scholarly journals Analysis of risk factors, maternal and fetal outcome of spontaneous preterm premature rupture of membranes: a cross sectional study

2017 ◽  
Vol 6 (9) ◽  
pp. 3781
Author(s):  
Surekha S. Mohan ◽  
Chamaraja Thippeveeranna ◽  
Naorem N. Singh ◽  
Laiphrakpam R. Singh
Keyword(s):  
Fetal Outcome ◽  
Cross Sectional Study ◽  
Perinatal Morbidity ◽  
Sectional Study ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Membrane Rupture ◽  
Preterm Premature Rupture ◽  
History Of

Background: Preterm premature rupture of membranes (PPROM) is one of the most common complications of pregnancy. It is an important cause of perinatal morbidity and mortality. Objective of present study was to determine incidence, risk factors, maternal, fetal outcome of PPROM occurring in patients attending a tertiary hospital in North Eastern India.Methods: This descriptive cross- sectional study was carried out in the department of Obstetrics and Gynecology, Regional Institute of Medical Sciences, Imphal, India. Out of 15,969 deliveries between July 2010 to December 2011, 358 pregnant patients with spontaneous preterm premature rupture of membranes from 28-0 to 36-6weeks gestation were reviewed. After excluding patients with uterine anomalies, intrauterine deaths and congenital anomalies 293 patients were included and evaluated in this study.Results: The incidence of PPROM was 2.2%. Out of 293 patients 86% were singleton pregnancies, 12.9% were twins and 1.02% were triplets. 48.4% had previous history of termination of pregnancy, 28.6% history of previous PPROM and 16.3% had urinary tract infection. The mean gestational age at the onset of membrane rupture was 34.1+2.4 weeks and the latency from the membrane rupture to delivery interval ranged from 0-72 days with a mean of 48.4 hours. There were 7stillbirths (2.38%) and 4 neonatal deaths (1.02%) resulting in perinatal deaths of 3.29% and perinatal mortality rate of 0.329 per 1000 births due to PPROM. Maternal morbidity was minimal with postpartum haemorrhage in 11 patients (4.1%), abruptio placentae in 7 patients (2.3%) and sepsis in 43patients (14.6%). 66 patients (22.5%) underwent caesarean section for which malpresentations were the major cause.Conclusions: Despite remarkable advances in perinatal care, preterm premature rupture of membranes continues to cause perinatal morbidity and mortality. Strategies should be developed for its prevention. Management protocol should be improved in regard to vaginal swab culture and use of specific antibiotics.

scholarly journals Predictors of Premature Rupture of Membranes among Pregnant Women in Rural Uganda: A Cross-Sectional Study at a Tertiary Teaching Hospital

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Simon Byonanuwe ◽  
Emmanuel Nzabandora ◽  
Baltazar Nyongozi ◽  
Theophilus Pius ◽  
David Santson Ayebare ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Pregnant Women ◽  
Gestational Age ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
History Of ◽  
Tract Infections

Background. Premature rupture of membranes (PROM) is a common condition in developed and developing countries and poses a serious threat to the maternal and fetal well-being if not properly managed. This study delineated the prevalence and predictors of PROM in the western part of Uganda so as to guide specific preventive measures. Methods. A cross-sectional study design was conducted in the months of September 2019 to November 2019. A total of 334 pregnant women above 28 weeks of gestation admitted at the maternity ward of KIU-TH were consecutively enrolled. Interviewer-administered questionnaires were used to obtain the data. Descriptive statistics followed by binary logistic regression were conducted. All data analyses were conducted using STATA 14.2. Results. Of the 334 pregnant women enrolled, the prevalence of PROM was found to be 13.8%. The significant independent predictors associated with lower odds of PROM were no history of urinary tract infection (UTI) in the month preceding enrollment into the study (aOR=0.5, 95% CI: 0.22-0.69, p=0.038) and gestational age of 37 weeks or more (aOR=0.3, 95% CI: 0.14-0.71, p=0.01) while history of 3 or more abortions (aOR=13.1, 95% CI: 1.12-153.62, p=0.05) was associated with higher likelihood of PROM. Conclusions. Majorly urinary tract infections, low gestational age, and abortions influence premature rupture of membranes among women. There is a great need for continuous screening and prompt treatment of pregnant women for UTI especially those with history of 3 or more abortions at less than 34 weeks of gestation.

scholarly journals A Cross-Sectional Study of Obstetrical and Gynecological Parameters in Twins – A Potential Increase in Premature Rupture of Membranes and Pre-eclampsia in Twin Women

