scholarly journals Awareness of PCOS (polycystic ovarian syndrome) in adolescent and young girls

2017 ◽  
Vol 6 (6) ◽  
pp. 2297 ◽  
Author(s):  
Jayshree J. Upadhye ◽  
Chaitanya A. Shembekar
Keyword(s):  
Adolescent Girls ◽  
Polycystic Ovarian Syndrome ◽  
Lifestyle Modification ◽  
Accurate Diagnosis ◽  
Reproductive Age ◽  
Young Girls ◽  
Younger Age ◽  
Ovarian Syndrome ◽  
Age Awareness

Background: Polycystic ovarian syndrome (PCOS) is an endocrine disorder which affects the adolescent girls It affects 5% to 10% of women in their reproductive age. Awareness and accurate diagnosis is the first step in managing PCOS as it improves quality of life of the patient. The study was conducted to assess the knowledge on PCOS among the medical students.Methods: Survey of 200 girls was done to assess the knowledge on the polycystic ovarian syndrome among the medical students of different colleges studying in 1st, 2nd, and 3rd year. The data was collected from the students by using structured questionnaire.Results: In present study, 51% girls had normal BMI, 19.5% were overweight, 16.5% were obese while 13% were underweight. 33.5% females had acne, 16% had irregularity of menses, 5% had hirsutism while 2% had infertility. In present study, 33% adolescent and young girls had information about PCOS from teacher, 19% got information from friend, 11.5% got information from a doctor, 3.5% got information from newspaper while 5% got information from internet. 28% adolescent and young girls were unaware of PCOS.Conclusions: Thorough knowledge of the disorder and counseling for adolescents should be included in the curriculum which will provide awareness towards the disorder and lifestyle modification. Accurate diagnosis at a younger age may be a key.

scholarly journals Study of prevalence and determinants of polycystic ovarian syndrome among adolescent girls in rural area: a prospective study

2019 ◽  
Vol 8 (8) ◽  
pp. 3135
Author(s):  
Manisha M. Laddad ◽  
Nitin S. Kshirsagar ◽  
Gauri P. Shinde ◽  
Vaishnavi S. Shivade
Keyword(s):  
Adolescent Girls ◽  
Polycystic Ovarian Syndrome ◽  
Lifestyle Modification ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Adult Women ◽  
Cross Sectional ◽  
A Prospective Study ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is the most frequent endocrinological disorder affecting 5-10% of women in the reproductive age. This prevalence ranging from 2.2% to 26% in adult women from 18-45 year. In a recent study the prevalence of a confirmed diagnosis of PCOS in adolescents aged 10 to 19 years was 5-15%, which increased to 10-22%. When undiagnosed cases with documented symptoms qualifying for PCOS according to NIH (National institute of Health) criteria were included. PCOS is a complex endocrine disorder which is most common in women of reproductive age. PCOS may first present in adolescence, but the incidence of PCOS in adolescence is not known, as diagnostic criteria for PCOS in the adolescent age-group is still not defined, PCOS symptoms tend to overlap with normal pubertal changes making the diagnosis even more challenging. The objective is to study prevalence and symptomatology of polycystic ovary syndrome (PCOS) in adolescent girls.Methods: Prospective Cross sectional study between April 2018 and March 2019. 150 adolescent girls aged 10 to 19 years attending OPD with oligomenorrhea, irregular menstrual cycle, obesity and/or hirsutism were advised for biochemical, hormonal, and ultrasonographic evaluation for diagnosis of PCOS on the basis of Rotterdam's criteria at the Department of Obstetrics and Gynaecology, Krishna Institute of Medical Sciences, Deemed University, Karad, Maharashtra, India.Results: Prevalence of PCOS in the study was 17.33% in the study group.Conclusions: PCOS is increasingly encountered during adolescence, although the overall prevalence is low and evaluation of PCOS in adolescents is challenging. At this age, lifestyle modification is imperative to prevent long-term metabolic and reproductive complications.

