysfunction of LV was detected both in patients with hypertension and in the patients with COPD, but it was most common in the patients with concomitant COPD and hypertension. The GLSLV values did not change in all patients, but the RLSLV values depended on the segment (basal, medial, apical) and were significantly lower in the patients with concomitant COPD and hypertension. Conclusion. Tobacco combustion products not only are risk factors of airflow restriction and systemic vascular dysfunction, but also cause preclinical myocardial damage, a marker of which is a violation of the longitudinal strain of the left ventricle.

scholarly journals Myocarditis in yound athletes

2015 ◽  
Vol 96 (4) ◽  
pp. 669-674
Author(s):  
E A Degtyareva ◽  
M G Kantemirova ◽  
O I Zhdanova ◽  
O N Trosheva
Keyword(s):  
Risk Factors ◽  
Left Ventricle ◽  
Myocardial Damage ◽  
Left Ventricular ◽  
Cardiac Conduction ◽  
Screening Tests ◽  
High Concentration ◽  
Infectious Risk ◽  
Conduction Disorders ◽  
High Concentrations

Aim. Development of informative differential diagnostic criteria of inflammatory myocardial involvement in young athletes. Methods. A total of 163 athletes (swimmers, football players and sailing athletes) aged 9 to 24 years (mean age 14.74±0,23 years, SD=3.03) were examined. Complete clinical and functional examination was performed. Remodeling of the left ventricle was studied in accordance with R. Devereux (1992) and B. Maron (2005) echocardiographic criteria. Myocardial morphometry results were compared with immunobiochemical markers of myocardial damage and titer of antimyocardial antibodies to the endothelium, cardiac conduction system, cardiomyocytes, and smooth muscle. Results. In 10 out of 40 athletes with echocardiographic signs of pathological remodeling of the left ventricle, the indicators of myocardial damage used as immunobiochemical screening tests, were increased, high titers of antimyocardial antibodies (more than 1:160), arrhythmias, sever conduction disorders, and high concentrations of infectious risk factors were revealed, allowing to diagnose subacute myocarditis. Conclusion. Subacute myocarditis should be excluded in athletes with echocardiographic signs of left ventricular myocardial remodeling and a high concentration of «infectious» risk factors based on immunobiochemical markers of myocardial damage and antimyocardial antibodies titer.

scholarly journals Neighborhood environment: the impact of alcohol and tobacco outlets availability on health of people living in a certain area

2021 ◽  
Vol 20 (6) ◽  
pp. 2959
Author(s):  
A. A. Antsiferova ◽  
A. V. Kontsevaya ◽  
D. K. Mukaneeva ◽  
O. M. Drapkina
Keyword(s):  
Risk Factors ◽  
Road Traffic ◽  
Significant Risk ◽  
Drunk Driving ◽  
High Density ◽  
Neighborhood Environment ◽  
Noncommunicable Diseases ◽  
Intersectoral Collaboration ◽  
Smoking Intensity ◽  
The Impact

Alcohol and tobacco consumption remain significant risk factors (RFs) for morbidity and mortality from noncommunicable diseases (NCDs), including cardiovascular ones, in Russia. The main risk factors contributing to NCDs in addition to traditional risk factors and lifestyle also include the neighborhood environment (NE). The term “neighborhood environment” describes the relationship between the area in immediate vicinity of a person's place of residence, environmental factors, social characteristics of the area, which can have both positive and negative effects on human health.The aim of this review was to analyze alcohol and tobacco outlets availability as a factor effecting health of people living in a certain area.It was demonstrated that a high density of alcohol outlets is associated with increased alcohol consumption among both adults and adolescents, with drunk driving and road traffic accidents, injuries, violent crimes, the risk of acute and chronic diseases. A high density of tobacco outlets is associated with an increase in smoking intensity among both adults and adolescents, as well as an increase of secondhand smoke, which increases the risk of NCDs.The consumption of alcohol and tobacco is associated with a significant increase in risk of NCDs, including cardiovascular ones, and injuries, leading to disability and death. The effectiveness of measures aimed at reducing the consumption of alcohol and tobacco may be reduced due to high density of outlets selling these products. It is necessary to conduct studies aimed at assessing the outlets density and its associations with prevalence of RFs and health status of Russian population. These data will stimulate intersectoral collaboration for planning health protection strategy at municipal level.