2020 ◽  
Author(s):  
Nathan Keller ◽  
Kevin C. Kiley
Keyword(s):  
General Population ◽  
Gestational Diabetes ◽  
Gynecological Cancer ◽  
Geographical Area ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Age Of Menarche

Abstract Background This cross-sectional study of 192 twins across a wide geographical area compared obstetrical and gynecological parameters between twins and the general population. Methods The study is a cross-sectional study. Gynecological variables included age of menarche, abnormal pap smears, birth control usage, endometriosis, fibroids, infertility, gynecological cancer, and osteoporosis. Obstetrical variables studied included pregnancy, ectopic pregnancies, hypertension, pre-eclampsia, gestational diabetes, and premature rupture of membranes (PROM). Chi Square and Fisher’s Exact tests were utilized to compare these binary variables between identical and fraternal twins. Finally, odds ratios were used to compare the rates of PROM, pre-eclampsia, hypertension, ectopic pregnancy, and gestational diabetes among twins compared to the general population using reputable literature sources. Results Identical twins reported the same age of menarche more frequently than their fraternal counterparts (p = 0.0021) with an odds ratio of 4.56 (95% CI = 1.62,12.83). There was also an increase in the odds of PROM 1.37 to 5.42 (95% CI = 0.95,1.96 and 4.21,6.98) and pre-eclampsia 1.17 to 3.16 (95% CI = 0.66,2.09 and 2.16,4.62) in our twin sample verse the general population. Finally, only 9.9% (18/184) reported knowledge of amnionicity and chorionicity. Conclusions Our findings suggest that further large scale research concerning PROM and pre-eclampsia in twin women may be warranted.

scholarly journals Vaginal flora in preterm premature rupture of membranes and their sensitivity to commonly used antibiotics

2014 ◽  
Vol 5 (4) ◽  
pp. 58-60 ◽  
Author(s):  
Shikha Rani ◽  
Reeti Mehra ◽  
Varsha Gupta ◽  
Anju Huria ◽  
Jagdish Chander
Keyword(s):  
Pregnant Women ◽  
Cross Sectional Study ◽  
Vaginal Flora ◽  
Gram Negative Bacteria ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Gram Negative ◽  
Preterm Premature Rupture ◽  
Ascending Infection

Background: Ascending infection is one of the most common etiologies in preterm premature rupture of membranes (PPROM). Antibiotics are used in PPROM to prolong the pregnancy and to prevent infection. But to prevent drug overuse and resistance, microorganism directed antibiotics should be used. So, this study was planned to evaluate vaginal flora in pregnant women with PPROM and their sensitivity to commonly used antibiotics. Methods: In this prospective cross-sectional study, 50 pregnant women (cases) preterm premature rupture of membranes and 28 pregnant women (controls) without complication were assessed for the type of vaginal flora and its sensitivity to commonly used antibiotics. Results: Among cases 18 (36%) women showed bacteria on Gram’s staining of vaginal swabs with Gram?negative bacteria (10/18) being the most common. Among controls, 16 (57%) women showed bacteria on Gram’s staining with Gram?positive bacteria being most common. Among cases Escherichia coli and Staphylococcus aureus were the commonest isolates. Of 8 (16%) positive bacterial cultures in cases, 6 (10%) were sensitive to Gentamicin and 2 (4%) to Ampicillin. Conclusion: Lower genital tract flora of pregnant women with PPROM predominantly consists of Gram?negative bacteria, which are sensitive to Gentamicin. DOI: http://dx.doi.org/10.3126/ajms.v5i4.9889 Asian Journal of Medical Sciences 2014 Vol.5(4); 58-60

scholarly journals Fetal outcome in Premature Rupture of Membrane – A study conducted in a tertiary level hospital in Bangladesh

Mediscope ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. 108-112
Author(s):  
Sanchita Adhikary ◽  
Shaorin Tanira ◽  
Arifa Sultana ◽  
Feroza Wazed ◽  
Saleha Begum Chowdhury
Keyword(s):  
Birth Weight ◽  
Apgar Score ◽  
Mode Of Delivery ◽  
Birth Asphyxia ◽  
Fetal Outcome ◽  
Cross Sectional Study ◽  
Premature Rupture ◽  
Birth Process ◽  
Cross Sectional ◽  
History Of

