scholarly journals Serum lactate dehydrogenase level in pre-eclampsia and its correlation with maternal and fetal outcome

2021 ◽  
Vol 10 (11) ◽  
pp. 4107
Author(s):  
Niyanta P. Vyas ◽  
Nandini Gopalakrishna ◽  
Jessica Fernandes
Keyword(s):  
Lactate Dehydrogenase ◽  
Pulmonary Edema ◽  
Apgar Score ◽  
Hellp Syndrome ◽  
Liver Enzymes ◽  
Biochemical Marker ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Close Monitoring ◽  
Medical Disorders

Background: Hypertensive disorders are the most common medical disorders during pregnancy. It increases maternal and perinatal morbidity and mortality. The incidence is 7 to 10%. Identifying high risk patients and close monitoring can reduce the complications. Lactate dehydrogenase is a useful biochemical marker and can be used to evaluate maternal complications like Disseminated intravascular coagulation (DIC), HELLP syndrome (Haemolysis, elevated liver enzymes and lowered platelets), pulmonary edema, renal failure and fetal complications like Fetal growth restriction (FGR) APGAR score ≤7 at 5 min and Neonatal intensive care unit (NICU) admissions. The objective of this study was to estimate serum Lactate dehydrogenase levels (LDH) in pre-eclampsia patients and study the correlation between increased LDH levels and maternal and fetal outcome.Methods: It was a prospective study from October 2015 to May 2017 at M. S. Ramaiah medical college and hospitals, Bangalore.Results: The incidence of maternal and foetal complications was increased with higher serum LDH levels. With serum LDH >than 600 IU/l the incidence of HELLP syndrome, DIC, pulmonary edema was statistically significant. It also correlated with increased creatinine levels and decreased platelets with p value<0.001. The foetal complications including FGR NICU admission and Apgar score <7 at 5 min was statistically significant. The liver enzymes and serum creatinine correlated with increased LDH levels.Conclusions: Maternal and foetal complications are increased with raised LDH levels, and it can be used as a biochemical marker to achieve a better outcome.

scholarly journals Evaluation of serum lactate dehydrogenase in hypertensive disorders of pregnancy and its comparison with normal pregnancy

2020 ◽  
Vol 9 (8) ◽  
pp. 3270
Author(s):  
Anil Kumar ◽  
Kushla Pathania ◽  
Meenakshi Kandoria
Keyword(s):  
Lactate Dehydrogenase ◽  
Pregnant Women ◽  
Lactic Dehydrogenase ◽  
Serum Lactate ◽  
Morbidity And Mortality ◽  
Serum Lactate Dehydrogenase ◽  
Close Monitoring ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Subsequent Decrease

Background: Hypertensive disorders of pregnancy and their complications rank as one of the major causes of maternal morbidity and mortality. The objective of the study was to compare the level of serum LDH in normotensive and hypertensive pregnant women and to correlate the levels with maternal and foetal outcome.Methods: Study was conducted in department of obstetrics and gynecology Kamla Nehru State Hospital for Mother and Child, Indira Gandhi Medical College, Shimla w.e.f. 15th July, 2014 to 14th July, 2015. Pregnant women enrolled in the study were divided into following groups: - Group 1- Age and parity matched 202 normotensive pregnant women. Group 2- 202 women with hypertensive disorders of pregnancy as per the inclusion and exclusion criteria. Subjects were also divided according to the serum LDH levels into following groups: LDH <600 IU/L, LDH-600-800 IU/L and LDH >800IU/L. The maternal and foetal outcome was correlated with the serum level of LDH. One-way analysis of variance (ANOVA) and the chi-square test were used to compare the results. Differences were considered significant when p<0.05.Results: Severely preeclamptic and eclamptic patients were significantly younger, with low gravidity and parity. The symptoms and complications of preeclampsia and eclampsia along with perinatal mortality were increased significantly in patients with LDH >800 IU/L as compared with those who had lower levels.Conclusions: Lactate dehydrogenase is a useful biochemical marker that reflects the severity of and the occurrence of complications of preeclampsia and eclampsia. Identification of high-risk patients with elevated levels of lactic dehydrogenase, their close monitoring, and prompt, correct management may prevent these complications, with a subsequent decrease in maternal foetal morbidity and mortality.

scholarly journals Serum lactate dehydrogenase (LDH) level in mild and severe preeclampsia as a prognostic marker

