Prevalence of anti-sperm antibodies, risk factors associated and their impact on spermatobioscopy in infertile men

Background: The first immunological correlation with male infertility was reported in 1954 by Wilson and Rumke with the identification of anti-sperm antibodies. The prevalence of anti-sperm antibodies in infertile men varies from 9%-36%, the main cause being the loss of the blood-testicular barrier and otherwise the association with chronic inflammation. It has been shown that immune infertility is found in 15% of patients with varicocele.Methods: A transversal comparative study was carried out with 360 infertile men who were tested for anti-sperm antibodies between January 2011 and July 2018. Two groups were integrated; Group 1, infertile men with positive anti-sperm antibodies >50%, group 2, infertile men with negative anti-sperm <50%. Seminogram parameters were evaluated according to the WHO 5th edition and associated risk factors with anti-sperm antibodies.Results: 360 infertile men were evaluated during the study, 42 were excluded because they did not meet the inclusion criteria, the prevalence of anti-sperm antibodies was 14.5%. Group 1; n=46 (14.5%) and group 2, n=272 (85.5%), the clinical characteristics and the hormonal profile were compared at study admission without significant difference. There was a significant decrease in progressive motility in group 1 (38.7±23.8) vs group 2 (50.1±18.9) p=0.03. Analyzing the risk factors, varicocele was found to be significant 23.7%, OR 2.14 (1.27-3.61) p=0.004 as well as retractable testicle 26.4%, OR 2.13 (1.23-3.70) p= 0.008.Conclusions: The affectation of motility was confirmed, which leads to the suspect varicocele and retractable testicle as risk factors.

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Normal Visual Recovery after Optic Neuritis Despite Significant Loss of Retinal Ganglion Cells in Patients with Multiple Sclerosis

Klinische Monatsblätter für Augenheilkunde ◽

10.1055/a-0853-1721 ◽

2019 ◽

Vol 236 (04) ◽

pp. 425-428

Author(s):

Mohamed Sherif ◽

Ciara Bergin ◽

François-Xavier Borruat

Keyword(s):

Multiple Sclerosis ◽

Visual Loss ◽

Full Recovery ◽

Retinal Ganglion ◽

Visual Recovery ◽

Inclusion Criteria ◽

Fellow Eye ◽

Significant Difference ◽

Group 2 ◽

Group 1

Abstract Background Optic neuritis (ON) is a frequent manifestation of demyelinating attack in multiple sclerosis (MS). Initial visual loss can vary from minimal to complete. Visual improvement occurs in about 95% of patients, some of them recovering to normal [visual acuity (VA), color vision, visual field (VF)]. We analyzed retinal ganglion cell layer (RGCL) thickness in MS patients who recovered their normal vision after ON to determine whether a relative preservation of RGCL existed in these patients. Materials and Methods We conducted a retrospective study of all patients with MS and ON examined by one of us (F. X. B.) between 2013 and 2018. Inclusion criteria were strictly unilateral ON, full recovery of vision, computerized visual field, and OCT examinations. Full recovery of vision was defined as VA ≥ 10/10, Ishihara ≥ 11/13, and VF mean defect (MD) ≤ 2.6 dB. Evaluation of RGCL was obtained with spectral domain optical coherence tomography (SD-OCT). The normal fellow eye of all patients served as the control group. Relative thinning of RGCL, expressed as percentage, was calculated by comparing results from the affected eye to the fellow eye of the same patient. Results Twenty-one patients (21 affected eyes – Group 1, 21 normal fellow eyes – Group 2) satisfying the inclusion criteria were retrieved from our database. All patients exhibited the relapsing-remitting form of MS. There were 16 women and 5 men. Mean age was 39.3 years old. There were no statistically significant differences between Group 1 and Group 2 for either VA (p = 0.3934) or Ishihara (p = 0.140), but a significant difference was found for VF MD (p = 0.0405). A markedly significant difference for RGCL thickness (p = 0.0001) was found, without any correlation with the degree of visual recovery. A subgroup of patients (n = 14) was examined at the time of initial visual loss. We correlated their results of visual function to the final RGCL thickness, and a correlation was found between either the initial VA loss or the initial VF loss and the final loss of RGCL (R2 = 0.4075 and R2 = 0.00739, respectively). Conclusions In our study, all patients with ON lost a significant amount of RGCL despite a full recovery of vision, as defined by our criteria. The percentage of RGCL loss varied from 5 – 27% and could not be correlated with any final visual indices. However, a correlation was found with the degree of initial visual loss. Despite sometimes marked RGCL loss after ON, patients with MS can recover normal visual function, according to standard clinical tests.