P–129 Follicular extracellular vesicles of women with polycystic ovarian syndrome inhibit oocyte maturation

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
C Liu ◽  
M Wang ◽  
H Yao ◽  
M Cui ◽  
X Gong ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Oocyte Maturation ◽  
Pregnancy Outcomes ◽  
Molecular Mechanisms ◽  
Polycystic Ovarian Syndrome ◽  
Reproductive Age ◽  
Maturation Rate ◽  
Abnormal Mitochondria ◽  
Ovarian Syndrome

Abstract Study question Does follicular extracellular vesicles of women with polycystic ovarian syndrome (PCOS-EVs) interfere with the quality of oocytes? Summary answer PCOS-EVs induced oxidative stress in the oocytes and inhibited oocyte maturation by increasing the abnormal mitochondria distribution and abnormal spindle rates. What is known already Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age, with a prevalence up to 10%. Women with PCOS are characterized by a clustering of features, including hyperandrogenism, polycystic ovarian morphology, and notably, anovulation. Although international guidelines recommend assisted reproduction techniques to be an effective resort for PCOS patients to conceive. However, even after overcoming ovulatory dysfunction via ovulation induction, the pregnancy outcomes of patients with PCOS were far from satisfying with lower fertilization, cleavage, and implantation rates, implicating that theoocyte quality of these patients are affected. Whereas the mechanisms have not been elucidated yet. Study design, size, duration Follicular fluid of PCOS patients (n = 10) and healthy controls (n = 10) were collected and used for extracellular vesicles (EVs) isolation via ultracentrifugation. Germinal vesicle (GV) oocytes collected from female ICR mice were cocultured with RIF-EVs or FER-EVs, respectively, and PBS served as a blank control. GV breakdown (GVBD) rate and maturation rate were calculated at two-hour and fourteen-hour of co-culture, respectively. Besides, oocyte mitochondria distribution, meiosis spindle morphology, and oxidative status were assessed in different groups. Participants/materials, setting, methods EVs were determined by western blotting, nanoparticle tracking analysis, and transmission electron microscopy. Fluorescence labeled EVs were used to visualize internalization by oocytes. Oocytes mitochondria and mitosis spindles were stained with fluorescence, and abnormal mitochondria rate or abnormal spindle rate was calculated. Reactive oxygen species (ROS) level was detected in the differently treated oocytes. Moreover, the expression of CAT, GSS, and SOD was determined in the oocytes using quantitative reverse transcription polymerase chain reaction. Main results and the role of chance Both PCOS-EVs and CTRL-EVs are bilayered vesicles, ranging from 100 to 150 nm, and enriched in Alix, TSG101, and CD9. EVs could be internalized by oocytes within one hour. After coculture, the GVBD rate was similar among the three groups; whereas the maturation rate was significantly decreased in the PCOS-EV group compared with CTRL-EV group or PBS group. In addition, the abnormal mitochondria distribution rate or abnormal spindle rate were significantly increased in the PCOS-EV group compared with PBS or CTRL-EV group. The ROS level was increased in the PCOS-EV group compared with CTRL-EV group, and the expression of CAT, GSS, and SOD was increased in the PCOS-EV-treated oocytes. Limitations, reasons for caution Our study did not identify the contents of PCOS-EVs and CTRL-EVs, and the molecular mechanisms of dysregulations induced by PCOS-EVs need further researches to investigate. Wider implications of the findings: This work confirmed that EV-conducted cellular communication played an important role in oocyte development in women with PCOS. The dysregulation of oocytes induced by PCOS-EVs might be related to the poor oocyte quality of women with PCOS, which may provide a novel target to improve pregnancy outcomes of these patients. Trial registration number Not applicable

Analysis of quality of life in women of reproductive age with polycystic ovarian syndrome

2019 ◽  
Author(s):  
Yana Naumenova ◽  
Elena Mahlina ◽  
Marya Rusalenko ◽  
Iryna Savasteeva ◽  
Tatyana Mokhort
Keyword(s):  
Quality Of Life ◽  
Polycystic Ovarian Syndrome ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Ovarian Syndrome

scholarly journals EFFECTIVENESS OF LIFESTYLE MODIFICATION ON WEIGHTLOSS AND QUALITY OF LIFE IN OBESE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

2018 ◽  
Vol 11 (9) ◽  
pp. 333
Author(s):  
Vinaya Rajendra Patil ◽  
Poovishnu Devi Thangavelu ◽  
Vaishali Krishnat Jagtap
Keyword(s):  
Quality Of Life ◽  
Weight Loss ◽  
Polycystic Ovarian Syndrome ◽  
Lifestyle Modification ◽  
Obese Women ◽  
Group A ◽  
Conventional Physiotherapy ◽  
Group B ◽  
Ovarian Syndrome

