scholarly journals FAQS on when to use Molecular Allergy Diagnosis (MD) in clinical practice

2021 ◽  
Vol 32 (1) ◽  
Author(s):  
O Luengo ◽  
M Labrador-Horrillo
Keyword(s):  
Clinical Practice ◽  
Molecular Biology ◽  
Cross Reactivity ◽  
Practical Approach ◽  
Allergy Diagnosis ◽  
The Core ◽  
Great Progress ◽  
Molecular Allergy ◽  
The Subject

In the last decades there has been a great progress in the field of molecular biology allowing the study of the sensitization to individual allergenic components of an allergenic source, a practice that has been termed Molecular Allergy Diagnosis (MD) or Component Resolved Diagnosis (CRD). The purpose of the present review is to offer the clinician a practical approach to the use of MD by answering frequently asked questions among physicians on how MD can help us improve allergy diagnosis in our daily clinical practice. The article is divided in three sections. First, a brief review on the importance for the clinician to know the main allergens of the different allergenic sources, their structure and their in vitro cross-reactivity before approaching MD (section A). Secondly the core of the review on the usefulness of MD in clinical practice (section B) answering FAQS on the subject, and finally a section (C) on the interpretation and integration of MD with the rest of available tools for allergy diagnosis.

Combined Antibiotic Therapy for the Suppression of Resistant Variants in Urinary Infection

PEDIATRICS ◽  
1956 ◽  
Vol 17 (4) ◽  
pp. 509-509
Keyword(s):  
Clinical Trial ◽  
Clinical Practice ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Urinary Infection ◽  
In Vitro Tests ◽  
The Subject ◽  
Resistant Strains ◽  
Tract Infections

The use of pairs of antibiotics to suppress the emergence of resistant strains has been the subject of several investigations and has been particularly successful in tuberculosis. The authors investigated the effect on the coliform group of organisms, commonly the cause of urinary tract infections, of combinations of streptomycin with chloramphenicol or tetracycline. The testing was done in vitro and the technique is described. Streptomycin plus tetracycline and streptomycin plus chloramphenicol proved to be the most effective combinations for suppressing resistant variants while at the same time maintaining bactericidal activity. The latter feature is considered an important factor in the prevention of relapses in urinary tract infections. The investigations did not include a clinical trial of the value of these antibiotic combinations but the in vitro tests indicate that good results are to be expected in application in clinical practice.

scholarly journals Molecular allergology and its impact in specific allergy diagnosis and therapy

2021 ◽  
Author(s):  
Domingo Barber Hernández ◽  
Araceli Diaz Perales ◽  
Maria Escribese ◽  
Jörg Kleine-Tebbe ◽  
Paolo Matricardi ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Molecular Diagnosis ◽  
Allergen Immunotherapy ◽  
Daily Life ◽  
Allergy Diagnosis ◽  
In Vitro Diagnostics ◽  
Progressive Development ◽  
Molecular Allergology ◽  
Underlying Mechanisms

Progressive knowledge of allergenic structures resulted in a broad availability of allergenic molecules for diagnosis. Component resolved diagnosis allowed a better understanding of patient sensitization patterns, facilitating allergen immunotherapy decisions. In parallel to the discovery of allergenic molecules, there was a progressive development of a regulation framework that affected both in vitro diagnostics and Allergen Immunotherapy products. With a progressive understanding of underlying mechanisms associated to Allergen immunotherapy and an increasing experience of application of molecular diagnosis in daily life, we focus in analyzing the evidences of the value provided by molecular allergology in daily clinical practice, with a focus on Allergen Immunotherapy decissions.

Mechanistic Pathways of Selenium in the Treatment of Graves’ Disease and Graves’ Orbitopathy

2018 ◽  
Vol 50 (12) ◽  
pp. 887-893 ◽  
Author(s):  
Michele Marinò ◽  
Giovanna Dottore ◽  
Marenza Leo ◽  
Claudio Marcocci
Keyword(s):  
Oxidative Stress ◽  
Clinical Practice ◽  
Graves Disease ◽  
Graves Orbitopathy ◽  
Antioxidant Agent ◽  
The Subject

AbstractBased on the role of oxidative stress in the pathogenesis of Graves’ hyperthyroidism and Graves’ orbitopathy, the use of the antioxidant agent selenium has been proposed and several studies on the subject have been conducted, both in vitro and in vivo. Whereas a true benefit related to the use of selenium in patients with Graves’ hyperthyroidism has been questioned, its use in patients with mild Graves’ orbitopathy is generally believed to be beneficial because of which selenium has entered in the clinical practice for this eye condition.