scholarly journals Layer-specific myocardial strain analysis: investigation of regional deformation in a rabbit model of diabetes mellitus during different stages.

2016 ◽  
Vol 18 (3) ◽  
pp. 339 ◽  
Author(s):  
Ying-Yan Qiao ◽  
Mu Zeng ◽  
Rong-Juan Li ◽  
Zhao-Ting Leng ◽  
Jiao Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Longitudinal Strain ◽  
Circumferential Strain ◽  
Myocardial Dysfunction ◽  
Myocardial Strain ◽  
Myocardial Damage ◽  
Left Ventricular ◽  
Myocardial Deformation ◽  
Control Group ◽  
Significant Difference

Aim: The purpose of the present study was to determine the characteristics of myocardial damage at different stages of diabetes mellitus (DM) using layer-specific myocardial strain. Material and methods: Thirty six New Zealand white rabbits were randomly divided into either the control group (n =18) or the DM group (induced with alloxan) (n=18). For the myocardial deformation studies echocardiography and layer-specific strain were performed at baseline and after 3, 6, and 9 months in all of the rabbits. Three-layer longitudinal strain (LS) was calculated in the apical 4-chamber view, and three-layer circumferential strain (CS) in the short-axis view at the level of mitral valve. Layer-specific longitudinal and circumferential strains were assessed from endocardium, mid-myocardium and epicardium. For histomorphological study of the heart structure, the rabbits were sacrificed at 3, 6 and 9 months. Routine hematoxylin and eosin staining was performed. Results: The highest absolute values of left ventricular longitudinal strain (LS) and circumferential strain (CS) were registered in the endocardium and the lowest in the epicardium in both groups. At 3 months, there was no significant difference in three-layer LS and CS (p>0.05), but at 6 months the LS of endocardium (LSendo) and CS of endocardium (CSendo) were lower in the DM group compared with the control group; at 9 months, the rest of the parameters were also decreased (p<0.05). Moreover, in ROC analysis at 6 months LSendo yielded better sensitivity and specificity in the detection of diabetic cardiomyopathy (AUC of LSendo was 0.897 and AUC of CSendo was 0.617). With the progression of untreated diabetes, the histopathological abnormalities intensified gradually beginning at 6 months. Conclusion: The progressive impairments in LV myocardial deformation and structure occurs early in diabetic rabbits, the myocardial damage may be nontransmural, and endocardial function is more susceptible to be affected by DM. Layer-specific myocardial strain echocardiography may identify subtle myocardial dysfunction in the early stages of DM.

scholarly journals Cardiovascular complications in patients with cancer: focus on anthracycline-induced cardiotoxicity

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
I. T. Murkamilov ◽  
K. A. Aitbaev ◽  
V. V. Fomin ◽  
I. O. Kudaibergenova ◽  
F. A. Yusupov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Late Onset ◽  
Beta Blockers ◽  
Myocardial Dysfunction ◽  
Myocardial Damage ◽  
Cardiovascular Complications ◽  
Left Ventricular ◽  
Type I ◽  
Patients With Cancer ◽  
Cardioprotective Effects

