A study to compare the efficacy, acceptability and side effect of combined contraceptive vaginal ring with the combined oral contraceptive pills in a tertiary health centre located in central India

Background: A study to compare the efficacy, acceptability and side effect of combined contraceptive vaginal ring with the combined oral contraceptive pills in a tertiary health centre (RKDF Medical College and Research Centre, Bhopal) located in central India.Methods: This prospective randomized comparative trial enrolled hundred women aged between 20 to 40 years seeking for contraception with no contraindication to hormonal contraception. After proper counseling and informed consent, women divided into two groups, study group (50) includes women using contraceptive vaginal ring and control group (50) include women using combined oral contraceptives. The contraceptive efficacy, acceptability, tolerability and adverse events were recorded at each follow-up visit at RKDF Medical College and Research Centre, Bhopal.Results: Vaginal ring and combined oral contraceptives were found to have comparable contraceptive efficacy. In study group no pregnancy reported during study period while one pregnancy reported in control group, which was statistically insignificant. Satisfaction, continuation and recommendation to others were more with vaginal ring which were not significant statistically. Cycle control is superior with vaginal ring. Incidence of adverse effects was same in both groups.Conclusions: Combined contraceptive vaginal ring is an effective and reliable contraception with excellent cycle control, well-tolerated and highly acceptable to most women.

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Ormeloxifene versus combined oral contraceptive pills to control blood loss in cases of dysfunctional uterine bleeding

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20195343 ◽

2019 ◽

Vol 8 (12) ◽

pp. 4909

Author(s):

Ankita Gupta ◽

Rishika Raj

Keyword(s):

Oral Contraceptive ◽

Blood Loss ◽

Endometrial Thickness ◽

Uterine Bleeding ◽

Menstrual Blood ◽

Control Group ◽

Dysfunctional Uterine Bleeding ◽

Oral Contraceptive Pills ◽

Combined Oral Contraceptive ◽

Contraceptive Pills

Background: Dysfunctional uterine bleeding is one of the most often encountered gynecologic problems causing anemia, reduced quality of life and unnecessary hysterectomies. A prospective study was conducted on women with DUB to study the effect of ormeloxifene versus combined oral contraceptive pills in controlling blood loss in them.Methods: 100 Women with DUB were enrolled randomly in three groups. After baseline assessment each patient in group A was treated with iron tablets, containing 100 mg elemental iron and folic acid 1.5 mg, for three months and were termed as control group. Group B patients were treated with ormeloxifene in dose of 60 mg twice a week for twelve weeks. Group C patients were treated with combined oral contraceptive pills for twenty- one days starting from third day of their LMP. The treatment was continued for three consecutive cycles. The efficacy of the studied drugs was analyzed by comparing the baseline and post treatment PBAC score, haemoglobin level and endometrial thickness, using appropriate statistical tests.Results: Ormeloxifene was more effective than only iron or combined oral contraceptive therapy in controlling menstrual blood loss (79.11% versus 58.57%). There was a reduction in endometrial thickness in group receiving ormeloxifene as well as in the group receiving combined oral contraceptive pills (p=0.486), however this was statistically not significant.Conclusions: Ormeloxifene was significantly better than combined OCP in reduction of menstrual blood flow in cases of DUB. It has better compliance and marked improvement in subjective symptoms as compared to OCP.

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Comparison of combined hormonal vaginal ring with ultralow-dose combined oral contraceptive pills in the management of heavy menstrual bleeding: A pilot study

Journal of Obstetrics and Gynaecology ◽

10.3109/01443615.2015.1024210 ◽

2015 ◽

Vol 36 (1) ◽

pp. 71-75 ◽

Cited By ~ 6

Author(s):

N. Agarwal ◽

M. Gupta ◽

A. Kriplani ◽

N. Bhatla ◽

N. Singh

Keyword(s):

Oral Contraceptive ◽

Pilot Study ◽

Vaginal Ring ◽

Heavy Menstrual Bleeding ◽

Menstrual Bleeding ◽

Oral Contraceptive Pills ◽

Ultralow Dose ◽

Combined Oral Contraceptive ◽

Contraceptive Pills

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The Effect of Combined Oral Contraceptive Pills on Beclin-1 and LC3B Transcript Levels in Ovarian Endometrioma

BioMed Research International ◽

10.1155/2021/5519538 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Wanwisa Waiyaput ◽

Ongarj Bovornsakulvong ◽

Srithean Lertvikool ◽

Areepan Sophonsritsuk

Keyword(s):

