Role of serum LDH in preeclampsia as a prognostic factor – a cross sectional case control study in tertiary care hospital

Background: LDH is an intracellular cytoplasmic enzyme. It is ubiquitous to all the major organ systems. Cellular enzymes in extracellular space have no metabolic function, although they serve as indicators of disturbances in cellular integrity. Serum LDH is abnormal in many disorders, therefore total serum LDH is highly sensitive but nonspecific test. In preeclampsia also LDH may be elevated and can indicate the prognosis for both mother and fetus. We conducted this study to examine the relationship between lactate dehydrogenase concentration and the severity of the disease and the occurrence of its complications.Methods: 200 pre-eclamptic women (121 with mild and 79 with severe pre-eclampsia) and 200 healthy normotensive controls were studied prospectively at Government Kilpauk medical college and hospital between January and December 2015. Demographic, hemodynamic, and laboratory data were compared among the three groups. The symptoms and complications of severe pre-eclampsia along with fetal outcome were analyzed according to the levels of LDH.Results: Severely pre-eclamptic patients were significantly younger, with low gravidity and parity. On the other hand, they had significantly increased systolic and diastolic pressure and liver enzymes, uric acid, urine albumin, and LDH levels. The symptoms and complications of pre-eclampsia along with perinatal mortality were increased significantly in patients with LDH >800 IU/l compared with those who had lower levels.Conclusions: Lactate dehydrogenase is a useful biochemical marker that reflects the severity of pre-eclampsia. In our study, LDH has been evaluated as a biochemical marker for preeclampsia and as a prognosticator of the disease severity. Detection of high-risk patients with increased levels of LDH mandate close monitoring and management to prevent maternal and fetal morbidity and mortality.

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A cross sectional study of clinical profile and evaluation of pulmonary hypertension in Chronic Obstructive Pulmonary Disease patients in a tertiary care hospital of Mangalore, India

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20191136 ◽

2019 ◽

Vol 6 (2) ◽

pp. 330

Author(s):

Kshama S. Ramesh ◽

Devdas B. Rai ◽

Shayma Sheikh Abdulla ◽

Jyothsna B. K.

Keyword(s):

Pulmonary Hypertension ◽

Tertiary Care ◽

Clinical Profile ◽

Cardiac Complications ◽

Chronic Obstructive ◽

Close Monitoring ◽

Care Hospital ◽

Cross Sectional ◽

Copd Patients ◽

Significant Difference

Background: The objectives was to study the clinical profile of COPD patients and to evaluate pulmonary hypertension in COPD patients by non-invasive methods.Methods: A prospective observational study of patients who satisfy all inclusion and exclusion criteria in OPD or admitted in medical wards of AJIMS Mangalore. The study was conducted from October 2017 to October 2018 with the sample size of 90 subjectsResults: Out of 90 subjects 53 (58.8%) of them had pulmonary hypertension. Among the subjects who had pulmonary hypertension 29 (54.72%) of them had moderate pulmonary hypertension, 17 (32.08%) of them had severe pulmonary hypertension and 7 (13.20%) of them had mild pulmonary hypertension. Mean age among the subjects who had pulmonary hypertension was 64.24+7.62yrs and mean age among the subjects who didn’t had pulmonary hypertension was 51.87+8.97yrs. There was a statistically significant difference found between mean age and pulmonary hypertension. Mean duration of diseases among the subjects who had pulmonary hypertension was 8.13+1.74yrs and Mean duration of diseases among the subjects who didn’t had pulmonary hypertension was 5.36+1.98yrs. There was a statistically significant difference found between mean duration of disease and pulmonary hypertension.Conclusions: Due to high prevalence of pulmonary hypertension we suggest screening for the all COPD patients for cardiac complications. This will help in identifying the individual who requires close monitoring and also in reducing the mortality.

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Prevalence and risk factors of self-medication in pregnancy: A cross-sectional study from a tertiary care hospital in Eastern India

Asian Journal of Medical Sciences ◽

10.3126/ajms.v12i12.39217 ◽

2021 ◽

Vol 12 (12) ◽

pp. 68-72

Author(s):

Mayank Gupta ◽

Chanchal Kumar Dalai ◽

Shah Newaz Ahmed ◽

Deblina Sarkar ◽

Rajath Rao UR ◽

...