The article describes prevalence and risk factors of cardiovascular in patients with cancer. The problems of anthracycline-induced cardiotoxicity, the deleterious effects of doxorubicin on the heart, as well as the cardioprotective effects of beta-blockers and agents acting on the renin-angiotensin-aldosterone system pathway are discussed. By cardiotoxicity is implied the development of various adverse cardiovascular events against the background of drug therapy for cancer patients. Depending on the severity of myocardial damage, there are type I (anthracycline-mediated cardiotoxicity, myocardial damage is irreversible) and type II (trastuzumab-mediated cardiotoxicity, myocardial dysfunction is reversible) cardiotoxicity. Anthracycline-induced cardiotoxicity, in turn, is divided into acute, early-onset chronic and late-onset chronic. At the same time, the main mechanisms of anthracycline cytotoxicity in relation to healthy cardiomyocytes are stimulation of intracellular oxidative stress, a decrease in reduced glutathione concentration, inhibition of cell redox potential, and a change in iron metabolism. The article discusses in detail the risk factors (age, hypertension, diabetes, asymptomatic left ventricular dysfunction, documented cardiovascular diseases, heart failure, etc.), as well as the mechanisms and treatment of anthracycline-mediated cardiotoxicity.

scholarly journals POS0559 SPECKLE TRACKING BETTER DETECTS SUBCLINICAL MYOCARDIAL DYSFUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 514.2-514
Author(s):  
I. Kirillova ◽  
T. Popkova ◽  
Y. Gorbunova ◽  
A. Volkov ◽  
E. Nasonov
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Left Ventricle ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Myocardial Dysfunction ◽  
Tissue Doppler ◽  
Left Ventricular Ejection ◽  
Control Group ◽  
Esc Guidelines

Background:The risk of developing cardiovascular complications and death in rheumatoid arthritis (RA) is 50% higher than in the total population. These clinical events depend from risk factors for cardiovascular diseases, chronic inflammation and inflammatory myocardial infiltration. А new method for detecting early myocardial dysfunction is echocardiography using speckle tracking echocardiography.Objectives:to determine the frequency of myocardial dysfunction (lower global longitudinal epicardial strain of left ventrical (LV), diastolic dysfunction of left ventricle (LVDD)) using standard and novel echocardiographic methods in patients (pts) with RA prior to therapy with bDMARDs, examine its relationship with markers of inflammation.Methods:a total of 28 pts with a valid diagnosis of RA (ACR/EULAR, 2010): 23 f (82%) /5 m (18%) were included, median (Me) age - 56 [interquartile range (IR) 34;65] years, Me RA duration-14,5 [IR 7;87] months; all pts with RA demonstrated a high disease activity (Me DAS28 6.06, [IR 5,4;6,6]), seropositive for IgM RF (88%) and/or ACCP (84%) without any experience of administration of bDMARDs. The control group consisted of 10 healthy subjects, which were matched by sex and age. All pts were assessed for traditional risk factors for cardiovascular disease (ESC guidelines, 2011), echocardiography, tissue Doppler imaging, and the speckle tracking assessment of left ventricle longitudinal strain. DD was allocated according to the ESC guidelines for the diagnosis and treatment of heart failure (2018). Arterial hypertension was detected in 5 pts with RA.Results:In pts with RA LVDD was more often detected (8 (31%) vs 0%, p=0.05) than in controls. The values of E LV (0.77 [0.62;0.94] ms vs 1.25 [1.03;1.51] ms, p=0.0001) were lower than in control group. Speckle-tracking method detected lower global longitudinal epicardial strain (–16.5 [-18.9; -13.6]% vs –21.58 [-22.1;-20.4] %, p=0.0001). 17(61%) RA pts showed a decrease global longitudinal epicardial strain. There were no between-group differences in left ventricular ejection fraction, LV sizes, LV myocardial mass index in RA pts with controls. There were correlations between the global longitudinal epicardial strain and DAS28 (r=0,9, p<0,02), tender joint score (r=0,6, p<0,02), radiological stage (r=0,6, p<0,008); the presence of systemic manifestations (r=0,5, p<0,03).Conclusion:In pts with RA frequently (61%) were detected lower global longitudinal epicardial strain, which are associated with a high activity of the inflammatory process. Speckle-tracking echocardiography is better at detecting early myocardial dysfunction than tissue Doppler.Disclosure of Interests:None declared