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P1817Assessment of carotid stiffness indices in patients with ischemic stroke

European Heart Journal ◽

10.1093/eurheartj/ehz748.0569 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

G Youssef ◽

D Mekkawy ◽

N El-Fayoumy ◽

A Abbas ◽

M Allam

Keyword(s):

Risk Factors ◽

Ischemic Stroke ◽

Carotid Arteries ◽

Tracking System ◽

Intima Media Thickness ◽

Control Subjects ◽

Carotid Stiffness ◽

Significant Difference ◽

Group 2 ◽

Group 1

Abstract Background Arterial stiffness is considered as an emerging new important risk factor for stoke development. Measuring carotid stiffness is easy and non-invasive and thus can be widely applicable. Purpose To evaluate the carotid stiffness indices in patients with ischemic stroke compared to normal healthy subjects. Methods Included in this study are 60 patients (group 1) with ischemic stroke and 60 healthy control subjects (group 2). Participants were exposed to routine clinical examination and Duplex assessment of both carotid arteries. A specific wall tracking system was used for the semiautomatic calculation of the carotid stiffness indices, which included; compliance coefficient (CC), distensibility coefficient (DC), carotid pulse wave velocity (PWV) and carotid intima media thickness (IMT). Results from both carotid arteries were averaged and data from group 1 patients were compared to group 2 subjects. Results The mean age was (60.1±6.9 years) in group 1 compared to (60.1±6.6 years) in group 2 (p=0.9). A significant difference was found between both groups in all carotid stiffness indices; including average CC (0.64±0.29 vs 0.82±0.36 m2/kpa, p=0.004); average DC (11.69±5.42 vs 18.61±11.87 1/kpa, p<0.001); average PWV (16.5±0.6 vs 12.5±3.7 m/s, p<0.001) and average IMT (0.78±0.13 vs 0.68±0.18 mm, p=0.001). Only the carotid PWV was found to be a predictor of vascular stroke (p=0.001) Conclusion Patients with vascular stroke have higher carotid stiffness indices than age matched control subjects. Measuring carotid stiffness indices in patients who have atherosclerotic risk factors may help predict those at risk of vascular stroke and thus guide a tighter and a more efficient risk factors control.

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Prevalence and risk factors associated with Maedi-Visna infection in sheep in the State of Maranhão, Brazil

Research Society and Development ◽

10.33448/rsd-v10i5.14440 ◽

2021 ◽

Vol 10 (5) ◽

pp. e2210514440

Author(s):

Michelle Lemos Vargens ◽

Margarida Paula Carreira de Sá Prazeres ◽

Rosiane de Jesus Barros ◽

Erlin Cely Cotrim Cavalcante ◽

Analy Castro Lustosa Cavalcante ◽

...

Keyword(s):

Risk Factors ◽

The State ◽

Risk Of Infection ◽

Factors Associated ◽

North East ◽

The North ◽

Visna Virus ◽

Group 2 ◽

Group 1 ◽

Control And Eradication

In order to determine Maedi-Visna virus (MVV) seroprevalence and risk factors associated with infection in sheep, 445 animals of both sexes and different ages were tested using the Agarose Gel Immunodiffusion technique (IDGA). The animals were divided into two groups: group 1 composed of exhibition animals (n=70) and group 2 composed of animals from properties from the north, east and central mesoregions of the state of Maranhão (n=375). The general prevalence of MVV infection was 2.02%; 1.42% in group 1 and 2.13% in group 2. In the north mesoregion the prevalence was 2.20%, while a total of 40% of the animals living in municipalities for MVV. It was observed that 1.15% of males and 2.23% of females were seropositive (p> 0.20). Regarding breeds, the Dorper (1.66%); Santa Inês (1.67%); White Dorper (33.33%) and Texel (4.34%) were the most affected. This was the only variable among all the risk factors studied that had a significant association in multivariate analysis (p <0.05). MVV infection is present regardless of the purpose of breeding, and the animals are exposed to the same risk of infection. This demonstrates the need to implement public policies for the prevention, control, and eradication of this disease.

