scholarly journals Vitamin A Supplementation in Pulmonary Tuberculosis Patients on Acceleration of Sputum Conversion in Medan City

2019 ◽  
Vol 7 (20) ◽  
pp. 3505-3508
Author(s):  
Dina Keumala Sari ◽  
Alexander Parlindungan Marpaung ◽  
Parluhutan Siagian ◽  
Nurfida Khairina Arrasyid

BACKGROUND: Indonesia is in the second rank for the most TB (Tuberculosis) cases in the world after India. It is estimated that there are 1 million cases per year in Indonesia. AIM: To find out the influence of Vitamin A supplementation in the medication of pulmonary TB on the acceleration of sputum conversion time at an intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict METHODS: This research was Quasi Experiment method. With two groups. The samples were 30 newly diagnosed pulmonary TB patients consisting of of15 patients in the treatment group and 15 patients in the control group. The statistical data were analysed with t independent test, significance 95% (p < 0.05) RESULTS: The treatment group discovered that they were mostly 18-27 years old 40.0%, male 73.3%, mostly university students 26.7%, had BTA conversion in the second week 80.0%; and the sputum conversion time was 2.4 weeks in average. The results of the research on the control group demonstrated that they were mostly 18-27 years old 33.3%, male 80.0%, mostly university students and entrepreneurs 20.0%, had BTA conversion in the second week 80%; and the sputum conversion time was 4.1 weeks in average. Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at the intensive phase (p ≤ 0.001). CONCLUSION: We concluded that Vitamin A in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at the intensive phase in the Medan Kota.

2018 ◽  
Vol 16 (2) ◽  
pp. 124
Author(s):  
Alexander Marpaung ◽  
Parluhutan Siagian ◽  
Dina Keumala Sari

Background: Indonesia is in the second rank for the most TB (Tuberculosis) cases in the world after India. It is estimated that there are 1 million cases per year in Indonesia. Objective: The objective of the research was to find out the influence of Vitamin A supplementation in the medication of pulmonary TB on the acceleration of sputum conversion time at intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict. Methods: This research applied clinical testing design with experimental approach and Experimental Quasi method. The samples were 30 newly diagnosed pulmonary TB patients consisting of15 patients in the treatment group and 15 patients in the control group. They were ³18 years old, regularly consumed category I OAT with BMI ³18.5. The statistical data were analyzed by Mann-Whitney statistical testing at reliability rate 95% (p<0.05).        Result: The results of the research on the treatment group discovered that they were mostly 18-27 years old 40.0%, male 73.3%, mostly university students 26.7%, had BTA conversion in the second week 80.0%; and the sputum conversion time was 2.4 weeks in average. The results of the research on the control group demonstrated that they were mostly 18-27 years old 33.3%, male 80.0%, mostly university students and entrepreneurs 20.0%, had BTA conversion in the second week 80%; and the sputum conversion time was 4.1 weeks in average. Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at intensive phase (p= <0.001) < (alpha = 0.05). Conclusion: Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict


2010 ◽  
Vol 9 (1) ◽  
Author(s):  
Trevino A Pakasi ◽  
Elvina Karyadi ◽  
Ni Made Desy Suratih ◽  
Michael Salean ◽  
Nining Darmawidjaja ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2370
Author(s):  
Ye Ding ◽  
Ping Hu ◽  
Yue Yang ◽  
Fangping Xu ◽  
Fang Li ◽  
...  

Background: The nutritional status of vitamin A in lactating mothers and infants is still not optimistic. Due to the dietary habits and dietary restrictions of postpartum customs in China, vitamin A supplementation has been advocated as a potential strategy to improve vitamin A status of lactating mothers with inadequate dietary vitamin A intake. Existing clinical trials are limited to single or double high-dose maternal administrations. However, in China, vitamin A supplements are readily available in the form of daily oral low-dose supplements, and the effect of these is unknown. This study aimed to evaluate the effects of daily oral low-dose vitamin A supplementation on the retinol levels in the serum and breast milk of lactating mothers and the health status of infants in China. Methods: Lactating mothers who met the inclusion criteria and planned to continue exclusive breastfeeding were randomly assigned to receive either daily oral vitamin A and D drops (one soft capsule of 1800 IU vitamin A and 600 IU vitamin D2), or a matching placebo for 2 months. Before and after the intervention, dietary intake was investigated by instant photography, and the retinol concentration in maternal serum and breast milk was determined by ultra-high performance liquid chromatography-tandem mass spectrometry. During the trial, the health status of infants was diagnosed by a paediatrician or reported by lactating mothers. A total of 245 participants completed the study, with 117 in the supplementation group and 128 in the control group. Results: After the 2-month intervention, maternal serum retinol concentrations increased in the supplementation group with no change in the control group. Although breast milk retinol concentrations decreased significantly in both groups, the decrease in the supplementation group was significantly lower than that in the control group. However, maternal vitamin A supplementation was not associated with a lower risk of infant febrile illness, respiratory tract infection, diarrhoea, and eczema. Conclusions: Daily oral low-dose vitamin A supplementation is helpful in improving maternal vitamin A status, despite having no effect on infant health status through breast milk.


Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2116
Author(s):  
Andrei V. Tarasov ◽  
Rofail S. Rakhmanov ◽  
Elena S. Bogomolova ◽  
Ludmila A. Perminova ◽  
Zhanna L. Malakhova

The Kaliningrad region is known for its specific climate, which can negatively affect the adaptive potential of the body. This manifests in an increased incidence of respiratory diseases and skin conditions. To prevent high morbidity, a plant protein product was included in the diet of first-year university students. This study aimed to assess the effectiveness of this food intervention in preventing the most common diseases among Kaliningrad students. Two groups of university students took part in the food trial. In the control group, catabolic processes prevailed in nutrient metabolism. Disadaptation manifested itself in the metabolism of proteins, vitamins, minerals, hematopoiesis and humoral immunity. Inflammation was indicated by α1- and α2-globulins, a weak immune response, and IgM and IgG. High oxidative stress and low antioxidative ability of blood serum were observed. The plant-based protein product (FP) helped preserve testosterone level and prevent an increase in catabolic reactions. Moreover, it had a positive effect on both red blood cell hematopoiesis (a smaller increase in the average volume of erythrocytes, the same average concentration and content of hemoglobin, an increased relative red cell distribution width (RDW) and white blood cell hematopoiesis (a beneficial effect for the immune system: lymphocytes, the relative content of neutrophils, monocytes, basophils and eosinophils). The stimulation of humoral immunity was evidenced by beta- and gamma-globulins, an active immune response, the level of IgM and IgG, antioxidant protection, reduction of peroxides and an increase in antioxidant activity of blood serum. The 34-week observation showed a 1.7-fold decrease in the incidence of respiratory illnesses and a 5.7-fold decrease in skin and subcutaneous tissue diseases. Acute respiratory infections were reduced 1.8-fold. There were no cases of community-acquired pneumonia in the treatment group, compared with 55.1‰ in the control group. The incidence of respiratory diseases was 3.3–10.6 times lower in the treatment group than in the control group in weeks 6–19. The findings testify to the prophylactic effect of functional food during social adaptation and acclimatization of students.


2019 ◽  
Vol 10 (4) ◽  
pp. 603-624
Author(s):  
Yingli Yang ◽  
Lawrence Jun Zhang ◽  
Ling Chen

AbstractThe present study explores the effects of recast plus form-focused instruction and form-focused instruction on vocabulary development and the mediating effect of working memory. Sixty-six university students were assigned to a recast plus form-focused instruction (FFI) group, a FFI group, and a control group. The instructor provided recasts on non-target vocabulary items in the recast plus FFI group, whereas the FFI group completed two form-focused vocabulary tasks only. Pretests, posttests, and delayed posttests were administered to examine learners’ development of target vocabulary items. A reading span test was employed to examine learners’ complex working memory capacities. Results show that the recast plus FFI group exhibited superior performance over the control group on both posttests and delayed posttests with large effect sizes. Working memory did not significantly correlate with vocabulary development in either treatment group.


2021 ◽  
Vol 6 (2) ◽  
pp. 126-132
Author(s):  
Eka Ariska Lubis ◽  
Albiner Siagian ◽  
Zulhaida Lubis

The condition of patients with pulmonary tuberculosis (TB) with poor nutritional status will slow down the healing period. Overcoming malnutrition in pulmonary tuberculosis patients is carried out by providing supplementary food (PMT), especially those based on local food ingredients. In addition to needing additional foods rich in macro nutrients, TB sufferers also need micronutrients that can trigger increased body immunity, such as vitamin C. This study aims to see the effect of giving cohi fish biscuits and vitamin C on the weight of patients with pulmonary tuberculosis in Percut Sei Tuan District in 2019. The design of this study was a quasi experimental pretest-posttest control group design which was carried out in Percut Sei Tuan District, Deli Serdang Regency, North Sumatra starting from May-July 2019. Subjects were 52 new cases of pulmonary tuberculosis patients with malnutrition who were divided into three groups: 16 people in the first group who received 100 g/day of cohi fish biscuits, 16 people in the second group who received 100 g/day of cohi fish biscuits and 500 mg/day of vitamin C, and 20 people in the control group. The treatment was carried out for 30 days. Giving 100 grams of cohi fish biscuits contributed 583.29 kcal of calories, 15.32 grams of carbohydrates, 25.54 grams of protein and 46.65 grams of fat. Statistical test using one-way ANOVA, the results obtained were no difference in pre-test weight of patients with pulmonary TB (p=0.616), there was no difference in post-test body weight of patients with pulmonary TB (p=0.674), there was a difference in changes in patient weight. Pulmonary TB (p=0.00). There was an increase in body weight in the second group of 0.7 kg, and even though there was no increase in body weight in the first group, giving cohi fish biscuits was able to withstand the weight loss compared to the control group. The conclusion of this study is that cohi fish biscuits and vitamin C can be an alternative to PMT to increase the weight of patients with TB. Keywords: Cohi Fish Biscuits, Vitamin C, Pulmonary Tuberculosis (TB).