2018 ◽  
Vol 7 (10) ◽  
pp. 3969
Author(s):  
Radheshyam Bairwa ◽  
Suhail Iqbal
Keyword(s):  
Lactate Dehydrogenase ◽  
Laboratory Data ◽  
Elevated Serum ◽  
Serum Lactate ◽  
Severe Preeclampsia ◽  
Serum Lactate Dehydrogenase ◽  
Close Monitoring ◽  
Intracellular Enzyme ◽  
Potential Marker ◽  
Control Serum

Background: Lactate Dehydrogenase (LDH) is mainly an intracellular enzyme. Its level is an useful biomarker for cellular injury which may suggested as a potential marker to predict the severity of preeclampsia and indicator for multi-organ involvement have significant role in management of preeclampsia. We conducted this study to examine the relationship between lactate dehydrogenase concentration and the severity of the disease and occurrence of complications. The objective of the present study was to assess role of serum LDH level in mild and severe preeclamptic womenMethods: This prospective study was conducted in the Department of obstetrics and gynecology in Jhalawar medical college from Jan 2017 to Oct 2017 Total 120 pregnant women during third trimester (32-40 weeks) aged 18 to 35 years were selected. Among them 40 were severe preeclampsia and 40 were mild preeclampsia patients and 40 were healthy normotensive control. Serum LDH level was estimated by continuous spectrophotometric method. Demographic, hemodynamic, and laboratory data were compared among the three groups. The symptoms and complications of severe pre-eclampsia along with foetal outcome were analyzed according to the levels of LDH.Results: In this study, serum LDH level was significantly higher (P<0.001) in preeclamptic compared to those of control. Again, this value was significantly higher in severe preeclamptic than those of mild preeclamptic. The symptoms and complications of preeclampsia along with perinatal mortality were increased significantly in patents with LDH> 800IU/I compared with those who had lower levels.Conclusions: From this study, it can be concluded that elevated serum LDH level is associated with severity of preeclampsia. LDH has been evaluated as a biochemical marker for preeclampsia and as a prognosticator of the disease severity. Detection of high-risk patients with increased levels of LDH mandate close monitoring and management to prevent maternal and fetal morbidity and mortality.

scholarly journals Inverse correlation of Serum Lactate Dehydrogenase and Haemoglobin Levels in patients with Oral Submucous Fibrosis

2019 ◽  
Vol 12 (04) ◽  
pp. 1755-1759
Author(s):  
Jimson Sudha ◽  
Amaladas Julius ◽  
Samson Jimson ◽  
Kesavaram Padmavathy
Keyword(s):  
Lactate Dehydrogenase ◽  
Biochemical Marker ◽  
Quantitative Estimation ◽  
Oral Submucous Fibrosis ◽  
Venous Blood ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
P Value ◽  
Healthy Individuals ◽  
Submucous Fibrosis

Serum lactate dehydrogenase (LDH) is a marker of cellular necrosis and is elevated in oral potentially malignant disorders, Oral Submucous Fibrosis (OSMF). Serum LDH levels have been used as a valuable biochemical marker in diagnosis of OSMF. To evaluate and compare the levels of serum LDH and haemoglobin in OSMF with normal healthy individuals. Two mL of venous blood was collected by under aseptic conditions and serum was separated from the normal healthy control subjects (Group 1, n= 22) and the OSMF (clinically and histopathologically confirmed cases) patients (Group 2, n= 22). Quantitative estimation of serum LDH and haemoglobin was performed. Significant rise was observed in the serum LDH levels (518.14 ± 48.62 IU/L) while the mean Hb levels (11.3 ± 1.14) were decreased in patients with OSMF in comparison with normal healthy individuals (LDH: 189.77 ± 28.30 IU/L, Hb: 12.94± 0.98 gm%) (P value < 0.0001, < 0.0001). Serum LDH and Hb estimation would serve as a valuable biochemical marker in the diagnosis of OSMF

scholarly journals Serum lactate dehydrogenase as a biochemical marker for maternal outcome in pre-eclampsia

2021 ◽  
Vol 10 (12) ◽  
pp. 4541
Author(s):  
Gitanjali Kumari ◽  
Vaishali Taralekar ◽  
Suchita Dabhadakr
Keyword(s):  
Lactate Dehydrogenase ◽  
Elevated Serum ◽  
Perinatal Outcomes ◽  
Serum Lactate ◽  
Cellular Damage ◽  
Serum Lactate Dehydrogenase ◽  
Hypertensive Disorder ◽  
Close Monitoring ◽  
Intracellular Enzyme ◽  
Organ Systems