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Pre-Engraftment Syndrome After Myeloablative Umbilical Cord Blood Transplantation: Risk Factors and How To Stratify

Blood ◽

10.1182/blood.v122.21.5482.5482 ◽

2013 ◽

Vol 122 (21) ◽

pp. 5482-5482

Author(s):

Zimin Sun ◽

Maojing Guan ◽

Huilan Liu ◽

Liangquan Geng ◽

Xingbing Wang ◽

...

Keyword(s):

Risk Factors ◽

Clinical Symptoms ◽

Cord Blood Transplantation ◽

Group 4 ◽

Significant Difference ◽

Engraftment Syndrome ◽

Group 3 ◽

Group 2 ◽

One Year ◽

Group 1

Abstract Introduction Pre-engraftment syndrome (PES) is a group of symptoms occurred after hematopoietic stem cell transplantation especially unrelated cord blood transplantation(UCBT) before the engraftment, including unexplained fever higher than 38.3°CAunexplained erythematous skin rashAdiarrheaAhepatic dysfunction Anon-cardiogenic edemaApulmonary infiltrates and weight gain. Severe PES can be fatal, however there’s no criteria to define it. We retrospectively analyzed the incidence, risk factors, manifestations and clinical outcomes of PES in CBT recipients, who had been treated for hematologic malignancies. All patients received TBI(12GY)/Ara-c(8g/ m2)/CY(120mg/kg) without ATG or Flu(120mg/ m2)/Ara-c(8g/ m2)+BU(12.8mg/kg)+CY (120mg/kg) myeloablative conditioning. Methods From April 2010 to July 2011, 61 patients underwent UCBT at our transplantation center and 40 patients(65.6%) developed PES at a median of 7 d (range 5–13) post-transplant. We analyze 8 factors related to treatment-related mortality (TRM) within 180 days : occurrence timeAthe maximum temperatureAclinical symptomsAconcentration of CyclosporinAthe initial dose of MPAmethylprednisolone (MP) effective daysAdays till MP reduced and reoccurrence after symptoms under control. Univariate analysis identified early occurrence time( day +5 or +6 ) AMP effective days and clinical symptoms as significant risk factors for higher TRM. In a multivariate analysis, we found these three factors are independent and have no interactions. We retrospectively analyze all the patients who developed PES from April 2010 to December 2012. Results There were 94 cases and we scored them based on these three factors. The patient got one score for each factor if he/she got a fever on day 5-6 after UCBT or had more than two clinical symptoms or not under control after 7 days of MP. We added the three scores together and divide the patients into four groups according to the total score(zero for Group 1Aone score for Group 2Atwo score for Group 3Athree for Group 4). The number of patients for Group 1-4 was 32A32A18 and 12. There is a significant difference for the TRM within 180 days between Group 4(58%) and Group 1(18.7%)AGroup 2(22.2%) (P<0.01). The TRM of Group 4 in one year is 66.7%, which is significantly higher than Group 1( 22.7%), Group 3(22.2%) (P<0.01), but shows less significant difference compared with TRM of group 2, which is 33%. The relapse rate of one year for each group from 1 to 4 was 9%A16.7%A5.5%A8.3%. The probability of one-year disease-free survival (DFS) was much higher in Group 1 (71.7%) and 3(72.2%) than Group 4(25%) (P<0.01). The difference was apparent as to the probability of one-year overall survival (OS) between Group 1 (74.8%) and 4(25%), the same is true whith Group 3 (71.3%) and 4(25%). The difference between Group 2(55.4%) and Group 4 was not clearly significant (P=0.06). Conclusions Recognizing and treating immediately severe PES will significantly reduce the TRM of UCBT. Our analyze confirmed that these three factors are crucial to define severe PES .We therefore put forward this ranking method to help to diagnosis and take effective treatment. Disclosures: No relevant conflicts of interest to declare.