Clinical and Morphological Features of Myocardial Damage and the Course of Fulminant Myocarditis on the Background of СOVID-19, Diagnosis and Treatment Tactics

2020 ◽  
Vol 75 (5S) ◽  
pp. 414-425
Author(s):  
Olga S. Oynotkinova ◽  
Evgenii L. Nikonov ◽  
Oleg V. Zayratyants ◽  
Elena V. Rzhevskaya ◽  
Evgenii V. Krukov ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Myocardial Damage ◽  
Heart Rhythm ◽  
Microvascular Dysfunction ◽  
Symptomatic Treatment ◽  
Clinical Situation ◽  
Diagnosis And Treatment ◽  
Screening Tests ◽  
Fulminant Myocarditis ◽  
Heart Rhythm Disorders

In a review article based on my own clinical experience of managing patients with acute myocardial injury and fulminant myocarditis, taking into account expert recommendations on the clinical treatment of myocardial damage associated with novel coronavirus infection a National clinical geriatric medical research center, division of cardiovascular diseases, the Chinese geriatrics society, Department of cardiology, Beijing Medical Association and European clinics discusses the pathogenesis, diagnosis and treatment of myocardial damage and FM patients, infected with SARS-CoV-2 in the context of the COVID-19 pandemic. Clinical features and diagnostic criteria are presented, including screening tests of markers of myocardial damage in the form of a highly sensitive troponin test, a natriuretic peptide. The article discusses in detail the pathogenesis and mechanisms of myocardial damage, including immune mechanisms, cytokine storm, systemic inflammation with macro- and microvascular dysfunction and the development of myocardial dysfunction with acute heart failure, hypotension, cardiogenic shock and/or life-threatening heart rhythm disorders caused by hypoxia and metabolic disorders at the cellular level. Features of the clinical course of fulminant myocarditis in infected patients (SARS-CoV-2) in the conditions of the COVID-19 pandemic are presented. For the first time, a detailed histo-morphological analysis of pathological myocardial injuries and complications is presented on the basis of unique autopsy material on post-mortem diagnostics of various pathoanatomic autopsies of those who died from COVID-19 in Moscow. Based on the clinical, functional and morphological material, the Protocol of etiopathogenetic treatment is presented. The basis of standard therapy is considered antiviral drugs, immunoglobulin G, the use of monoclonal antibodies to interleukin-6, anticoagulants, glucocorticoids, depending on the clinical situation, cardioprotectors and symptomatic treatment are recommended to maintain the heart, which in combination can achieve a certain clinical effectiveness. As adjuvant cardioprotective targeted therapy, the sodium salt of phosphocreatine is considered in order to preserve the myocardium, maintain its contractility and vital activity.

scholarly journals Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3203
Author(s):  
Syed Mohammed Basheeruddin Asdaq ◽  
Obulesu Challa ◽  
Abdulhakeem S. Alamri ◽  
Walaa F. Alsanie ◽  
Majid Alhomrani ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Combined Therapy ◽  
Myocardial Damage ◽  
Thiobarbituric Acid ◽  
Significant Rise ◽  
Garlic Extract ◽  
High Dose ◽  
Aged Garlic Extract ◽  
Active Constituent ◽  
Aged Garlic