Keyword(s):

Risk Factors ◽

Tertiary Care ◽

Laboratory Data ◽

Antenatal Clinic ◽

Cross Sectional Study ◽

Care Hospital ◽

Self Medication ◽

Cross Sectional ◽

Pregnant Mothers ◽

In Pregnancy

Background: Self-medication in pregnancy is a common but unsafe practice. There is a possibility of surreptitious exposure of the developing fetus to the teratogenic and abortifacient effects of the drugs. Aims and Objectives: In this study, we assessed the prevalence and risk factors of self-medication in pregnant mothers visiting the antenatal clinic in our hospital. Materials and Methods: A standard questionnaire seeking information on the socio-demographic profile, clinical characteristics, laboratory data, and knowledge and habits was administered to the pregnant mothers (n=190). The risk factors of self-medication were determined using Fischer’s exact test. P<0.05 was deemed statistically significant. Results: The prevalence of self-medication in pregnancy was found to be 6.3%. Low education level (P<0.027), employed women (P<0.031), and history of miscarriage (P<0.036) in the previous pregnancy were the main determinants of self-medication in the present pregnancy. Conclusion: The prevalence of self-medication in the study sample was low as compared to contemporary studies. High literacy (94.2%) and easy availability of health facility (98%) may be the possible reasons. Further studies are warranted to confirm the prevalence and risk factors of self-medication in this part of the country.

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Acute pancreatitis in diabetics: a twoyear retrospective study in a tertiary care hospital in Peshawar, Pakistan

Anaesthesia, Pain & Intensive Care ◽

10.35975/apic.v23i2.1076 ◽

2019 ◽

pp. 211-216

Author(s):

Zubair Ahmad Khan ◽

Khalid Saifullah Baig ◽

Zunnoor Ahmad ◽

Maryam Afridi

Keyword(s):

Acute Pancreatitis ◽

Retrospective Study ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Total Serum ◽

Diabetic Patients ◽

Care Hospital ◽

Cross Sectional ◽

Serum Lipase ◽

Glucose Levels

Introduction: Acute pancreatitis (AP) is an acute inflammatory disease of the pancreas. After diagnosis the initial management is preferably done in intensive care unit along with 4-6 hourly insulin sliding scale monitoring for hyperglycemia. Individuals with type II DM are more prone to develop AP. Glycosylated hemoglobin (HbA1c) reflects the blood glucose levels of over past two months and daily glucose levels do not affect its levels in the blood.Objectives: To find out the frequency of acute pancreatitis in diabetic patients both in type 1 and type 2.Study Design: Cross-sectional, comparative studyMethodology: This was a retrospective cross-sectional, comparative study based on 154 patients with acute pancreatitis in our tertiary care hospital over the duration of two years i.e. from January 2016 to December 2017. The data were entered and coded where necessary and statistically analyzed using SPSS version 20. Descriptive analysis was done to summarize data in the form of percentages and numbers for categorical data while continuous variables were shown by using mean and standard deviation.Results: The mean age was 48.6 year with a standard deviation of 16.9 years, the total cases were 154 for the duration two years from January 2016 to December 2017. Out of 147 patients, 72 (44.4%) were male and 75 (46.3%) were female. Only 13 (8.8%) out of 154 patients were diabetics. Total serum pancreatic lipase and serum pancreatic amylase levels were significantly higher in non-diabetic subjects as compared to diabetics. Also, high serum lipase levels were seen in slightly more females than males.Conclusion: The results of our study documented that the prevalence of acute pancreatitis is more common in non-diabetics as compared to diabetics, and those who were diabetic were between 41 to 60 years of age. We recommend further studies in this area to reach a general agreement on the prevalence of acute pancreatitis and factors affecting its prevalence as well as on the relation of diabetes and severity of acute pancreatitis.Citation: Khan ZA, Baig KS, Ahmad Z, Afridi M. Acute pancreatitis in diabetics: a twoyear retrospective study in a tertiary care hospital in Peshawar, Pakistan. Anaesthesia, pain & intensiv care 2019;23(2):211-216

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Analysis of adverse drug reactions encountered in a tertiary care hospital: a cross sectional study

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20182100 ◽

2018 ◽

Vol 7 (6) ◽

pp. 1164

Author(s):

Syed Hussain F. ◽

Sathyanarayanan V. ◽

Jamuna Rani R.