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Preservation of retinoblastoma group E eyes with neovascular glaucoma using intravenous chemotherapy: risk factors and outcomes

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-313442 ◽

2019 ◽

pp. bjophthalmol-2018-313442 ◽

Cited By ~ 2

Author(s):

Raksha Rao ◽

Santosh G Honavar ◽

Vijayanand Palkonda Reddy

Keyword(s):

Risk Factors ◽

Univariate Analysis ◽

Case Series ◽

Neovascular Glaucoma ◽

Orbital Cellulitis ◽

Intravenous Chemotherapy ◽

Duration Of Symptoms ◽

Significant Difference ◽

Group 2 ◽

Group 1

Background/aimTo report the outcomes of retinoblastoma group E eyes with neovascular glaucoma (NVG) treated conservatively with intravenous chemotherapy and investigate factors associated with eye salvage and secondary enucleation.MethodsThis is a retrospective, comparative, interventional case series. The outcome measures were life salvage, eye salvage and vision salvage.ResultsOf the 37 eyes managed by intravenous chemotherapy, secondary enucleation was necessary in 21 eyes (group 1) and eye salvage was possible in 16 eyes (group 2). A comparison of both groups revealed significant difference with group 1 demonstrating greater duration of symptoms (18.8 weeks vs 5.4 weeks, p=0.016), greater intraocular pressure (IOP) at presentation (36 mm Hg vs 30 mm Hg, p=0.044), greater increase in corneal diameter (1.52 mm vs 0.50 mm, p=0.013) and the presence of sterile orbital cellulitis (9 vs 1, p=0.023). Further, the risk factors for secondary enucleation by univariate analysis were duration of symptoms >10 weeks (p=0.003), presenting IOP >26 mm Hg (p=0.045), buphthalmos (p=0.014) and sterile orbital cellulitis (p=0.023) and by multivariate analysis were age at presentation >6 months (p=0.012) and buphthalmos (p=0.017). At a mean follow-up of 20.5 months, none of the patients in either group developed systemic metastasis.ConclusionFor retinoblastoma group E eyes presenting with NVG, the chance of eye salvage with intravenous chemotherapy is better when the age at diagnosis is <6 months, duration of symptoms is <10 weeks, IOP is <26 mm Hg, and in the absence buphthalmos and sterile orbital inflammation.

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Strabismus in Retinopathy of Prematurity: Risk Factors and the Effect of Macular Ectopia

10.21203/rs.3.rs-553257/v1 ◽

2021 ◽

Author(s):

Selin Şahin Karamert ◽

H. Tuba Atalay ◽

Şengül Özdek

Keyword(s):

Risk Factors ◽

Retinopathy Of Prematurity ◽

Spontaneous Regression ◽

Strongly Correlated ◽

Factors Associated ◽

Group 3 ◽

Group 2 ◽

Retinal Pathologies ◽

The Relationship ◽

Group 1

Abstract PurposeThis study aimed to examine factors associated with strabismus in patients with retinopathy of prematurity (ROP) and the relationship between strabismus and macular ectopia.MethodsPatients with ROP were divided into three groups: Group 1, patients with spontaneous regression (n=45); Group 2, patients who received laser treatment (n=70); and Group 3, patients who underwent surgical treatment (n=91). Rates of anisometropia, amblyopia, nystagmus, macular ectopia, and retinal pathologies were evaluated and their impacts on strabismus development were determined. Disc-to-fovea distance (DFD) was measured from coloured fundus pictures and the correlation of macular ectopia with severity of strabismus was evaluated.ResultsA total of 206 patients were included. Rates of anisometropia, amblyopia, nystagmus, macular ectopia, retinal pathologies causing blindness, and strabismus were higher in Group 3 (p=0.0001) and correlated with higher stages of ROP (p=0.0001). Macular ectopia (p=0.005), retinal pathologies (p=0.005), and amblyopia (p=0.012) had the strongest impact on strabismus development in ROP patients. DFD and severity of strabismus were not significantly correlated (p=0.364). Mean visual acuity (VA) was significantly higher in orthophoric patients compared to those with esotropia and exotropia (p=0.027). Patients with esotropia had lower VA compared to patients with exotropia, but this finding was not statistically significant (p=0.729).ConclusionPresence of macular ectopia, retinal pathologies, and amblyopia were the most strongly correlated risk factors for strabismus development in ROP patients. DFD was not associated with severity of strabismus. Exotropia was mostly related to higher DFD and a possible relationship between esotropia and lower VA was encountered.

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Impact of lordotic cages in the restoration of spinopelvic parameters after dorsal lumbar interbody fusion: a retrospective case control study

International Orthopaedics ◽

10.1007/s00264-020-04719-2 ◽

2020 ◽

Vol 44 (12) ◽

pp. 2665-2672

Author(s):

Stavros Oikonomidis ◽

Vincent Heck ◽

Sonja Bantle ◽

Max Joseph Scheyerer ◽

Christoph Hofstetter ◽

...