Social innovation for modified consumption by means of the school subject Art and craft

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Anita NEUBERG
Keyword(s):  
General Education ◽  
Primary Schools ◽  
Social Innovation ◽  
School Subject ◽  
Art And Design ◽  
The Core ◽  
Causal Mechanisms ◽  
The Subject

In this paper I will take a look at how one can facilitate the change in consumption through social innovation, based on the subject of art and design in Norwegian general education. This paper will give a presentation of books, featured relevant articles and formal documents put into context to identify different causal mechanisms around our consumption. The discussion will be anchored around the resources and condition that must be provided to achieve and identify opportunities for action under the subject of Art and craft, a subject in Norwegian general education with designing at the core of the subject, ages 6–16. The question that this paper points toward is: "How can we, based on the subject of Art and craft in primary schools, facilitate the change in consumption through social innovation?”

Rights, Authority, and Workability: An Examination of Universal Jurisdiction

2019 ◽  
Vol 3 ◽  
pp. 7-17
Author(s):  
Srdan Durica
Keyword(s):  
Universal Jurisdiction ◽  
Scholarly Work ◽  
Contemporary State ◽  
The Core ◽  
Core Areas ◽  
The Subject

In this paper, I conceptualize ‘universal jurisdiction’ along three axes: rights, authority, and workability to reduce the compendium of scholarly work on the subject into three prominent focus areas. I then review the longstanding debates between critics and supports, and ultimately show the vitality of this debate and persuasiveness of each side’s sets of arguments. By using these three axes as a sort of methodological filter, one can develop a richer understanding of universal jurisdiction, its theoretical pillars, practical barriers, and the core areas of contention that form the contemporary state of knowledge.

Jalan Kesempurnaan Menurut Jamaah Insan Al-Kamil di Cijati Desa Cikareo Selatan Sumedang

2020 ◽  
Vol 2 (1) ◽  
pp. 23-37
Author(s):  
Syarifudin Syarifudin
Keyword(s):  
Qualitative Method ◽  
Human Beings ◽  
The Core ◽  
The World ◽  
The Subject ◽  
Religious Sect ◽  
Descriptive Qualitative

Each religious sect has its own characteristics, whether fundamental, radical, or religious. One of them is Insan Al-Kamil Congregation, which is in Cijati, South Cikareo Village, Wado District, Sumedang Regency. This congregation is Sufism with the concept of self-purification as the subject of its teachings. So, the purpose of this study is to reveal how the origin of Insan Al-Kamil Congregation, the concept of its purification, and the procedures of achieving its purification. This research uses a descriptive qualitative method with a normative theological approach as the blade of analysis. In addition, the data generated is the result of observation, interviews, and document studies. From the collected data, Jamaah Insan Al-Kamil adheres to the core teachings of Islam and is the tenth regeneration of Islam Teachings, which refers to the Prophet Muhammad SAW. According to this congregation, self-perfection becomes an obligation that must be achieved by human beings in order to remember Allah when life is done. The process of self-purification is done when human beings still live in the world by knowing His God. Therefore, the peak of self-purification is called Insan Kamil. 

Follicular fluid and assisted reproductive technology programs outcomes (literature review)

GYNECOLOGY ◽  
2020 ◽  
Vol 21 (6) ◽  
pp. 36-40
Author(s):  
Anna G. Burduli ◽  
Natalia A. Kitsilovskaya ◽  
Yuliya V. Sukhova ◽  
Irina A. Vedikhina ◽  
Tatiana Y. Ivanets ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Assisted Reproductive Technology ◽  
Follicular Fluid ◽  
Economic Cost ◽  
Reproductive Technology ◽  
Art Programs ◽  
Vitro Fertilization ◽  
Non Invasive ◽  
Established Fact