Gene Expression ◽

Oral Contraceptive ◽

Ethinyl Estradiol ◽

Demographic Data ◽

Control Group ◽

Oral Contraceptive Pills ◽

Combined Oral Contraceptive ◽

Contraceptive Pills ◽

Significant Difference ◽

Endometriotic Cyst

Background. Autophagy is likely altered in patients with endometriosis. Ovarian steroid hormones seem to affect this changing of the autophagic process. Objective. To study the effect of combined oral contraceptive (COC) pills on the expression of autophagic-related gene BECN1 and LC3B in the ectopic and eutopic endometria of patients with endometriosis. Material and Methods. The present quasiexperimental study recruited 36 women (18–45 years old) with endometrioma and nonendometrioma who were scheduled for surgery. Patients with endometrioma were randomly assigned to either a no-treatment group ( n = 12 ) or a COC group ( n = 12 ). The COC group was prescribed a daily oral pill composed of 3 mg drospirenone and 0.03 mg ethinyl estradiol for 6 weeks before surgery. The control group ( n = 12 ) was composed of women without endometrioma. Ectopic endometriotic and endometrium tissues were collected from the no-treatment and COC groups, whereas the only endometrium was collected from the control group. These tissues were used for real-time PCR to measure the expression of the BECN1 and LC3B genes. Results. The baseline demographic data were not different among the three groups. The BECN1 gene expression in endometrium tissue in the COC group was significantly less than that in the no-treatment and control groups ( P = 0.011 and 0.029, respectively). No significant difference of endometriotic cyst BECN1 and LC3B gene expression was found between COC and no treatment. Conclusions. Oral COC pills for 6 weeks continuously before surgery decreased the eutopic endometrial expression (mRNA) of the BECN1 gene compared to those from healthy normal women and nontreated patients with an endometriotic cyst. The change in the expression of autophagy-related genes was more distinct in eutopic than ectopic endometria. This trial is registered with TCTR20170720002. Registered and enrolled the first patient on 20 July 2017.

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Combined Oral Contraceptive Pills Containing Desogestrel or Drospirenone Enhance Large Vessel and Microvasculature Vasodilation in Healthy Premenopausal Women

Microcirculation ◽

10.1111/j.1549-8719.2011.00094.x ◽

2011 ◽

Vol 18 (5) ◽

pp. 339-346 ◽

Cited By ~ 16

Author(s):

ABBY K. THOMPSON ◽

AGNIESZKA PRZEMSKA ◽

DAFNI VASILOPOULOU ◽

KATIE J. NEWENS ◽

CHRISTINE M. WILLIAMS

Keyword(s):

Oral Contraceptive ◽

Premenopausal Women ◽

Large Vessel ◽

Oral Contraceptive Pills ◽

Combined Oral Contraceptive ◽

Contraceptive Pills

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Comparative study of ormeloxifene and low dose oral contraceptive pill for the treatment of dysfunctional uterine bleeding in peri-menopausal age group

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20212964 ◽

2021 ◽

Vol 10 (8) ◽

pp. 3112

Author(s):

Maitri Shah ◽

Chirayu Parmar ◽

Riddhi Gor

Keyword(s):

Oral Contraceptive ◽

Blood Loss ◽

Uterine Bleeding ◽

T Test ◽

Wilcoxon Test ◽

Age Group ◽

Dysfunctional Uterine Bleeding ◽

Oral Contraceptive Pills ◽

Combined Oral Contraceptive ◽

Contraceptive Pills

Background: Dysfunctional uterine bleeding (DUB) is the most common menstrual disorder of women in any age group and is a diagnosis of exclusion. Medical management of menorrhagia is a difficult task as there are wide variations in the available drugs and a lot of different regimes are available. Present study evaluates efficacy and safety of ormeloxifene a selective estrogen receptor modulator (SERMs) as compared to combined oral contraceptive pills in treatment of dysfunctional uterine bleeding in perimenopausal women.Methods: Total 60 patients meeting with our inclusion and exclusion criteria were enrolled in the study over a time period of 6 months and were further divided randomly into two groups. One group was given Ormeloxifene and the other group was treated with combined oral contraceptive pills (COCP) over a period of six months. The outcome variables noted were pictorial blood loss assessment chart (PBAC) score, Hb level and combined endometrial thickness (CET). Quantitative variables were compared using independent t test/Mann-Whitney test between the two groups and paired t Test/Wilcoxon test was used for comparison between pre and post within the group.Results: Both ormeloxifene and COCP significantly reduce blood loss in these patients evidenced by decrease of PBAC score, rise in hemoglobin levels and decrease in CET levels. However, ormeloxifene was found to be superior to COCP in reducing the menstrual blood loss. Ormeloxifene was also tolerated better compared to COCP with fewer side effects experienced by patients.

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Histological changes of uterus after comparative treatment of female rats by Trigonella foenum-graecum seeds and combined oral contraceptive pills

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v15i1.1373 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Ahmed Kaid Naji Allow ◽

Ayah Rebhi Hilles ◽

Zainab Yousef ◽

Norbaiyah Mohamed Bakrim ◽

Belqees Ahmed ◽

...

Keyword(s):

Body Weight ◽

Oral Contraceptive ◽

Treated Group ◽

Sprague Dawley ◽

Histological Changes ◽

Fenugreek Seeds ◽

Oral Contraceptive Pills ◽

Trigonella Foenum Graecum ◽

Combined Oral Contraceptive ◽

Contraceptive Pills

Introduction: This study evaluates the histological changes of uterine tissue in the female Sprague Dawley rats after administration of Trigonella foenum-graecum (fenugreek) seeds in comparison to combined oral contraceptive pills (COCPs). Methods: Twenty four female Sprague Dawley strain rats of 8 weeks old were divided into A, B, and C groups. Group A was the control and B was administrated with 0.05 mg/kg body weight of COCPs for 15 days. Group C was treated with 750 mg/kg body weight of fenugreek seed aqueous (FSA) extract for 15 days. The uterine tissues were isolated and studied histologically. Results: The uterine weight in the FSA extract treated group was normal, while in the COCPs treated group it was insignificantly increased. The endometrial thickness and endometrial gland density were normal in the FSA extract treated group, while in the COCPs treated group it was atrophied. Decidual-like cells were observed in the COCPs treated group only. Conclusions: Endometrial atrophy and decidual-like cells were noted after COCPs treatment while in the FSA extract and control groups they were absent. The findings suggest that fenugreek seeds could be used as an alternative natural and safe contraceptive product.

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