Keyword(s):

Lumbar Lordosis ◽

Lumbar Region ◽

Inclusion Criteria ◽

Spinopelvic Parameters ◽

Long Distance ◽

Significant Difference ◽

Group 2 ◽

Segmental Lordosis ◽

Lumbar Spondylodesis ◽

Group 1

Abstract Purpose Aim of this study was to compare the reconstruction of radiological sagittal spinopelvic parameters between lordotic (10°) and normal cages (0°) after dorsal lumbar spondylodesis. Methods This retrospective monocentric study included patients who received dorsal lumbar spondylodesis between January 2014 and December 2018. Inclusion criteria were degenerative lumbar diseases and mono- or bi-segmental fusions in the middle and lower lumbar region. Exclusion criteria were long-distance fusions (3 segments and more) and infectious and tumour-related diseases. The sagittal spinopelvine parameters (lumbar lordosis, segmental lordosis, sacral slope, pelvic incidence, and pelvic tilt) were measured pre- and post-operatively by two examiners at two different times. The patients were divided into 2 groups (group 1: lordotic cage, group 2: normal cage). Results One hundred thirty-eight patients (77 female, 61 male) with an average age of 66.6 ± 11.2 years (min.: 26, max.: 90) were included in the study based on the inclusion criteria. Ninety-two patients (66.7%) received 0° cages and 46 (33.3%) lordotic cages (10°). Segmental lordosis was increased by 4.2° on average in group 1 and by 6.5° in group 2 (p = 0.074). Average lumbar lordosis was increased by 2.1° in group 1 and by 0.6° in group 2 (p = 0.378). There was no significant difference in the correction of sagittal spinopelvic parameters. Inter- and inter-class reliability was between 0.887 and 0.956. Conclusion According to the results of our study, no advantages regarding sagittal radiological parameters for the implantation of a lordotic cage could be demonstrated.

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Risk Factors for Malignant Gallbladder Polyps

Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy ◽

10.5222/bmj.2021.60783 ◽

2021 ◽

Author(s):

Serhan Yılmaz ◽

Hakan Bölükbaşı ◽

Mehmet Abdussamet Bozkurt

Keyword(s):

Risk Factors ◽

Gallstone Disease ◽

Polyp Size ◽

Gallbladder Polyps ◽

Asymptomatic Patients ◽

Increased Risk ◽

Significant Difference ◽

Group 2 ◽

Malignant Polyps ◽

Group 1

PURPOSE: The aim of this study is to determine risk factors for malignancy in gallbladder polyps. METHODS: 92 patients who underwent laparoscopic cholecystectomy due to gallbladder polyp were retrospectively analyzed. Demographic data of the patients, size and number of polyp, the presence of gallstones and histopathological features of the polyps were recorded. RESULTS: 92 patients were included. Mean age was 45.78±11.21 years (21-72). 59 of the patients (64.1%) were female and 33 (35.9%) were male. Mean polyp size was 8.17±2.19 mm and 35 patients (38.0%) had a single polyp, while 57 (62.0%) had multiple polyps (≥2). 47 of the patients (51.1%) had gallstone disease, while 45 (48.9%) had no stone disease. Benign polyps (Group 1) were found in 79 patients (85.9%) and adenocarcinomas (Group 2) were found in 13 (14.1%). Of the benign polyps, 71 (77.1%) were non-neoplastic polyps and 8 (8.8%) were neoplastic polyps (adenomas). Of the 13 patients with adenocarcinomas, 11 (11.9%) were T1a and 2 (2.2%) were T1b. Mean age was 44.32±11.03 years in Group 1 and 54.61±8.07 years in Group 2, the latter being significantly older (p=0.002). Mean polyp size was 7.47±5.51 mm in Group 1 and 12.46±1.89 mm in Group 2, with a significant difference (p<0.001). The cut-off value to detect malignant polyps was a polyp size of 10.5 mm with 92.3% sensitivity, 84.8% specificity, and 0.934 accuracy (p< 0.001). The cut-off value to detect malignant polyps was an age of 50.5 years with 76.9% sensitivity, 67.1% specificity, and 0.767 accuracy (p=0.002). Polyp size and age were important risk factors for malignant gallbladder polyps (p<0.001, OR=2.313; 95% CI: 1.502–3.561), (p=0.004, OR=1.100, 95% CI: 1.030–1.175). CONCLUCISION: We recommend cholecystectomy for asymptomatic patients aged above 50 years with gallbladder polyps larger than 10 mm due to the increased risk of malignancy.