Objectives: (1) The objectives of this study were to determine the effectiveness of lifestyle modification on weight loss and the quality of life in obese women with the polycystic ovarian syndrome and (2) to determine the effectiveness of conventional physiotherapy on weight loss and the quality of life in obese women with polycystic ovarian syndrome.Methods: Ethical clearance was obtained from the Institutional Ethical Committee. A total of 40 obese women with the polycystic ovarian syndrome (PCOS) were selected and divided into two groups, Group A (N=17) received conventional physiotherapy alone, and Group B (n=15) received lifestyle modification along with conventional physiotherapy. The preassessment of body weight is measured by body mass index (BMI); the waist-hip ratio (W-H ratio) and body fat percentage and the quality of life were scored as per the PCOS questionnaire (PCOSQ); and postinterventional assessment was taken for the same after 9 months.Result: Intergroup statistical analysis for BMI revealed extremely significant in postintervention for Group B (P<0.0001). W-H ratio and PCOSQ were extremely significant for Group B (P<0.0001). While postintervention analysis showed extremely significant difference between Group A and Group B (P<0.0001). Group B treated with lifestyle modification, and conventional physiotherapy was extremely significant.Conclusion: Lifestyle modification with conventional physiotherapy helped in reducing weight and showed the increased quality of life in women with PCOS.

scholarly journals Effectiveness of lifestyle modification package among overweight and obese adolescent girls between 15-19 years with polycystic ovarian syndrome

2016 ◽  
Vol 4 (1) ◽  
pp. 84 ◽  
Author(s):  
Anju Krishnan Nair ◽  
Bindu Nambisan ◽  
Sreekumary Radha ◽  
Jayasree Leelamma
Keyword(s):  
Adolescent Girls ◽  
Intervention Program ◽  
Polycystic Ovarian Syndrome ◽  
Lifestyle Modification ◽  
Polycystic Ovary ◽  
Obese Adolescent ◽  
Menstrual Cycles ◽  
Cost Effective Treatment ◽  
Increased Risk ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is the most common female endocrine disorder which is often diagnosed during late adolescence, with anovulation and hyperandrogenism. Adolescent girls with PCOS, are at an increased risk for the development of type 2 diabetes mellitus and metabolic syndrome. Early diagnosis and early intervention may prevent long term sequelae and improve quality of life. The objectives were to study the effectiveness of lifestyle modification package among overweight and obese adolescent girls between 15-19 years with polycystic ovary syndrome (PCOS).Methods: In this study 144 adolescent girls (postmenarchal by 2 years) diagnosed as PCOS as per Rotterdam criteria after ruling out other causes of menstrual abnormality listed in the exclusion criteria, were selected. Informed consent taken from the participant or their parent if less than 18 years. Their anthropometric measurements and their menstrual cycles recorded at the beginning of the study and a lifestyle modification package including dietary modification and exercise, given to each of them. Participants were followed up telephonically every month to know their compliance towards the intervention program along with reinforcement of the package.  After 6 months of intervention they were reviewed to assess the effectiveness of the intervention package.Results: Significant weight loss was seen in 66.4% of the participants and15.2% had weight stabilization (weight gain <1.5kg). There was significant change in BMI with mean change in BMI 1.9. 58.4% of the girls improved their menstrual cycle after 6 months. There was significant reduction in body fat% and W/H ratio.Conclusions: Lifestyle modification is a simple, cost effective treatment in the management of overweight and obese adolescent PCOS in improving their BMI and regularization of menstrual cycles.

scholarly journals Structured teaching programme on knowledge about polycystic ovarian syndrome among adolescent girls

2017 ◽  
Vol 5 (11) ◽  
pp. 5004 ◽  
Author(s):  
Sonia Rawat ◽  
Gomathi B. ◽  
Laxmi Kumar ◽  
Mahalingam V.
Keyword(s):  
Adolescent Girls ◽  
Polycystic Ovarian Syndrome ◽  
Knowledge Score ◽  
Reproductive Age ◽  
Teaching Programme ◽  
Structured Teaching ◽  
Post Test ◽  
Structured Knowledge ◽  
The Mean ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome is a common female endocrine disorder affecting 4 – 18% of women in their reproductive age. It is common in adolescent girls. Polycystic Ovarian Syndrome affects throughout the life and produce gynaecological and metabolic health problems. The aim of this study to create the awareness about the polycystic ovarian syndrome to the adolescent girls.Methods: A Quantitative approach with pre- experimental design was used to study the effectiveness of STP on Poly Cystic Ovarian Syndrome. Ninety-four adolescent girls aged between 15 – 18 years were conveniently selected. Data was collected by using Structured Knowledge questionnaire.Results: The mean post-test knowledge score (22.55± 3.57) was higher than that of mean pre-test mean knowledge score (11.13± 3.32) and the mean difference was11.42. The ‘t’ calculated value was 23.45 which is higher than the tabulated value of 1.98 (df 93 at p< 0.05). Therefore, research hypothesis was accepted. So, it can be interpreting that structured teaching programme is effective in improving the knowledge of adolescent girls.Conclusions: The findings of the study revealed that STP was effective in enhancing the knowledge of adolescent girls on PCOS. Hence the study concluded that structured teaching programme had a great potentiality to increase the awareness on PCOS.

