scholarly journals Contemporary Condition and Tendencies of the Civil Aviation's Development in Russia

2019 ◽  
Vol 9 (4) ◽  
pp. 607-617
Author(s):  
D. L. Kaparulin

Purpose:taking to attention exclusive role of air transport concerning necessity of providing the conditions for normal function of state economy and to satisfy the demands of population, the author put the purpose to analyze the modern condition of the Russian civil aviation development and to propose innovative arrangements in the field of modernization it's material-technical base future development and using.Methods:the author uses the system approach to perform this research; results of the scientific research of the other specialists in the problem; structure and function analysis; the theory of competitor's struggle for market; complex analyses of statistics and expert evaluations methods.Results:the system critical analyses of the modern condition of the Russian civil aviation material-technical base development is performed and innovative arrangements in the field of modernization Russian civil aviation material-technical base future development and using are proposed.Conclusions and Relevance:Russian civil aviation is the single one among all another universal types of transport reached growth of all basic technic-economical indexes for last several years. Due to keeping such positive tendencies and guaranteeing modernization Russian civil aviation material-technical base future development and using on the base of innovative technologies state assistance is necessary in the field of increasing taxes, fuel prices and rent fees for using main productive funds.

2021 ◽  
Vol 534 ◽  
pp. 206-211
Author(s):  
Jianzhong Huang ◽  
Xiaoqiu Wu ◽  
Kaiting Sun ◽  
Zhiyong Gao

2021 ◽  
Vol 234 ◽  
pp. 105023
Author(s):  
Ruishen Fan ◽  
Gui Cai ◽  
Xuanyuan Zhou ◽  
Yuxin Qiao ◽  
Jiabao Wang ◽  
...  

2021 ◽  
Vol 35 (1) ◽  
pp. 862-872
Author(s):  
Chunliu Li ◽  
Dejia Hou ◽  
Lin Zhang ◽  
Xiaohong Li ◽  
Jiangbo Fan ◽  
...  

2021 ◽  
Vol 22 (15) ◽  
pp. 7923
Author(s):  
Santiago Alvarez-Argote ◽  
Caitlin C. O’Meara

Macrophages were first described as phagocytic immune cells responsible for maintaining tissue homeostasis by the removal of pathogens that disturb normal function. Historically, macrophages have been viewed as terminally differentiated monocyte-derived cells that originated through hematopoiesis and infiltrated multiple tissues in the presence of inflammation or during turnover in normal homeostasis. However, improved cell detection and fate-mapping strategies have elucidated the various lineages of tissue-resident macrophages, which can derive from embryonic origins independent of hematopoiesis and monocyte infiltration. The role of resident macrophages in organs such as the skin, liver, and the lungs have been well characterized, revealing functions well beyond a pure phagocytic and immunological role. In the heart, recent research has begun to decipher the functional roles of various tissue-resident macrophage populations through fate mapping and genetic depletion studies. Several of these studies have elucidated the novel and unexpected roles of cardiac-resident macrophages in homeostasis, including maintaining mitochondrial function, facilitating cardiac conduction, coronary development, and lymphangiogenesis, among others. Additionally, following cardiac injury, cardiac-resident macrophages adopt diverse functions such as the clearance of necrotic and apoptotic cells and debris, a reduction in the inflammatory monocyte infiltration, promotion of angiogenesis, amelioration of inflammation, and hypertrophy in the remaining myocardium, overall limiting damage extension. The present review discusses the origin, development, characterization, and function of cardiac macrophages in homeostasis, cardiac regeneration, and after cardiac injury or stress.


2021 ◽  
Vol 10 (5) ◽  
pp. 1114
Author(s):  
Kerstin Jurk ◽  
Yavar Shiravand

Patients who suffer from inherited or acquired thrombocytopenia can be also affected by platelet function defects, which potentially increase the risk of severe and life-threatening bleeding complications. A plethora of tests and assays for platelet phenotyping and function analysis are available, which are, in part, feasible in clinical practice due to adequate point-of-care qualities. However, most of them are time-consuming, require experienced and skilled personnel for platelet handling and processing, and are therefore well-established only in specialized laboratories. This review summarizes major indications, methods/assays for platelet phenotyping, and in vitro function testing in blood samples with reduced platelet count in relation to their clinical practicability. In addition, the diagnostic significance, difficulties, and challenges of selected tests to evaluate the hemostatic capacity and specific defects of platelets with reduced number are addressed.


2021 ◽  
Vol 16 ◽  
Author(s):  
Jinghao Peng ◽  
Jiajie Peng ◽  
Haiyin Piao ◽  
Zhang Luo ◽  
Kelin Xia ◽  
...  

Background: The open and accessible regions of the chromosome are more likely to be bound by transcription factors which are important for nuclear processes and biological functions. Studying the change of chromosome flexibility can help to discover and analyze disease markers and improve the efficiency of clinical diagnosis. Current methods for predicting chromosome flexibility based on Hi-C data include the flexibility-rigidity index (FRI) and the Gaussian network model (GNM), which have been proposed to characterize chromosome flexibility. However, these methods require the chromosome structure data based on 3D biological experiments, which is time-consuming and expensive. Objective: Generally, the folding and curling of the double helix sequence of DNA have a great impact on chromosome flexibility and function. Motivated by the success of genomic sequence analysis in biomolecular function analysis, we hope to propose a method to predict chromosome flexibility only based on genomic sequence data. Method: We propose a new method (named "DeepCFP") using deep learning models to predict chromosome flexibility based on only genomic sequence features. The model has been tested in the GM12878 cell line. Results: The maximum accuracy of our model has reached 91%. The performance of DeepCFP is close to FRI and GNM. Conclusion: The DeepCFP can achieve high performance only based on genomic sequence.


2011 ◽  
Vol 121-126 ◽  
pp. 4350-4356
Author(s):  
Yan Pei Liu ◽  
Jun Hui Fu ◽  
Hong Yu Feng

With the larger and more complex of the size and function of software products,choosing an efficient modeling technique for analyzing complicated and ever-changing system plays a vital role.Object-Oriented Petri nets for its unique characteristics which are simple and laconic modeling method and strong mathematical analysis capacity becomes a hot research.In this paper,it explain that the object-oriented technology how to combine with Petri nets.The typical Object-Oriented Petri net modeling steps and analysis methods are expounded. Up-to-date research about OOPN and its main improved models OOCPN, OOAPN and OOTPN are summarized, the pros and cons of each modeling are analyzed.The interrelated topics and the future development about OOPN are also mentioned.


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