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Cut-out Risk Factor Analysis after Intramedullary Nailing for the Treatment of Extracapsular Fractures of the Proximal Femur: A Retrospective Study

10.21203/rs.3.rs-948144/v1 ◽

2021 ◽

Author(s):

Jae Youn Yoon ◽

Saehan Park ◽

Taehyun Kim ◽

Gun-Il Im

Keyword(s):

Risk Factors ◽

Multivariate Analysis ◽

Surgical Treatment ◽

Clinical Outcomes ◽

Univariate Analysis ◽

High Body Mass Index ◽

Positive Correlation ◽

Factors Associated ◽

Group 2 ◽

Group 1

Abstract BackgroundsThe basic method of surgical treatment for extracapsular hip fracture (ECF), including intertrochanteric fracture and basicervical fracture (BCF), is osteosynthesis. Intramedullary nails are among the most commonly used fixation devices for such fractures. Our study aimed to report the clinical outcomes of ECF treatment with two different nail devices and to analyze the risk factors associated with screw cut-out.MethodsWe retrospectively reviewed the medical records of 273 patients (300 cases) from a single institution who underwent surgical treatment for ECF between January 2013 and October 2018. Overall, 138 patients were eligible for the study and were divided into two groups according to the osteosynthesis device used. We evaluated the clinical outcomes of fracture surgery and performed univariate and multivariate regression analyses to identify risk factors associated with screw cut-out in each group.ResultsWe used proximal femoral nails (group 1) to treat 83 patients and cephalomedullary nails (group 2) to treat 55 patients. Nine cut-outs (group 1, 6 cases; group 2, 3 cases) occurred during follow-up. The patients’ high body mass index (BMI) (p=0.019), BCFs (p=0.007), non-extramedullary reduction in the anteroposterior and lateral planes (p=0.032 and p=0.043, respectively), and anti-rotation screw pull-outs (p=0.041) showed a positive correlation to screw cut-out in the univariate analysis of group 1. In group 2, only BCFs was positively correlated (p=0.020). In the multivariate analysis of group 1, the patients’ BMIs (p=0.024) and BCFs (p=0.024) showed a positive correlation with cut-out. Meanwhile, the multivariate analysis of group 2 did not identify any factors associated with cut-out.ConclusionsThe cut-out risk was significantly higher in the BCF cases, regardless of the nail design used. Considerable attention should be paid to treating such unstable fractures. We expect that new-generation nails using a helical blade, or interlocking derotation and interlocking screws may improve surgical outcomes.

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Risk factors associated with complications of acute appendicitis

Revista do Colégio Brasileiro de Cirurgiões ◽

10.1590/0100-69912017006002 ◽

2017 ◽

Vol 44 (6) ◽

pp. 560-566 ◽

Cited By ~ 2

Author(s):

ANA PAULA MARCONI IAMARINO ◽

YARA JULIANO ◽

OTTO MAURO ROSA ◽

NEIL FERREIRA NOVO ◽

MURILLO DE LIMA FAVARO ◽

...

Keyword(s):

Risk Factors ◽

Acute Appendicitis ◽

Demographic Data ◽

Signs And Symptoms ◽

Control Group ◽

Duration Of Symptoms ◽

Factors Associated ◽

Group 2 ◽

Secondary Hospital ◽

Group 1

ABSTRACT Objective : to identify the main risk factors associated with the development of complications in patients with acute appendicitis. Methods: we conducted a case-control study of 402 patients with acute appendicitis hospitalized in a secondary hospital, divided into two groups: the control group, with 373 patients who progressed without postoperative complications (Group 1) and the study group, with 29 patients who presented complications (Group 2). We evaluated demographic data, signs and symptoms of the disease, imaging tests and hospitalization data. Results: factors associated with complications were fever, radiological and sonographic changes, abrupt positive decompression and diarrhea. Migration of pain, nausea, vomiting and abrupt positive decompression were the findings that were significantly more frequent in both groups (p = 0.05). The duration of signs and symptoms in days in group 2 was significantly higher than in group 1, with a median of three days for the group with complications (p = 0.05). Conclusion: alterations in imaging, fever, diarrhea, positive abrupt decompression, duration of symptoms and lower age are associated with a higher frequency of complications in acute appendicitis, which reinforces the importance of anamnesis, physical examination and indication of complementary exams in the approach of these patients.

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