The review presents data on metabolites in the follicular fluid (FF) from the perspective of reproductive medicine and their use in order to predict outcomes of assisted reproductive technology (ART) programs. It considers various components of this biological medium (hormones, lipids, melatonin, etc.) with an assessment of their predictive value in prognosis of the effectiveness of in vitro fertilization (IVF) programs. The data on experimental directions in this field and the prospects for their use in clinical practice are presented. The article emphasizes that the growing clinical need and the unsolved problem of increasing the effectiveness of ART programs determine the need for further studies of the FF composition. Materials and methods. The review includes data related to this topic from foreign and Russian articles found in PubMed which were published in recent years. Results. Given the established fact of a direct effect of FF composition on growth and maturation of oocytes, and further, on the fertilization process, various FF metabolites are actively investigated as non-invasive markers of quality of oocytes/embryos. The article provides data on the experimental directions in this field and the prospects for their use in clinical practice. However, clinical studies of a relation between various FF metabolites levels and outcomes of IVF programs are contradictory. Conclusion. Owing large economic cost for treatment of infertility with IVF, there is need for expansion and intensification of studies to identify and use reliable predictors in prognosis of ART programs outcomes.

A view on Practical Utility of Paradi Gunas

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Sachin Bagali ◽  
Umapati Baragi ◽  
M. R. Sajjanshetti
Keyword(s):  
Clinical Practice ◽  
Professional Practice ◽  
Continuous Process ◽  
Clinical Activity ◽  
Successful Management ◽  
Knowledge Domain ◽  
Practical Utility ◽  
The Subject ◽  
The Way

In the present day scenario prime need of Ayurveda is practical applicability of Ayurvedic fundamental principles and research should be more focused on all aspects where scientific inputs should confirm Ayurveda’s principles and philosophy. In Ayurveda, Gunas are described as the way of presentation of action without which no Karma (action) can be possible. Ayurveda has provided significance to every Guna so that they become useful in clinical practice. Clinical practice or research is a continuous process including a series of events which need to be performed in a sequential manner. Though there are many factors on which accomplishment of treatment depends, among these Charaka has given prime importance to Paradi Gunas. In clinical practice, Guna which are to be with Bhishak are mainly the Paradi Gunas which can also be called as miscellaneous Gunas. As rightly quoted by Acarya Charaka, for getting success in the treatment Paradi Gunas are the best. The Sutra quotes "Sidhyupaya Chikitsayam" which means that Chikitsa i.e. Dhatusamya will be done mainly with the help of Paradi Gunas. Knowledge of Paradi Gunas are required to be present in pharmacists, physicians and Researchers. Acharya Charaka says that Chikitsa Siddhi i.e. successful management of disease is not possible without the knowledge of Paradi Gunas. Paradi Gunas play an important role in selection, adaption and manifestation of drug as per condition of the disease and the patient in particular Desha and Kala. The ultimate goal of any clinical activity is to contribute in the knowledge domain and to improve professional practice. Thus this literary review of Paradi Gunas serves to explore the subject of the clinical practice.

Relationship between ambient temperature and acetylating capacity of human blood

1963 ◽  
Vol 18 (5) ◽  
pp. 955-958 ◽  
Author(s):  
S. H. Blondheim ◽  
Gabriel Neumann ◽  
Edna Kott ◽  
Zena Ben-Ishai
Keyword(s):  
Ambient Temperature ◽  
Human Blood ◽  
Aromatic Amines ◽  
September 11 ◽  
Aminobenzoic Acid ◽  
Heat Acclimatization ◽  
The Subject

The ability of human blood to acetylate p-aminobenzoic acid, determined in vitro, varied directly with the ambient temperature to which the subject was exposed before the blood was drawn. This was demonstrated by 135 determinations of the acetylating ability of the blood of 49 subjects performed over a period of 3 years, and also in acute experiments in which subjects were exposed to 6 and 37 C for up to 2 hr. Variations in the acetylating ability of blood may reflect the activity of metabolic mechanisms involved in thermal homeostasis. aromatic amines; p-aminobenzoic acid; cold; heat acclimatization; (blood) enzymes; weather; environment Submitted on September 11, 1962

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