2021 ◽  
Vol 10 (4) ◽  
pp. 251-256
Author(s):  
Tri Marta Fadhilah ◽  
Elfira Maya Sari

Background: The tuberculosis morbidity rate in Bekasi area based on data from the Republic of Indonesia Ministry of Health has reached 101 people per 100,000 population in 2012. Indonesia’s Ministry of Health showed that tuberculosis patients have less economic status poor nutritional status. Patients with tuberculosis need foods that contain lots of protein and albumin such as cork fish and chicken egg white without yolk to speed up the repair of cells and tissues damaged by Mycobacterium Tuberculosis bacteria. Objective: The study was conducted to determine the increase in blood albumin levels and body weight in patients with tuberculosis by giving cork fish and egg white snacks. Methods: Analysis of the data used was a paired t-test for increases in blood albumin levels and bodyweight of the treatment group before and after giving snacks and an unpaired t-test for increases in blood albumin levels and bodyweight of tuberculosis patients between the treatment and the control group. Results: The study showed the most characteristics of tuberculosis patients ismale, age range 26-30 years, elementary-junior high school education level, labor work, income <Rp. 1,500,000,00, and the number of dependents of families consist of 4-6 people. Data analysis of blood albumin levels in the control group was significantly different from the treatment group before and after with a value of P = 0.002 which means that there was an increase in blood albumin levels and in the results of weight gain the control group was significantly different from the treatment groups before and after with a value of P = 0.004 means there is a significant increase in body weight for 15 days after being given  snack. Conclusion: There was an increase in blood albumin levels and body weight in patients with tuberculosis after treatment for 15 days.


2017 ◽  
Vol 4 (1) ◽  
pp. 51
Author(s):  
Fara Disa Durry ◽  
Bambang Wirjatmadi

The epidemiology of Tuberculosis (TB) showed that TB is a disease which is associated with malnutrition. Malnutrition and lacking of certain essential nutrients required by immune system might cause immune function deficiency resulting higher susceptibility to bacterial and viral infections. There is positive correlation between immune system and high nutrient contents, such as Vitamin C, zinc, and antioxidants that brings good effect on infections, including Tuberculosis. One of the efforts conducted to help promoting improving albumin level on pulmonary tuberculosis patients is through zinc and sulphate provision followed by Omega-3 supplementation. This study was conducted in 2015 aimed to analyze the role of Zinc Sulphate Omega-3 provision in improving albumin level on pulmonary tuberculosis patients in Paru Hospital, Surabaya.This study applied randomized study design using Pre-test and Post-test Control group design on patients suffering pulmonary tuberculosis. This study was conducted by administering Zinc Sulphate and Omega-3 on treatment group and placebo on the control group. The samples of this study consisted of 20 pulmonary tuberculosis patients divided into two groups: treatment group and control group. Each group consisted of 10 patients. Statistical analysis was conducted using paired T-test and independent t-test. The results is There were significant differences in albumin level (p = 0.001) in the treatment group before and after supplementation Zinc Sulphate And Omega 3. While in the control group between before and after supplementation Zinc Sulphate And Omega 3 showed no significant differences in body weight (p = 0.224). The conclusions is Zinc Sulphate and Omega 3 plays a role in increasing albumin level respondents. There are significant differences on albumin level before and after supplementation Zinc Sulphate And Omega 3.


Author(s):  
Sandhya S. Chaudhary ◽  
Tanvi D. Manat ◽  
Virendra Kumar Singh ◽  
Sanjay B. Patel

The present study was undertaken to study levels of vitamin A and β-carotene in blood of postpartum Surti goats. 40 Surti goats were selected comprising of 20 goats with recent parturition (treatment group) and 20 non-pregnant animals (control group). Blood collection was done on 0, 7, 14, 21, 30 and 45 day post-kidding (treatment group) and once from control group and analyzed for Vitamin A and β-carotene. Both the analytes were significantly low on 0 day. Significant difference (P Less Than 0.05) in vitamin A as well as β-carotene (P Less Than 0.01) was observed between 0 and 21st day postpartum followed by non-significant difference in vitamin A after 21 days. However, β-carotene values at 21st day significantly differed from those at 30th and 45th day. Non–significant difference between control and treatment group from 7th day onwards was observed in vitamin A. β-carotene values of treatment group were significantly lower at 0 and 21st day postpartum as compared to control. It was concluded that on the day of kidding there is decrease in circulatory levels of vitamin A and β-carotene and this decrease can be used as an indicator of stress.


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