Background: Perinatal mortality is high if premature rupture of membrane (PROM) occurs when fetuses are of previable gestational age. Objective: To find out the effect of premature rupture of membrane in pregnancy on its fetal outcome. Methods: A cross-sectional study was conducted in Department of Obstetrics and Gynaecology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from February to July of 2008, on 50 pregnant women with more than 28 weeks of pregnancy both primigravid and multigravid with rupture of membranes prior to labour. Women who were admitted with rupture of membranes with established labour, or having antepartum hemorrhage, pre-eclampsia or eclampsia were excluded from the study. Out of 775, only 95 patients were admitted with history of premature rupture of membrane (PROM). Among those patients, 50 cases were included in this study as per inclusion and exclusion criteria. Then their mode of delivery and outcome of fetal parameters were recorded. Results: 48 live births were observed and there were 2 fetal losses. Among 48 live newborns, 28 (58.33%) were male and 20 (41.66%) were female. 54.16% of babies had APGAR score at 5 minutes after birth was >7 and those needed no treatment. APGAR score was 7 in 45.82% babies; all of them were treated and cured. Among the newborns, 52.08% babies had birth weight >2500 gm, 45.83% had their birth weight in between 1500 and 2500 gm, while 1 (2.08%) was between 1000 and 1500 gm. However, 22 (45.83%) were affected by the consequences of PROM and birth process. Among them, 36.36% developed jaundice, 29.27% suffered from birth asphyxia, and RTI and neonatal sepsis were evident in 18.18% each. 15% babies were treated conservatively in Department of Obstetrics, while 7% babies were treated in the Neonatal Ward under Department of Paediatrics after admission.There was no neonatal loss. Conclusion: Despite progress in obstetric and neonatal care over the past few years, fetal outcomes in pregnancies with PROM remains disappointing to date. Mediscope Vol. 7, No. 2: July 2020, Page 108-112

scholarly journals The Protect Role of Serum Uric Acid to Premature Rupture of Membranes in Gestational Diabetes: a Cross-sectional Study

2020 ◽  
Author(s):  
Meixiang Guo ◽  
Jun Lu ◽  
Xiaowen Hu ◽  
Wenjing Hou ◽  
Xuemei Yu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Weight Gain ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Weight Gain During Pregnancy

Abstract Background: Uric acid has strong antioxidant activity whereas its oxidative damage is closely related to many diseases. We assessed the association between serum uric acid (SUA) levels and premature rupture of membranes (PROM) in pregnant women with Gestational diabetes (GDM) in china. Method: In this cross-sectional study, a total of 456 pregnant women were enrolled. Anthropometric parameters for pregnant women were collected within 12 weeks of gestation. Weight gain during pregnancy was obtained from patients’ record. GDM was diagnosed according to 75-g oral glucose tolerance tests at 24-28th week’s gestation, and SUA was determined simultaneously. PROM was identified as the natural rupture of fetal membranes before the first stage of labor. Logistic models were fitted to identify the presence of PROM using clinical characteristics with (Model 1) or without serum uric acid (Model 2).Results: There exist differences in BMI, haemoglobin A1c, fasting blood glucose, 1-hour postprandial glucose, 2h PG, insulin levels, weight gain during pregnancy, the rate of macrosomia, PROM between women with and without GDM (all P<0.05). Furthermore, individuals with PROM had lower level of SUA than those without PROM in GDM women (P=0.030). The odds ratio of PROM decreases with the increase of SUA level. The area under the receiver operating characteristic curves for PROM based on Model 1 was larger than that in Model 2 (0.86 versus 0.71, p<0.05).Conclusion: Elevated relatively SUA levels at the 24-28th weeks of gestation were associated with a lower risk of PROM in women with GDM. SUA may be a protective factor for PROM in GDM patient. The optimal concentration of uric acid in different diseases and different populations needs to be further studied.

scholarly journals The Role of Tumor Necrosis Factor  (TNF ) and Matrix Metalloproteinase9 (MMP9) Serum in Preterm Premature Rupture of Membranes

2017 ◽  
pp. 199
Author(s):  
Ardiles Ardiles ◽  
Desmiwarti Desmiwarti ◽  
Hafni Bachtiar
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
P Value ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Preterm Premature Rupture ◽  
The Mean ◽  
Necrosis Factor

Objective: To investigate the role of TNF- and MMP-9 serum in preterm premature rupture of membranes (PPROM). Methods: We used cross-sectional study design. Subjects were all pregnant women with and without PPROM who underwent checkup at Obstetrics and Gynecology Functional Medical Staff General Hospital Dr. M. Djamil and networking hospital. Results: A total of 48 subjects were enrolled in this study. The mean serum levels of TNF- in patients with PPROM 17.43 ng/ml  12.4 ng/ml and without PPROM 8.45 ng/ml  6.86 ng/ml. The mean serum levels of MMP-9 in patients with PPROM 8.77 ng/ml  4.41 ng/ml, and without PPROM 4.46 ng/ml  3.04 ng/ml. Statistical test result p value <0.05, it can be conclude there are differences in the levels of TNF- and MMP-9 serum in premature rupture of membranes and without premature rupture of membranes pregnancy of preterm. Conclusion: There are differences in the levels of TNF- and MMP-9 serum in PPROM and without PPROM.Keywords: MMP-9, premature rupture of membranes, TNF-

scholarly journals Healthcare Workers’ Perspectives on the Upcoming COVID-19 Vaccine in Terms of Their Exposure to the Influenza Vaccine in Riyadh, Saudi Arabia: A Cross-Sectional Study