scholarly journals Effectiveness of structured teaching programme regarding polycystic ovarian syndrome among adolescent girls

2021 ◽  
Vol 10 (7) ◽  
pp. 2818
Author(s):  
Soniya John
Keyword(s):  
Adolescent Girls ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Sampling Technique ◽  
Reproductive Age ◽  
Teaching Programme ◽  
Structured Teaching ◽  
Prevention And Health Promotion ◽  
Quasi Experimental ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome is an endocrine disorder that affects approximately 5% of all women. It occurs amongst all races and nationalities. It is the most common hormonal disorder among women of reproductive age and is a leading cause of infertility. As polycystic ovarian syndrome is an ovarian disorder marked by a lack of estrogen, hyperandrogenaemia, obesity, hyper insulinaemia and starts early in the adolescent period. So, we should teach them regarding the clinical features treatment and prevention.Methods: A quasi experimental one group pre-test post design was adopted to assess the effectiveness of structured teaching programme on knowledge regarding polycystic ovarian syndrome among adolescent girls, Bangalore. A sample of 60 adolescent girls was selected from NRI higher secondary school, Bangalore by purposive sampling technique. Collected data was analysed by using descriptive and inferential statistics.Results: More than half 54 (90.0%) were having inadequate knowledge and 6 (10%) were having moderate knowledge regarding PCOS before STP.Conclusions: Structured teaching programme was significantly effective in increasing the knowledge of polycystic ovarian syndrome. The most important role of the nurse is to provide awareness on prevention and health promotion. 

scholarly journals QUALITY OF LIFE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: REQUISITE OF CLINICAL PHARMACIST INTERVENTION

2019 ◽  
pp. 100-105
Author(s):  
RAMYA R ◽  
SHARON ANN JOSE ◽  
MAMATHA K ◽  
SURYA NARAYANA KM
Keyword(s):  
Quality Of Life ◽  
Psychological Health ◽  
Clinical Pharmacist ◽  
Polycystic Ovarian Syndrome ◽  
Lifestyle Modification ◽  
Well Being ◽  
World Health ◽  
The Impact ◽  
Ovarian Syndrome

Objective: Polycystic ovarian syndrome (PCOS) is a lifestyle disorder known to cause profound distress in the physical and emotional well-being of the patient that implicates the need for treatment and lifestyle management. Unawareness and ignorance among patients may be a predominant cause of compromised quality of life (QOL) that necessitates education from health-care professionals. The existing study was designed to assess the impact of counseling on QOL in the above patients. Methods: This hospital-based interventional study was carried out for 6 months. A total of 173 subjects were recruited for the study. The World Health Organization BREF, a validated, reliable tool to assess QOL was administered in two phases of the study, pre-interventional, and post-interventional phase. Awareness regarding disease and lifestyle modification were detailed by a clinical pharmacist to the patients, and its impact was assessed using suitable statistical techniques. Results: The average age of study participants was 23.9±4.5 years. Decreased QOL was observed in the women affected with PCOS when compared to healthy controls, wherein the psychological domain was the most affected. Post-intervention, a positive impact was reflected as higher scores in all the 4 QOL domains. Conclusion: Women suffering from PCOS exhibit varied symptoms which affect both physical and psychological health. The key factor in management is to create awareness on the complications of the disease and the lifestyle modification to minimize severity and progression. The study findings reveal that women with PCOS showed an improved QOL post participation in awareness programs imparted by the clinical pharmacists.

Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations

2018 ◽  
Vol 25 (15) ◽  
pp. 1792-1804 ◽  
Author(s):  
Silvana R. Ferreira ◽  
Alicia B. Motta
Keyword(s):  
Endometrial Cancer ◽  
Adhesion Molecules ◽  
Polycystic Ovarian Syndrome ◽  
Cellular Proliferation ◽  
Steroid Receptors ◽  
Reproductive Age ◽  
Present Review ◽  
Implantation Failure ◽  
Uterine Function ◽  
Ovarian Syndrome

Background: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations. Methods: We conducted a search at the http://www.ncbi.nlm.nhi.gov/pubmed/electronic database using the following key words: endometrial steroid receptors, endometrium, uterine function, endometrium and PCOS, implantation window, implantation and PCOS, implantation markers, inflammation, oxidative stress. We selected the articles based on their titles and abstracts, then we analyzed the full text and classified the articles depending on the information provided according to the sections of the present review. Results: The endocrine and metabolic abnormalities displayed in women with PCOS promote complex effects on the endometrium, leading to a low rate of implantation and even infertility. Women with PCOS show alterations in the Hypothalamic-Pituitary- Ovarian axis, which results in constant circulating levels of estrogen, similar to those at the early follicular phase, and a deficiency in the withdrawal of estrogen and progesterone. Besides this deficiency in the withdrawal of estrogen and progesterone, the insulin/ glucose pathway, adhesion molecules, cytokines and the inflammatory cascade, together with the establishment of a pro-oxidative status, lead to an imbalance in the uterine function, which in turn leads to implantation failure or even endometrial cancer. Conclusion: Women with PCOS display a dysregulation of the Hypothalamic-Pituitary- Ovarian axis, which alters the steroid pathway. In addition, the deficiency in the withdrawal of estrogen and progesterone in the endometrium results in abnormal endometrial cellular proliferation. The imbalance in adipose tissue observed in PCOS patients reinforces the increase in circulating hormones. The present review describes the role of hormones, metabolites, cytokines, adhesion molecules and the insulin/glucose pathway related to the uterine endometrium in women with PCOS and their role in implantation failure and development of endometrial cancer.

scholarly journals To Study the Effect on Fertility Outcome by Gonadotropins vs Laparoscopic Ovarian Drilling in Clomiphene-resistant Cases of Polycystic Ovarian Syndrome

2017 ◽  
Vol 9 (4) ◽  
pp. 336-340 ◽  
Author(s):  
Richa Singh ◽  
Meenal Jain ◽  
Poonam Yadav ◽  
Sarvesh Awasthi ◽  
Pallavi Raj
Keyword(s):  
Statistical Analysis ◽  
Ovulation Induction ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Clomiphene Citrate ◽  
Reproductive Age ◽  
Multiple Pregnancies ◽  
Laparoscopic Ovarian Drilling ◽  
Ovarian Drilling ◽  
Ovarian Syndrome

ABSTRACT Introduction The polycystic ovary syndrome (PCOS) is the most common condition associated with chronic anovulation affecting 4 to 6% of reproductive age women. Aim To compare the effectiveness of laparoscopic ovarian drilling (LOD) for ovulation induction with gonadotropins in clomiphene-resistant PCOS in terms of ovulation, pregnancy, live birth, abortion, multiple pregnancies, and complication like ovarian hyperstimulation syndrome (OHSS). Setting and design A prospective hospital-based randomized trial. Materials and methods It was a prospective study, which was carried out from January 2012 to May 2015. Totally, 89 women were evaluated in the study, out of which 44 women were in gonadotropin group and 45 were in LOD group. Statistical analysis Standard statistical analysis was done and significance of difference in results was tested by chi-square test. Results Ovulation rate in gonadotropin group was 75.0% at 6 months, whereas in LOD group, it was 20% at 3 months and was increased up to 66.66% after addition of clomiphene citrate and gonadotropin. The primary outcome in terms of pregnancy in gonadotropin group was 45.45% after 6 cycles and in LOD group was 11.11% after 3 cycles and 40.00% after 6 cycles with supplementation of clomiphene citrate and gonadotropin. Conclusion The ongoing pregnancy rate from ovulation induction with LOD alone was significantly less but if supplemented by clomiphene citrate and gonadotropin, it seems equivalent to ovulation induction with gonadotropin, but the former procedure carries a lower risk of multiple pregnancies. How to cite this article Yadav P, Singh S, Singh R, Jain M, Awasthi S, Raj P. To Study the Effect on Fertility Outcome by Gonadotropins vs Laparoscopic Ovarian Drilling in Clomiphene-resistant Cases of Polycystic Ovarian Syndrome. J South Asian Feder Obst Gynae 2017;9(4):336-340.

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