This study was conducted to determine the potential interaction of aged garlic extract (AGE) with carvedilol (CAR), as well as to investigate the role of S-allyl-l-cysteine (SAC), an active constituent of AGE, in rats with isoproterenol (ISO)-induced myocardial dysfunction. At the end of three weeks of treatment with AGE (2 and 5 mL/kg) or SAC (13.1 and 32.76 mg/kg), either alone or along with CAR (10 mg/kg) in the respective groups of animals, ISO was administered subcutaneously to induce myocardial damage. Myocardial infarction (MI) diagnostic predictor enzymes, lactate dehydrogenase (LDH) and creatinine kinase (CK-MB), were measured in both serum and heart tissue homogenates (HTH). Superoxide dismutase (SOD), catalase, and thiobarbituric acid reactive species (TBARS) were estimated in HTH. When compared with other groups, the combined therapy of high doses of AGE and SAC given alone or together with CAR caused a significant decrease in serum LDH and CK-MB activities. Further, significant rise in the LDH and CK-MB activities in HTH was noticed in the combined groups of AGE and SAC with CAR. It was also observed that both doses of AGE and SAC significantly increased endogenous antioxidants in HTH. Furthermore, histopathological observations corroborated the biochemical findings. The cytoprotective potential of SAC and AGE were dose-dependent, and SAC was more potent than AGE. The protection offered by aged garlic may be attributed to SAC. Overall, the results indicated that a high dose of AGE and its constituent SAC, when combined with carvedilol, has a synergistic effect in preventing morphological and physiological changes in the myocardium during ISO-induced myocardial damage.

scholarly journals ASSOCIATION OF HEART FAILURE RISK FACTORS WITH LEFT VENTRICLE LONGITUDINAL CHANGE IN HISPANICS: THE ECHOCARDIOGRAPHIC STUDY OF LATINOS (ECHO-SOL)

2021 ◽  
Vol 77 (18) ◽  
pp. 3380
Author(s):  
Nestor Vasquez ◽  
Ayana April-Sanders ◽  
Katrina Swett ◽  
Jorge Kizer ◽  
Bharat Thyagarajan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Left Ventricle ◽  
Longitudinal Change ◽  
Failure Risk ◽  
Echocardiographic Study

scholarly journals Path Analysis on Determinants of Childhood Obesity and Associated Risk Factors of Cardiovascular, Renal, and Hepatic Diseases: The CASPIAN-V Study

2020 ◽  
Vol 10 (01) ◽  
pp. e148-e158
Author(s):  
Vahid Mansouri ◽  
Marjan Mansourian ◽  
Mostafa Qorbani ◽  
Roya Riahi ◽  
Rahele Karimi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Childhood Obesity ◽  
Latent Variables ◽  
Mutual Influence ◽  
Risk Indicators ◽  
Noncommunicable Diseases ◽  
Surveillance Program ◽  
Predisposing Factor ◽  
Blood Samples ◽  
Hepatic Diseases

AbstractThe interaction between several lifestyle and obesogenic environmental factors is considered as the main underlying factor for the escalating trend of childhood obesity and its adverse consequences. In this study, we assessed the mutual influence of lifestyle habits and body mass index (BMI) as well as risk factors for cardiometabolic, hepatic, and renal disorders to define the causality power of each item. This nationwide cross-sectional study was conducted as the fifth round of a school-based surveillance program. Overall, 14,800 students living in Iran were studied, and blood samples were obtained from 4,200 of them. Demographic factors, anthropometric and biochemical measures were used to define lifestyle-related latent variables as well as cardiac, renal, and hepatic risk indicators. Total, direct, and indirect effects between factors were analyzed using the standardized regression weights for each pathway. Data from 14,274 students (participation rate of 99%) and 3,843 blood samples were included. All of the latent variables had a significant direct effect on BMI, with the most potent effect of unhealthy nutrition (β ≅ 0.63) in boys and girls. BMI has significant direct effects on risk indicators of cardiovascular, renal, and hepatic diseases with the most powerful effect on cardiovascular risk factors (β ≅  − 0.08). The most important predisposing factor for obesity was unhealthy nutrition, whereas increased activity, adequate sleep, and better hygiene had protective roles. BMI shows the strongest association with indicator of cardiovascular diseases. These findings underscore the importance of implementing public health programs for the prevention of chronic noncommunicable diseases.

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