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 465
Author(s):  
Leena R. Baghdadi ◽  
Shatha G. Alghaihb ◽  
Alanoud A. Abuhaimed ◽  
Dania M. Alkelabi ◽  
Rawan S. Alqahtani
Keyword(s):  
Saudi Arabia ◽  
Influenza Vaccine ◽  
Work Experience ◽  
Healthcare Workers ◽  
Seasonal Influenza ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Seasonal Influenza Vaccine ◽  
History Of

In 2019, a novel severe acute respiratory syndrome (SARS-CoV-2 (COVID-19)) caused a global pandemic. There was an urgent need to develop a vaccine against COVID-19 to reduce its spread and economic burden. The main objective of this study was to understand the attitudes and concerns of healthcare workers (HCWs) towards the upcoming COVID-19 vaccine, whether their decision was influenced by their history of taking the seasonal influenza vaccine, and factors that influence the acceptance of the upcoming COVID-19 vaccine. This was a cross-sectional study conducted in Riyadh, Saudi Arabia. We selected and surveyed 356 HCWs via an electronic self-administered questionnaire. A total of 61.16% of HCWs were willing to receive the COVID-19 vaccine, and 55.9% of them had received the seasonal influenza vaccine in the preceding year (2019–2020). The strongest predictors for taking the COVID-19 vaccine were the HCWs’ belief that the COVID-19 vaccine would be safe, needed even for healthy people, that all HCWs should be vaccinated against COVID-19, and that HCWs will have time to take the vaccine. Being female, being middle aged, having <5 years of work experience, having no fear of injections, and being a non-smoker were predictive factors for taking the upcoming COVID-19 vaccine. No associations were found between the intention to take the COVID-19 vaccine and a history of taking the seasonal influenza vaccine.

scholarly journals Prevalence of latent tuberculosis infection and feasibility of TB preventive therapy among Thai prisoners: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sivaporn Gatechompol ◽  
Weerakit Harnpariphan ◽  
Ruamthip Supanan ◽  
Gompol Suwanpimolkul ◽  
Jiratchaya Sophonphan ◽  
...  
Keyword(s):  
Latent Tuberculosis ◽  
Cross Sectional Study ◽  
Preventive Therapy ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ltbi Prevalence ◽  
History Of ◽  
Chest X Ray ◽  
Latent Tb ◽  
Latent Tb Infection

Abstract Background Prisons are considered as major reservoirs for tuberculosis. Preventive therapy for latent TB infection (LTBI) is an adjunctive strategy to control TB. However, LTBI data in Thai prisoners is limited. This study assessed the prevalence of LTBI and feasibility of isoniazid preventive therapy (IPT). Methods A cross-sectional study was conducted among prisoners in Klong Prem Central Prison, Bangkok. Participants were screened for active TB by questionnaire and chest X-ray. LTBI was evaluated by Tuberculin skin test (TST) and QuantiFERON-TB Gold Plus (QFTP) among subgroup. Participants with positive TST or QFTP were considered to have LTBI. Participants with LTBI were offered IPT. Results From August 2018–November 2019, 1002 participants were analyzed. All participants were male with a median age of 38 (IQR 32–50) years. LTBI identified by either TST/QFTP was present in 466 (46.5%) participants. TST was positive in 359 (36%) participants. In the subgroup of 294 participants who had both TST and QFTP results, 181/294 (61.6%) tested positive by QFTP. Agreement between TST and QFTP was 55.1% (Kappa = 0.17). The risk factors associated with LTBI were previous incarceration (aOR 1.53, 95%CI, 1.16–2.01, p = 0.002), history of prior active TB (aOR 3.02, 95%CI, 1.74–5.24, p < 0.001) and duration of incarceration ≥10 years (aOR 1.86, 95%CI, 1.24–2.79, p = 0.003). Majority of LTBI participants (82%) agreed to take IPT. Three hundred and 56 (93%) participants completed treatment whereas 27 (7%) participants discontinued IPT due to the side effects of INH. Conclusion This is the first study to evaluate the prevalence of LTBI and feasibility of IPT among Thai prisoners. LTBI prevalence in male prisoners in Thailand is high. LTBI screening and treatment should be implemented together with other preventive components.

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