Background: LDH is a cytoplasmic intracellular enzyme present in the heart, kidney, muscle, leukocytes and erythrocytes, of all major organ systems. The presence of LDH in extracellular space points towards cellular damage, endothelial dysfunction. Preeclampsia is a multisystem disorder during pregnancy causing cellular damage or death. Hence, serum LDH levels can be helpful in determining the extent of cell damage and the seriousness of this disease. The present study aimed to correlate the maternal serum lactate dehydrogenase levels with maternal and perinatal outcomes in women with pre-eclampsia.Methods: It was a prospective observational study. A total of 120 antenatal patients diagnosed with hypertensive disorder of pregnancy were included in this study. Serum LDH levels were estimated by enzymatic method on the autoanalyzer. Patients were grouped into 3 categories according to serum LDH levels: a) <600 IU/l, b) 600-800 IU/l c) >800 IU/l. Clinical manifestation of development of complications of hypertensive disease and its relation with serum LDH in respective patients were analyzed.Results: An LDH level of more than 800 IU/l was seen in 19.2% while between 600 to 800 IU/l was seen in 16.7% cases. A significant association was observed between incidence of maternal complications with high LDH levels (p<0.01). High LDH levels were observed to be associated with development of ante-partum haemorrhage, eclampsia and requirement of ICU admission. No significant association was found between different categories of LDH and deep tendon reflexes, levels of proteinuria at the time of admission in these preeclamptic women.Conclusions: Close monitoring and early intervention of the preeclampsia patients with elevated serum LDH levels can help avoid adverse effects of the disease and thereby help improve maternal and perinatal outcomes in pregnant women with preeclampsia.

Lactate Dehydrogenase: Role in the Prediction of Severity in Pre-Eclampsia

2020 ◽  
Vol 16 ◽  
Author(s):  
Feriha Fatima Khidri ◽  
Fozia Shaikh ◽  
Imran-ul-Hassan Khowaja ◽  
Hina Riaz
Keyword(s):  
Lactate Dehydrogenase ◽  
Prognostic Marker ◽  
Biochemical Marker ◽  
Late Onset ◽  
Cross Sectional Study ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional

Background: Pre-eclampsia is the hypertensive pregnancy disorder accompanied by the proteinuria. Serum lactate dehydrogenase (LDH) is a biochemical marker that reflects the severity and progression of pre-eclampsia. Methods: A cross sectional study was conducted at the Liaquat University of medical and health sciences (LUMHS). One hundred pre-eclamptic women were enrolled and grouped into mild (n=30) and severe pre-eclamptic women (n=70) to ascertain the function of LDH as a prognostic marker and to assess its association with severity and gestational age in preeclamptic women. Results: The significant differences in mean concentrations of LDH between mild and severe pre-eclamptic women (P value '0.0001) and early and late onset pre-eclamptic women (P value=0.049) were found. Significant differences were also found in the LDH range between mild and severe pre-eclamptic women presented with late onset pre-eclampsia (P value= 0.004). Statistically significant differences (P value= 0.019) in the levels of LDH were found with systolic blood pressure and proteinuria (P value= 0.048). Conclusion: LDH is the prognostic marker representing the severity of pre-eclampsia. An increased level of LDH directs the adequate monitoring and management; and by early detection of pre-eclampsia serious consequences and complications may be prevented.

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme

A Rapid Electrophoretic Method for the Determination of the Isoenzymes of Serum Lactate Dehydrogenase

1966 ◽  
Vol 12 (5) ◽  
pp. 308-313 ◽  
Author(s):  
Albert W Opher ◽  
Charles S Collier ◽  
Joseph M Miller
Keyword(s):  
Enzyme Activity ◽  
Lactate Dehydrogenase ◽  
Quantitative Determination ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Electrophoretic Method ◽  
The Individual ◽  
Electrophoretic Procedure ◽  
Purple Formazan

Abstract A convenient electrophoretic procedure for the separation and quantitation of lactate dehydrogenase (LDH) isoenzymes is described. The system uses polyacetate Sepraphore III strips.* The areas of activity are shown by incubation with an LDH substrate combined with tetra-nitro-blue-tetrazolium. The reduction of the latter to the purple formazan is quantitatively related to the enzyme activity. Quantitative determination of the individual colored areas is performed by densitometry.

Sign in / Sign up

Export Citation Format

Share Document