Keyword(s):

Adverse Drug Reactions ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Cross Sectional Study ◽

Assessment Scale ◽

Care Hospital ◽

Sectional Study ◽

Drug Reactions ◽

Cross Sectional ◽

Organ Systems

Background: Adverse drug reactions are due to hazards of drug therapy and can occur with any class of drugs. The aim of this study was to evaluate and record adverse drug reactions reported from various departments of a tertiary care hospital.Methods: A Cross Sectional study conducted in a tertiary care hospital for a period of 4 months from March to June 2017 after Institutional Ethics Committee approval. ADRs reports collected and analyzed for causality, severity and preventability by international standardized scales.Results: A total of 38 ADR’s were reported during the study period with male predominance (58%). Most of the ADR’s (42%) were common in patients in the age group 19-39 years. More number of ADR’s were from Medicine (29%). Most commonly affected organ systems were skin (45%). The drugs mostly accounted were antibiotics (55%) especially Cephalosporins (33%). According to Naranjo’s causality assessment scale 74% of reactions were probable, 26% were possible, Modified Hartwig and Seigel severity assessment scale revealed 45% ADRs to be moderate, 42% were mild and 13% were severe, Modified Schumock and Thorton Preventability assessment scale which revealed 61% ADRs were not preventable, 32% were probably preventable,7% were definitively preventable.Conclusions: Adverse Drug Reactions are common and some of them resulted in increased healthcare cost due to need of some interventions and increased length of hospital stay. The health system should promote the spontaneous reporting of ADR’s. The proper documentation and periodic reporting to Pharmacovigilance Centres is required to ensure drug safety.

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Scenario of Sepsis in Intensive Care Unit in a Tertiary Care Hospital

Journal of Nepal Health Research Council ◽

10.33314/jnhrc.v18i1.2498 ◽

2020 ◽

Vol 18 (1) ◽

pp. 99-102

Author(s):

Ram Hari Ghimire ◽

Sampanna Budhathoki ◽

Rupesh Kumar Shreewastav

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Tertiary Care ◽

Laboratory Data ◽

Age Groups ◽

Common Source ◽

Care Hospital ◽

Cross Sectional ◽

Medical College ◽

Source Of Infection

Background: Sepsis has been defined as life-threatening organ dysfunction caused by dysregulated host response to infection. Sepsis is an important cause of mortality in intensive care unit worldwide. The study aims to identify the outcome of sepsis patient admitted at tertiary care hospital.Methods: This is a descriptive cross-sectional hospital based study on 76 adult patients admitted at intensive care unit of Nobel Medical College with diagnosis of sepsis with an objective of estimating mortality of sepsis and identifying associated symptoms with it. Baseline demographics, clinical and laboratory data were collected and analyzed. Results: Out of 76 patients with sepsis, mean age of the patients was 50.07±18.15 years. Majority of patients 31.6% with sepsis were above age groups >60 years. The most common symptoms among the patients were fever, which was seen in 69 (90.8%) patients. The most common source of infection in those patients was found to be unknown, which was seen in 36.8% of patients. While analyzing the outcome, it was noted that 25 patients with sepsis (32.9%) died during treatment.Conclusions: Sepsis is related with high mortality. Elderly patients are at more risk. Fever is the commonest presentation and source is not identified in majority of cases. Keywords: Intensive care unit; mortality; sepsis.

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Correlation of serum bilirubin and transcutaneous bilirubin in newborns

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20213316 ◽

2021 ◽

Vol 8 (9) ◽

pp. 1547

Author(s):

Pavitra V. Arunachalmath

Keyword(s):

Serum Bilirubin ◽

Tertiary Care ◽

Cross Sectional Study ◽

Total Serum ◽

Care Hospital ◽

Time Data ◽

Cross Sectional ◽

Transcutaneous Bilirubin ◽

Transcutaneous Bilirubinometer ◽

Transcutaneous Bilirubinometry

Background: Hyperbilirubinemia is a very common entity in newborns. Screening all the babies for hyperbilirubinemia is must. Serum bilirubin is the standard method of checking the bilirubin in newborns. This is very cumbersome, invasive and time consuming method. Hence many newborns will be discharged without screening. Transcutaneous bilirubinometry would help us in making this task easy and safe. Hence the present study was planned.Methods: This is an institutional cross sectional study conducted in a tertiary care hospital for a period of 6 months. After a written informed consent from parents/ guardians and considering selection criteria, 500 newborns with clinical jaundice were included in study. Each newborn was examined, transcutaneous bilirubin checked at forehead and sternum and serum bilirubin was done at the same time. Data was statistically analyzed to see the correlation between TcB and TSB.Results: Out of 500 newborns, 316 were males, 184 were females and 475 were term gestation and 25 were preterm. Coefficient of correlation was 0.73 and 0.72 for total serum bilirubin versus forehead and sternum respectively which were statistically significant.Conclusions: Transcutaneous bilirubinometer readings closely correlate with that of serum bilirubin. Hence TcB can be used as a safer, economical and effective tool in screening newborns for hyperbilirubinemia.

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